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inquiry5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]- Cas no. 302964-08-5 Dasatinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in th
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryN-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino] Cas 302964-08-5 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its interme
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/562.html Product Name N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amin
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inquiryTIANFUCHEM-- 302964-08-5 -- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine c
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryName: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Synonyms: 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methy
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiryN-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide CAS:302964-08-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and t
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Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryN-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide CAS: 302964-08-5 Specification Item Specification Appearance Pale Yellow Powder Assay 98%min Density 1.5
Cas:302964-08-5
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiry2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-meth-ylphenyl)thiazole-5-carboxami-de is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:Off-white to light yellow solid Storage
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryN-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 3h; | 99% |
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 3h; | 99% |
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 9h; Inert atmosphere; | 97.6% |
With trifluorormethanesulfonic acid; trifluoroacetic acid Inert atmosphere; | 97% |
2,4-dichloro-2-methylpyrimidine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With potassium hydride In tetrahydrofuran at -25 - -10℃; for 4h; Reagent/catalyst; Temperature; | 98.7% |
Stage #1: 2,4-dichloro-2-methylpyrimidine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In tetrahydrofuran at 5 - 20℃; for 0.75h; Stage #2: With sodium t-butanolate In tetrahydrofuran at 5 - 10℃; for 2.25h; | 97% |
Stage #1: 2,4-dichloro-2-methylpyrimidine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide With sodium t-butanolate In tetrahydrofuran at 10 - 20℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0 - 5℃; for 2h; pH=2 - 3; Temperature; Reagent/catalyst; | 94% |
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-chloro-succinimide; palladium dichloride In acetonitrile at 100℃; for 12h; | 96.8% |
N-(6-chloro-2-methylpyrimidin-4-yl)hydroxylamine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With sodium methylate In N,N-dimethyl-formamide at 100℃; for 5h; Temperature; | 95% |
2-chloro-N-(2-chloro-6-methylphenyl)acetamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
In methanol for 24h; Solvent; Reflux; | 74% |
1-(6-chloro-2-methylpyrimidin-4-yl)thiourea
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-Bromosuccinimide In tetrahydrofuran; water at 0 - 22℃; for 3h; Stage #2: 1-(6-chloro-2-methylpyrimidin-4-yl)thiourea In tetrahydrofuran; water for 2h; Heating / reflux; | 71% |
Multi-step reaction with 2 steps 1: ethanol / 4 h 2: methanol / 24 h / Reflux View Scheme |
4-amino-6-chloro-2-methylpyrimidine
2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With sodium hydride |
2-chloro-6-methylphenyl isocyanate
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 - -75 °C 1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: NaH / dimethylformamide / 0.5 h 2.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 83 percent / tetrahydrofuran / 4 h / Heating 4.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: NaH / dimethylformamide / 0.5 h / 20 °C 2.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 83 percent / tetrahydrofuran / 4 h / Heating 4.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere 2.1: caesium carbonate / acetone / 10 h / Reflux; Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / Reflux; Inert atmosphere 4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: sodium hydride / tetrahydrofuran / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / Inert atmosphere 4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / Inert atmosphere View Scheme |
2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 83 percent / tetrahydrofuran / 4 h / Heating 3.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0.5 h / 20 °C 1.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 83 percent / tetrahydrofuran / 4 h / Heating 3.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: caesium carbonate / acetone / 10 h / Reflux; Inert atmosphere 2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 4 h / Reflux; Inert atmosphere 3.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / Inert atmosphere 2: sodium hydride / tetrahydrofuran / Inert atmosphere 3: trifluorormethanesulfonic acid; trifluoroacetic acid / Inert atmosphere View Scheme |
N-(4-methoxybenzyl)-2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 83 percent / tetrahydrofuran / 4 h / Heating 2.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 83 percent / tetrahydrofuran / 4 h / Heating 2.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 4 h / Reflux; Inert atmosphere 2.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / Inert atmosphere 2: trifluorormethanesulfonic acid; trifluoroacetic acid / Inert atmosphere View Scheme |
2-chloro-6-methylaniline
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: i-Pr2NEt / tetrahydrofuran 2: TFA / CH2Cl2 3: NaH / tetrahydrofuran View Scheme | |
Multi-step reaction with 4 steps 1: i-Pr2NEt / tetrahydrofuran 2: TFA / CH2Cl2 3: NaNO2; CuBr 4: NaH View Scheme | |
Multi-step reaction with 3 steps 1: pyridine / tetrahydrofuran 2: N-Bromosuccinimide / -10 - 80 °C 3: sodium t-butanolate / tetrahydrofuran / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-chloro-succinimide / acetonitrile / 1.5 h 2: iron(III) chloride; tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide / acetonitrile; water / 5 h / 80 °C 3: sodium methylate / N,N-dimethyl-formamide / 5 h / 100 °C View Scheme |
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaNO2; CuBr 2: NaH View Scheme |
[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: TFA / CH2Cl2 2: NaH / tetrahydrofuran View Scheme | |
Multi-step reaction with 3 steps 1: TFA / CH2Cl2 2: NaNO2; CuBr 3: NaH View Scheme | |
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane 2: sodium t-butanolate / dichloromethane View Scheme | |
Multi-step reaction with 2 steps 1.1: trifluoroacetic acid / 2 h / 25 - 30 °C 2.1: sodium t-butanolate / tetrahydrofuran / 10 - 20 °C 2.2: 2 h / 0 - 5 °C / pH 2 - 3 View Scheme | |
Multi-step reaction with 2 steps 1: trifluoroacetic acid / 25 - 30 °C 2: sodium t-butanolate / tetrahydrofuran / 10 - 30 °C / Inert atmosphere View Scheme |
2,4-dichloro-2-methylpyrimidine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 20 h / 20 °C 2.1: triethylamine / tetrahydrofuran; water / 0.17 h / 120 °C / Microwave irradiation 2.2: 0.17 h / 20 °C 3.1: tert.-butylhydroperoxide; sodium iodide / water / 4 h / 80 °C / Inert atmosphere 4.1: N-chloro-succinimide; palladium dichloride / acetonitrile / 12 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; triethylamine / ethanol / 1.5 h / 110 °C 2: sodium methylate / N,N-dimethyl-formamide / 5 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / N,N-dimethyl-formamide / 72 h / 0 - 20 °C / Inert atmosphere 2: sodium hydroxide; water / methanol; water / 16 h / 20 °C 3: N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere View Scheme |
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / methanol; water / 2 h / 60 °C 2: methanol / 4 h 3: methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / methanol; water / 2 h / 60 °C 2: ethanol / 4 h 3: methanol / 24 h / Reflux View Scheme |
4-amino-6-chloro-2-methylpyrimidine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 24 h / Reflux 2: sodium hydroxide / 2 h / 50 °C 3: methanol / 4 h 4: methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 24 h / Reflux 2: sodium hydroxide / 2 h / 50 °C 3: ethanol / 4 h 4: methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 8 h / Reflux 2: sodium hydroxide / methanol; water / 2 h / 60 °C 3: methanol / 4 h 4: methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 8 h / Reflux 2: sodium hydroxide / methanol; water / 2 h / 60 °C 3: ethanol / 4 h 4: methanol / 24 h / Reflux View Scheme |
6-chloro-2-methylpyrimidin-4-ylcarbamothioylcarbamate
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / 2 h / 50 °C 2: methanol / 4 h 3: methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / 2 h / 50 °C 2: ethanol / 4 h 3: methanol / 24 h / Reflux View Scheme |
(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-Bromosuccinimide / water; 1,4-dioxane / 3 h / 25 - 30 °C 1.2: 2 h / 25 - 70 °C 2.1: sodium t-butanolate / tetrahydrofuran / 8 h / 5 - 30 °C View Scheme |
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / -10 - 80 °C 2: sodium t-butanolate / tetrahydrofuran / 0 - 5 °C View Scheme |
(6-chloro-2-methylpyrimidin-4-yl)thiazol-2-yl-amine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran; water / 0.17 h / 120 °C / Microwave irradiation 1.2: 0.17 h / 20 °C 2.1: tert.-butylhydroperoxide; sodium iodide / water / 4 h / 80 °C / Inert atmosphere 3.1: N-chloro-succinimide; palladium dichloride / acetonitrile / 12 h / 100 °C View Scheme |
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tert.-butylhydroperoxide; sodium iodide / water / 4 h / 80 °C / Inert atmosphere 2: N-chloro-succinimide; palladium dichloride / acetonitrile / 12 h / 100 °C View Scheme |
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iron(III) chloride; tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide / acetonitrile; water / 5 h / 80 °C 2: sodium methylate / N,N-dimethyl-formamide / 5 h / 100 °C View Scheme |
ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide; water / methanol; water / 16 h / 20 °C 2: N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere View Scheme |
2-chloro-6-methylaniline
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; Inert atmosphere; | 480 mg |
piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 100℃; for 4h; | 98% |
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 110 - 120℃; | 81.2% |
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 110℃; for 16h; Inert atmosphere; | 80% |
1-(2-hydroxyethyl)piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
With tetrabutylammomium bromide In acetonitrile at 30 - 80℃; | 97% |
In propan-1-ol at 115 - 120℃; Temperature; | 93% |
With copper(l) chloride In N,N-dimethyl-formamide at 65℃; for 2h; Temperature; Reagent/catalyst; | 91.6% |
1-(2-hydroxyethyl)piperazine
thymin
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
In methanol at 25 - 67℃; Solvent; | 91.38% |
1-(2-hydroxyethyl)piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In 1,4-dioxane for 12h; Reflux; Stage #2: With hydrogenchloride In water | 91% |
1-t-Butoxycarbonylpiperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 80℃; for 12h; | 89% |
Stage #1: 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0333333h; Stage #2: 1-t-Butoxycarbonylpiperazine In N,N-dimethyl-formamide at 110℃; for 16h; | 89.9% |
With N-ethyl-N,N-diisopropylamine In pentan-1-ol for 8h; Reflux; | 84% |
With triethylamine In N,N-dimethyl-formamide at 80℃; | 56.28% |
1-(Ethoxycarbonylmethyl)piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
ethyl 2-(4-(6-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)acetate
Conditions | Yield |
---|---|
In ethanol at 20 - 150℃; for 1.75h; Microwave irradiation; | 89% |
In ethanol at 150℃; for 0.75h; Irradiation; | 89% |
1-(2-hydroxyethyl)piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 0.416667h; | 88.7% |
1-t-Butoxycarbonylpiperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20 - 80℃; for 1h; Inert atmosphere; | 86% |
4-(2-Hydroxyethyl)piperidine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 16h; | 84% |
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 16h; | 84% |
1-(2-hydroxyethyl)piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
dasatinib monohydrate
Conditions | Yield |
---|---|
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In butan-1-ol at 118℃; for 4.5h; Stage #2: With water In ethanol | 83.2% |
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; for 2.5h; Stage #2: With water In N,N-dimethyl-formamide at 20 - 100℃; for 2h; |
1-(2-hydroxyethyl)piperazine
i-Amyl alcohol
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide isoamyl alcohol
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine at 140℃; for 6h; Inert atmosphere; | 81% |
1-(2-hydroxyethyl)piperazine
1-methyl-pyrrolidin-2-one
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide N-methyl-2-pyrrolidone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine at 90℃; for 1.16667h; Inert atmosphere; | 80% |
piperazine-1-carbaldehyde
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80 - 85℃; for 5h; | 79% |
ethylenediamine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
In 1,4-dioxane for 90h; Inert atmosphere; | 76.2% |
at 120℃; for 6h; Inert atmosphere; | 57% |
3-amino-1-(t-butoxycarbonyl)pyrrolidine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 80℃; for 12h; | 75% |
1-(2-hydroxyethyl)piperazine
N,N-dimethyl-formamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide N,N-dimethylformamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine at 90℃; for 3h; Inert atmosphere; | 73% |
3-chloro-aniline
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
C22H18Cl2N6OS
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h; | 73% |
4-chloro-aniline
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-((6-((4-chlorophenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h; | 73% |
3,4-dimethoxyaniline
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-((6-((3,4-dimethoxyphenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h; | 69% |
3-amino-1-(t-butoxycarbonyl)pyrrolidine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20 - 80℃; for 1h; Inert atmosphere; | 68% |
1-(2-hydroxyethyl)piperazine
dimethyl sulfoxide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide dimethylsulfoxide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine at 90℃; for 3h; Inert atmosphere; | 67% |
4-methoxy-aniline
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-((6-((4-methoxyphenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h; | 67% |
3-fluoro-4-bromophenylamine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
2-((6-((4-bromo-3-fluorophenyl)amino)-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h; | 59% |
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