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Hangzhou Maytime Bio-Tech Co.,Ltd.

We are Top Manufacturer of Dasatinib intermediates with high quality and competitive price. Appearance:pale yellow to yellow powder Storage:store in well closed container Package:25kgs/fiber drum Application:Dasatinib intermediate

High quality Dasatinib intermediate CAS:302964-08-5

Cas:302964-08-5

Min.Order:100 Gram

Negotiable

Type:Other

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Yangzhou Qinyuan Pharmatech Co.,Ltd

5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]- Cas no. 302964-08-5 Dasatinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in th

5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-

Cas:302964-08-5

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Wuhan Fortuna Chemical Co.,Ltd

N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino] Cas 302964-08-5 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its interme

N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino] Cas 302964-08-5

Cas:302964-08-5

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Cas:302964-08-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/562.html Product Name N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amin

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Cas:302964-08-5

Min.Order:1 Gram

FOB Price: $6.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 302964-08-5 -- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine c

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Cas:302964-08-5

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Antineoplastic CAS 302964-08-5 Dasatinib 99% Purity Dasatinib Powder Anti-Cancer Dasatinib

Cas:302964-08-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 302964-08-5 with best quality

Cas:302964-08-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2-(6-CHLORO-2-METHYLPYRIMIDIN-4-YLAMINO)-N-(2-CHLORO-6-METHYL

Cas:302964-08-5

Min.Order:10 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Synonyms: 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methy

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl CAS NO 302964-08-5

Cas:302964-08-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]- 302964-08-5

Cas:302964-08-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Qingdao Beluga Import and Export Co., LTD

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide CAS:302964-08-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and t

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-

Cas:302964-08-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide CAS: 302964-08-5 Specification Item Specification Appearance Pale Yellow Powder Assay 98%min Density 1.5

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-

Cas:302964-08-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Nanjing Fred Technology Co.,Ltd.

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-meth-ylphenyl)thiazole-5-carboxami-de is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:Off-white to light yellow solid Storage

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-meth-ylphenyl)thiazole-5-carboxami-de

Cas:302964-08-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-(6-CHLORO-2-METHYLPYRIMIDIN-4-YLAMINO)-N-(2-CHLORO-6-METHYL

Cas:302964-08-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

N-(2-CHLORO-6-METHYLPHENYL)-2-[(6-CHLORO-2-METHYL-4-PYRIMIDINYL)AMINO]-5-THIAZOLECARBOXAMIDE

Cas:302964-08-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Cas:302964-08-5

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N-(2-Chloro-6-methylphenyl)-2-((6-chloro-2-methyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Cas:302964-08-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Dasatinib intermediate

Cas:302964-08-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

N-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
834888-64-1

N-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 3h;99%
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 3h;99%
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 9h; Inert atmosphere;97.6%
With trifluorormethanesulfonic acid; trifluoroacetic acid Inert atmosphere;97%
2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-24-5

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With potassium hydride In tetrahydrofuran at -25 - -10℃; for 4h; Reagent/catalyst; Temperature;98.7%
Stage #1: 2,4-dichloro-2-methylpyrimidine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In tetrahydrofuran at 5 - 20℃; for 0.75h;
Stage #2: With sodium t-butanolate In tetrahydrofuran at 5 - 10℃; for 2.25h;
97%
Stage #1: 2,4-dichloro-2-methylpyrimidine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide With sodium t-butanolate In tetrahydrofuran at 10 - 20℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0 - 5℃; for 2h; pH=2 - 3; Temperature; Reagent/catalyst;
94%
N-(2-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)-amino]-5-thiazolecarboxamide

N-(2-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)-amino]-5-thiazolecarboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With N-chloro-succinimide; palladium dichloride In acetonitrile at 100℃; for 12h;96.8%
N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(6-chloro-2-methylpyrimidin-4-yl)hydroxylamine
126827-01-8

N-(6-chloro-2-methylpyrimidin-4-yl)hydroxylamine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With sodium methylate In N,N-dimethyl-formamide at 100℃; for 5h; Temperature;95%
2-chloro-N-(2-chloro-6-methylphenyl)acetamide
6307-67-1

2-chloro-N-(2-chloro-6-methylphenyl)acetamide

C9H12ClN5S

C9H12ClN5S

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
In methanol for 24h; Solvent; Reflux;74%
1-(6-chloro-2-methylpyrimidin-4-yl)thiourea
77296-31-2

1-(6-chloro-2-methylpyrimidin-4-yl)thiourea

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-Bromosuccinimide In tetrahydrofuran; water at 0 - 22℃; for 3h;
Stage #2: 1-(6-chloro-2-methylpyrimidin-4-yl)thiourea In tetrahydrofuran; water for 2h; Heating / reflux;
71%
Multi-step reaction with 2 steps
1: ethanol / 4 h
2: methanol / 24 h / Reflux
View Scheme
4-amino-6-chloro-2-methylpyrimidine
1749-68-4

4-amino-6-chloro-2-methylpyrimidine

2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-07-4

2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With sodium hydride
2-chloro-6-methylphenyl isocyanate
40398-01-4

2-chloro-6-methylphenyl isocyanate

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 - -75 °C
1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: NaH / dimethylformamide / 0.5 h
2.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 83 percent / tetrahydrofuran / 4 h / Heating
4.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 83 percent / tetrahydrofuran / 4 h / Heating
4.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
2.1: caesium carbonate / acetone / 10 h / Reflux; Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / Inert atmosphere
4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / Inert atmosphere
View Scheme
2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-11-0

2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 4 h / Heating
3.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: NaH / dimethylformamide / 0.5 h / 20 °C
1.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 4 h / Heating
3.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: caesium carbonate / acetone / 10 h / Reflux; Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 4 h / Reflux; Inert atmosphere
3.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / Inert atmosphere
2: sodium hydride / tetrahydrofuran / Inert atmosphere
3: trifluorormethanesulfonic acid; trifluoroacetic acid / Inert atmosphere
View Scheme
N-(4-methoxybenzyl)-2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
834888-63-0

N-(4-methoxybenzyl)-2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 83 percent / tetrahydrofuran / 4 h / Heating
2.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 83 percent / tetrahydrofuran / 4 h / Heating
2.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 4 h / Reflux; Inert atmosphere
2.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / Inert atmosphere
2: trifluorormethanesulfonic acid; trifluoroacetic acid / Inert atmosphere
View Scheme
2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: i-Pr2NEt / tetrahydrofuran
2: TFA / CH2Cl2
3: NaH / tetrahydrofuran
View Scheme
Multi-step reaction with 4 steps
1: i-Pr2NEt / tetrahydrofuran
2: TFA / CH2Cl2
3: NaNO2; CuBr
4: NaH
View Scheme
Multi-step reaction with 3 steps
1: pyridine / tetrahydrofuran
2: N-Bromosuccinimide / -10 - 80 °C
3: sodium t-butanolate / tetrahydrofuran / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: N-chloro-succinimide / acetonitrile / 1.5 h
2: iron(III) chloride; tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide / acetonitrile; water / 5 h / 80 °C
3: sodium methylate / N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-24-5

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaNO2; CuBr
2: NaH
View Scheme
[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester
302964-06-3

[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2
2: NaH / tetrahydrofuran
View Scheme
Multi-step reaction with 3 steps
1: TFA / CH2Cl2
2: NaNO2; CuBr
3: NaH
View Scheme
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane
2: sodium t-butanolate / dichloromethane
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / 2 h / 25 - 30 °C
2.1: sodium t-butanolate / tetrahydrofuran / 10 - 20 °C
2.2: 2 h / 0 - 5 °C / pH 2 - 3
View Scheme
Multi-step reaction with 2 steps
1: trifluoroacetic acid / 25 - 30 °C
2: sodium t-butanolate / tetrahydrofuran / 10 - 30 °C / Inert atmosphere
View Scheme
2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 20 h / 20 °C
2.1: triethylamine / tetrahydrofuran; water / 0.17 h / 120 °C / Microwave irradiation
2.2: 0.17 h / 20 °C
3.1: tert.-butylhydroperoxide; sodium iodide / water / 4 h / 80 °C / Inert atmosphere
4.1: N-chloro-succinimide; palladium dichloride / acetonitrile / 12 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; triethylamine / ethanol / 1.5 h / 110 °C
2: sodium methylate / N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / N,N-dimethyl-formamide / 72 h / 0 - 20 °C / Inert atmosphere
2: sodium hydroxide; water / methanol; water / 16 h / 20 °C
3: N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere
View Scheme
C13H11ClN4OS

C13H11ClN4OS

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol; water / 2 h / 60 °C
2: methanol / 4 h
3: methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol; water / 2 h / 60 °C
2: ethanol / 4 h
3: methanol / 24 h / Reflux
View Scheme
4-amino-6-chloro-2-methylpyrimidine
1749-68-4

4-amino-6-chloro-2-methylpyrimidine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrahydrofuran / 24 h / Reflux
2: sodium hydroxide / 2 h / 50 °C
3: methanol / 4 h
4: methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 24 h / Reflux
2: sodium hydroxide / 2 h / 50 °C
3: ethanol / 4 h
4: methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 8 h / Reflux
2: sodium hydroxide / methanol; water / 2 h / 60 °C
3: methanol / 4 h
4: methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 8 h / Reflux
2: sodium hydroxide / methanol; water / 2 h / 60 °C
3: ethanol / 4 h
4: methanol / 24 h / Reflux
View Scheme
6-chloro-2-methylpyrimidin-4-ylcarbamothioylcarbamate
77296-30-1

6-chloro-2-methylpyrimidin-4-ylcarbamothioylcarbamate

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / 2 h / 50 °C
2: methanol / 4 h
3: methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / 2 h / 50 °C
2: ethanol / 4 h
3: methanol / 24 h / Reflux
View Scheme
(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide
863127-76-8

(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / water; 1,4-dioxane / 3 h / 25 - 30 °C
1.2: 2 h / 25 - 70 °C
2.1: sodium t-butanolate / tetrahydrofuran / 8 h / 5 - 30 °C
View Scheme
N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide

N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / -10 - 80 °C
2: sodium t-butanolate / tetrahydrofuran / 0 - 5 °C
View Scheme
(6-chloro-2-methylpyrimidin-4-yl)thiazol-2-yl-amine
1034919-70-4

(6-chloro-2-methylpyrimidin-4-yl)thiazol-2-yl-amine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran; water / 0.17 h / 120 °C / Microwave irradiation
1.2: 0.17 h / 20 °C
2.1: tert.-butylhydroperoxide; sodium iodide / water / 4 h / 80 °C / Inert atmosphere
3.1: N-chloro-succinimide; palladium dichloride / acetonitrile / 12 h / 100 °C
View Scheme
2-(6-chloro-2-methylpyrimidine-4-yl)amino-5-hydroxymethylthiazole

2-(6-chloro-2-methylpyrimidine-4-yl)amino-5-hydroxymethylthiazole

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tert.-butylhydroperoxide; sodium iodide / water / 4 h / 80 °C / Inert atmosphere
2: N-chloro-succinimide; palladium dichloride / acetonitrile / 12 h / 100 °C
View Scheme
C7H7Cl2N

C7H7Cl2N

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iron(III) chloride; tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide / acetonitrile; water / 5 h / 80 °C
2: sodium methylate / N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate
1202357-66-1

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; water / methanol; water / 16 h / 20 °C
2: N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere
View Scheme
2-((6-chloro-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxylic acid

2-((6-chloro-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxylic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; Inert atmosphere;480 mg
piperazine
110-85-0

piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
910297-51-7

N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 100℃; for 4h;98%
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 110 - 120℃;81.2%
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 110℃; for 16h; Inert atmosphere;80%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With tetrabutylammomium bromide In acetonitrile at 30 - 80℃;97%
In propan-1-ol at 115 - 120℃; Temperature;93%
With copper(l) chloride In N,N-dimethyl-formamide at 65℃; for 2h; Temperature; Reagent/catalyst;91.6%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

thymin
65-71-4

thymin

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatinib-thymine

dasatinib-thymine

Conditions
ConditionsYield
In methanol at 25 - 67℃; Solvent;91.38%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Dasatinib hydrochloride

Dasatinib hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In 1,4-dioxane for 12h; Reflux;
Stage #2: With hydrogenchloride In water
91%
1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

tbutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

tbutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 12h;89%
Stage #1: 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0333333h;
Stage #2: 1-t-Butoxycarbonylpiperazine In N,N-dimethyl-formamide at 110℃; for 16h;
89.9%
With N-ethyl-N,N-diisopropylamine In pentan-1-ol for 8h; Reflux;84%
With triethylamine In N,N-dimethyl-formamide at 80℃;56.28%
1-(Ethoxycarbonylmethyl)piperazine
40004-08-8

1-(Ethoxycarbonylmethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

ethyl 2-(4-(6-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)acetate
910297-62-0

ethyl 2-(4-(6-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)acetate

Conditions
ConditionsYield
In ethanol at 20 - 150℃; for 1.75h; Microwave irradiation;89%
In ethanol at 150℃; for 0.75h; Irradiation;89%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-(6-(4-(3-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide ethanolate

N-(2-chloro-6-methylphenyl)-2-(6-(4-(3-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide ethanolate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 0.416667h;88.7%
1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
910297-51-7

N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20 - 80℃; for 1h; Inert atmosphere;86%
4-(2-Hydroxyethyl)piperidine
622-26-4

4-(2-Hydroxyethyl)piperidine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 16h;84%
methyl piperidine-4-acetate hydrochloride

methyl piperidine-4-acetate hydrochloride

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

C24H27ClN6O3S

C24H27ClN6O3S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 16h;84%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In butan-1-ol at 118℃; for 4.5h;
Stage #2: With water In ethanol
83.2%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; for 2.5h;
Stage #2: With water In N,N-dimethyl-formamide at 20 - 100℃; for 2h;
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

i-Amyl alcohol
123-51-3

i-Amyl alcohol

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide isoamyl alcohol
1613319-06-4

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide isoamyl alcohol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 140℃; for 6h; Inert atmosphere;81%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide N-methyl-2-pyrrolidone
1613319-05-3

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide N-methyl-2-pyrrolidone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 90℃; for 1.16667h; Inert atmosphere;80%
piperazine-1-carbaldehyde
7755-92-2

piperazine-1-carbaldehyde

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-(4-formylpiperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-(4-formylpiperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80 - 85℃; for 5h;79%
ethylenediamine
107-15-3

ethylenediamine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
910297-59-5

2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
In 1,4-dioxane for 90h; Inert atmosphere;76.2%
at 120℃; for 6h; Inert atmosphere;57%
3-amino-1-(t-butoxycarbonyl)pyrrolidine
186550-13-0

3-amino-1-(t-butoxycarbonyl)pyrrolidine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

C25H30ClN7O3S

C25H30ClN7O3S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 80℃; for 12h;75%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide N,N-dimethylformamide
1229345-36-1

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide N,N-dimethylformamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 90℃; for 3h; Inert atmosphere;73%
3-chloro-aniline
108-42-9

3-chloro-aniline

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

C22H18Cl2N6OS
1587622-91-0

C22H18Cl2N6OS

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h;73%
4-chloro-aniline
106-47-8

4-chloro-aniline

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-((4-chlorophenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
1587623-11-7

N-(2-chloro-6-methylphenyl)-2-((6-((4-chlorophenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h;73%
3,4-dimethoxyaniline
6315-89-5

3,4-dimethoxyaniline

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-((3,4-dimethoxyphenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
1587622-97-6

N-(2-chloro-6-methylphenyl)-2-((6-((3,4-dimethoxyphenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h;69%
3-amino-1-(t-butoxycarbonyl)pyrrolidine
186550-13-0

3-amino-1-(t-butoxycarbonyl)pyrrolidine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

C20H22ClN7OS

C20H22ClN7OS

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20 - 80℃; for 1h; Inert atmosphere;68%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide dimethylsulfoxide
1228188-51-9

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide dimethylsulfoxide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 90℃; for 3h; Inert atmosphere;67%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-((4-methoxyphenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
1587622-96-5

N-(2-chloro-6-methylphenyl)-2-((6-((4-methoxyphenyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h;67%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-((6-((4-bromo-3-fluorophenyl)amino)-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
1587622-95-4

2-((6-((4-bromo-3-fluorophenyl)amino)-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 110℃; for 12h;59%

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