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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Bromo-3-fluoroaniline Manufacturer/High quality/Best price/In stock

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

4-Bromo-3-fluoroaniline CAS No.:656-65-5 Name: 4-Bromo-3-fluoroaniline Molecular Structure Molecular Formula: C6H5BrFN Molecular Weight: 190.01 CAS Registry Number: 656-65-5 D

High purity 4-Bromo-3-fluoroaniline CAS No.:656-65-5

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Bromo-3-Fluoroaniline

Cas:656-65-5

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

4-Bromo-3-fluoroaniline Basic information Product Name: 4-Bromo-3-fluoroaniline Synonyms: 4-BROMO-3-FLUOROPHENYLAMINE;4-BROMO-3-FLUOROANILINE;4-Bromo-3-fluoroanilin

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-Fluoro-4-broMoaniline 656-65-5

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 656-65-5 with fast shipping

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

4-Bromo-3-fluoroaniline CAS656-65-5

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name 4-Bromo-3-fluoroaniline Synonyms 4-Bromo-3-fluoroaniline98%;4-Bromo-3-fluorobenzenamine;4-Bromo-3-fluoroanil;4-BroMo-3-fluoroaniline, 98% 5GR;4-BroMo-3-fluoroaniline, 97+%;4 - broMin

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Bromo-3-fluoroaniline 656-65-5

Cas:656-65-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

4-Bromo-3-fluoroaniline CAS:656-65-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

4-Bromo-3-fluoroaniline CAS:656-65-5

Cas:656-65-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Bromo-3-fluoroaniline/ LIDE PHARMA- Factory supply / Best price

Cas:656-65-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 656-65-5 4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:656-65-5

Cas:656-65-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Bromo-3-fluoroaniline 656-65-5

Cas:656-65-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Bromo-3-fluoroaniline/Manufacturer/High quality/Best price

Cas:656-65-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-Bromo-3-fluoroaniline 656-65-5

Cas:656-65-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

4-Bromo-3-fluoroaniline Basic information Product Name: 4-Bromo-3-fluoroaniline Synonyms: 4-BROMO-3-FLUOROPHENYLAMINE;4-BROMO-3-FLUOROANILINE;4-Bromo-3-fluoroaniline98%;4-Bromo-3-fluorobenzenamine;4-Bromo-3-fluoroanil;4-BroMo-3-fluoroaniline,

4-Bromo-3-fluoroaniline

Cas:656-65-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-(4-bromo-3-fluorophenyl)ethanamide
351-30-4

N-(4-bromo-3-fluorophenyl)ethanamide

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

Conditions
ConditionsYield
With hydrogenchloride; water In ethanol at 80℃; for 4h;100%
With hydrogenchloride In ethanol for 2h; Heating;99%
meta-fluoroaniline
372-19-0

meta-fluoroaniline

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

Conditions
ConditionsYield
With 1-hexyl-3-methyl-1-imidazolium bromide; copper(ll) bromide for 0.166667h; regioselective reaction;90%
With tetrabutylammomium bromide; copper(ll) bromide In ethanol at 25℃; regioselective reaction;80%
Multi-step reaction with 3 steps
1: 70 percent / acetic acid / 0.33 h / Heating
2: 100 percent / NBS / CH2Cl2 / a) reflux, 5 h, b) room temp., 16 h
3: 99 percent / 36percent HCl / ethanol / 2 h / Heating
View Scheme
With N-Bromosuccinimide In dimethyl sulfoxide at 20℃; regioselective reaction;> 95 %Chromat.
Multi-step reaction with 3 steps
1: acetic acid / 3 h / 105 °C
2: N-Bromosuccinimide / dichloromethane / 24 h / 60 °C
3: hydrogenchloride; water / ethanol / 4 h / 80 °C
View Scheme
4-bromo-3-fluorobenzonitrile
133059-44-6

4-bromo-3-fluorobenzonitrile

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

Conditions
ConditionsYield
Stage #1: 4-bromo-3-fluorobenzonitrile With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran at -5 - 5℃; for 2h;
Stage #2: With sodium hypochlorite In water at -5 - 5℃; for 8h; Temperature;
79%
N-(3-fluorophenyl)acetamide
351-28-0

N-(3-fluorophenyl)acetamide

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / NBS / CH2Cl2 / a) reflux, 5 h, b) room temp., 16 h
2: 99 percent / 36percent HCl / ethanol / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: N-bromo-succinimide
View Scheme
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / dichloromethane / 24 h / 60 °C
2: hydrogenchloride; water / ethanol / 4 h / 80 °C
View Scheme
meta-fluoroaniline
372-19-0

meta-fluoroaniline

A

2-bromo-5-fluoroaniline
1003-99-2

2-bromo-5-fluoroaniline

B

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

Conditions
ConditionsYield
With N-Bromosuccinimide In DCE at 20℃;A 11 %Chromat.
B 89 %Chromat.
3,4-Difluorobenzonitrile
64248-62-0

3,4-Difluorobenzonitrile

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonia / ethanol / 24 h / 70 - 80 °C
2.1: hydrogen bromide; copper(I) bromide; sodium nitrite / water / 4 h / -5 - 5 °C
3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 2 h / -5 - 5 °C
3.2: 8 h / -5 - 5 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

tert-butyl N-(4-bromo-3-fluorophenyl)carbamate
868735-43-7

tert-butyl N-(4-bromo-3-fluorophenyl)carbamate

Conditions
ConditionsYield
In 1,4-dioxane; water at 80℃;100%
In water at 20℃; for 40h;94%
In water at 20℃; for 16h;76%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

N-(4-bromo-5-fluoro-2-nitrophenyl)-2,2,2-trifluoroacetamide
929279-27-6

N-(4-bromo-5-fluoro-2-nitrophenyl)-2,2,2-trifluoroacetamide

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-bromophenylamine; trifluoroacetic anhydride at 0℃; for 0.5h;
Stage #2: With potassium nitrate at 0 - 25℃;
100%
With ammonium nitrate In chloroform for 2h;95%
Stage #1: 3-fluoro-4-bromophenylamine; trifluoroacetic anhydride With ammonium nitrate In chloroform at 20℃; for 2.16667h;
Stage #2: With sodium hydrogencarbonate In chloroform; water pH=~ 8;
95%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

benzyl chloroformate
501-53-1

benzyl chloroformate

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester
510729-01-8

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In acetone at 15 - 22℃; for 1.5h;100%
Stage #1: 3-fluoro-4-bromophenylamine With sodium hydrogencarbonate In tetrahydrofuran at 0℃; for 0.0833333h;
Stage #2: benzyl chloroformate In tetrahydrofuran at 0℃; for 3h;
100%
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 24h;94%
hexamethylene imine
111-49-9

hexamethylene imine

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

4-bromophenyl isocyanate
2493-02-9

4-bromophenyl isocyanate

5-azepan-1-yl-pentanoic acid (4-bromo-3-fluoro-phenyl)-amide
948883-08-7

5-azepan-1-yl-pentanoic acid (4-bromo-3-fluoro-phenyl)-amide

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-bromophenylamine; 4-bromophenyl isocyanate With triethylamine In dichloromethane at 20℃; for 2h;
Stage #2: hexamethylene imine With triethylamine In 1,2-dichloro-ethane at 55℃; for 4h;
100%
(5-cyano-1-methyl-1H-pyrrol-2-yl)boronic acid
860617-71-6

(5-cyano-1-methyl-1H-pyrrol-2-yl)boronic acid

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

5-(4-amino-2-fluorophenyl)-1-methyl-1H-pyrrole-2-carbonitrile
922505-85-9

5-(4-amino-2-fluorophenyl)-1-methyl-1H-pyrrole-2-carbonitrile

Conditions
ConditionsYield
Stage #1: (5-cyano-1-methyl-1H-pyrrol-2-yl)boronic acid; 3-fluoro-4-bromophenylamine With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran for 0.166667h;
Stage #2: tri-tert-butyl phosphine In tetrahydrofuran; hexanes at 25℃; for 16h;
98%
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In tetrahydrofuran; hexanes at 25℃; for 16.08h;98%
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In tetrahydrofuran27%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

ethyl acrylate
140-88-5

ethyl acrylate

ethyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate
865137-76-4

ethyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate

Conditions
ConditionsYield
With palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 110℃; for 5h; Heck reaction; Inert atmosphere;96%
With palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 80℃; for 4h; Heck reaction; Inert atmosphere;86%
With N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 110℃; for 5h; Mitsunobu reaction;
With N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate In N,N-dimethyl-formamide at 110℃; for 5h;
2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
660867-80-1

2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

3-fluoro-4-(2-methylpyridin-4-yl)aniline
1314787-88-6

3-fluoro-4-(2-methylpyridin-4-yl)aniline

Conditions
ConditionsYield
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 95℃; for 16h;96%
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 95℃; for 16h;96%
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 95℃; for 16h;96%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

methyl chloroformate
79-22-1

methyl chloroformate

(4-bromo-3-fluoro-phenyl)-carbamic acid methyl ester
396076-65-6

(4-bromo-3-fluoro-phenyl)-carbamic acid methyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 20℃; for 5h;94.3%
With sodium hydrogencarbonate In dichloromethane; water at 20℃; for 4.5h; Inert atmosphere;92%
With pyridine In dichloromethane at 25℃; for 2h;84.6%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

phenylacetylene
536-74-3

phenylacetylene

3-fluoro-4-(phenylethynyl)aniline

3-fluoro-4-(phenylethynyl)aniline

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In dimethyl sulfoxide at 20℃; for 5h; Sonogashira Cross-Coupling;94%
1,2-bis-(chlorodimethylsilyl)ethane
13528-93-3

1,2-bis-(chlorodimethylsilyl)ethane

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

1-(4-bromo-3-fluorophenyl)-2,2,5,5-tetramethyl-1,2,5-azadisilalidine
195817-59-5

1-(4-bromo-3-fluorophenyl)-2,2,5,5-tetramethyl-1,2,5-azadisilalidine

Conditions
ConditionsYield
With triethylamine In dichloromethane93%
With triethylamine In dichloromethane for 48h;93%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

N-(4-bromo-3-fluoro-phenyl)-methanesulfonamide
879486-59-6

N-(4-bromo-3-fluoro-phenyl)-methanesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 1h;93%
In pyridine; ethyl acetate1.235 g (88%)
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

3,4,5-trifluorophenylboronic acid
143418-49-9

3,4,5-trifluorophenylboronic acid

2,3',4',5'-tetrafluoro-4-benzidine

2,3',4',5'-tetrafluoro-4-benzidine

Conditions
ConditionsYield
With bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium carbonate In water; N,N-dimethyl-formamide for 6h; Reagent/catalyst; Reflux; Inert atmosphere;91.3%
5-chloro-2-hydroxybenzoic acid
321-14-2

5-chloro-2-hydroxybenzoic acid

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

N-(4-bromo-3-fluorophenyl)-5-chloro-2-hydroxybenzamide
1000054-74-9

N-(4-bromo-3-fluorophenyl)-5-chloro-2-hydroxybenzamide

Conditions
ConditionsYield
With phosphorus trichloride In toluene for 2h; Heating / reflux;90%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

4-bromo-5-fluoro-2-iodoaniline
1219741-79-3

4-bromo-5-fluoro-2-iodoaniline

Conditions
ConditionsYield
With N-iodo-succinimide In acetic acid at 25℃; for 1.5h;90%
With N-iodo-succinimide; acetic acid In ethyl acetate at 20℃; for 1.5h;87%
With N-iodo-succinimide; acetic acid at 0℃;62.5%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

C6H3BrFN3
1492715-10-2

C6H3BrFN3

Conditions
ConditionsYield
With hydrogenchloride; sodium azide; sodium nitrite In water at 0 - 5℃; for 2h;89%
With hydrogenchloride; sodium azide; sodium nitrite In water at 0 - 20℃; for 2h;
C8H6F3O3S2(1-)*Na(1+)

C8H6F3O3S2(1-)*Na(1+)

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

N-(4-bromo-3-fluorophenyl)-4-(trifluoromethyl)-benzothioamide

N-(4-bromo-3-fluorophenyl)-4-(trifluoromethyl)-benzothioamide

Conditions
ConditionsYield
With 1H-imidazole; sodium carbonate; dimethyl sulfoxide at 135℃; for 48h; Inert atmosphere; Schlenk technique;86%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

glycerol
56-81-5

glycerol

6-bromo-7-fluoroquinoline
127827-52-5

6-bromo-7-fluoroquinoline

Conditions
ConditionsYield
With sulfuric acid; sodium 3-nitrobenzenesulfonate In water at 120 - 140℃;85.8%
With sulfuric acid; sodium 3-nitrobenzenesulfonate In water at 110 - 140℃;81%
Stage #1: 3-fluoro-4-bromophenylamine; glycerol With sulfuric acid; iron(II) sulfate In nitrobenzene at 130℃; for 14h;
Stage #2: With ammonia; water In nitrobenzene at 20℃; pH=~ 8;
51.9%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

4-amino-6-chloro-pyrimidine-5-carbaldehyde
14160-93-1

4-amino-6-chloro-pyrimidine-5-carbaldehyde

C11H8BrFN4O*ClH
1004956-71-1

C11H8BrFN4O*ClH

Conditions
ConditionsYield
With hydrogenchloride In acetonitrile at 70 - 75℃;85%
methyl 3-cyclopropyl-3-oxopropanoate
32249-35-7

methyl 3-cyclopropyl-3-oxopropanoate

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

methyl 3-(4-bromo-3-fluorophenylamino)-2-(cyclopropanecarbonyl)acrylate
1356953-34-8

methyl 3-(4-bromo-3-fluorophenylamino)-2-(cyclopropanecarbonyl)acrylate

Conditions
ConditionsYield
at 140℃;85%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

trimethyl orthoformate
149-73-5

trimethyl orthoformate

5-(((4-bromo-3-fluorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
1581270-02-1

5-(((4-bromo-3-fluorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Stage #1: cycl-isopropylidene malonate; trimethyl orthoformate at 100℃; for 1.5h;
Stage #2: 3-fluoro-4-bromophenylamine In acetonitrile at 80 - 100℃; for 3.5h;
85%
Stage #1: cycl-isopropylidene malonate; trimethyl orthoformate at 100℃; for 1.5h;
Stage #2: 3-fluoro-4-bromophenylamine at 80 - 100℃; for 3.5h;
71.3%
Stage #1: cycl-isopropylidene malonate; trimethyl orthoformate at 100℃; for 2h; Inert atmosphere;
Stage #2: 3-fluoro-4-bromophenylamine at 100℃; Inert atmosphere;
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

acetophenone
98-86-2

acetophenone

3-(4-bromo-3-fluorophenylamino)-1-phenyl-3-ptolylpropan-1-one

3-(4-bromo-3-fluorophenylamino)-1-phenyl-3-ptolylpropan-1-one

Conditions
ConditionsYield
With 1-butyl-1,2,4-triazolium methanesulfonate In ethanol at 20℃; for 0.333333h; Reagent/catalyst; Mannich Aminomethylation;85%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

diethyl 2-[[(4-bromo-3-fluorophenyl)amino]methylidene]propanedioate
953803-86-6

diethyl 2-[[(4-bromo-3-fluorophenyl)amino]methylidene]propanedioate

Conditions
ConditionsYield
In ethanol at 80℃; for 4h; Inert atmosphere;84%
In ethanol at 80℃; for 4h; Inert atmosphere;84%
In ethanol at 80℃; for 4h; Inert atmosphere;84%
chloral ethyl hemiacetal
515-83-3

chloral ethyl hemiacetal

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

5‐bromo‐6‐fluoro‐1H‐indole‐2,3‐dione
118897-99-7

5‐bromo‐6‐fluoro‐1H‐indole‐2,3‐dione

Conditions
ConditionsYield
Stage #1: chloral ethyl hemiacetal; 3-fluoro-4-bromophenylamine With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water at 55℃; for 20h;
Stage #2: With sulfuric acid at 60 - 80℃; for 0.333333h;
83%
Stage #1: chloral ethyl hemiacetal; 3-fluoro-4-bromophenylamine With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water at 55℃; for 20h;
Stage #2: With sulfuric acid at 60 - 80℃; for 0.333333h;
83%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

isoquinoline 5-boronic acid
371766-08-4

isoquinoline 5-boronic acid

3-fluoro-4-(isoquinolin-5-yl)benzenamine
1038867-89-8

3-fluoro-4-(isoquinolin-5-yl)benzenamine

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 110℃; for 4h;82%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

(4-bromo-3-fluorophenyl)hydrazine hydrochloride

(4-bromo-3-fluorophenyl)hydrazine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-bromophenylamine With hydrogenchloride; sodium nitrite In water at -10℃; for 0.5h;
Stage #2: With tin(II) chloride hydrate In water at 20℃; for 1h;
82%
Stage #1: 3-fluoro-4-bromophenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h;
Stage #2: With hydrogenchloride; tin(ll) chloride In water at 20℃; for 0.25h;
17%
tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

tert-butyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate
865138-40-5

tert-butyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate

Conditions
ConditionsYield
With palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 110℃; Heck reaction; Inert atmosphere;80%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

benzaldehyde
100-52-7

benzaldehyde

acetophenone
98-86-2

acetophenone

3-(4-bromo-3-fluorophenylamino)-1,3-diphenylpropan-1-one

3-(4-bromo-3-fluorophenylamino)-1,3-diphenylpropan-1-one

Conditions
ConditionsYield
With 1-butyl-1,2,4-triazolium methanesulfonate In ethanol at 20℃; for 0.333333h; Reagent/catalyst; Mannich Aminomethylation;80%
3-fluoro-4-bromophenylamine
656-65-5

3-fluoro-4-bromophenylamine

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

acetophenone
98-86-2

acetophenone

3-(4-bromo-3-fluorophenylamino)-3-(4-chlorophenyl)-1-phenylpropan-1-one

3-(4-bromo-3-fluorophenylamino)-3-(4-chlorophenyl)-1-phenylpropan-1-one

Conditions
ConditionsYield
With 1-butyl-1,2,4-triazolium methanesulfonate In ethanol at 20℃; for 0.0833333h; Reagent/catalyst; Mannich Aminomethylation;79%

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