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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Fluoro-4-iodoaniline Manufacturer/High quality/Best price/In stock

Cas:656-66-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

3-fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

3-Fluoro-4-iodoaniline Basic information Product Name: 3-Fluoro-4-iodoaniline Synonyms: 3-FLUORO-4-IODOANILINE;BUTTPARK 120\07-56;3-Fluoro-4-iodobenzenamine;3-Fluor

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-Fluoro-4-iodoaniline 656-66-6

Cas:656-66-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

CAS: 656-66-6 MF: C6H5FIN MW: 237.01 EINECS: 690-811-1

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzenamine,3-fluoro-4-iodo-

Cas:656-66-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Gram

FOB Price: $1148.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenamine,3-fluoro-4-iodo-

Cas:656-66-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:656-66-6

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Fluoro-4-iodoaniline Synonyms: 3-FLUORO-4-IODOANILINE;BUTTPARK 120\07-56;3-Fluoro-4-iodo-phenylaMine;3-Fluoro-4-iodobenzenamine;3-Fluoro-4-iodoaniline, 98%+;Benzenamine, 3-fluoro-4-iodo- CAS: 656-66-6 MF: C6H5FIN MW: 23

3-Fluoro-4-iodoaniline 656-66-6 C6H5FIN

Cas:656-66-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--High purity 4-Bromo-3-fluoroaniline factory price3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceuti

3-Fluoro-4-iodoaniline Manufacturer/High quality/Best price/In stock CAS NO.656-66-6

Cas:656-66-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--High purity 4-Bromo-3-fluoroaniline factory price3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--High purity 4-Bromo-3-fluoroaniline factory price3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

Capability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--High purity 4-Bromo-3-fluoroaniline factory price3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Fluoro-4-Iodoaniline cas no. 656-66-6 98%

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-Fluoro-4-Iodoaniline

Cas:656-66-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 3-Fluoro-4-iodoaniline 5g

Cas:656-66-6

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Grams, Kilograms Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

3-Fluoro-4-iodoaniline

Cas:656-66-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

meta-fluoroaniline
372-19-0

meta-fluoroaniline

A

3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

B

5-fluoro-2,4-diiodoaniline

5-fluoro-2,4-diiodoaniline

C

5-fluoro-2-iodoaniline

5-fluoro-2-iodoaniline

Conditions
ConditionsYield
With iodine; sodium hydrogencarbonate In water at 20℃; for 0.5h;A 74%
B 6%
C 4%
meta-fluoroaniline
372-19-0

meta-fluoroaniline

3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

Conditions
ConditionsYield
With iron(III) chloride; N-iodo-succinimide; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 20℃; for 2h; Inert atmosphere;62%
With iodine; sodium hydrogencarbonate In water at 20℃; for 3h;62%
With sodium periodate; sulfuric acid; iodine In acetic acid at 80℃; for 4h;50%
With iodine; mercury(II) oxide In ethanol
With iodine; sodium hydrogencarbonate In water at 20℃;
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

3-fluoro-4-[(trimethylsilyl)ethynyl]aniline

3-fluoro-4-[(trimethylsilyl)ethynyl]aniline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In triethylamine at 20℃; for 46h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;97%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 21h; Sonogashira Cross-Coupling; Inert atmosphere;
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

phenyl trimethylsiloxane
2996-92-1

phenyl trimethylsiloxane

2-fluoro-1,1'-biphenyl-4-amine

2-fluoro-1,1'-biphenyl-4-amine

Conditions
ConditionsYield
With sodium hydroxide In ethylene glycol at 100℃; for 2h; Hiyama Coupling;92%
cyclobutanone
1191-95-3

cyclobutanone

3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

N-cyclobutyl-3-fluoro-4-iodoaniline

N-cyclobutyl-3-fluoro-4-iodoaniline

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 2h;70%
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

acetone
67-64-1

acetone

3-fluoro-4-iodo-N-isopropylaniline

3-fluoro-4-iodo-N-isopropylaniline

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 2h;70%
benzoyl cyanide
613-90-1

benzoyl cyanide

3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

N-(4-cyano-3-fluorophenyl)benzamide

N-(4-cyano-3-fluorophenyl)benzamide

Conditions
ConditionsYield
With copper(I) oxide In dimethyl sulfoxide at 130℃; for 10h;65%
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

1,4-anhydro-3,5-di-O-benzyl-2-deoxy-L-erythro-pent-1-enitol
320592-15-2

1,4-anhydro-3,5-di-O-benzyl-2-deoxy-L-erythro-pent-1-enitol

4-(5-((benzyloxy)methyl)-4-(benzyloxy)-2,5-dihydro-β-L-furan-2-yl)-3-fluoroaniline
320592-21-0

4-(5-((benzyloxy)methyl)-4-(benzyloxy)-2,5-dihydro-β-L-furan-2-yl)-3-fluoroaniline

Conditions
ConditionsYield
With triphenyl-arsane; triethylamine; palladium diacetate In acetonitrile at 70℃; for 24h;57%
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

2-methyl-but-3-yn-2-ol
115-19-5

2-methyl-but-3-yn-2-ol

4-(4-amino-2-fluorophenyl)-2-methylbut-3-yn-2-ol

4-(4-amino-2-fluorophenyl)-2-methylbut-3-yn-2-ol

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 20 - 60℃; for 1.5h; Sonogashira Cross-Coupling; Inert atmosphere;54%
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

1-carbamimidamido-N-(3-fluoro-4-iodophenyl)methanimidamide hydrochloride

1-carbamimidamido-N-(3-fluoro-4-iodophenyl)methanimidamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 100℃; for 18h; Inert atmosphere; Sealed tube;54%
Cyclopropylacetylene
6746-94-7

Cyclopropylacetylene

3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

4-(cyclopropylethynyl)-3-fluoroaniline
1255041-93-0

4-(cyclopropylethynyl)-3-fluoroaniline

Conditions
ConditionsYield
With triethylamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran at -5 - 20℃; Inert atmosphere;45%
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

4-methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-1H-pyrrole-2-carboxylic acid

4-methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-1H-pyrrole-2-carboxylic acid

N-(3-fluoro-4-iodophenyl)-4-methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-1H-pyrrole-2-carboxamide

N-(3-fluoro-4-iodophenyl)-4-methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-1H-pyrrole-2-carboxamide

Conditions
ConditionsYield
With triethylamine; HATU In N,N-dimethyl-formamide at 70℃; for 16h;41%
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

acetic anhydride
108-24-7

acetic anhydride

N-(3-fluoro-4-iodophenyl)acetamide
705-80-6

N-(3-fluoro-4-iodophenyl)acetamide

Conditions
ConditionsYield
In diethyl ether
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

3,5-bis-O,O-(tert-butyldimethylsilyl)-1,2-didehydro-1,2-dideoxy-D-ribofuranose
173327-56-5

3,5-bis-O,O-(tert-butyldimethylsilyl)-1,2-didehydro-1,2-dideoxy-D-ribofuranose

(2R,5R)-5-(4-Amino-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-dihydro-furan-3-one

(2R,5R)-5-(4-Amino-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-dihydro-furan-3-one

Conditions
ConditionsYield
With triphenyl-arsane; palladium diacetate; triethylamine In acetonitrile at 60℃; for 20h;
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

3-fluoro-4-(β-D-glycero-pentofuran-3-ulos-1-yl)aniline
307306-09-8

3-fluoro-4-(β-D-glycero-pentofuran-3-ulos-1-yl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium acetate; Ph3As; Et3N / acetonitrile / 20 h / 60 °C
2: n-Bu4NF / acetonitrile / 2 h / 25 °C
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

3-fluoro-4-[1-(2-deoxy-β-D-ribofuranosyl)]aniline

3-fluoro-4-[1-(2-deoxy-β-D-ribofuranosyl)]aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium acetate; Ph3As; Et3N / acetonitrile / 20 h / 60 °C
2: n-Bu4NF / acetonitrile / 2 h / 25 °C
3: 75 percent / NaB(OAc)3H / acetonitrile / 2 h / 0 °C
View Scheme
hydrated copper sulfate

hydrated copper sulfate

formaldoxime
75-17-2

formaldoxime

3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

3-Fluoro-4-iodobenzaldoxime

3-Fluoro-4-iodobenzaldoxime

Conditions
ConditionsYield
With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; sodium sulfite; sodium nitrite; paraformaldehyde In methanol; dichloromethane; water
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

2-ethynyl-5-isopropyl-3-(4-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b] quinoline-8-carbonitrile

2-ethynyl-5-isopropyl-3-(4-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b] quinoline-8-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
3.1: copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride / 80 °C / Inert atmosphere
4.1: diphenylether / 3 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 120 - 140 °C
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

methyl 6-cyano-2-((3-fluoro-4-iodophenyl)(isopropyl)amino)-1H-indole-3-carboxylate

methyl 6-cyano-2-((3-fluoro-4-iodophenyl)(isopropyl)amino)-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

methyl 6-cyano-2-((3-fluoro-4-(2-(trimethylsilyl)ethynyl)phenyl)(isopropyl)amino)-1H-indole-3-carboxylate

methyl 6-cyano-2-((3-fluoro-4-(2-(trimethylsilyl)ethynyl)phenyl)(isopropyl)amino)-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
3.1: copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride / 80 °C / Inert atmosphere
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

2-(trimethylsilyl)ethynyl-3-fluoro-5-isopropyl-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile

2-(trimethylsilyl)ethynyl-3-fluoro-5-isopropyl-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
3.1: copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride / 80 °C / Inert atmosphere
4.1: diphenylether / 3 h / Reflux
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

5-cyclobutyl-2-ethynyl-3-(4-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b] quinoline-8-carbonitrile

5-cyclobutyl-2-ethynyl-3-(4-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b] quinoline-8-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / diethylamine / 80 °C / Inert atmosphere
4.1: diphenylether / 3 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 120 - 140 °C
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

methyl 6-cyano-2-(cyclobutyl(3-fluoro-4-iodophenyl)amino)-1H-indole-3-carboxylate

methyl 6-cyano-2-(cyclobutyl(3-fluoro-4-iodophenyl)amino)-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

methyl 6-cyano-2-(cyclobutyl(3-fluoro-4-((trimethylsilyl)ethynyl)phenyl)amino)-1H-indole-3-carboxylate

methyl 6-cyano-2-(cyclobutyl(3-fluoro-4-((trimethylsilyl)ethynyl)phenyl)amino)-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / diethylamine / 80 °C / Inert atmosphere
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

5-cyclobutyl-2-(trimethylsilyl)ethynyl-3-fluoro-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile

5-cyclobutyl-2-(trimethylsilyl)ethynyl-3-fluoro-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 2 h / 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C
2.2: 2 h / 20 °C
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / diethylamine / 80 °C / Inert atmosphere
4.1: diphenylether / 3 h / Reflux
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

4-ethynyl-3-fluoroaniline

4-ethynyl-3-fluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere
2: potassium carbonate; methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 1.5 h / 20 - 60 °C / Inert atmosphere
2: potassium hydroxide / benzene / 4 h / 20 °C / Reflux
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

4-(cyclopropylbuta-1,3-diyn-1-yl)-3-fluoroaniline

4-(cyclopropylbuta-1,3-diyn-1-yl)-3-fluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere
2: potassium carbonate; methanol / 0.5 h / 20 °C
3: copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 24 h / 20 °C
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

C17H16FNO3

C17H16FNO3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere
2: potassium carbonate; methanol / 0.5 h / 20 °C
3: copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 24 h / 20 °C
4: lithium trifluoromethanesulfonate / acetonitrile / 21 h / 60 °C / Inert atmosphere
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

(S)-methyl 3-(4-(cyclopropylbuta-1,3-diyn-1-yl)-3-fluorophenyl)oxazolidin-2-one-5-carboxylate

(S)-methyl 3-(4-(cyclopropylbuta-1,3-diyn-1-yl)-3-fluorophenyl)oxazolidin-2-one-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere
2: potassium carbonate; methanol / 0.5 h / 20 °C
3: copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 24 h / 20 °C
4: lithium trifluoromethanesulfonate / acetonitrile / 21 h / 60 °C / Inert atmosphere
5: acetonitrile / 3 h / 65 °C / Inert atmosphere
View Scheme
3-fluoro-4-iodoaniline
656-66-6

3-fluoro-4-iodoaniline

(S)-3-(4-(cyclopropylbuta-1,3-diyn-1-yl)-3-fluorophenyl)-N-hydroxyoxazolidin-2-one-5-carboxamide

(S)-3-(4-(cyclopropylbuta-1,3-diyn-1-yl)-3-fluorophenyl)-N-hydroxyoxazolidin-2-one-5-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere
2: potassium carbonate; methanol / 0.5 h / 20 °C
3: copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 24 h / 20 °C
4: lithium trifluoromethanesulfonate / acetonitrile / 21 h / 60 °C / Inert atmosphere
5: acetonitrile / 3 h / 65 °C / Inert atmosphere
6: hydroxylamine / tetrahydrofuran; isopropyl alcohol; water / 3 h / 20 °C
View Scheme

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