5-Thiazolecarboxamide,2-amino-N-(2-chloro-6-methylphenyl)- Cas no. 302964-24-5 Dasatinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below:
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/561.html Product Name 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
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inquiryPurity 98% with good quality Fast delivery Prompt shipment Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing
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inquiryName: 5-Thiazolecarboxamide,2-amino-N-(2-chloro-6-methylphenyl)- CAS No.: 302964-24-5 Formula: C11H10ClN3OS
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inquiry2-Amino-N-(2-chloro-6-methyl-phenyl)thiazole-5-carboxamide[CAS:302964-24-5] Dasatinib monohydrate[CAS:863127-77-9 ] N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide[CAS:302964-08-5] Ethyl 2-aminothiazole-5
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inquiry2-amino-n-(2-chloro-6-methylphenyl)thiazole-5-carboxamide CAS: 302964-24-5 Specification product name 2-amino-n-(2-chloro-6-methylphenyl)thiazole-5-carboxamide cas no. 302964-24-5 appearance white powde
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiry2-Amino-N-(2-chloro-6-methyl-phenyl)thiazole -5-carboxamide is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to off-white solid Storage:Room temperature, Keep in Dark Place. P
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inquirythiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide With 1-butyl-3-methylimidazolium Tetrafluoroborate; copper(I) bromide In tetrahydrofuran for 0.5h; Stage #2: thiourea In tetrahydrofuran at 40℃; for 1.5h; Temperature; Solvent; Reagent/catalyst; | 98.9% |
Stage #1: N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide With N-Bromosuccinimide In 1,4-dioxane; water at 0 - 10℃; Stage #2: thiourea In 1,4-dioxane; water at 20 - 80℃; | 85 g |
With N-Bromosuccinimide at -10 - 80℃; |
(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide In tetrahydrofuran at 40℃; Stage #2: thiourea In tetrahydrofuran for 1.5h; Temperature; Concentration; Solvent; Reagent/catalyst; | 98.8% |
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-Bromosuccinimide In 1,4-dioxane; water at -10 - 22℃; for 3h; Stage #2: thiourea In 1,4-dioxane; water at 100℃; for 2h; Stage #3: With ammonia In 1,4-dioxane; water at 20 - 22℃; | 90% |
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-Bromosuccinimide In 1,4-dioxane at -10 - 22℃; for 3h; Stage #2: thiourea In 1,4-dioxane at 100℃; for 2h; Stage #3: With ammonium hydroxide In 1,4-dioxane; water at 20 - 22℃; | 90% |
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-Bromosuccinimide In 1,4-dioxane; water at 25 - 30℃; for 3h; Stage #2: thiourea In 1,4-dioxane; water at 25 - 70℃; for 2h; | 213 g |
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
for 0.0611111h; Microwave irradiation; | 97.23% |
at 20℃; for 1h; | 95.94% |
In water at 20℃; for 2h; Solvent; | 95.94% |
C10H10ClNO2
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With copper(ll) bromide In tetrahydrofuran; water at 35 - 40℃; for 0.5h; Reagent/catalyst; Solvent; | 96.13% |
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-Bromosuccinimide In 1,4-dioxane; water at -10 - 22℃; for 3h; Stage #2: thiourea In 1,4-dioxane; water at 80℃; for 2h; | 94.9% |
3-oxo-propionic acid ethyl ester
thiourea
2-chloro-6-methylaniline
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 3-oxo-propionic acid ethyl ester With sodium methylate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2-chloro-6-methylaniline In tetrahydrofuran for 0.75h; Reflux; Stage #3: thiourea Solvent; Further stages; | 92.31% |
Stage #1: 3-oxo-propionic acid ethyl ester; 2-chloro-6-methylaniline With sodium methylate In tetrahydrofuran for 0.75h; Reflux; Stage #2: With copper(ll) bromide In tetrahydrofuran for 1h; Reflux; Stage #3: thiourea In tetrahydrofuran at 20 - 25℃; for 0.25h; Reagent/catalyst; | 90.94% |
[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With trifluoroacetic acid at 25 - 30℃; for 2h; | 89% |
With trifluoroacetic acid In dichloromethane at -5 - 20℃; for 10.5h; | 85% |
With trifluoroacetic acid at 25 - 30℃; Reagent/catalyst; Temperature; | 78% |
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With formic acid In ethanol Heating / reflux; | 70% |
2-chloro-6-methylaniline
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: i-Pr2NEt / tetrahydrofuran 2: TFA / CH2Cl2 View Scheme | |
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran 2: N-Bromosuccinimide / -10 - 80 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium methylate / tetrahydrofuran / 0.17 h / 20 °C 1.2: 1 h / Reflux 1.3: 2 h / Reflux 2.1: water / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium methylate / tetrahydrofuran / 10 h / 20 °C 1.2: 1 h / Reflux 2.1: copper(ll) bromide / tetrahydrofuran; water / 0.5 h / 35 - 40 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium methylate / tetrahydrofuran / 1 h / Reflux 1.2: 2 h / Reflux 2.1: 0.06 h / Microwave irradiation View Scheme |
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 2-chloro-N-(2-chloro-6-methyl-phenyl)-3,3-dimethoxy-propionamide; thiourea With hydrogenchloride; acetic acid at 50 - 65℃; for 11h; Industry scale; Stage #2: With sodium methylate In methanol pH=8 - 9; Industry scale; |
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: C12H13BrClNO2; thiourea In 1,4-dioxane; water at 80℃; for 2h; Stage #2: With ammonium hydroxide In 1,4-dioxane; water at 20 - 22℃; | 5.3 g |
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
In dichloromethane at 20℃; |
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / 1,4-dioxane; water 2: dichloromethane / 20 °C View Scheme |
(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide; water / 1,4-dioxane / 3 h / -10 - 22 °C 2: 1,4-dioxane; water / 2 h / 80 °C View Scheme |
C12H15BrClNO3
thiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
In 1,4-dioxane; water at 80℃; for 2h; | 2.4 g |
2-amino-thiazole-5-carboxylic acid ethyl ester
2-chloro-6-methylaniline
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 2-chloro-6-methylaniline With ethyl bromide; iodine; magnesium In tetrahydrofuran at 0 - 20℃; Stage #2: 2-amino-thiazole-5-carboxylic acid ethyl ester In tetrahydrofuran | 17.0 g |
N-tritylthiourea
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide With N-Bromosuccinimide In 1,4-dioxane; water at 0 - 10℃; Stage #2: N-tritylthiourea In 1,4-dioxane; water at 20 - 80℃; | 85 g |
3-ethoxyacryloyl chloride
thiourea
2-chloro-6-methylaniline
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 3-ethoxyacryloyl chloride; 2-chloro-6-methylaniline Stage #2: thiourea With N-Bromosuccinimide |
2,4-dichloro-2-methylpyrimidine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With potassium hydride In tetrahydrofuran at -25 - -10℃; for 4h; Reagent/catalyst; Temperature; | 98.7% |
Stage #1: 2,4-dichloro-2-methylpyrimidine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In tetrahydrofuran at 5 - 20℃; for 0.75h; Stage #2: With sodium t-butanolate In tetrahydrofuran at 5 - 10℃; for 2.25h; | 97% |
Stage #1: 2,4-dichloro-2-methylpyrimidine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide With sodium t-butanolate In tetrahydrofuran at 10 - 20℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0 - 5℃; for 2h; pH=2 - 3; Temperature; Reagent/catalyst; | 94% |
Conditions | Yield |
---|---|
Stage #1: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide With trimethylaluminum In hexane; dichloromethane at 20℃; for 2h; Stage #2: C10H18N2O4 In hexane; dichloromethane at 60℃; for 5h; Solvent; Reagent/catalyst; | 98% |
1-(2-hydroxyethyl)piperazine
2,4-dichloro-2-methylpyrimidine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With potassium phosphate; 1-butyl-3-methylimidazolium aminoethanic acid salt at 80℃; for 1.5h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide at 20 - 80℃; for 2h; Reagent/catalyst; | 92.27% |
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With potassium phosphate; 1-butyl-3-methylimidazolium aminoethanic acid salt In N,N-dimethyl acetamide at 80℃; for 2h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In N,N-dimethyl acetamide at 80℃; for 3h; Solvent; | 89.31% |
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With copper(l) iodide; dimethylaminoacetic acid; O4P(3-)*O4P(3-)*3K(1+) In N,N-dimethyl-formamide at 20℃; for 0.666667h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide at 120℃; for 6h; Inert atmosphere; | 88.41% |
Monomethyl terephthalate
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: Monomethyl terephthalate With triethylamine; HATU In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In tetrahydrofuran at 20℃; | 85% |
2,4-dichloro-2-methylpyrimidine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With sodium t-butanolate In tetrahydrofuran at 10 - 30℃; Inert atmosphere; Large scale; | 83.5% |
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
In 1,4-dioxane at 75℃; for 3h; Concentration; | 83.2% |
With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl at 100 - 110℃; for 20h; |
chloroacetyl chloride
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(2-chloroacetamido)-5-thiazolecarboxamide
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 0 - 60℃; for 3.08h; | 80.6% |
With triethylamine In dichloromethane at 0 - 20℃; | 73.6% |
p-(chloromethyl)benzoyl chloride
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide With triethylamine In tetrahydrofuran for 0.25h; Cooling; Stage #2: p-(chloromethyl)benzoyl chloride In tetrahydrofuran for 3h; | 76.44% |
2-((pyridin-4-ylmethyl)amino)nicotinic acid
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 2-((pyridin-4-ylmethyl)amino)nicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In N,N-dimethyl-formamide at 20℃; for 16h; Cooling with ice; | 74.1% |
6-bromohexanoic acid
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 60℃; | 62% |
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With tert.-butylnitrite; copper(ll) bromide In acetonitrile at 20℃; | 51% |
With copper(I) bromide; sodium nitrite |
tert.-butylnitrite
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With copper(ll) bromide In acetonitrile at 20℃; | 51% |
1,3,5-trichloro-2,4,6-triazine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide With sodium t-butanolate In tetrahydrofuran at 0 - 20℃; for 1.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; water | 40% |
2,4-dichloro-6-methyl-1,3,5-triazine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
C15H12Cl2N6OS
Conditions | Yield |
---|---|
With diisopropylamine In tetrahydrofuran at 0 - 20℃; for 2.5h; | 33% |
With diisopropylamine In tetrahydrofuran at 0 - 20℃; for 2.5h; | 33% |
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Tert-butyl isocyanate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 0℃; for 1h; | 28% |
cyclopropanecarboxylic anhydride
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
In 1,4-dioxane at 93℃; | 17% |
In 1,4-dioxane at 93℃; | 11 mg |
2,4-dichloro-6-iso-butyl-1,3,5-triazine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
C18H18Cl2N6OS
Conditions | Yield |
---|---|
With diisopropylamine In tetrahydrofuran at 0℃; for 6h; | 9% |
2-furancarbonyl chloride
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran |
cyclopropanecarboxylic acid chloride
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran |
benzoyl chloride
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran |
4-chloro-2-methylpyrimidine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran |
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