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China Synchem Technology Co.,Ltd

2-Chloro-6-methylaniline CAS No.: 87-63-8 Customization Sythesis Company Profile: Synchem is dedicated to custom synthesis and manufacturing services for small molecules. We serve the needs of customers in the pharmaceutical, agrochemical, and

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

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Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

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Shanghai Hohance Chemical Co., ltd

1)Entity factory, can batch production 2)Sample service 3)the most competitive price with good quality: we do this products so many years with Skilled craft can control the cost. so we can provide the most competitive price for our customers. 4)Af

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Chloro-6-methylaniline Manufacturer/High quality/Best price/In stock

Cas:87-63-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloro-6-Methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

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Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name 2-Chloro-6-methylaniline CAS number 87-63-8 Assay ≥99% Appearance Colorless to red liquid Capacity 100mt/year Application Pharmaceutical/pes

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-chloro-o-toluidine

Cas:87-63-8

Min.Order:1

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Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 87-63-8 2-Chloro-6-methylaniline Manufacturer

Cas:87-63-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Chloro-o-toluidine (NH2=1)

Cas:87-63-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: 2-Chloro-6-methylaniline Synonyms: 6COT;6-CHLORO-2-METHYLANILINE;6-CHLORO-2-TOLUIDINE;6-CHLORO-O-TOLUIDINE;3-CHLORO-2-AMINOTOLUENE;1-AMINO-2-CHLORO-6-METHYLBENZENE;2-METHYL-6-CHLORO ANILINE;2-

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2-Chloro-6-methylaniline 87-63-8

Cas:87-63-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 87-63-8 with competitive price

Cas:87-63-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-Chloro-6-methylaniline/ LIDE PHARMA- Factory supply / Best price

Cas:87-63-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product name 2-Chloro-6-methylaniline CAS 87-63-8 Molecular Formula C7H8ClN Molecular Weight 141.6 Melting Point 1

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Chloro-6-methylaniline 87-63-8

Cas:87-63-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

2-Chloro-6-methylaniline Basic information Product Name: 2-Chloro-6-methylaniline Synonyms: benzenamine,2-chloro-6-methyl-;benzenamine,2-chloro-6-methyl-(6-cot);o-Toluidine, 6-chloro-;2-chloro-6-methylbenzenamine;2-Chloro-6-methyl-phenylamine;2

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2-Chloro-6-methylaniline with CAS:87-63-8

Cas:87-63-8

Min.Order:5 Kilogram

FOB Price: $248.0 / 276.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-Chloro-6-methylaniline CAS:87-63-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

2-Chloro-6-methylaniline CAS:87-63-8

Cas:87-63-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:87-63-8

Cas:87-63-8

Min.Order:0

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 70.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-6-Methylaniline

Cas:87-63-8

Min.Order:0

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Type:Manufacturers

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Hangzhou Maytime Bio-Tech Co.,Ltd.

We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for

CAS NO.87-63-8 2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Kilogram

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Type:Other

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DASATINIB - 2-CHLORO-6-METHYLANILINE

Cas:87-63-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:0 Metric Ton

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Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:0

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Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Chloro-6-methylaniline(87-63-8)

Cas:87-63-8

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-Chloro-6-methylaniline

Cas:87-63-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Chloro-6-Methylaniline

Cas:87-63-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Synthetic route

3-chloro-5-methyl-4-nitroaniline

3-chloro-5-methyl-4-nitroaniline

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
Stage #1: 3-chloro-5-methyl-4-nitroaniline With sulfuric acid; sodium nitrite In water at 0℃; for 0.5h;
Stage #2: With hypophosphorous acid In water at 0℃; for 3h;
Stage #3: With iron In water at 90℃; for 4h; Reagent/catalyst;
82.5%
2-bromo-1-chloro-3-methylbenzene
69190-56-3

2-bromo-1-chloro-3-methylbenzene

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With ammonium hydroxide; L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate In 1-methyl-pyrrolidin-2-one at 110℃; for 12h;82%
o-toluidine
95-53-4

o-toluidine

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With N-chloro-succinimide; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(mesitylselanyl)-2,3-dihydro-1H-inden-1-yl)thiourea In chloroform-d1 at 0℃; for 12h; regioselective reaction;65%
N-(2-chloro-6-methylphenyl)acetamide
21352-09-0

N-(2-chloro-6-methylphenyl)acetamide

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With hydrogenchloride In water at 50 - 55℃; for 7h; Time;61.7%
C9H10ClNO4S

C9H10ClNO4S

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With hydrogenchloride In sulfolane; water at 120℃; for 26h;60%
1-azido-2-methyl-benzene
31656-92-5

1-azido-2-methyl-benzene

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With hydrogenchloride
6-amino-5-chloro-toluene-3-sulfonic acid
6387-14-0

6-amino-5-chloro-toluene-3-sulfonic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With sulfuric acid at 165℃;
With sulfuric acid at 150 - 160℃;
N-(o-tolyl)hydroxylamine
611-22-3

N-(o-tolyl)hydroxylamine

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With hydrogenchloride
N-(2-chloro-6-methylphenyl)pivalamide
150545-04-3

N-(2-chloro-6-methylphenyl)pivalamide

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With hydrogen bromide for 4.5h; Heating; Yield given;
N-(o-tolyl)hydroxylamine
611-22-3

N-(o-tolyl)hydroxylamine

A

4-amino-3-methylphenol
2835-99-6

4-amino-3-methylphenol

B

o-toluidine
95-53-4

o-toluidine

C

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

D

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

Conditions
ConditionsYield
With perchloric acid; sodium perchlorate; sodium chloride In water; acetonitrile at 25℃; Rate constant;
hydrogenchloride
7647-01-0

hydrogenchloride

N-(o-tolyl)hydroxylamine
611-22-3

N-(o-tolyl)hydroxylamine

A

N,N'-Di-o-tolyl-diazene N-oxide
956-31-0, 51284-68-5, 116723-89-8

N,N'-Di-o-tolyl-diazene N-oxide

B

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

C

5-chloro-2-methyl-benzenamine
95-79-4

5-chloro-2-methyl-benzenamine

D

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

hydrogenchloride
7647-01-0

hydrogenchloride

1-azido-2-methyl-benzene
31656-92-5

1-azido-2-methyl-benzene

A

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

B

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

Conditions
ConditionsYield
Aufbewahren an einem kuehlen dunklen Ort;
hydrogenchloride
7647-01-0

hydrogenchloride

ethanol
64-17-5

ethanol

1-methyl-2-nitrobenzene
88-72-2

1-methyl-2-nitrobenzene

tin dichloride

tin dichloride

A

o-toluidine
95-53-4

o-toluidine

B

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

C

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

hydrogenchloride
7647-01-0

hydrogenchloride

ethanol
64-17-5

ethanol

1-methyl-2-nitrobenzene
88-72-2

1-methyl-2-nitrobenzene

tin

tin

A

o-toluidine
95-53-4

o-toluidine

B

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

C

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

sulfuric acid
7664-93-9

sulfuric acid

6-amino-5-chloro-toluene-3-sulfonic acid
6387-14-0

6-amino-5-chloro-toluene-3-sulfonic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
at 150 - 160℃;
N-(2-chlorophenyl)-2,2,2-trimethylacetamide
62662-74-2

N-(2-chlorophenyl)-2,2,2-trimethylacetamide

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72.1 percent / TMEDA, n-BuLi / various solvent(s); hexane / 1.) -12 to -20 deg C, 50min, 2.) -20 deg C, 2 h
2: conc. aq. HBr / 4.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: TMEDA, BuLi / various solvent(s); hexane / 1.) 65min, 2.) 1 h
2: conc. aq. HBr / 4.5 h / Heating
View Scheme
2-Chloroaniline
95-51-2

2-Chloroaniline

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 25 percent aq. NaOH / various solvent(s)
2: 72.1 percent / TMEDA, n-BuLi / various solvent(s); hexane / 1.) -12 to -20 deg C, 50min, 2.) -20 deg C, 2 h
3: conc. aq. HBr / 4.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 25 percent aq. NaOH / various solvent(s)
2: TMEDA, BuLi / various solvent(s); hexane / 1.) 65min, 2.) 1 h
3: conc. aq. HBr / 4.5 h / Heating
View Scheme
2-aminotoluene-5-sulfonic acid
98-33-9

2-aminotoluene-5-sulfonic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 2 h / 50 °C
2: acetic acid; hydrogenchloride; dihydrogen peroxide / water / 40 - 50 °C
3: hydrogenchloride / water; sulfolane / 26 h / 120 °C
View Scheme
3-chloro-2-nitrotoluene
5367-26-0

3-chloro-2-nitrotoluene

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
With hydrogen In ethanol at 80℃; under 15001.5 Torr; for 2.5h; Catalytic behavior; chemoselective reaction;
o-toluidine
95-53-4

o-toluidine

A

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

B

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

Conditions
ConditionsYield
With N-chloro-succinimide In chloroform-d1 at 0℃; for 12h;
2-Methyl-6-nitroaniline
570-24-1

2-Methyl-6-nitroaniline

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloroform / 12 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 40 °C / 1800.18 - 3000.3 Torr / Inert atmosphere; Autoclave
3.1: sodium nitrite; hydrogenchloride / water / 0.5 h / -3 - 3 °C
3.2: 5.5 h / -3 - 3 °C
4.1: hydrogenchloride / water / 7 h / 50 - 55 °C
View Scheme
N-(2-methyl-6-nitrophenyl)acetamide
59907-22-1

N-(2-methyl-6-nitrophenyl)acetamide

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 40 °C / 1800.18 - 3000.3 Torr / Inert atmosphere; Autoclave
2.1: sodium nitrite; hydrogenchloride / water / 0.5 h / -3 - 3 °C
2.2: 5.5 h / -3 - 3 °C
3.1: hydrogenchloride / water / 7 h / 50 - 55 °C
View Scheme
2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

4-bromo-2-chloro-6-methylphenylamine hydrobromide salt
877149-11-6

4-bromo-2-chloro-6-methylphenylamine hydrobromide salt

Conditions
ConditionsYield
With bromine; acetic acid In methanol at 0℃;99%
C21H22O4
1300605-91-7

C21H22O4

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

C28H28ClNO3
1309360-29-9

C28H28ClNO3

Conditions
ConditionsYield
With hafnium tetrakis(trifluoromethanesulfonate) In dichloromethane at 20℃; for 0.5h; Friedel Crafts alkylation;99%
In dichloromethane for 72h; Inert atmosphere; Reflux;51%
(E)-1,3-diphenyl-2-propen-1-ol
62668-02-4

(E)-1,3-diphenyl-2-propen-1-ol

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

(E)-2-chloro-4-(1,3-diphenylallyl)-6-methylaniline

(E)-2-chloro-4-(1,3-diphenylallyl)-6-methylaniline

Conditions
ConditionsYield
With 1,3-bis(carboxymethyl)imidazolium iodide In neat (no solvent) at 80℃; for 6h; regioselective reaction;99%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-chloro-N-(2-chloro-6-methylphenyl)acetamide
6307-67-1

2-chloro-N-(2-chloro-6-methylphenyl)acetamide

Conditions
ConditionsYield
Stage #1: 2-chloro-6-methylaniline With pyridine In dichloromethane at -10℃; for 0.166667h;
Stage #2: chloroacetyl chloride In dichloromethane at -10 - 20℃; for 2h;
98%
at 0 - 25℃; for 2.5h;87.6%
With sodium acetate In water; acetone at 20 - 50℃; for 16h;71%
2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2,6-dichloroimidazo[1,5-a]pyrido[3,2-e]pyrazine
240815-53-6

2,6-dichloroimidazo[1,5-a]pyrido[3,2-e]pyrazine

2-Chloro-N-(2-chloro-6-methylphenyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine
240813-70-1

2-Chloro-N-(2-chloro-6-methylphenyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine

Conditions
ConditionsYield
Stage #1: 2-chloro-6-methylaniline With sodium hexamethyldisilazane In tetrahydrofuran for 0.5h; Heating;
Stage #2: 2,6-dichloroimidazo[1,5-a]pyrido[3,2-e]pyrazine In tetrahydrofuran for 0.5h; Heating;
98%
3-oxo-propionic acid ethyl ester
34780-29-5

3-oxo-propionic acid ethyl ester

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

C10H10ClNO2
1044209-25-7

C10H10ClNO2

Conditions
ConditionsYield
Stage #1: 3-oxo-propionic acid ethyl ester With sodium methylate In tetrahydrofuran at 20℃; for 10h;
Stage #2: 2-chloro-6-methylaniline In tetrahydrofuran for 1h; Solvent; Reflux;
97.3%
acetylacetone
123-54-6

acetylacetone

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

(Z)-4-(2-chloro-6-methylphenylamino)pent-3-en-2-one
1590398-72-3

(Z)-4-(2-chloro-6-methylphenylamino)pent-3-en-2-one

Conditions
ConditionsYield
With iron(III) trifluoromethanesulfonate In neat (no solvent) at 20℃; for 0.1h; Green chemistry;97%
With zinc trifluoromethanesulfonate In neat (no solvent) at 20℃; for 0.2h; stereoselective reaction;96%
2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid
1245157-80-5

2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide
1245157-85-0

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide

Conditions
ConditionsYield
Stage #1: 2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid With thionyl chloride; sodium hydroxide In water; 1,2-dichloro-ethane at 55 - 60℃; for 4h;
Stage #2: 2-chloro-6-methylaniline With triethylamine In 1,2-dichloro-ethane at 40 - 45℃; for 1h; Solvent; Reagent/catalyst; Temperature;
95.6%
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;71.7%
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;71.7%
aqueous trimethylamine

aqueous trimethylamine

2-methyl-4,6-dichloroaniline
30273-00-8

2-methyl-4,6-dichloroaniline

o-toluidine
95-53-4

o-toluidine

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

4-chloro-2-methylbenzeneamine
95-69-2

4-chloro-2-methylbenzeneamine

trimethylammonium 4-chloro-2-methylphenyl dithiocarbamate

trimethylammonium 4-chloro-2-methylphenyl dithiocarbamate

Conditions
ConditionsYield
With carbon disulfide In acetone95.5%
2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid
302964-02-9

2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid

[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester
302964-06-3

[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With Dichlorophenylphosphine; N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 20℃; for 14h;95%
Stage #1: 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 4h;
Stage #2: 2-chloro-6-methylaniline With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 24h;
48%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

(Z)-ethyl 3-(2-chloro-6-methylphenylamino)but-2-enoate
1590398-71-2

(Z)-ethyl 3-(2-chloro-6-methylphenylamino)but-2-enoate

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate In neat (no solvent) at 20℃; for 0.25h; stereoselective reaction;94%
With iron(III) trifluoromethanesulfonate In neat (no solvent) at 20℃; for 0.133333h; Green chemistry;93%
2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-chloro-6-methylbenzenediazonium tetrafluoroborate
85070-46-8

2-chloro-6-methylbenzenediazonium tetrafluoroborate

Conditions
ConditionsYield
With tetrafluoroboric acid; sodium nitrite In ethanol; water at 0℃;94%
3-oxo-propionic acid ethyl ester
34780-29-5

3-oxo-propionic acid ethyl ester

thiourea
17356-08-0

thiourea

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-24-5

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

Conditions
ConditionsYield
Stage #1: 3-oxo-propionic acid ethyl ester With sodium methylate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2-chloro-6-methylaniline In tetrahydrofuran for 0.75h; Reflux;
Stage #3: thiourea Solvent; Further stages;
92.31%
Stage #1: 3-oxo-propionic acid ethyl ester; 2-chloro-6-methylaniline With sodium methylate In tetrahydrofuran for 0.75h; Reflux;
Stage #2: With copper(ll) bromide In tetrahydrofuran for 1h; Reflux;
Stage #3: thiourea In tetrahydrofuran at 20 - 25℃; for 0.25h; Reagent/catalyst;
90.94%
3-oxo-propionic acid ethyl ester
34780-29-5

3-oxo-propionic acid ethyl ester

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

C10H9BrClNO2

C10H9BrClNO2

Conditions
ConditionsYield
Stage #1: 3-oxo-propionic acid ethyl ester With sodium methylate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2-chloro-6-methylaniline In tetrahydrofuran for 1h; Reflux;
Stage #3: With copper(ll) bromide In tetrahydrofuran for 2h; Reagent/catalyst; Solvent; Reflux;
91.6%
Stage #1: 3-oxo-propionic acid ethyl ester With sodium methylate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2-chloro-6-methylaniline In tetrahydrofuran for 1h; Reflux;
Stage #3: With copper(I) bromide In tetrahydrofuran for 2h; Reagent/catalyst; Solvent; Reflux;
91.6%
Stage #1: 3-oxo-propionic acid ethyl ester; 2-chloro-6-methylaniline With sodium methylate In tetrahydrofuran for 1h; Reflux;
Stage #2: With copper(I) bromide In tetrahydrofuran for 2h; Solvent; Reflux;
91.6%
2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

1,8-dimethyl-9H-carbazole
6558-83-4

1,8-dimethyl-9H-carbazole

Conditions
ConditionsYield
With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate In toluene at 160℃; for 3h; microwave irradiation;91.5%
4-oxo-5-{[(trifluoromethyl)sulfonyl]oxy}-4H-pyran-2-carboxylic acid
1191276-41-1

4-oxo-5-{[(trifluoromethyl)sulfonyl]oxy}-4H-pyran-2-carboxylic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

6-(2-chloro-6-methylphenylcarbamoyl)-4oxo-4H-pyran-3-yl trifluoromethanesulfonate
1191276-46-6

6-(2-chloro-6-methylphenylcarbamoyl)-4oxo-4H-pyran-3-yl trifluoromethanesulfonate

Conditions
ConditionsYield
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0℃; Inert atmosphere;90%
(Z)-but-2-ene-1,4-diyl dimethanesulfonate
1953-56-6, 70886-56-5, 2303-47-1

(Z)-but-2-ene-1,4-diyl dimethanesulfonate

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

1-(2-Chloro-6-methyl-phenyl)-2,5-dihydro-1H-pyrrole
127839-96-7

1-(2-Chloro-6-methyl-phenyl)-2,5-dihydro-1H-pyrrole

Conditions
ConditionsYield
In dichloromethane Ambient temperature;89%
para-bromotoluene
106-38-7

para-bromotoluene

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

N-(2'-chloro-6'-methylphenyl)-4-methylaniline
332903-62-5

N-(2'-chloro-6'-methylphenyl)-4-methylaniline

Conditions
ConditionsYield
With tri-tert-butyl phosphine; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) In toluene at 60 - 90℃; Buchwald-Hartwig coupling;89%
carbon disulfide
75-15-0

carbon disulfide

allyl bromide
106-95-6

allyl bromide

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

S-allyl-N-(2-chloro-6-methylphenyl)dithiocarbamate
1273422-92-6

S-allyl-N-(2-chloro-6-methylphenyl)dithiocarbamate

Conditions
ConditionsYield
With tin(II) chloride dihdyrate at 20℃; neat (no solvent);89%
2-bromoanisole
578-57-4

2-bromoanisole

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

1-Methoxy-8-methyl-9H-carbazole
73910-81-3

1-Methoxy-8-methyl-9H-carbazole

Conditions
ConditionsYield
With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate In toluene at 160℃; for 3h; microwave irradiation;88%
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid
956388-76-4

2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

2-chloro-N-(2-chloro-6-methylphenyl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

2-chloro-N-(2-chloro-6-methylphenyl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 80℃; for 0.5h;86.8%
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
885618-31-5

2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-(2-chloro-6-methylphenyl)methanimine

1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-(2-chloro-6-methylphenyl)methanimine

Conditions
ConditionsYield
With acetic acid In ethanol at 80℃; for 3h;86.5%
benzoyl chloride
98-88-4

benzoyl chloride

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

N-(2-chloro-6-methylphenyl)benzamide
10286-86-9

N-(2-chloro-6-methylphenyl)benzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 3h; Inert atmosphere;86%
With triethylamine In toluene Heating;70%
With triethylamine In dichloromethane at 20℃;52%
Schotten-Baumann reaction;
With triethylamine
Benzoyl isothiocyanate
532-55-8

Benzoyl isothiocyanate

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

1-Benzoyl-3-(2-chloro-6-methyl-phenyl)-thiourea
82635-64-1

1-Benzoyl-3-(2-chloro-6-methyl-phenyl)-thiourea

Conditions
ConditionsYield
In benzene86%
In acetone at 20℃; for 2h;
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