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YUNBIO TECH CO.,LTD

Our Strength: -Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs. -Innovative: We are focusing on the development of new products and keep close relationships with

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Thymine

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Thymine supplier in China

Cas:65-71-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Thymine CAS number 65-71-4 Assay ≥99% Appearance White crystalline powder Capacity 200mt/year Application Pharmaceutical intermediate

Thymine

Cas:65-71-4

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Thymine CAS 65-71-4 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the pro

Thymine CAS 65-71-4

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $50.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long

Thymine

Cas:65-71-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Thymine

Cas:65-71-4

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory price Cosmetic THYMINE 65-71-4 Manufacturer

Cas:65-71-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Thymine

Cas:65-71-4

Min.Order:5 Milligram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Thymine

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Thymine

Cas:65-71-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Thymine CAS:65-71-4 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Produc

High quality Thymine supplier in China

Cas:65-71-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Thymine / LIDE PHARMA- Factory supply / Best price

Cas:65-71-4

Min.Order:1 Milligram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Thymine Basic information Product Name: Thymine Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-methyl-;2,4(1H,3H)-Pyrimidinedione,5-methyl-;2,4-Dihydroxy-5-methylpyrimidin;3h)-pyrimidinedione,5

65-71-4

Cas:65-71-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

CAS 65-71-4 Thymine

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 65-71-4 with best quality

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

CAS 65-71-4 Name Thymine Appearance White powder Application Used as intermediate Appearance:White powder Storage:Store in cool and

Thymine

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Thymine

Cas:65-71-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4(1H,3H)-Pyrimidinedione,5-methyl- 65-71-4

Cas:65-71-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At presen

Thymine

Cas:65-71-4

Min.Order:1 Metric Ton

FOB Price: $970.0 / 980.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Thymine CAS:65-71-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, stero

Thymine CAS:65-71-4

Cas:65-71-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,4(1H,3H)-Pyrimidinedione,5-methyl-

Cas:65-71-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Top qualityThymine with best price 65-71-4

Cas:65-71-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists

Thymine 65-71-4

Cas:65-71-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:65-71-4

Cas:65-71-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Thymine

Cas:65-71-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply Thymine

Cas:65-71-4

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Thymine powder

Cas:65-71-4

Min.Order:25 Kilogram

FOB Price: $47.0

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

supply high quality Thymine 99% min CAS NO.65-71-4

Cas:65-71-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Thymine

Cas:65-71-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-methyl-2-thiouracil
636-26-0

5-methyl-2-thiouracil

thymin
65-71-4

thymin

Conditions
ConditionsYield
With sodium hydroxide; methyloxirane In water at 20℃;100%
With iodosylbenzene In acetone for 15h; Ambient temperature;65%
thymidine
50-89-5

thymidine

A

α-D-2′-deoxyribofuranose-1-O-phosphate barium salt

α-D-2′-deoxyribofuranose-1-O-phosphate barium salt

B

thymin
65-71-4

thymin

Conditions
ConditionsYield
Stage #1: thymidine With magnesium(II) chloride hexahydrate; E. coli thymidine phosphorylase In aq. phosphate buffer at 40℃; for 120h; pH=7.0;
Stage #2: With ammonium hydroxide; barium(II) acetate In aq. phosphate buffer at 4℃; pH=8.0;
A 93%
B n/a
5-bromo-6-hydroxy-5,6-dihydrothymine
1195-73-9

5-bromo-6-hydroxy-5,6-dihydrothymine

thymin
65-71-4

thymin

Conditions
ConditionsYield
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature;92.9%
With sodium formate; iron(II) sulfate In water Irradiation;
bis(1-methyl-1-phenylethyl)peroxide
80-43-3

bis(1-methyl-1-phenylethyl)peroxide

uracil
66-22-8

uracil

thymin
65-71-4

thymin

Conditions
ConditionsYield
With acetic acid at 120℃;87%
3'-azido-2',3'-deoxythymidine
30516-87-1

3'-azido-2',3'-deoxythymidine

thymin
65-71-4

thymin

Conditions
ConditionsYield
With iodine; hypophosphorous acid; acetic acid for 12h; Heating;81%
2-amino-5-methylpyrimidin-4-one
15981-91-6

2-amino-5-methylpyrimidin-4-one

thymin
65-71-4

thymin

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water at 70℃; for 8h;80%
5-methylcytosin
554-01-8

5-methylcytosin

thymin
65-71-4

thymin

Conditions
ConditionsYield
With 4-phenylnaphthalene-1,2-dione In water; dimethyl sulfoxide at 140℃; for 48h;71%
With water at 95℃; Rate constant; pH 1.14; further pH (4.58);
With Escherichia coli K12 D314A cytosine deaminase In aq. buffer at 30℃; pH=7.5; Kinetics; Temperature; Reagent/catalyst; Concentration; Enzymatic reaction;
2,2'-anhydro-5-methyluridine

2,2'-anhydro-5-methyluridine

2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

A

C23H32N4O12

C23H32N4O12

B

thymin
65-71-4

thymin

C

2'-O-(2-methoxyethyl)-5-methyluridine
163759-49-7

2'-O-(2-methoxyethyl)-5-methyluridine

Conditions
ConditionsYield
Stage #1: 2,2'-anhydro-5-methyluridine; 2-methoxy-ethanol With tris(2-methoxyethyl)borate; sodium hydrogencarbonate at 130℃; under 760.051 Torr; for 21h; Argon atmosphere;
Stage #2: With water for 0.5h; Heating / reflux;
A n/a
B n/a
C 69.4%
O-2,2'-cyclo-5-methyluridine
22423-26-3

O-2,2'-cyclo-5-methyluridine

tris(2-methoxyethyl)borate
14983-42-7

tris(2-methoxyethyl)borate

A

C23H32N4O12

C23H32N4O12

B

thymin
65-71-4

thymin

C

2'-O-(2-methoxyethyl)-5-methyluridine
163759-49-7

2'-O-(2-methoxyethyl)-5-methyluridine

Conditions
ConditionsYield
Stage #1: O-2,2'-cyclo-5-methyluridine; tris(2-methoxyethyl)borate; sodium hydrogencarbonate In 2-methoxy-ethanol at 130℃; for 21h;
Stage #2: With water for 0.5h; Heating / reflux;
A n/a
B n/a
C 69.4%
Stage #1: O-2,2'-cyclo-5-methyluridine; tris(2-methoxyethyl)borate; sodium hydrogencarbonate In 2-methoxy-ethanol at 130℃; for 21h;
Stage #2: With water for 0.5h; Heating / reflux;
A n/a
B n/a
C 69.4%
(2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate
56070-42-9

(2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate

benzyl alcohol
100-51-6

benzyl alcohol

A

(benzyloxy)(tert-butyl)dimethylsilane
53172-91-1

(benzyloxy)(tert-butyl)dimethylsilane

B

3'-O-acetylthymidine
21090-30-2

3'-O-acetylthymidine

C

thymin
65-71-4

thymin

D

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate In xylene for 2h; Heating;A n/a
B 69%
C n/a
D n/a
(+)-trans-(5R,6R)-5-bromo-6-hydroxy-5,6-dihydrothymidine
43179-29-9

(+)-trans-(5R,6R)-5-bromo-6-hydroxy-5,6-dihydrothymidine

A

thymin
65-71-4

thymin

B

1-(2-Deoxy-β-D-erythro-pentopyranosyl)thymine
13091-56-0

1-(2-Deoxy-β-D-erythro-pentopyranosyl)thymine

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature;A 15.1%
B 14%
C 61.9%
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature;A 15.1%
B 14%
C 61.9%
2-bromo-1,9-dihydro-6H-purin-6-one
87781-93-9

2-bromo-1,9-dihydro-6H-purin-6-one

thymidine
50-89-5

thymidine

A

2-bromo-2'-deoxyinosine
123994-87-6

2-bromo-2'-deoxyinosine

B

thymin
65-71-4

thymin

Conditions
ConditionsYield
With purine nucleoside phosphorylase; thymidine phosphorylase In phosphate buffer at 37℃; for 20h; pH=7.4;A 60%
B n/a
5-methyl-2-thiouracil
636-26-0

5-methyl-2-thiouracil

A

5-methyl-4(3H)-pyrimidinone
17758-52-0

5-methyl-4(3H)-pyrimidinone

B

thymin
65-71-4

thymin

C

SO2, H2SO4

SO2, H2SO4

Conditions
ConditionsYield
With oxygen; ozone In acetic acid for 0.166667h; Ambient temperature;A 58%
B 7%
C n/a
(-)-trans-(5S,6S)-5-bromo-6-hydroxy-5,6-dihydrothymidine
43179-28-8

(-)-trans-(5S,6S)-5-bromo-6-hydroxy-5,6-dihydrothymidine

A

thymin
65-71-4

thymin

B

1-(2-Deoxy-β-D-erythro-pentopyranosyl)thymine
13091-56-0

1-(2-Deoxy-β-D-erythro-pentopyranosyl)thymine

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature;A 14.3%
B 16.8%
C 57.5%
3',5'-O-di(tert-butyldimethylsilyl)thymidine
40733-26-4

3',5'-O-di(tert-butyldimethylsilyl)thymidine

benzyl alcohol
100-51-6

benzyl alcohol

A

(benzyloxy)(tert-butyl)dimethylsilane
53172-91-1

(benzyloxy)(tert-butyl)dimethylsilane

B

thymin
65-71-4

thymin

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate In xylene Heating;A 0.76 g
B n/a
C 55%
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine
64911-18-8

3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

benzyl alcohol
100-51-6

benzyl alcohol

A

(benzyloxy)(tert-butyl)dimethylsilane
53172-91-1

(benzyloxy)(tert-butyl)dimethylsilane

B

2'-deoxyuridine
951-78-0

2'-deoxyuridine

C

thymin
65-71-4

thymin

Conditions
ConditionsYield
With copper(II) sulfate In xylene Heating;A 0.92 g
B 53%
C n/a
3′,5′-di-O-trityl-thymidine
52417-07-9

3′,5′-di-O-trityl-thymidine

benzyl alcohol
100-51-6

benzyl alcohol

A

triphenylmethane
519-73-3

triphenylmethane

B

benzyl trityl ether
5333-62-0

benzyl trityl ether

C

thymin
65-71-4

thymin

D

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate In xylene for 5h; Heating;A n/a
B n/a
C n/a
D 51%
1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
76223-04-6

1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

benzyl alcohol
100-51-6

benzyl alcohol

A

(benzyloxy)(tert-butyl)dimethylsilane
53172-91-1

(benzyloxy)(tert-butyl)dimethylsilane

B

2'-deoxyuridine
951-78-0

2'-deoxyuridine

C

thymin
65-71-4

thymin

Conditions
ConditionsYield
With copper(II) sulfate In xylene Heating;A n/a
B 49%
C n/a
5'-O-tritylthymidine
7791-71-1

5'-O-tritylthymidine

benzyl alcohol
100-51-6

benzyl alcohol

A

triphenylmethane
519-73-3

triphenylmethane

B

benzyl trityl ether
5333-62-0

benzyl trityl ether

C

thymin
65-71-4

thymin

D

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate In xylene for 5h; Heating;A n/a
B n/a
C n/a
D 49%
5'-tert-butyldimethylsilyloxy-2'-deoxythymidine
40733-28-6

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

benzyl alcohol
100-51-6

benzyl alcohol

A

(benzyloxy)(tert-butyl)dimethylsilane
53172-91-1

(benzyloxy)(tert-butyl)dimethylsilane

B

thymin
65-71-4

thymin

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With copper(II) sulfate In xylene Heating;A 0.76 g
B n/a
C 49%
5,10-bis(uracil-5-ylmethyl)tetrahydropteroylglutamic acid
82949-83-5

5,10-bis(uracil-5-ylmethyl)tetrahydropteroylglutamic acid

thymin
65-71-4

thymin

Conditions
ConditionsYield
at 250 - 275℃; for 5h; in vacuo;39%
at 255℃; Product distribution; i. vac.;39%
With other (uracil-5-ylmethyl)tetrahydropteroylglutamic acid at 250 - 275℃; for 5h; Mechanism;
thymin
65-71-4

thymin

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

2,4-bis(trimethylsiloxy)-5-methylpyrimidine
7288-28-0

2,4-bis(trimethylsiloxy)-5-methylpyrimidine

Conditions
ConditionsYield
With ammonium bisulphate In 1,2-dichloro-ethane Reflux; Inert atmosphere; Schlenk technique;100%
With ammonium sulfate at 160℃; for 4h;97.95%
With ammonium sulfate In toluene at 120℃; for 0.5h; Inert atmosphere;96.6%
propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

thymin
65-71-4

thymin

(E)-3-[3-((E)-2-Methoxycarbonyl-vinyl)-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acrylic acid methyl ester
287727-77-9

(E)-3-[3-((E)-2-Methoxycarbonyl-vinyl)-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acrylic acid methyl ester

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃; for 2h; hetero-Michael addition;100%
C19H29FO4Si
1148114-29-7

C19H29FO4Si

thymin
65-71-4

thymin

C22H31FN2O4Si
1148114-32-2

C22H31FN2O4Si

Conditions
ConditionsYield
Stage #1: C19H29FO4Si; thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; for 2h;
100%
(1S,2R,4S,6S)-2-[(tert-butyldimethylsilyl)oxy]-4-[(ethoxycarbonyl)methyl]-6-trimethylsilyloxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]non-7-ene
1374576-25-6

(1S,2R,4S,6S)-2-[(tert-butyldimethylsilyl)oxy]-4-[(ethoxycarbonyl)methyl]-6-trimethylsilyloxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]non-7-ene

thymin
65-71-4

thymin

1-[(3'R,5'R,6'S)-3'-O-trimethylsilyl-5'-O-(tert-butyldimethylsilyl)-6'-[(ethoxycarbonyl)methyl]-2'-deoxy-2'-iodo-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl]thymine
1374576-26-7

1-[(3'R,5'R,6'S)-3'-O-trimethylsilyl-5'-O-(tert-butyldimethylsilyl)-6'-[(ethoxycarbonyl)methyl]-2'-deoxy-2'-iodo-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl]thymine

Conditions
ConditionsYield
With N-iodo-succinimide; N,O-Bis(trimethylsilyl)trifluoroacetamide In dichloromethane at 0℃;100%
With N-iodo-succinimide; N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0℃;100%
Stage #1: thymin With BSA In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: (1S,2R,4S,6S)-2-[(tert-butyldimethylsilyl)oxy]-4-[(ethoxycarbonyl)methyl]-6-trimethylsilyloxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]non-7-ene With N-iodo-succinimide In dichloromethane at 0 - 20℃; Inert atmosphere;
2-methyl-3-bromo-1-propene
1458-98-6

2-methyl-3-bromo-1-propene

thymin
65-71-4

thymin

N1-2′-methylallyl-thymine

N1-2′-methylallyl-thymine

Conditions
ConditionsYield
Stage #1: thymin In acetonitrile for 0.0833333h; Inert atmosphere; Reflux;
Stage #2: 2-methyl-3-bromo-1-propene With chloro-trimethyl-silane; sodium iodide In acetonitrile for 16h; Inert atmosphere; Reflux;
100%
5-O-(o-toluoyl)-1,2-diacetyl-3-deoxyxylofuranose

5-O-(o-toluoyl)-1,2-diacetyl-3-deoxyxylofuranose

thymin
65-71-4

thymin

5'-O-(o-toluoyl)-2'-O-acetyl-3'-deoxythymidine

5'-O-(o-toluoyl)-2'-O-acetyl-3'-deoxythymidine

Conditions
ConditionsYield
Stage #1: thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 20℃; for 0.333333h; Vorbrueggen Nucleoside Synthesis;
Stage #2: 5-O-(o-toluoyl)-1,2-diacetyl-3-deoxyxylofuranose With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -20 - 70℃; for 2h; Vorbrueggen Nucleoside Synthesis; stereoselective reaction;
100%
benzyl bromide
100-39-0

benzyl bromide

thymin
65-71-4

thymin

N,N'-dibenzylthymine
78450-19-8

N,N'-dibenzylthymine

Conditions
ConditionsYield
Stage #1: thymin With potassium carbonate for 1h; Milling;
Stage #2: benzyl bromide In N,N-dimethyl-formamide for 1h; Milling;
99%
With potassium hydroxide; tetrabutylammomium bromide 1.) 80 deg C, 2 h, 2.) 1 h; Yield given. Multistep reaction;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

thymin
65-71-4

thymin

2,4-bis(trimethylsiloxy)-5-methylpyrimidine
7288-28-0

2,4-bis(trimethylsiloxy)-5-methylpyrimidine

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane Ambient temperature;99%
With triethylamine In benzene for 2h; Inert atmosphere; Reflux;93%
With triethylamine In benzene Inert atmosphere;89%
thymin
65-71-4

thymin

ethyl acrylate
140-88-5

ethyl acrylate

3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-yl)propionic acid ethyl ester
101852-97-5

3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-yl)propionic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 60℃; Aza-Micheal reaction;99%
With tetrabutylammomium bromide; zinc(II) oxide at 100℃; for 0.416667h; Michael addition; microwave irradiation;89%
With ethanol; sodium In benzene for 24h; Michael Addition; Reflux;86%
thymin
65-71-4

thymin

1,2-di-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-D-erythro-pentofuranose
293751-03-8

1,2-di-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-D-erythro-pentofuranose

1-(2-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-β-D-erythro-pentofuranosyl)thymine
293751-04-9

1-(2-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-β-D-erythro-pentofuranosyl)thymine

Conditions
ConditionsYield
Stage #1: thymin; 1,2-di-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-benzyl-D-erythro-pentofuranose With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 80℃; Large scale;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 80℃; for 1.33333h; Vorbrueggen Nucleoside Synthesis; Large scale;
99%
Stage #1: thymin; 1,2-di-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-benzyl-D-erythro-pentofuranose With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 1h; Heating;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 4h; Heating; Further stages.;
88%
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile88%
Stage #1: thymin; 1,2-di-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-benzyl-D-erythro-pentofuranose With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 1h; Heating / reflux;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 2h; Heating / reflux;
85%
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 60℃; Vorbrueggen Nucleoside Synthesis; Inert atmosphere;
thymin
65-71-4

thymin

1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol
92283-88-0

1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol

1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol
401906-49-8

1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 85℃; for 36h;99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80 - 90℃; for 3h;75%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 85℃; for 12h;65.6%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 85℃; for 7h;
C40H46O9Si
1352230-42-2

C40H46O9Si

thymin
65-71-4

thymin

C43H48N2O9Si
1352230-43-3

C43H48N2O9Si

Conditions
ConditionsYield
Stage #1: C40H46O9Si; thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 55℃; for 1.5h;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 60℃;
99%
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile
thymin
65-71-4

thymin

5-methyl-4-thiouracil
35455-79-9

5-methyl-4-thiouracil

Conditions
ConditionsYield
With diphosphorus pentasulfide; sodium hydrogencarbonate In diethylene glycol dimethyl ether at 110℃; for 2h;98%
With Lawessons reagent In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 2h;74%
Conditions
ConditionsYield
With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 65℃; Condensation;98%
Substitution;92%
With ammonium sulfate; N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 80℃; for 3.5h; Reflux; stereoselective reaction;60%
1,8-diazabicyclo[5.4.0]undec-7-ene
6674-22-2

1,8-diazabicyclo[5.4.0]undec-7-ene

thymin
65-71-4

thymin

2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine; compound with 5-methyl-1H-pyrimidine-2,4-dione

2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine; compound with 5-methyl-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
In acetonitrile at 20℃;98%
thymin
65-71-4

thymin

Acetic acid (3aR,5R,6R,7S,7aS)-6,7-bis-benzyloxy-5-benzyloxymethyl-hexahydro-furo[3,2-b]pyran-2-yl ester
364335-62-6

Acetic acid (3aR,5R,6R,7S,7aS)-6,7-bis-benzyloxy-5-benzyloxymethyl-hexahydro-furo[3,2-b]pyran-2-yl ester

1-((3aR,5R,6R,7S,7aS)-6,7-Bis-benzyloxy-5-benzyloxymethyl-hexahydro-furo[3,2-b]pyran-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

1-((3aR,5R,6R,7S,7aS)-6,7-Bis-benzyloxy-5-benzyloxymethyl-hexahydro-furo[3,2-b]pyran-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
With chloro-trimethyl-silane; potassium nonaflate; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 20℃; for 0.5h;98%
thymin
65-71-4

thymin

(S)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate
426836-31-9

(S)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate

(S)-1-[(2-benzoyloxy-1-phenylethoxy)methyl]thymine
426836-32-0

(S)-1-[(2-benzoyloxy-1-phenylethoxy)methyl]thymine

Conditions
ConditionsYield
Stage #1: thymin With NH4(SO4)2; 1,1,1,3,3,3-hexamethyl-disilazane Heating;
Stage #2: (S)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate With dibenzo-18-crown-6; potassium iodide In toluene; acetonitrile
98%
thymin
65-71-4

thymin

(R)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate
871118-07-9

(R)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate

(R)-1-[(2-benzoyloxy-1-phenylethoxy)methyl]thymine
499203-31-5

(R)-1-[(2-benzoyloxy-1-phenylethoxy)methyl]thymine

Conditions
ConditionsYield
Stage #1: thymin With NH4(SO4)2; 1,1,1,3,3,3-hexamethyl-disilazane Heating;
Stage #2: (R)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate With dibenzo-18-crown-6; potassium iodide In toluene; acetonitrile
98%
2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
942428-83-3

2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate

thymin
65-71-4

thymin

(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
3180-74-3

(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Stage #1: 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate; thymin With N,O-Bis(trimethylsilyl)trifluoroacetamide In nitromethane at 20℃; for 0.5h;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In nitromethane at 20℃;
98%
Stage #1: thymin With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 20℃; for 0.5h;
Stage #2: 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; Further stages.;
91%
2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate
1055317-41-3

2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate

thymin
65-71-4

thymin

2',3',5'-tri-O-benzoyluridine
3180-76-5

2',3',5'-tri-O-benzoyluridine

Conditions
ConditionsYield
Stage #1: 2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate; thymin With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 20℃; for 0.5h;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃;
98%
Stage #1: thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 20℃; for 0.5h;
Stage #2: 2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; Further stages.;
88%
benzyl chloride
100-44-7

benzyl chloride

thymin
65-71-4

thymin

N,N'-dibenzylthymine
78450-19-8

N,N'-dibenzylthymine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride for 8h;97%
With sodium hydroxide; tetrabutylammomium bromide In benzene at 80℃; for 14h;73%
methyl bromide
74-83-9

methyl bromide

thymin
65-71-4

thymin

1,3-dimethylthymine
4401-71-2

1,3-dimethylthymine

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 3h;97%
thymin
65-71-4

thymin

dimethyl sulfate
77-78-1

dimethyl sulfate

1,3-dimethylthymine
4401-71-2

1,3-dimethylthymine

Conditions
ConditionsYield
With sodium hydroxide; water for 1h; Methylation;97%
With sodium hydroxide In water at 20 - 50℃; for 20.5h;94%
With potassium hydroxide Heating;85%
With sodium hydroxide
With sodium hydroxide In water at 20 - 40℃; for 20h;
thymin
65-71-4

thymin

{[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-difluoro-methyl}-phosphonothioic acid O,O-diethyl ester

{[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-difluoro-methyl}-phosphonothioic acid O,O-diethyl ester

O,O-diethyl (2S,3S)-[2-{[tert-butyl(diphenyl)siloxy]methyl}-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl](difluoro)methylphosphonothioate

O,O-diethyl (2S,3S)-[2-{[tert-butyl(diphenyl)siloxy]methyl}-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl](difluoro)methylphosphonothioate

Conditions
ConditionsYield
Stage #1: thymin; {[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-difluoro-methyl}-phosphonothioic acid O,O-diethyl ester With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane for 4h; Heating;
Stage #2: With titanium tetrachloride In dichloromethane at 0℃; for 3h;
97%
thymin
65-71-4

thymin

2,3,4-tri-O-acetyl-L-rhamnopyranosyl (N-phenyl)-2,2,2-trifluoroacetimidate
339276-10-7

2,3,4-tri-O-acetyl-L-rhamnopyranosyl (N-phenyl)-2,2,2-trifluoroacetimidate

1-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)thymine
31506-00-0

1-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)thymine

Conditions
ConditionsYield
Stage #1: thymin; 2,3,4-tri-O-acetyl-L-rhamnopyranosyl (N-phenyl)-2,2,2-trifluoroacetimidate With N,O-Bis(trimethylsilyl)trifluoroacetamide In nitromethane at 20℃; for 0.5h;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In nitromethane at 20℃;
97%
thymin
65-71-4

thymin

thymine-potassium

thymine-potassium

Conditions
ConditionsYield
With potassium hydroxide In water for 0.166667h;97%
3,5-di-O-benzoyl-α-D-ribofuranose-1,2-(pent-4-enyl orthobenzoate)

3,5-di-O-benzoyl-α-D-ribofuranose-1,2-(pent-4-enyl orthobenzoate)

thymin
65-71-4

thymin

2',3',5'-tri-O-benzoyluridine
3180-76-5

2',3',5'-tri-O-benzoyluridine

Conditions
ConditionsYield
Stage #1: thymin With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane at 85℃; Inert atmosphere;
Stage #2: 3,5-di-O-benzoyl-α-D-ribofuranose-1,2-(pent-4-enyl orthobenzoate) With N-iodo-succinimide; ytterbium(III) triflate In acetonitrile at 0 - 20℃; for 4h;
97%
thymin
65-71-4

thymin

1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-ethynyl-D-ribo-pentofuranose
233266-81-4

1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-ethynyl-D-ribo-pentofuranose

1-(2-O-acetyl-3,5-di-O-benzyl-4-C-ethynyl-β-D-ribo-pentofuranosyl)thymine
233266-83-6

1-(2-O-acetyl-3,5-di-O-benzyl-4-C-ethynyl-β-D-ribo-pentofuranosyl)thymine

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane for 13h; Heating;96.1%
thymin
65-71-4

thymin

2,4-dihydroxypyrimidine-5-carboxylic acid
23945-44-0

2,4-dihydroxypyrimidine-5-carboxylic acid

Conditions
ConditionsYield
With dihydrogen peroxide; 1-hydroxy-1,2,3-benzotriazine-4(3H)-one In water at 130℃; for 3h; Temperature; Autoclave;96.1%
Multi-step reaction with 2 steps
1: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction
2: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 3 steps
1: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction
2: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction
3: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction
View Scheme

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