Our Strength: -Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs. -Innovative: We are focusing on the development of new products and keep close relationships with
Cas:65-71-4
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct description: Product name Thymine CAS number 65-71-4 Assay ≥99% Appearance White crystalline powder Capacity 200mt/year Application Pharmaceutical intermediate
Thymine CAS 65-71-4 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the pro
high quality Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:65-71-4
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inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Thymine CAS:65-71-4 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Produc
Cas:65-71-4
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryThymine Basic information Product Name: Thymine Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-methyl-;2,4(1H,3H)-Pyrimidinedione,5-methyl-;2,4-Dihydroxy-5-methylpyrimidin;3h)-pyrimidinedione,5
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:65-71-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:65-71-4
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inquiryCAS 65-71-4 Name Thymine Appearance White powder Application Used as intermediate Appearance:White powder Storage:Store in cool and
1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At presen
Thymine CAS:65-71-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, stero
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:65-71-4
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:65-71-4
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)
Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie
Cas:65-71-4
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Type:Lab/Research institutions
inquiryShanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye
Cas:65-71-4
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Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:65-71-4
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Type:Trading Company
inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Conditions | Yield |
---|---|
With sodium hydroxide; methyloxirane In water at 20℃; | 100% |
With iodosylbenzene In acetone for 15h; Ambient temperature; | 65% |
Conditions | Yield |
---|---|
Stage #1: thymidine With magnesium(II) chloride hexahydrate; E. coli thymidine phosphorylase In aq. phosphate buffer at 40℃; for 120h; pH=7.0; Stage #2: With ammonium hydroxide; barium(II) acetate In aq. phosphate buffer at 4℃; pH=8.0; | A 93% B n/a |
Conditions | Yield |
---|---|
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature; | 92.9% |
With sodium formate; iron(II) sulfate In water Irradiation; |
Conditions | Yield |
---|---|
With acetic acid at 120℃; | 87% |
3'-azido-2',3'-deoxythymidine
thymin
Conditions | Yield |
---|---|
With iodine; hypophosphorous acid; acetic acid for 12h; Heating; | 81% |
2-amino-5-methylpyrimidin-4-one
thymin
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite In water at 70℃; for 8h; | 80% |
Conditions | Yield |
---|---|
With 4-phenylnaphthalene-1,2-dione In water; dimethyl sulfoxide at 140℃; for 48h; | 71% |
With water at 95℃; Rate constant; pH 1.14; further pH (4.58); | |
With Escherichia coli K12 D314A cytosine deaminase In aq. buffer at 30℃; pH=7.5; Kinetics; Temperature; Reagent/catalyst; Concentration; Enzymatic reaction; |
Conditions | Yield |
---|---|
Stage #1: 2,2'-anhydro-5-methyluridine; 2-methoxy-ethanol With tris(2-methoxyethyl)borate; sodium hydrogencarbonate at 130℃; under 760.051 Torr; for 21h; Argon atmosphere; Stage #2: With water for 0.5h; Heating / reflux; | A n/a B n/a C 69.4% |
O-2,2'-cyclo-5-methyluridine
tris(2-methoxyethyl)borate
B
thymin
C
2'-O-(2-methoxyethyl)-5-methyluridine
Conditions | Yield |
---|---|
Stage #1: O-2,2'-cyclo-5-methyluridine; tris(2-methoxyethyl)borate; sodium hydrogencarbonate In 2-methoxy-ethanol at 130℃; for 21h; Stage #2: With water for 0.5h; Heating / reflux; | A n/a B n/a C 69.4% |
Stage #1: O-2,2'-cyclo-5-methyluridine; tris(2-methoxyethyl)borate; sodium hydrogencarbonate In 2-methoxy-ethanol at 130℃; for 21h; Stage #2: With water for 0.5h; Heating / reflux; | A n/a B n/a C 69.4% |
(2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate
benzyl alcohol
A
(benzyloxy)(tert-butyl)dimethylsilane
B
3'-O-acetylthymidine
C
thymin
D
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene for 2h; Heating; | A n/a B 69% C n/a D n/a |
(+)-trans-(5R,6R)-5-bromo-6-hydroxy-5,6-dihydrothymidine
A
thymin
B
1-(2-Deoxy-β-D-erythro-pentopyranosyl)thymine
C
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature; | A 15.1% B 14% C 61.9% |
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature; | A 15.1% B 14% C 61.9% |
2-bromo-1,9-dihydro-6H-purin-6-one
thymidine
A
2-bromo-2'-deoxyinosine
B
thymin
Conditions | Yield |
---|---|
With purine nucleoside phosphorylase; thymidine phosphorylase In phosphate buffer at 37℃; for 20h; pH=7.4; | A 60% B n/a |
Conditions | Yield |
---|---|
With oxygen; ozone In acetic acid for 0.166667h; Ambient temperature; | A 58% B 7% C n/a |
(-)-trans-(5S,6S)-5-bromo-6-hydroxy-5,6-dihydrothymidine
A
thymin
B
1-(2-Deoxy-β-D-erythro-pentopyranosyl)thymine
C
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate; ascorbic acid In water for 0.0833333h; Ambient temperature; | A 14.3% B 16.8% C 57.5% |
3',5'-O-di(tert-butyldimethylsilyl)thymidine
benzyl alcohol
A
(benzyloxy)(tert-butyl)dimethylsilane
B
thymin
C
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene Heating; | A 0.76 g B n/a C 55% |
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine
benzyl alcohol
A
(benzyloxy)(tert-butyl)dimethylsilane
B
2'-deoxyuridine
C
thymin
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene Heating; | A 0.92 g B 53% C n/a |
3′,5′-di-O-trityl-thymidine
benzyl alcohol
A
triphenylmethane
B
benzyl trityl ether
C
thymin
D
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene for 5h; Heating; | A n/a B n/a C n/a D 51% |
1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
benzyl alcohol
A
(benzyloxy)(tert-butyl)dimethylsilane
B
2'-deoxyuridine
C
thymin
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene Heating; | A n/a B 49% C n/a |
5'-O-tritylthymidine
benzyl alcohol
A
triphenylmethane
B
benzyl trityl ether
C
thymin
D
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene for 5h; Heating; | A n/a B n/a C n/a D 49% |
5'-tert-butyldimethylsilyloxy-2'-deoxythymidine
benzyl alcohol
A
(benzyloxy)(tert-butyl)dimethylsilane
B
thymin
C
thymidine
Conditions | Yield |
---|---|
With copper(II) sulfate In xylene Heating; | A 0.76 g B n/a C 49% |
5,10-bis(uracil-5-ylmethyl)tetrahydropteroylglutamic acid
thymin
Conditions | Yield |
---|---|
at 250 - 275℃; for 5h; in vacuo; | 39% |
at 255℃; Product distribution; i. vac.; | 39% |
With other (uracil-5-ylmethyl)tetrahydropteroylglutamic acid at 250 - 275℃; for 5h; Mechanism; |
thymin
1,1,1,3,3,3-hexamethyl-disilazane
2,4-bis(trimethylsiloxy)-5-methylpyrimidine
Conditions | Yield |
---|---|
With ammonium bisulphate In 1,2-dichloro-ethane Reflux; Inert atmosphere; Schlenk technique; | 100% |
With ammonium sulfate at 160℃; for 4h; | 97.95% |
With ammonium sulfate In toluene at 120℃; for 0.5h; Inert atmosphere; | 96.6% |
propynoic acid methyl ester
thymin
(E)-3-[3-((E)-2-Methoxycarbonyl-vinyl)-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acrylic acid methyl ester
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; for 2h; hetero-Michael addition; | 100% |
Conditions | Yield |
---|---|
Stage #1: C19H29FO4Si; thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; for 2h; | 100% |
(1S,2R,4S,6S)-2-[(tert-butyldimethylsilyl)oxy]-4-[(ethoxycarbonyl)methyl]-6-trimethylsilyloxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]non-7-ene
thymin
1-[(3'R,5'R,6'S)-3'-O-trimethylsilyl-5'-O-(tert-butyldimethylsilyl)-6'-[(ethoxycarbonyl)methyl]-2'-deoxy-2'-iodo-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl]thymine
Conditions | Yield |
---|---|
With N-iodo-succinimide; N,O-Bis(trimethylsilyl)trifluoroacetamide In dichloromethane at 0℃; | 100% |
With N-iodo-succinimide; N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0℃; | 100% |
Stage #1: thymin With BSA In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: (1S,2R,4S,6S)-2-[(tert-butyldimethylsilyl)oxy]-4-[(ethoxycarbonyl)methyl]-6-trimethylsilyloxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]non-7-ene With N-iodo-succinimide In dichloromethane at 0 - 20℃; Inert atmosphere; |
Conditions | Yield |
---|---|
Stage #1: thymin In acetonitrile for 0.0833333h; Inert atmosphere; Reflux; Stage #2: 2-methyl-3-bromo-1-propene With chloro-trimethyl-silane; sodium iodide In acetonitrile for 16h; Inert atmosphere; Reflux; | 100% |
thymin
Conditions | Yield |
---|---|
Stage #1: thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 20℃; for 0.333333h; Vorbrueggen Nucleoside Synthesis; Stage #2: 5-O-(o-toluoyl)-1,2-diacetyl-3-deoxyxylofuranose With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -20 - 70℃; for 2h; Vorbrueggen Nucleoside Synthesis; stereoselective reaction; | 100% |
Conditions | Yield |
---|---|
Stage #1: thymin With potassium carbonate for 1h; Milling; Stage #2: benzyl bromide In N,N-dimethyl-formamide for 1h; Milling; | 99% |
With potassium hydroxide; tetrabutylammomium bromide 1.) 80 deg C, 2 h, 2.) 1 h; Yield given. Multistep reaction; |
chloro-trimethyl-silane
thymin
2,4-bis(trimethylsiloxy)-5-methylpyrimidine
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane Ambient temperature; | 99% |
With triethylamine In benzene for 2h; Inert atmosphere; Reflux; | 93% |
With triethylamine In benzene Inert atmosphere; | 89% |
thymin
ethyl acrylate
3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-yl)propionic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 60℃; Aza-Micheal reaction; | 99% |
With tetrabutylammomium bromide; zinc(II) oxide at 100℃; for 0.416667h; Michael addition; microwave irradiation; | 89% |
With ethanol; sodium In benzene for 24h; Michael Addition; Reflux; | 86% |
thymin
1,2-di-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-D-erythro-pentofuranose
1-(2-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-β-D-erythro-pentofuranosyl)thymine
Conditions | Yield |
---|---|
Stage #1: thymin; 1,2-di-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-benzyl-D-erythro-pentofuranose With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 80℃; Large scale; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 80℃; for 1.33333h; Vorbrueggen Nucleoside Synthesis; Large scale; | 99% |
Stage #1: thymin; 1,2-di-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-benzyl-D-erythro-pentofuranose With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 1h; Heating; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 4h; Heating; Further stages.; | 88% |
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile | 88% |
Stage #1: thymin; 1,2-di-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-benzyl-D-erythro-pentofuranose With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 1h; Heating / reflux; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 2h; Heating / reflux; | 85% |
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 60℃; Vorbrueggen Nucleoside Synthesis; Inert atmosphere; |
thymin
1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol
1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 85℃; for 36h; | 99% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80 - 90℃; for 3h; | 75% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 85℃; for 12h; | 65.6% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 85℃; for 7h; |
Conditions | Yield |
---|---|
Stage #1: C40H46O9Si; thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 55℃; for 1.5h; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 60℃; | 99% |
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile |
thymin
5-methyl-4-thiouracil
Conditions | Yield |
---|---|
With diphosphorus pentasulfide; sodium hydrogencarbonate In diethylene glycol dimethyl ether at 110℃; for 2h; | 98% |
With Lawessons reagent In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 2h; | 74% |
Conditions | Yield |
---|---|
With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 65℃; Condensation; | 98% |
Substitution; | 92% |
With ammonium sulfate; N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 80℃; for 3.5h; Reflux; stereoselective reaction; | 60% |
Conditions | Yield |
---|---|
In acetonitrile at 20℃; | 98% |
thymin
Acetic acid (3aR,5R,6R,7S,7aS)-6,7-bis-benzyloxy-5-benzyloxymethyl-hexahydro-furo[3,2-b]pyran-2-yl ester
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; potassium nonaflate; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 20℃; for 0.5h; | 98% |
thymin
(S)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate
(S)-1-[(2-benzoyloxy-1-phenylethoxy)methyl]thymine
Conditions | Yield |
---|---|
Stage #1: thymin With NH4(SO4)2; 1,1,1,3,3,3-hexamethyl-disilazane Heating; Stage #2: (S)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate With dibenzo-18-crown-6; potassium iodide In toluene; acetonitrile | 98% |
thymin
(R)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate
(R)-1-[(2-benzoyloxy-1-phenylethoxy)methyl]thymine
Conditions | Yield |
---|---|
Stage #1: thymin With NH4(SO4)2; 1,1,1,3,3,3-hexamethyl-disilazane Heating; Stage #2: (R)-[2-(acetoxymethoxy)-2-phenyl]ethyl benzoate With dibenzo-18-crown-6; potassium iodide In toluene; acetonitrile | 98% |
2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
thymin
(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Conditions | Yield |
---|---|
Stage #1: 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate; thymin With N,O-Bis(trimethylsilyl)trifluoroacetamide In nitromethane at 20℃; for 0.5h; Stage #2: With trimethylsilyl trifluoromethanesulfonate In nitromethane at 20℃; | 98% |
Stage #1: thymin With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 20℃; for 0.5h; Stage #2: 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; Further stages.; | 91% |
2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate
thymin
2',3',5'-tri-O-benzoyluridine
Conditions | Yield |
---|---|
Stage #1: 2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate; thymin With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 20℃; for 0.5h; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; | 98% |
Stage #1: thymin With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 20℃; for 0.5h; Stage #2: 2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; Further stages.; | 88% |
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride for 8h; | 97% |
With sodium hydroxide; tetrabutylammomium bromide In benzene at 80℃; for 14h; | 73% |
Conditions | Yield |
---|---|
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 3h; | 97% |
Conditions | Yield |
---|---|
With sodium hydroxide; water for 1h; Methylation; | 97% |
With sodium hydroxide In water at 20 - 50℃; for 20.5h; | 94% |
With potassium hydroxide Heating; | 85% |
With sodium hydroxide | |
With sodium hydroxide In water at 20 - 40℃; for 20h; |
thymin
Conditions | Yield |
---|---|
Stage #1: thymin; {[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-difluoro-methyl}-phosphonothioic acid O,O-diethyl ester With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane for 4h; Heating; Stage #2: With titanium tetrachloride In dichloromethane at 0℃; for 3h; | 97% |
thymin
2,3,4-tri-O-acetyl-L-rhamnopyranosyl (N-phenyl)-2,2,2-trifluoroacetimidate
1-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)thymine
Conditions | Yield |
---|---|
Stage #1: thymin; 2,3,4-tri-O-acetyl-L-rhamnopyranosyl (N-phenyl)-2,2,2-trifluoroacetimidate With N,O-Bis(trimethylsilyl)trifluoroacetamide In nitromethane at 20℃; for 0.5h; Stage #2: With trimethylsilyl trifluoromethanesulfonate In nitromethane at 20℃; | 97% |
thymin
Conditions | Yield |
---|---|
With potassium hydroxide In water for 0.166667h; | 97% |
Conditions | Yield |
---|---|
Stage #1: thymin With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane at 85℃; Inert atmosphere; Stage #2: 3,5-di-O-benzoyl-α-D-ribofuranose-1,2-(pent-4-enyl orthobenzoate) With N-iodo-succinimide; ytterbium(III) triflate In acetonitrile at 0 - 20℃; for 4h; | 97% |
thymin
1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-ethynyl-D-ribo-pentofuranose
1-(2-O-acetyl-3,5-di-O-benzyl-4-C-ethynyl-β-D-ribo-pentofuranosyl)thymine
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane for 13h; Heating; | 96.1% |
thymin
2,4-dihydroxypyrimidine-5-carboxylic acid
Conditions | Yield |
---|---|
With dihydrogen peroxide; 1-hydroxy-1,2,3-benzotriazine-4(3H)-one In water at 130℃; for 3h; Temperature; Autoclave; | 96.1% |
Multi-step reaction with 2 steps 1: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction 2: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction View Scheme | |
Multi-step reaction with 3 steps 1: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction 2: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction 3: ascorbic acid; iron(II) ammonium sulfate; magnesium chloride; ATP; coenzyme A; NADH; succinyl-CoA synthetase, His6-tag fused protein; pyruvate kinase; lactate dehydrogenase; Neurospora crassa thymine-7-hydroxylase, wild-type, full-length, residues 1–333 / aq. buffer / 25 °C / pH 7.5 / Enzymatic reaction View Scheme |
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