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YUNBIO TECH CO.,LTD

Our Strength: -Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs. -Innovative: We are focusing on the development of new products and keep close relationships with

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White crystalline powder Qualified Assay by HPLC Not

High purity Various Specifications Thymidine CAS:50-89-5

Cas:50-89-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2'-Deoxythymidine supplier in China

Cas:50-89-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

CAS: 50-89-5, HP8100, 2'-deoxythymidine, zidovudine intermediate Product Name BETA-THYMIDINE Synonyms 2,4(1H,3H)-Pyrimidinedione,

CAS:50-89-5 Thymidine lower price

Cas:50-89-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

CAS:50-89-5 Thymidine lower price

Cas:50-89-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or off-white crystalline powder Storage:0-6°C Package:1

Manufacturer supply Thymidine CAS 50-89-5 with favorable price

Cas:50-89-5

Min.Order:5 Metric Ton

FOB Price: $100.0 / 120.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Thymidine

Cas:50-89-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Thymidine

Cas:50-89-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Thymidine 50-89-5 ISO Producer

Cas:50-89-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Thymidine

Cas:50-89-5

Min.Order:10 Metric Ton

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

1-(2-Deoxy-beta-D-ribofuranosyl)-5-methyluracil

Cas:50-89-5

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Thymidine 50-89-5 /manufacturer/low price/high quality/in stock

Cas:50-89-5

Min.Order:1 Kilogram

FOB Price: $12.0 / 13.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

β-Thymidine

Cas:50-89-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Thymidine Basic information Product Name: Thymidine Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-methyl-;2-Desoxy-thymidine;5-Methyldeoxyurindine;beta-D-Ribof

TIANFU-CHEM CAS:50-89-5 Thymidine

Cas:50-89-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

CAS50-89-5 Beta Thymidine/2'-Deoxythymidine Powder

Cas:50-89-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 50-89-5 with best quality

Cas:50-89-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name Thymidine CAS NO. 50-89-5 English name Thymidine Alias β-thymidine Molecular formula C10H14N2O5 Molecular weight 242.2286 Structural formula

Thymidine CAS:50-89-5

Cas:50-89-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Crystalline Powder Storage:Store in sealed containers at coo

Nutrition powder CAS 50-89-5 Thymidine

Cas:50-89-5

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Thymidine 50-89-5

Cas:50-89-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, Thymidine CAS:50-89-5

Cas:50-89-5

Min.Order:1 Kilogram

FOB Price: $34.5 / 42.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Thymidine CAS:50-89-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, st

Thymidine CAS:50-89-5

Cas:50-89-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Thymidine

Cas:50-89-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Thymidine/ LIDE PHARMA- Factory supply / Best price

Cas:50-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail

2'- deoxythymidine; Beta-thymidine;Thymidine CAS:50-89-5

Cas:50-89-5

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Thymidine CAS 50-89-5

Cas:50-89-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details

China Biggest Factory Manufacturer Supply Thymidine CAS 50-89-5

Cas:50-89-5

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Thymidine

Cas:50-89-5

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Thymidine

Cas:50-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Beta-Thymidine

Cas:50-89-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

5'-O-(4-4'-dimethoxytrityl)thymidine
40615-39-2

5'-O-(4-4'-dimethoxytrityl)thymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With zinc dibromide In nitromethane for 0.0166667h; Ambient temperature;100%
With zinc dibromide In nitromethane Kinetics; Ambient temperature; in various solvent:CH2Cl2, THF, Acetone, Dioxane; other 5'-deoxytritylnucleosides;100%
With β-naphthol In dichloromethane for 0.166667h; Product distribution / selectivity; Irradiation with mercury arc lamp;97%
5'-O-tritylthymidine
7791-71-1

5'-O-tritylthymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With silica gel; trifluoroacetic acid In methanol; chloroform100%
Stage #1: 5'-O-tritylthymidine With carbon tetrabromide In methanol for 0.5h; Irradiation;
Stage #2: In methanol at 20℃; for 12.5h;
97%
With carbon tetrabromide In methanol at 20℃; for 13h; Irradiation;97%
1-[(2R,4S,5R)-5-(hydroxymethyl)-4-[2-(4-hydroxyphenyl)-2-oxoethoxy]tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
1335224-06-0

1-[(2R,4S,5R)-5-(hydroxymethyl)-4-[2-(4-hydroxyphenyl)-2-oxoethoxy]tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
In methanol; water for 0.00416667h; Photolysis;100%
3',5'-diacetylthymidine
6979-97-1, 97834-40-7, 142405-86-5

3',5'-diacetylthymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With lipase A from Aspergillus niger In aq. phosphate buffer; acetonitrile at 25℃; for 2h; pH=7; Enzymatic reaction;99%
With ammonium hydroxide at 20℃; Inert atmosphere;
With methanol; sodium methylate at 44℃; under 760.051 Torr; for 1h; Large scale reaction;295.6 g
With methanol; sodium methylate for 1h; Reflux;
3',5'-O-di(tert-butyldimethylsilyl)thymidine
40733-26-4

3',5'-O-di(tert-butyldimethylsilyl)thymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide for 1h; Ambient temperature;98%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;95%
With acetyl chloride In methanol for 2.5h;90%
thymidine 5'-(3'',5''-dimethoxybenzoin)carbonate
167872-02-8

thymidine 5'-(3'',5''-dimethoxybenzoin)carbonate

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
In benzene for 1h; Irradiation;98%
5'-O-(9-phenylthioxanthyl)-2'-deoxythimidine
82161-35-1

5'-O-(9-phenylthioxanthyl)-2'-deoxythimidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
In water; acetonitrile Hydrolysis; Irradiation;97%
3',5'-diacetylthymidine
6979-97-1, 97834-40-7, 142405-86-5

3',5'-diacetylthymidine

p2(Ac-Cys-(Asp)4-Asp-COOH)-modified immobilized BTL*S196C enzyme

p2(Ac-Cys-(Asp)4-Asp-COOH)-modified immobilized BTL*S196C enzyme

A

5'-O-acetylthymidine
35898-31-8

5'-O-acetylthymidine

B

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With sodium acetate In acetonitrile at 25℃; for 100h; pH=5; pH-value; Time; Reagent/catalyst; regioselective reaction;A 97%
B 3%
5'-tert-butyldimethylsilyloxy-2'-deoxythymidine
40733-28-6

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With Decaborane In tetrahydrofuran; methanol at 20℃; for 6h;96%
With iodine(I) bromide In methanol; dichloromethane for 2h; Ambient temperature;95%
With potassium tert-butylate In N,N-dimethyl-formamide for 24h; Ambient temperature;92%
C23H31BN2O7

C23H31BN2O7

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With dihydrogen peroxide In aq. phosphate buffer; dimethyl sulfoxide at 20℃; for 0.333333h; pH=7.2; Reagent/catalyst;96%
3-methylthymidine
958-74-7

3-methylthymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With manganese(IV) oxide; C17H20N4O9P(1-)*Na(1+); oxygen In water; acetonitrile at 20℃; under 760.051 Torr; for 7h; Irradiation; chemoselective reaction;94%
5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine
166758-13-0

5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide for 1.5h; Ambient temperature;93%
5'-O-trityl-3'-O-tert-butyldimethylsilyl thymidine
213552-25-1

5'-O-trityl-3'-O-tert-butyldimethylsilyl thymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide for 1h; Ambient temperature;93%
Carbonic acid (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-trimethylsilanyl-ethyl ester
78687-52-2

Carbonic acid (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-trimethylsilanyl-ethyl ester

A

ethene
74-85-1

ethene

B

trimethylsilyl fluoride
420-56-4

trimethylsilyl fluoride

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
zinc dibromide In tetrahydrofuran at 20℃; for 0.166667h; deprotection of TMSEC derivat with various catalyst;A n/a
B n/a
C 92%
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine
42926-80-7

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With cerium(IV) triflate; water In acetonitrile at 25℃; for 0.5h;92%
With zinc dibromide In nitromethane Kinetics; Ambient temperature;
Multi-step reaction with 7 steps
1: 82 percent / 1.)collidine 2.)I2, H2O / tetrahydrofuran
2: 91 percent
3: 25 percent / 1.)Dowex(Py+) 2.)Ph3P-CCl4
4: 76 percent / NaH/CS2 / dimethylformamide
5: 80 percent / 80percent acetic acid
6: ClCN/H2O/collidine / tetrahydrofuran
7: snake venom phosphodiesterase
View Scheme
phenacyl 5'-thymidine carbonate
252979-74-1

phenacyl 5'-thymidine carbonate

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With 9,10-dimethylanthracene In acetonitrile for 4h; UV-irradiation;91%
With N-methylcarbazole In acetonitrile for 4h; UV-irradiation;81%
In acetonitrile for 3h; UV-irradiation;
3',5'-diacetylthymidine
6979-97-1, 97834-40-7, 142405-86-5

3',5'-diacetylthymidine

BTL*-A193C enzyme

BTL*-A193C enzyme

A

3'-O-acetylthymidine
21090-30-2

3'-O-acetylthymidine

B

5'-O-acetylthymidine
35898-31-8

5'-O-acetylthymidine

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With sodium acetate In acetonitrile at 25℃; for 72h; pH=5; regioselective reaction;A 91%
B 3%
C 6%
2'-bromo-2'-deoxy-5-methyluridine

2'-bromo-2'-deoxy-5-methyluridine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol; toluene at 45℃; under 2068.65 Torr; for 6h;90.9%
2'-chlorothymidine
54898-34-9

2'-chlorothymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With hydrogen; nickel In aq. phosphate buffer at 40℃; under 760.051 Torr; for 8h; pH=7.2; Reagent/catalyst; Temperature; pH-value; Green chemistry;90.3%
2'-bromothymidine
95585-76-5

2'-bromothymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With hydrogen; nickel In methanol under 2327.2 Torr;90%
With hydrogen; nickel In aq. phosphate buffer at 10 - 20℃; under 760.051 Torr; for 10h; pH=7.4; Green chemistry;38.6g
3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine
118068-35-2

3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide for 1h; Ambient temperature;89%
5-(benzyloxy)methyl-2′-deoxyuridine
19083-35-3

5-(benzyloxy)methyl-2′-deoxyuridine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 0.5h; Inert atmosphere;88%
3',5'-di-O-levulinylthymidine
440327-37-7

3',5'-di-O-levulinylthymidine

A

3'-O-levulinoylthymidine
78635-98-0

3'-O-levulinoylthymidine

B

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With Candida antarctica lipase B; phosphate buffer In 1,4-dioxane at 40℃; for 24h; pH=7;A 85%
B n/a
5-Methyluridine
1463-10-1

5-Methyluridine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With bis(phenyl) carbonate; sodium hydrogencarbonate In water; ethyl acetate; N,N-dimethyl-formamide for 1h; Heating / reflux;85%
With hydrogenchloride; hydrogen; nickel; carbonic acid dimethyl ester; sodium hydroxide In methanol; N,N-dimethyl acetamide at 50 - 110℃; under 4500.45 Torr; for 28h; Solvent; Reagent/catalyst; Temperature; Pressure; Industrial scale;
Multi-step reaction with 3 steps
1: sodium hydroxide; Diethyl carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
2: hydrogen bromide / N,N-dimethyl-formamide / 4 h / 40 °C
3: hydrogen; nickel / aq. phosphate buffer / 10 h / 10 - 20 °C / 760.05 Torr / pH 7.4 / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide; Diethyl carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
2: hydrogenchloride / N,N-dimethyl acetamide / 5 h / 60 °C
3: hydrogen; nickel / aq. phosphate buffer / 8 h / 40 °C / 760.05 Torr / pH 7.2 / Green chemistry
View Scheme
3',5'-O-di(tert-butyldimethylsilyl)thymidine
40733-26-4

3',5'-O-di(tert-butyldimethylsilyl)thymidine

A

3'-O-(t-butyldimethylsilyl)thymidine
40733-27-5

3'-O-(t-butyldimethylsilyl)thymidine

B

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With phosphomolybdic acid In methanol at 20℃; for 3h; Solvent; Reagent/catalyst; regioselective reaction;A 85%
B 9%
3',5'-di-O-methoxyacetylthymidine
92447-12-6

3',5'-di-O-methoxyacetylthymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20℃; for 1h;84%
N3-benzoyl thymidine
94189-75-0

N3-benzoyl thymidine

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With benzyl alcohol at 90℃; for 30h;82%
With ammonium hydroxide for 1h; Ambient temperature;
3',5'-diacetylthymidine
6979-97-1, 97834-40-7, 142405-86-5

3',5'-diacetylthymidine

p6(Ac-Cys-(Phe-Gly)2-Asp-Asp-CONH2)-modified immobilized BTL*-S196C enzyme

p6(Ac-Cys-(Phe-Gly)2-Asp-Asp-CONH2)-modified immobilized BTL*-S196C enzyme

A

3'-O-acetylthymidine
21090-30-2

3'-O-acetylthymidine

B

5'-O-acetylthymidine
35898-31-8

5'-O-acetylthymidine

C

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With sodium acetate In acetonitrile at 25℃; for 48h; pH=5; regioselective reaction;A 2%
B 82%
C 16%
C31H33N3O5
1220688-60-7

C31H33N3O5

thymidine
50-89-5

thymidine

Conditions
ConditionsYield
With methanol for 1h; UV-irradiation;81%
acetic anhydride
108-24-7

acetic anhydride

thymidine
50-89-5

thymidine

3',5'-diacetylthymidine
6979-97-1, 97834-40-7, 142405-86-5

3',5'-diacetylthymidine

Conditions
ConditionsYield
With pyridine for 2h;100%
With pyridine at 20℃;99%
With dmap98%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

thymidine
50-89-5

thymidine

3',5'-O-bis-(trimethylsilyl)-thymidine
10457-18-8

3',5'-O-bis-(trimethylsilyl)-thymidine

Conditions
ConditionsYield
With pyridine; N-ethyl-N,N-diisopropylamine at 20℃; for 0.5h;100%
With N-ethyl-N,N-diisopropylamine In pyridine for 0.5h; Ambient temperature;
With pyridine at 20℃;
Isopropenyl acetate
108-22-5

Isopropenyl acetate

thymidine
50-89-5

thymidine

5'-O-acetylthymidine
35898-31-8

5'-O-acetylthymidine

Conditions
ConditionsYield
With subtilisin 8350 In N,N-dimethyl-formamide at 45℃; for 36h;100%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

thymidine
50-89-5

thymidine

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine
40733-28-6

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 5h;100%
With silver nitrate In tetrahydrofuran98%
With dmap In pyridine at 20℃; for 10h;97%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

thymidine
50-89-5

thymidine

3',5'-O-di(tert-butyldimethylsilyl)thymidine
40733-26-4

3',5'-O-di(tert-butyldimethylsilyl)thymidine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 25℃;100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;100%
With pyridine; 1H-imidazole Inert atmosphere;100%
tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

thymidine
50-89-5

thymidine

5'-O-tert-butyldiphenylsilylthymidine
101527-40-6

5'-O-tert-butyldiphenylsilylthymidine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at -50 - 20℃; for 4h;100%
With pyridine; dmap for 6h; Ambient temperature;95%
With dmap In pyridine for 48h; Ambient temperature;93%
4-bromo-1-fluorobutane
462-72-6

4-bromo-1-fluorobutane

thymidine
50-89-5

thymidine

N-3-(4-fluoro-n-butyl)thymidine

N-3-(4-fluoro-n-butyl)thymidine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide; acetone at 20℃; for 72h;100%
mono-4-methoxytrityl chloride
14470-28-1

mono-4-methoxytrityl chloride

thymidine
50-89-5

thymidine

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine
42926-80-7

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

Conditions
ConditionsYield
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 3.5h;99%
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;97%
With pyridine94%
thymidine
50-89-5

thymidine

2'-deoxy-5-(trideuteriomethyl)uridine
74848-84-3

2'-deoxy-5-(trideuteriomethyl)uridine

Conditions
ConditionsYield
With d(4)-methanol; palladium on activated charcoal; hydrogen at 160℃; for 24h;99%
With deuterium; platinum(IV) oxide In water-d2 at 75 - 80℃; for 72h;85%
With hydrogen; water-d2; platinum(IV) oxide at 50 - 60℃; for 192h;75%
thymidine
50-89-5

thymidine

5’-bromo-5’-deoxythymidine
25905-51-5

5’-bromo-5’-deoxythymidine

Conditions
ConditionsYield
With carbon tetrabromide; triphenylphosphine In N,N-dimethyl acetamide at 20℃; for 5.5h; Appel Halogenation; Inert atmosphere;99%
With carbon tetrabromide; triphenylphosphine In pyridine for 1h;66%
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

thymidine
50-89-5

thymidine

(+)-5-methyl-1-((2R,4S,5R)-4-((triisopropylsilyl)oxy)-5-(((triisopropyl-silyl)oxy)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)dione
54925-58-5

(+)-5-methyl-1-((2R,4S,5R)-4-((triisopropylsilyl)oxy)-5-(((triisopropyl-silyl)oxy)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)dione

Conditions
ConditionsYield
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 50℃; for 16h;99%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

thymidine
50-89-5

thymidine

3',5'-dimethanesulfonylthymidine

3',5'-dimethanesulfonylthymidine

Conditions
ConditionsYield
With pyridine In water98.6%
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

thymidine
50-89-5

thymidine

1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine
97626-18-1

1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine

Conditions
ConditionsYield
With pyridine at 20℃; for 24h;98%
With pyridine at 20℃; for 4h; Inert atmosphere;95%
With pyridine for 0.333333h; Ambient temperature;85%
With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide at 0℃; for 4h;49.9 g
With pyridine at 20℃; for 40h; Inert atmosphere;
thymidine
50-89-5

thymidine

5,6-dihydrothymidine
5627-00-9

5,6-dihydrothymidine

Conditions
ConditionsYield
With Rh/Al2O3; hydrogen In methanol; water for 168h;98%
With hydrogen; Rh/Al2O3 In methanol; water under 2585.7 Torr; for 48h;96%
With Rh/Al2O3; hydrogen In water at 20℃; under 22502.3 Torr;85%
2,2-dimethylpropanoic anhydride
1538-75-6

2,2-dimethylpropanoic anhydride

thymidine
50-89-5

thymidine

3',5'-O-bis(trimethylacetyl)thymidine

3',5'-O-bis(trimethylacetyl)thymidine

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate In dichloromethane; water at 25℃; for 24h;98%
vinyl benzoate
769-78-8

vinyl benzoate

thymidine
50-89-5

thymidine

5'-benzoylthymidine
35898-29-4, 65475-51-6

5'-benzoylthymidine

Conditions
ConditionsYield
With Candida antarctica lipase B In tetrahydrofuran at 60℃; for 63h;98%
With Candida antarctica lipase B In tetrahydrofuran at 60℃; for 116h; Inert atmosphere; Enzymatic reaction; regioselective reaction;93%
thymidine
50-89-5

thymidine

5-((tert-butoxycarbonyl)amino)-4-oxopentanoic acid
72072-06-1

5-((tert-butoxycarbonyl)amino)-4-oxopentanoic acid

3',5'-di-O-(Boc-ALA)thymidine
1131245-46-9

3',5'-di-O-(Boc-ALA)thymidine

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In 1,4-dioxane; dichloromethane at 0 - 20℃;98%
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

thymidine
50-89-5

thymidine

5-methyl-1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione

5-methyl-1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
In pyridine at 20℃; for 24h;98%
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

thymidine
50-89-5

thymidine

1-[(6aS,8R,9aR)-2,2,4,4-tetraisopropyl-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-5-methylpyrimidine-2,4-dione
137174-38-0

1-[(6aS,8R,9aR)-2,2,4,4-tetraisopropyl-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-5-methylpyrimidine-2,4-dione

Conditions
ConditionsYield
With pyridine at 20℃; for 24h;98%
trityl chloride
76-83-5

trityl chloride

thymidine
50-89-5

thymidine

5'-O-tritylthymidine
7791-71-1

5'-O-tritylthymidine

Conditions
ConditionsYield
With pyridine at 20℃; for 21.5h;97.1%
In pyridine at 20℃; for 48h;92%
With pyridine at 100℃; for 0.5h;91%
4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

thymidine
50-89-5

thymidine

5'-O-(4-4'-dimethoxytrityl)thymidine
40615-39-2

5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 5h;97%
With pyridine; dmap at 20℃; for 24h;96%
With pyridine at 20℃; for 12h;96%
4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

thymidine
50-89-5

thymidine

3',5'-di-O-toluoylthymidine
4449-39-2

3',5'-di-O-toluoylthymidine

Conditions
ConditionsYield
With pyridine for 3h; Ambient temperature;97%
With pyridine at 20℃; for 1h;96%
at 0 - 55℃;
With dmap In dichloromethane
3,4,5,6-tetrachlorophthalimide
1571-13-7

3,4,5,6-tetrachlorophthalimide

thymidine
50-89-5

thymidine

4,5,6,7-Tetrachloro-2-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-isoindole-1,3-dione
210490-66-7

4,5,6,7-Tetrachloro-2-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-isoindole-1,3-dione

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran Mitsunobu reaction;97%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran97%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran97%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 0.25h;
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