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HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

Ribosylthymine

Cas:1463-10-1

Min.Order:1 Metric Ton

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

Ribosylthymine TOP1 supplier

Cas:1463-10-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ribosylthymine supplier in China

Cas:1463-10-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

High quality 5-Methyluridine CAS 1463-10-1 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additiv

High quality 5-Methyluridine CAS 1463-10-1 with factory price

Cas:1463-10-1

Min.Order:1 Gram

FOB Price: $10.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

5-Methyluridine

Cas:1463-10-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 5-Methyluridine 1463-10-1 GMP Manufacturer

Cas:1463-10-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Methyluridine

Cas:1463-10-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

discount 5-Methyluridine

Cas:1463-10-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

5-Methyluridine

Cas:1463-10-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

top quality 5-Methyluridine

Cas:1463-10-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 1463-10-1 with best quality

Cas:1463-10-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name: 5-Methyluridine Synonyms: Ribosylthymine; 5-Methyl-Uridine CAS No.: 1463-10-1 Molecular Formula: C10H14N2O6 Assay(Purity) or Standard:99% Properties: white or semi-white crystalline powder Specifications: Assay: HPLC

5-Methyluridine 99% CAS 1463-10-1

Cas:1463-10-1

Min.Order:25 Kilogram

FOB Price: $70.0 / 100.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or almost white powder Storage:R.T Package:25kg/drum Application:Intermediate for pharma Transportation:Express/Sea/Air Port:Any port in China

Low Price for 5-Methyluridine cas 1463-10-1

Cas:1463-10-1

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu

Factory Supply 5-Methyluridine CAS 1463-10-1

Cas:1463-10-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ribosylthymine 1463-10-1

Cas:1463-10-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

High quality 5-Methyluridine

Cas:1463-10-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Methyluridine

Cas:1463-10-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Original Largest Manufacturer sales 5-Methyluridine CAS 1463-10-1

Cas:1463-10-1

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ribosylthymine

Cas:1463-10-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

5-Methyluridine

Cas:1463-10-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

5-Methyluridine

Cas:1463-10-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 1463-10-1 5-Methyluridine

Cas:1463-10-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-methyluridine; 5-methyluridine; 5-methyluracil nucleoside

Cas:1463-10-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-METHYLURIDINE

Cas:1463-10-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

5-Methyl-Uridine;5-Me-U

Cas:1463-10-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ribosylthymine

Cas:1463-10-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 5-Methyluridine

Cas:1463-10-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and als

5-Methyluridine

Cas:1463-10-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

5-methyluridine; 5-methyluridine; 5-methyluracil nucleoside

Cas:1463-10-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

supplier in China Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:A primary degradation product of tRNA, Transportati

5-Methyluridine -

Cas:1463-10-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

2',3',5'-tri-O-benzoyluridine
3180-76-5

2',3',5'-tri-O-benzoyluridine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With sodium methylate In methanol98%
With ammonia In methanol for 96h;98%
With sodium methylate In methanol for 0.5h; Heating;93%
2',3',5'-tri-O-benzoyluridine
3180-76-5

2',3',5'-tri-O-benzoyluridine

A

benzoic acid ethyl ester
93-89-0

benzoic acid ethyl ester

B

benzamide
55-21-0

benzamide

C

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With ammonia In ethanol at 20℃;A n/a
B n/a
C 95%
1-(5'-O-trityl-β-D-ribofuranosyl)thymine
101796-28-5

1-(5'-O-trityl-β-D-ribofuranosyl)thymine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With carbon tetrabromide In methanol at 20℃; for 12h; Irradiation;94%
With sulfuric acid; water; silica gel In acetonitrile at 25℃; for 0.283333h;93%
1-[5'-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]thymine
119794-52-4

1-[5'-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]thymine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With chloro-methylsulfanyl-methane; water; potassium iodide In 1,4-dioxane at 50℃; for 5.3h;93%
3-Methylthymidin
3650-91-7

3-Methylthymidin

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With manganese(IV) oxide; C17H20N4O9P(1-)*Na(1+); oxygen In water; acetonitrile at 20℃; under 760.051 Torr; for 7h; Irradiation; chemoselective reaction;88%
2',3'-O-isopropylidene-5'-O-methoxymethyl-5-methyluridine
87817-95-6

2',3'-O-isopropylidene-5'-O-methoxymethyl-5-methyluridine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With trifluoroacetic acid for 19h; Ambient temperature;87%
1,2,3,5-tetra-O-acetyl-β-L-ribofuranose
144490-03-9

1,2,3,5-tetra-O-acetyl-β-L-ribofuranose

2,4-bis(trimethylsiloxy)-5-methylpyrimidine
7288-28-0

2,4-bis(trimethylsiloxy)-5-methylpyrimidine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
Stage #1: 1,2,3,5-tetra-O-acetyl-β-L-ribofuranose; 2,4-bis(trimethylsiloxy)-5-methylpyrimidine With tin(IV) chloride In dichloromethane for 12h; Reflux;
Stage #2: With acetic acid In dichloromethane at 20℃; for 1h;
Stage #3: With ammonia In methanol at 20℃; for 12h;
85.06%
thymin
65-71-4

thymin

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With purine nucleoside phosphorylase; uridine phosphorylase at 90℃; for 48h; pH=9; aq. phosphate buffer; Enzymatic reaction;85%
In water; dimethyl sulfoxide at 25℃; pH=7.4; aq. phosphate buffer; Enzymatic reaction;79.1%
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
4336-39-4

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 6h; Inert atmosphere; Schlenk technique;81%
With ammonia In methanol at 20℃;
With Amberlite IRA 120 H+ In 1,4-dioxane; methanol14.1 g
5-(2,5-dimethoxythiophenyl)-5-methyl-5,6-dihydrouridine
1391764-47-8

5-(2,5-dimethoxythiophenyl)-5-methyl-5,6-dihydrouridine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
In water for 0.0666667h; Photolysis;78%
thymin
65-71-4

thymin

inosine
58-63-9

inosine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With potassium phosphate; xanthine oxidase; purine and pyrimidine nucleoside phosphorylase (PUNP, PYNP) at 40℃; for 11h;76%
With potassium phosphate; xanthine oxidase; PUNP, PYNP at 40℃; for 11h; Equilibrium constant;76%
7-methylguanosine hydroiodide
81100-62-1

7-methylguanosine hydroiodide

thymin
65-71-4

thymin

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With potassium dihydrogenphosphate; E. coli purine nucleoside phosphorylase; E. coli uridine phosphorylase In aq. buffer at 20℃; for 20h; pH=7.5; Enzymatic reaction;75%
stavudin
3056-17-5

stavudin

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With osmium(VIII) oxide In pyridine; N,N-dimethyl-formamide; benzene for 1.5h; Ambient temperature;74%
thymin
65-71-4

thymin

A

2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With mutant Escherichia coli uridine phosphorylase Lys235Arg, Gln236Ala; purine nucleoside phosphorylase from Bacillus halodurans at 60℃; for 2h; pH=7; Kinetics; Reagent/catalyst; Temperature; aq. buffer; Enzymatic reaction;A n/a
B 73.1%
5-(p-tolylthiomethyl)uridine

5-(p-tolylthiomethyl)uridine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With nickel In ethanol Heating;65%
2',3',5'-tris-O-(tert-butyldimethylsilyl)uridine
64898-15-3

2',3',5'-tris-O-(tert-butyldimethylsilyl)uridine

methyl iodide
74-88-4

methyl iodide

A

6-methyluridine
16710-13-7

6-methyluridine

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
Yield given. Multistep reaction;A n/a
B 61%
Yield given. Multistep reaction;A 4%
B n/a
thymin
65-71-4

thymin

Inosine
58-63-9

Inosine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
BM-11 E. coli cells, 0.015 M potassium phosphate buffer (pH 7.25); 1.) 60 deg C, 2 h, 2.) 4 deg C, 18 h;45%
thymin
65-71-4

thymin

α-D-ribofuranosyl-1-phosphate
18646-11-2

α-D-ribofuranosyl-1-phosphate

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
uridine phosphorylase;45%
(S)-2',3'-O-(2-bromo-1-diethylphosphonoethylidene)-5'-O-tert-butyldiphenylsilyl-5-methyluridine
214039-19-7

(S)-2',3'-O-(2-bromo-1-diethylphosphonoethylidene)-5'-O-tert-butyldiphenylsilyl-5-methyluridine

A

3-N-ethyl-5-methyluridine

3-N-ethyl-5-methyluridine

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With potassium fluoride In N,N-dimethyl-formamide at 130℃; for 6h; Ring cleavage; desilylation;A 35%
B 39%
5,S2-Dimethyl-2',3',5'-tri-O-acetyl-2-thiouridine
175875-24-8

5,S2-Dimethyl-2',3',5'-tri-O-acetyl-2-thiouridine

A

5-Methyluridine
1463-10-1

5-Methyluridine

B

2,5'-Anhydro-5-methyluridine
29789-17-1

2,5'-Anhydro-5-methyluridine

Conditions
ConditionsYield
With ammonium hydroxide at 55℃;A 25%
B 33%
5-(hydroxymethyl)uridine
30414-00-7

5-(hydroxymethyl)uridine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With acetic acid; platinum Hydrogenation;
trimethylaluminum
75-24-1

trimethylaluminum

1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-5-bromo-4-trimethylsilanyloxy-1H-pyrimidin-2-one
111582-94-6

1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-5-bromo-4-trimethylsilanyloxy-1H-pyrimidin-2-one

A

uridine
58-96-8

uridine

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With water; ammonium chloride; triphenylphosphine 1) THF, reflux, 10 h, 2) MeOH, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
With tetrakis(triphenylphosphine) palladium(0); water; ammonium chloride 1) THF, reflux, 2.5 h, 2) MeOH, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
trimethylaluminum
75-24-1

trimethylaluminum

1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-5-iodo-4-trimethylsilanyloxy-1H-pyrimidin-2-one
111582-84-4

1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-5-iodo-4-trimethylsilanyloxy-1H-pyrimidin-2-one

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With water; ammonium chloride; triphenylphosphine 1) THF, reflux, 4 h, 2) MeOH, reflux, 3 h; Yield given. Multistep reaction;
orotate anion
73-97-2

orotate anion

C10H14N2O6(1-)

C10H14N2O6(1-)

A

2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid anion
73-97-2

2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid anion

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
In water at 20℃; Rate constant; Equilibrium constant; pH 8.5;
N-methylnicotineamide iodide
6456-44-6

N-methylnicotineamide iodide

C10H14N2O6(1-)

C10H14N2O6(1-)

A

C7H9N2O
42986-37-8

C7H9N2O

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
In water at 20℃; Rate constant; Equilibrium constant; pH 8.4-8.7;
1-methyl-4-carboxypyridinium chloride
5746-18-9

1-methyl-4-carboxypyridinium chloride

C10H14N2O6(1-)

C10H14N2O6(1-)

A

C7H8NO2
36455-39-7

C7H8NO2

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
In water at 20℃; Rate constant; Equilibrium constant; pH 8.4-8.7;
2',3'-O,O-isopropylidene-5-methyluridine
2073-43-0

2',3'-O,O-isopropylidene-5-methyluridine

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
With trifluoroacetic acid Yield given;
Multi-step reaction with 5 steps
1.1: 5% rhodium on alumina; hydrogen / methanol / 12 h / 4654.46 Torr
2.1: pyridine; silver nitrate; triethylamine / tetrahydrofuran / 4 h
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
3.2: 0.42 h / -78 °C
4.1: trifluoroacetic acid / water / 1.5 h
5.1: water / 0.07 h / Photolysis
View Scheme
terephthalaldehyde,
623-27-8

terephthalaldehyde,

C10H14N2O6(1-)

C10H14N2O6(1-)

A

Benzene-1,4-dicarbaldehyde
623-27-8

Benzene-1,4-dicarbaldehyde

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
In water at 20℃; Rate constant; pH 8.4-8.7;
N-methyl-4-methylpyridinium iodide
2301-80-6

N-methyl-4-methylpyridinium iodide

C10H14N2O6(1-)

C10H14N2O6(1-)

A

1,4-dimethylpyridinyl radical

1,4-dimethylpyridinyl radical

B

5-Methyluridine
1463-10-1

5-Methyluridine

Conditions
ConditionsYield
In water at 20℃; Rate constant; Equilibrium constant; pH 8-8.5, var. pH;
tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

5-Methyluridine
1463-10-1

5-Methyluridine

5′-O-tert-butyldiphenylsilyl-O2-2′-anhydro-5-methyluridine
134821-75-3

5′-O-tert-butyldiphenylsilyl-O2-2′-anhydro-5-methyluridine

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 18h; Inert atmosphere;100%
With pyridine at 20℃; for 24h; silylation;
With 1H-imidazole In N,N-dimethyl-formamide Molecular sieve; Inert atmosphere;
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

5-Methyluridine
1463-10-1

5-Methyluridine

1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H.3H)-dione
130983-87-8

1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H.3H)-dione

Conditions
ConditionsYield
With pyridine for 6h; Ambient temperature;98%
In pyridine for 15h; Ambient temperature;84%
With pyridine80%
Acetyl bromide
506-96-7

Acetyl bromide

5-Methyluridine
1463-10-1

5-Methyluridine

1-(3,5-di-O-acetyl-2-bromo-2-deoxy-β-D-ribofuranosyl)thymine
110483-43-7

1-(3,5-di-O-acetyl-2-bromo-2-deoxy-β-D-ribofuranosyl)thymine

Conditions
ConditionsYield
In acetonitrile Heating;97%
With Trimethyl orthoacetate; hydrogen bromide 1.) acetic acid, 50 deg C, 1 h, 2.) 50 - 60 deg C, 5 h; Yield given. Multistep reaction;
acetic anhydride
108-24-7

acetic anhydride

5-Methyluridine
1463-10-1

5-Methyluridine

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
4336-39-4

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With dmap; triethylamine In acetonitrile for 1h; Ambient temperature;97%
With pyridine for 10h; Ambient temperature;94%
With pyridine; dmap at 20℃; for 12h;90%
With pyridine at 0℃; for 5h;
Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
84416-80-8

Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

5-Methyluridine
1463-10-1

5-Methyluridine

C42H47N4O14P

C42H47N4O14P

Conditions
ConditionsYield
With 1H-tetrazole; silica gel In acetonitrile for 0.25h;97%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

5-Methyluridine
1463-10-1

5-Methyluridine

2′,3′,5′-tris(methanesulfonyl)-5-methyluridine
99614-96-7

2′,3′,5′-tris(methanesulfonyl)-5-methyluridine

Conditions
ConditionsYield
With 4-methyl-morpholine In acetone at 5 - 50℃; for 2.5h;97%
With triethylamine In dichloromethane at 20℃; for 0.00416667h; Reagent/catalyst; Temperature; Sonication; Flow reactor;97%
With 4-methyl-morpholine In acetone
4-Vinylphenylboronic acid
2156-04-9

4-Vinylphenylboronic acid

5-Methyluridine
1463-10-1

5-Methyluridine

C18H19BN2O6
1085524-26-0

C18H19BN2O6

Conditions
ConditionsYield
In 1,4-dioxane for 10h; Reflux;97%
benzoyl cyanide
613-90-1

benzoyl cyanide

5-Methyluridine
1463-10-1

5-Methyluridine

2',3',5'-tri-O-benzoyluridine
3180-76-5

2',3',5'-tri-O-benzoyluridine

Conditions
ConditionsYield
With dmap; 1-ethylene glycol monomethyl ether-3-methylimidazolium methanesulfonate at 25 - 35℃;96%
With dmap In various solvent(s) at 25 - 30℃; for 1.5h;96%
With pyridine; dmap at 40℃; for 3h;89%
With triethylamine In 1,4-dioxane at 20℃; for 0.666667h;70%
5-Methyluridine
1463-10-1

5-Methyluridine

O-2,2'-cyclo-5-methyluridine
22423-26-3

O-2,2'-cyclo-5-methyluridine

Conditions
ConditionsYield
With sodium hydroxide; Diethyl carbonate In N,N-dimethyl-formamide at 120℃; for 8h; Reagent/catalyst;95.6%
With bis(phenyl) carbonate; sodium hydrogencarbonate In N,N-dimethyl-formamide at 100℃;90%
With bis(phenyl) carbonate; sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide) for 1h; Heating / reflux;85%
Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
78635-91-3

Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

5-Methyluridine
1463-10-1

5-Methyluridine

C42H47N4O14P

C42H47N4O14P

Conditions
ConditionsYield
With 1H-tetrazole; silica gel In acetonitrile for 0.25h; Product distribution; other reagent, other amount of reagent;95%
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

5-Methyluridine
1463-10-1

5-Methyluridine

2',3'-O,O-isopropylidene-5-methyluridine
2073-43-0

2',3'-O,O-isopropylidene-5-methyluridine

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 20℃; for 24h;95%
92%
With toluene-4-sulfonic acid In acetone at 20℃;58%
1,1-dimethoxycyclopentane
931-94-2

1,1-dimethoxycyclopentane

5-Methyluridine
1463-10-1

5-Methyluridine

1-(2'-O,3'-O-Cyclopentyl-5'-hydroxy-β-D-erythro-pentofuranosyl)-5-methyluracil
161824-82-4

1-(2'-O,3'-O-Cyclopentyl-5'-hydroxy-β-D-erythro-pentofuranosyl)-5-methyluracil

Conditions
ConditionsYield
With toluene-4-sulfonic acid In 1,2-dichloro-ethane at 65℃; for 1.33333h;95%
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

5-Methyluridine
1463-10-1

5-Methyluridine

2',3'-O-methoxyethylidene-5-methyluridine

2',3'-O-methoxyethylidene-5-methyluridine

Conditions
ConditionsYield
With acetic acid at 50℃; for 1h;95%
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

5-Methyluridine
1463-10-1

5-Methyluridine

2',3'-O-methoxyethylidene-5-methyluridine

2',3'-O-methoxyethylidene-5-methyluridine

Conditions
ConditionsYield
In chloroform; acetic acid95%
benzylamine hydrochloride
3287-99-8, 39110-74-2

benzylamine hydrochloride

5-Methyluridine
1463-10-1

5-Methyluridine

(2'R,6'R)-2'-thymin-1-yl-6'-hydroxymethyl-N-benzyl morpholine
1221295-59-5

(2'R,6'R)-2'-thymin-1-yl-6'-hydroxymethyl-N-benzyl morpholine

Conditions
ConditionsYield
Stage #1: benzylamine hydrochloride; 5-Methyluridine With sodium periodate; sodium tetraborate decahydrate In methanol for 2.5h;
Stage #2: With sodium cyanoborohydride; triethylamine In methanol for 1h;
Stage #3: With trifluoroacetic acid In methanol for 3h;
95%
acetone
67-64-1

acetone

5-Methyluridine
1463-10-1

5-Methyluridine

2',3'-O,O-isopropylidene-5-methyluridine
2073-43-0

2',3'-O,O-isopropylidene-5-methyluridine

Conditions
ConditionsYield
With sulfuric acid; copper(II) sulfate for 48h; sealed bottle;94%
With sulfuric acid at 0 - 20℃;91%
With sulfuric acid; copper(II) sulfate75%
4-heptanone
123-19-3

4-heptanone

5-Methyluridine
1463-10-1

5-Methyluridine

1-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dipropyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

1-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dipropyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With hydrogenchloride; orthoformic acid triethyl ester In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; for 25h;94%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

5-Methyluridine
1463-10-1

5-Methyluridine

1-[5'-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]thymine
119794-52-4

1-[5'-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]thymine

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 18h; Inert atmosphere;93%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;85%
With 1H-imidazole In N,N-dimethyl-formamide for 20h;73%
With 1H-imidazole In dichloromethane at 20℃; for 48h;50%
n-tetradecanoic acid
544-63-8

n-tetradecanoic acid

5-Methyluridine
1463-10-1

5-Methyluridine

C52H92N2O9

C52H92N2O9

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; Inert atmosphere;93%
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

5-Methyluridine
1463-10-1

5-Methyluridine

3-(2-chloroethyl)-2'-hydroxythymidine
1085484-19-0

3-(2-chloroethyl)-2'-hydroxythymidine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 0.05h; microwave irradiation;92%
cycloxexanone dimethyl ketal
933-40-4

cycloxexanone dimethyl ketal

5-Methyluridine
1463-10-1

5-Methyluridine

2',3'-O-cyclohexylidene-5-methyluridine
1191255-79-4

2',3'-O-cyclohexylidene-5-methyluridine

Conditions
ConditionsYield
Stage #1: cycloxexanone dimethyl ketal; 5-Methyluridine With toluene-4-sulfonic acid In tetrahydrofuran for 0.5h; Reflux;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;
92%
With camphor-10-sulfonic acid In 1,2-dichloro-ethane for 2h; Reflux; Inert atmosphere;
5-Methyluridine
1463-10-1

5-Methyluridine

trimethyl orthoformate
149-73-5

trimethyl orthoformate

2',3'-di-O-methoxymethylidene-5-methyluridine
79137-02-3

2',3'-di-O-methoxymethylidene-5-methyluridine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃;91%
di-tert-butylsilyl bis(trifluoromethanesulfonate)
85272-31-7

di-tert-butylsilyl bis(trifluoromethanesulfonate)

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

5-Methyluridine
1463-10-1

5-Methyluridine

1-[2,2-di-tert-butyl-7-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-6-yl]-5-methyl-1H-pyrimidine-2,4-dione
922508-15-4

1-[2,2-di-tert-butyl-7-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-6-yl]-5-methyl-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
Stage #1: di-tert-butylsilyl bis(trifluoromethanesulfonate); 5-Methyluridine In N,N-dimethyl-formamide at 20℃;
Stage #2: tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 20℃;
91%
benzoic acid anhydride
93-97-0

benzoic acid anhydride

5-Methyluridine
1463-10-1

5-Methyluridine

2',3',5'-tri-O-benzoyluridine
3180-76-5

2',3',5'-tri-O-benzoyluridine

Conditions
ConditionsYield
With dmap In various solvent(s) at 50℃; for 2h;90%
di-tert-butylsilyl bis(trifluoromethanesulfonate)
85272-31-7

di-tert-butylsilyl bis(trifluoromethanesulfonate)

5-Methyluridine
1463-10-1

5-Methyluridine

1-((4aR,6R,7R,7aS)-2,2-di-tert-butyl-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

1-((4aR,6R,7R,7aS)-2,2-di-tert-butyl-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With 2,6-dimethylpyridine In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;90%
With 2,6-dimethylpyridine In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere;90%

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