DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:73231-34-2
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Type:Lab/Research institutions
inquiryFlorfenicol Technical Data Sheet Chemical name: [R-(R*, R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide; 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]aceta
Cas:73231-34-2
Min.Order:25 Kilogram
FOB Price: $75.0 / 80.0
Type:Lab/Research institutions
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Cas:73231-34-2
Min.Order:25 Kilogram
Negotiable
Type:Other
inquiryIt conforms to CPV2010. Appearance:Almost white crystalline powder Storage:room temperature Package:25kg/drum or customer requirements Application:feed grade ,feed additive Transportation:by sea air or express Port:Hangzhou or Shanghai,China
Cas:73231-34-2
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryWe are very compeitive on Florfenicol.Our mfr is GMP certified for this item with DMF document. Product Name: Florfenicol CAS: 73231-34-2 MF: C12H14Cl2FNO4S MW: 358.21 EINECS: 642-986-0
Cas:73231-34-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:73231-34-2
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Type:Manufacturers
inquiryProduct name: Florfenicol Molecular formula: C12H14CL2FNO4S Molecular Weight: 358.2 (1). Florfenicol is to treat the infection and respiratory diseases. (2). Florfenicol is to prevent and treat sudden death, high fever, emaciation
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:73231-34-2
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FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:0-6°C Packag
Cas:73231-34-2
Min.Order:25 Kilogram
FOB Price: $70.0 / 100.0
Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:73231-34-2
Min.Order:1 Kilogram
FOB Price: $69.0 / 89.0
Type:Manufacturers
inquiryService we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to
Cas:73231-34-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:73231-34-2
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:73231-34-2
Min.Order:1 Gram
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Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:73231-34-2
Min.Order:1 Gram
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Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:73231-34-2
Min.Order:1 Kilogram
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inquirySuperiority 1.Competitive price with high quality material along with proper and complete documents; 2.Your stable supply channel for your choice; Earliest delivery time ; 3.Supply full range of APIs & Chemicals to reduce
Cas:73231-34-2
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Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Name:Florfenicol CAS NO: 73231-34-2 Grade:Medical scientific research and export Molecular formula:C12H14CL2FNO4S Molecular weight:358.2 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability
Cas:73231-34-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryFlorfenicol Basic information Veterinary antibiotics Pharmacological effects Indications Uses Product Name: Florfenicol Synonyms: (r-(r*,s*))-methyleste;2,2-dichloro-n-(1-(fluoromethyl)-2
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:73231-34-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:73231-34-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:73231-34-2
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquirycas 73231-34-2 99% Florfenicol powder Product Name: Florfenicol CAS: 73231-34-2 MF: C12H14Cl2FNO4S MW: 358.21 EINECS: 642-986-0 Appearance:white Storage:room Package:drum Appli
Cas:73231-34-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryName: Florfenicol Synonyms: 2,2-dichloro-N-{1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfanyl)phenyl]ethyl}acetamide CAS:73231-34-2 C12H14Cl2FNO4S Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/d
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at cool & d
Cas:73231-34-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiryAppearance:White to off-white powder Storage:Inert atmosphere,2-8°C Package:25kg/drum Application:It is a kind of antibacterial drug. It is used as the veterinary antimicrobial drugs for treating bacterial diseases of pigs, chickens and fish. It ha
Cas:73231-34-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:73231-34-2
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:73231-34-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:73231-34-2
Min.Order:10 Gram
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Type:Trading Company
inquiryProduct Detail CAS Number:73231-34-2/76639-94-6 Name:Florfenicol Formula:C12H14Cl2FNO4S Molecular Weight:358.21 Deleted CAS:76639-94-6, 81588-76-3, 173008-78-1 Synonyms:Acetamide,2,2-dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(meth
Cas:73231-34-2
Min.Order:1 Milligram
Negotiable
Type:Other
inquiry(4S,5R)-2-dichloromethyl-4-fluoromethyl-4,5-dihydro-5-(4-(methylsulfonyl)phenyl)oxazoline
Florfenicol
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at 70℃; for 5h; pH=6; | 99% |
With potassium acetate In methanol; water; isopropyl alcohol for 3h; Heating; pH 5; Yield given; | |
With ammonium hydroxide; water at 25℃; | |
With sodium acetate In water; isopropyl alcohol for 3h; pH=5; Reflux; | 4.15 g |
In water; isopropyl alcohol at 80℃; for 1h; | 9.2 g |
dichloroacetic acid methyl ester
(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol
Florfenicol
Conditions | Yield |
---|---|
With triethylamine In methanol at 20℃; | 96% |
With triethylamine In methanol for 18h; Ambient temperature; | 84% |
With triethylamine for 3.5h; Heating; Yield given; |
(1R,2S)-1-(4-methylsulfonylphenyl)-2-benzylamino-3-fluoro-1-propanol
ethyl 1,1-dichloroacetate
Florfenicol
Conditions | Yield |
---|---|
Stage #1: (1R,2S)-1-(4-methylsulfonylphenyl)-2-benzylamino-3-fluoro-1-propanol With sulfuric acid; hydrogen; palladium on activated charcoal In ethanol at 20℃; for 2h; Stage #2: ethyl 1,1-dichloroacetate With triethylamine In methanol at 30℃; for 6h; Further stages.; | 96% |
dichloroacetic acid methyl ester
Florfenicol
Conditions | Yield |
---|---|
With triethylamine In methanol Heating; | 95% |
With sodium hydrogencarbonate In methanol at 50℃; for 16h; | 5.6 g |
With triethylamine In methanol at 50℃; for 10h; | 7.1 g |
Florfenicol
Conditions | Yield |
---|---|
With methanol; sodium acetate at 60℃; for 1h; Reagent/catalyst; | 95% |
D-threo-2-(dichloromethyl)-5-(4-methanesulfonylphenyl)-4,5-dihydro-1,3-oxazol-4-yl methanol
Florfenicol
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; under 1520.1 - 2280.15 Torr; for 24h; | 93% |
Multi-step reaction with 2 steps 1: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 2: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 25 °C 2: triethylamine tris(hydrogen fluoride) / acetonitrile / 10 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: phosgene / dichloromethane / 16 h / 20 - 25 °C / Cooling with ice 2: sodium fluoride / N,N-dimethyl-formamide / 7 h / 80 °C / Inert atmosphere 3: hydrogenchloride / isopropyl alcohol; water / 5 h / 70 °C / pH 6 View Scheme |
dichloroacetic acid methyl ester
Florfenicol
Conditions | Yield |
---|---|
Stage #1: (1R,2S)-3-fluoro-1-(4-(methylsulfonyl)phenyl)-2-nitropropan-1-ol With palladium 10% on activated carbon; hydrogen In methanol Stage #2: dichloroacetic acid methyl ester With triethylamine In methanol at 20℃; for 18h; | 70% |
C13H15Cl2NO6S2
Florfenicol
Conditions | Yield |
---|---|
With triethylamine tris(hydrogen fluoride) In acetonitrile for 10h; Reflux; | 65% |
dichloroacetic acid methyl ester
(4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
Florfenicol
Conditions | Yield |
---|---|
Stage #1: (4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone With sodium hydroxide In ethanol at 80℃; for 3h; Stage #2: With sodium acetate In tetrahydrofuran at 0℃; for 0.166667h; Stage #3: dichloroacetic acid methyl ester In tetrahydrofuran at 25℃; for 5h; | 56% |
Florfenicol
Conditions | Yield |
---|---|
Stage #1: 2,2-dichloro-N-{(4R,5R)-4-[4-(methylsulfonyl)phenyl]-2,2-dioxido-1,3,2-dioxathian-5-yl}acetamide With triethylamine tris(hydrogen fluoride) In 1,2-dichloro-ethane at 70℃; for 8h; Stage #2: With hydrogenchloride In ethyl acetate at 0℃; for 2h; | 35% |
Conditions | Yield |
---|---|
With sodium hydroxide In water pH=4.54 - 5.53; Conversion of starting material; | A 0.17% B 0.93% |
With ethanolamine In water pH=4.48 - 5.51; Conversion of starting material; | A 0.18% B 0.7% |
dichloroacetic acid methyl ester
(1R,2S)-2-(2,3-dimethylbenzoyl)amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol
A
thiamphenicol
B
Florfenicol
Conditions | Yield |
---|---|
With hydrogenchloride; triethylamine 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given; |
(1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol
Florfenicol
Conditions | Yield |
---|---|
Multistep reaction; |
dichloroacetic acid methyl ester
(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol
B
Florfenicol
Conditions | Yield |
---|---|
In methanol; water; toluene |
para-methanesulfonylbenzaldehyde
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 83 percent / piperidine / pyridine / 4 h / 95 - 100 °C 2: 1.) SOCl2, 2.) NaBH4 / 1) reflux, 1 h; 2) CH2Cl2, EtOH, 10 deg C, 1 h 3: 82 percent / 4 Anstroem molecular sieves, diisopropyl L-tartrate, Ti(OPr-i)4, t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / 4 h / -20 °C 4: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h 5: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5 6: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 7: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme | |
Multi-step reaction with 7 steps 1.1: ethanol / 3 h / Inert atmosphere; Reflux 2.1: (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane / toluene / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere 2.2: 19 h / -10 - 20 °C / Molecular sieve; Inert atmosphere 3.1: lithium borohydride / tetrahydrofuran / 50 °C / Inert atmosphere 3.2: 1 h / 20 °C / Inert atmosphere 4.1: diethylamino-sulfur trifluoride; triethylamine / dichloromethane / 8 h / -40 - 20 °C / Inert atmosphere 5.1: water; toluene-4-sulfonic acid / acetonitrile / 24 h / 40 °C / Inert atmosphere 5.2: Inert atmosphere 6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 6 h / 20 °C / 760.05 Torr 7.1: triethylamine / methanol / 3 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide / dichloromethane; ethanol / 0 - 20 °C 1.2: 1 h / 20 °C / Cooling with ice 2.1: thionyl chloride / 8 h / 0 - 60 °C 2.2: 2 h / 20 - 60 °C 3.1: hydrogenchloride / water; methanol / 6 h / Reflux 3.2: 8 h / 0 - 60 °C 3.3: 6 h / 20 °C 4.1: sodium tetrahydroborate; methanol / 5 h / 0 - 20 °C 5.1: triethylamine; thionyl chloride / dichloromethane / 0 °C 5.2: 20 °C 6.1: triethylamine tris(hydrogen fluoride) / 1,2-dichloro-ethane / 8 h / 70 °C 6.2: 2 h / 0 - 20 °C 7.1: triethylamine / methanol / Heating View Scheme |
3-(4-methanesulfonyl-phenyl)-acrylic acid
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) SOCl2, 2.) NaBH4 / 1) reflux, 1 h; 2) CH2Cl2, EtOH, 10 deg C, 1 h 2: 82 percent / 4 Anstroem molecular sieves, diisopropyl L-tartrate, Ti(OPr-i)4, t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / 4 h / -20 °C 3: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h 4: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5 5: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 6: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme |
(1R,2R)-2-amino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / conc. H2SO4 / propan-2-ol / 1) 70 deg C, 1.5-2 h; 2) 50 deg C, 14 h 2: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 3: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme | |
Multi-step reaction with 6 steps 1: K2CO3 / H2O / 1 h / Ambient temperature 2: EtONa / ethanol 3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 5: 70 percent / KOH / methanol / 7 h / -30 °C 6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme | |
Multi-step reaction with 4 steps 1: 95 percent / K2CO3 / glycerol / 18 h / 115 °C 2: 95 percent Chromat. / (1,1,2,3,3,3-hexafluoropropyl)diethylamine (FPA) / CH2Cl2 / 2 h / 100 °C / 5171.5 Torr 3: 95 percent / 6 N HCl / 12 h / 100 - 105 °C 4: 84 percent / Et3N / methanol / 18 h / Ambient temperature View Scheme |
(E)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-ol
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 82 percent / 4 Anstroem molecular sieves, diisopropyl L-tartrate, Ti(OPr-i)4, t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / 4 h / -20 °C 2: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h 3: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5 4: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 5: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme | |
Multi-step reaction with 10 steps 1: tert.-butylhydroperoxide; C3H7O(1-)*C34H32N2O4(2-)*V(3+) / dichloromethane; water / 72 h / 0 °C 2: N,N-dimethyl-formamide / 10 h / 20 °C 3: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 4: triethylamine / dichloromethane / 2 h / 0 - 20 °C 5: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C 6: potassium hydroxide / methanol; water / 1 h / Reflux; Inert atmosphere 7: palladium 10% on activated carbon; formic acid / methanol / 10 h / 20 °C / Inert atmosphere 8: hydrogenchloride / water; isopropyl alcohol / 16 h / 50 - 70 °C 9: Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 12 h / 20 °C 10: sodium acetate / water; isopropyl alcohol / 3 h / pH 5 / Reflux View Scheme |
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h 2: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5 3: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 4: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme | |
Multi-step reaction with 9 steps 1: N,N-dimethyl-formamide / 10 h / 20 °C 2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 3: triethylamine / dichloromethane / 2 h / 0 - 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C 5: potassium hydroxide / methanol; water / 1 h / Reflux; Inert atmosphere 6: palladium 10% on activated carbon; formic acid / methanol / 10 h / 20 °C / Inert atmosphere 7: hydrogenchloride / water; isopropyl alcohol / 16 h / 50 - 70 °C 8: Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 12 h / 20 °C 9: sodium acetate / water; isopropyl alcohol / 3 h / pH 5 / Reflux View Scheme |
(3S,4R)-2-(dichloromethyl)-4,5-dihydro-α-[4-(methylsulfonyl)phenyl]oxazole-4-methanol
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5 2: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C 3: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5 View Scheme |
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 27 percent Chromat. / hexadecyltributylphosphonium chloride, potassium fluoride hydrate / toluene; H2O / 7 h / Heating 2: 2N HCl / 6 h / Heating 3: Et3N / 3.5 h / Heating View Scheme |
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 92.8 percent / pyridine / 0 °C 2: 27 percent Chromat. / hexadecyltributylphosphonium chloride, potassium fluoride hydrate / toluene; H2O / 7 h / Heating 3: 2N HCl / 6 h / Heating 4: Et3N / 3.5 h / Heating View Scheme |
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2N HCl / 6 h / Heating 2: Et3N / 3.5 h / Heating View Scheme |
(R*,R*)-(+)-thiomicamine
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: K2CO3 / H2O / 1 h / Ambient temperature 2: t-BuOK / ethanol / 3 h / Heating 3: 81 percent / H2O2 / H2O / 20 h / 45 °C 4: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 5: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 6: 70 percent / KOH / methanol / 7 h / -30 °C 7: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme | |
Multi-step reaction with 7 steps 1: K2CO3 / H2O / 1 h / Ambient temperature 2: t-BuOK / toluene / 3 h / Heating 3: 81 percent / H2O2 / H2O / 20 h / 45 °C 4: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 5: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 6: 70 percent / KOH / methanol / 7 h / -30 °C 7: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme | |
Multi-step reaction with 4 steps 1: 1.) K2CO3, 2.) CH3CO3H / 1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h 2: 95 percent Chromat. / (1,1,2,3,3,3-hexafluoropropyl)diethylamine (FPA) / CH2Cl2 / 2 h / 100 °C / 5171.5 Torr 3: 95 percent / 6 N HCl / 12 h / 100 - 105 °C 4: 84 percent / Et3N / methanol / 18 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: 1.) K2CO3, 2.) CH3CO3H / 1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h 2: (2-chloro-1,1,2-trifluoroethyl)diethylamine (FAR) / CH2Cl2 / 5 h / 100 °C 3: 95 percent / 6 N HCl / 12 h / 100 - 105 °C 4: 84 percent / Et3N / methanol / 18 h / Ambient temperature View Scheme |
(4R,5R)-4-hydroxymethyl-5-<4-(methylthio)phenyl>-2-oxazolidinone
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 81 percent / H2O2 / H2O / 20 h / 45 °C 2: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 3: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 4: 70 percent / KOH / methanol / 7 h / -30 °C 5: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme |
(1R,2R)-2-ethoxycarbonylamino-1-<4-(methylthio)phenyl>-1,3-propanediol
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: t-BuOK / ethanol / 3 h / Heating 2: 81 percent / H2O2 / H2O / 20 h / 45 °C 3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 5: 70 percent / KOH / methanol / 7 h / -30 °C 6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme | |
Multi-step reaction with 6 steps 1: t-BuOK / toluene / 3 h / Heating 2: 81 percent / H2O2 / H2O / 20 h / 45 °C 3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 5: 70 percent / KOH / methanol / 7 h / -30 °C 6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme |
(4R,5R)-4-hydroxymethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 2: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 3: 70 percent / KOH / methanol / 7 h / -30 °C 4: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme | |
Multi-step reaction with 3 steps 1: hexafluoropropene-diethylamine adduct / dichloromethane / 1 h / 105 - 110 °C / Autoclave 2: hydrogenchloride / 1 h / Reflux 3: triethylamine / methanol / 20 °C View Scheme |
(4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 2: 70 percent / KOH / methanol / 7 h / -30 °C 3: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / 1 h / Reflux 2: triethylamine / methanol / 20 °C View Scheme |
(1R,2R)-2-ethoxycarbonylamino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: EtONa / ethanol 2: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 3: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 4: 70 percent / KOH / methanol / 7 h / -30 °C 5: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme |
(4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
Florfenicol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / KOH / methanol / 7 h / -30 °C 2: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme |
succinic acid
Florfenicol
sodium 4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propoxy)-4-oxobutanoate
Conditions | Yield |
---|---|
Stage #1: succinic acid; Florfenicol With triethylamine In ethyl acetate at 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In ethyl acetate at 0 - 5℃; for 2h; Solvent; | 97.8% |
N-benzyloxycarbonyl-L-alanyl chloride
Florfenicol
Conditions | Yield |
---|---|
With triethylamine In 1,2-dichloro-ethane at 20 - 90℃; for 10h; Reagent/catalyst; Solvent; Temperature; | 94.3% |
Florfenicol
methyl chloroformate
Conditions | Yield |
---|---|
With dmap; triethylamine In tetrahydrofuran at 0℃; | 93% |
Conditions | Yield |
---|---|
With pyridine In chloroform at 20℃; for 8h; Reflux; | 89.64% |
succinic acid anhydride
Florfenicol
4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propoxy)-4-oxobutanoic acid
Conditions | Yield |
---|---|
With dmap In acetone at 60℃; for 4h; | 88.1% |
With dmap In acetone at 40 - 70℃; |
Conditions | Yield |
---|---|
With pyridine; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 10h; Reflux; | 83.29% |
Florfenicol
bis((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl) hydrogen phosphate
Conditions | Yield |
---|---|
Stage #1: Florfenicol With pyridine; trichlorophosphate In acetonitrile at 0 - 25℃; for 12.5h; Stage #2: With water In acetonitrile at 0 - 25℃; for 8.16667h; Reagent/catalyst; Solvent; | 80.72% |
(S)-benzyloxycarbonyl-proline acid chloride
Florfenicol
Conditions | Yield |
---|---|
With pyridine In chloroform at 20℃; for 10h; Reflux; | 70.39% |
ethylenebis(chloroformate)
Florfenicol
Conditions | Yield |
---|---|
With dmap; triethylamine In tetrahydrofuran at 0 - 20℃; | 62% |
Florfenicol
2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranoside
Conditions | Yield |
---|---|
Stage #1: 2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranoside With trifluoromethylsulfonic anhydride; beta-pinene In dichloromethane at -50℃; for 0.75h; Stage #2: Florfenicol In dichloromethane at -50 - 20℃; for 18h; stereoselective reaction; | 55% |
N,O-bis-(trimethylsilyl)-acetamide
Florfenicol
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 0.166667h; |
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