Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Florfenicol Manufacturer/High quality/Best price/In stock

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Florfenicol Technical Data Sheet Chemical name: [R-(R*, R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide; 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]aceta

Florfenicol

Cas:73231-34-2

Min.Order:25 Kilogram

FOB Price: $75.0 / 80.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

High quality Florfenicol supplier at best price

Cas:73231-34-2

Min.Order:25 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

It conforms to CPV2010. Appearance:Almost white crystalline powder Storage:room temperature Package:25kg/drum or customer requirements Application:feed grade ,feed additive Transportation:by sea air or express Port:Hangzhou or Shanghai,China

Florfenicol CP2010 GMP China VETERINARY

Cas:73231-34-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

We are very compeitive on Florfenicol.Our mfr is GMP certified for this item with DMF document. Product Name: Florfenicol CAS: 73231-34-2 MF: C12H14Cl2FNO4S MW: 358.21 EINECS: 642-986-0

factory supply GMP,DMF Florfenicol

Cas:73231-34-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Kono Chem Co.,Ltd

Product name: Florfenicol Molecular formula: C12H14CL2FNO4S Molecular Weight: 358.2 (1). Florfenicol is to treat the infection and respiratory diseases. (2). Florfenicol is to prevent and treat sudden death, high fever, emaciation

CAS:73231-34-2 Florfenicol

Cas:73231-34-2

Min.Order:5 Gram

Negotiable

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Florfenicol CAS NO.73231-34-2

Cas:73231-34-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:0-6°C Packag

High quality API Florfenicol CAS 73231-34-2/76639-94-6 supplied by Manufacturer

Cas:73231-34-2

Min.Order:25 Kilogram

FOB Price: $70.0 / 100.0

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Veterinary Drug 99% florfenicol powder Florfenicol price CAS 73231-34-2

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $69.0 / 89.0

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

Service we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to

Good quality Florfenicol//73231-34-2 manufacturer

Cas:73231-34-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Florfenicol CAS:73231-34-2

Cas:73231-34-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Florfenicol manufacturer with low price

Cas:73231-34-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Florfenicol 73231-34-2 ISO Producer

Cas:73231-34-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Florfenicol

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Superiority 1.Competitive price with high quality material along with proper and complete documents; 2.Your stable supply channel for your choice; Earliest delivery time ; 3.Supply full range of APIs & Chemicals to reduce

Florfenicol CAS NO.73231-34-2

Cas:73231-34-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

FLORFENICOL

Cas:73231-34-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Florfenicol CAS NO: 73231-34-2 Grade:Medical scientific research and export Molecular formula:C12H14CL2FNO4S Molecular weight:358.2 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability

Florfenicol/cas:73231-34-2 /Raw material spot

Cas:73231-34-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Ality Chemical Corporation

Florfenicol Basic information Veterinary antibiotics Pharmacological effects Indications Uses Product Name: Florfenicol Synonyms: (r-(r*,s*))-methyleste;2,2-dichloro-n-(1-(fluoromethyl)-2

Factory Supply Florfenicol

Cas:73231-34-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS:73231-34-2 Florfenicol

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 73231-34-2 with best quality

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

best quality Florfenicol Wholesaler Best price 73231-34-2

Cas:73231-34-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

cas 73231-34-2 99% Florfenicol powder Product Name: Florfenicol CAS: 73231-34-2 MF: C12H14Cl2FNO4S MW: 358.21 EINECS: 642-986-0 Appearance:white Storage:room Package:drum Appli

cas 73231-34-2 99% Florfenicol powder

Cas:73231-34-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Florfenicol Synonyms: 2,2-dichloro-N-{1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfanyl)phenyl]ethyl}acetamide CAS:73231-34-2 C12H14Cl2FNO4S Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/d

Florfenicol CAS:73231-34-2

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at cool & d

Supplier Top quality Lincomycin hydrochloride CAS:73231-34-2

Cas:73231-34-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:Inert atmosphere,2-8°C Package:25kg/drum Application:It is a kind of antibacterial drug. It is used as the veterinary antimicrobial drugs for treating bacterial diseases of pigs, chickens and fish. It ha

Florfenicol factory price

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory Price Florfenicol Powder Veterinary API CAS 73231-34-2 Florfenicol

Cas:73231-34-2

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Florfenicol 73231-34-2

Cas:73231-34-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Factory supply high quality Florfenicol raw Powder Veterinary API powder Florfenicol

Cas:73231-34-2

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

Product Detail CAS Number:73231-34-2/76639-94-6 Name:Florfenicol Formula:C12H14Cl2FNO4S Molecular Weight:358.21 Deleted CAS:76639-94-6, 81588-76-3, 173008-78-1 Synonyms:Acetamide,2,2-dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(meth

Florfeniol CPV2010 CAS No.73231-34-2 /76639-94-6

Cas:73231-34-2

Min.Order:1 Milligram

Negotiable

Type:Other

inquiry

Synthetic route

(4S,5R)-2-dichloromethyl-4-fluoromethyl-4,5-dihydro-5-(4-(methylsulfonyl)phenyl)oxazoline
143026-79-3

(4S,5R)-2-dichloromethyl-4-fluoromethyl-4,5-dihydro-5-(4-(methylsulfonyl)phenyl)oxazoline

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 70℃; for 5h; pH=6;99%
With potassium acetate In methanol; water; isopropyl alcohol for 3h; Heating; pH 5; Yield given;
With ammonium hydroxide; water at 25℃;
With sodium acetate In water; isopropyl alcohol for 3h; pH=5; Reflux;4.15 g
In water; isopropyl alcohol at 80℃; for 1h;9.2 g
dichloroacetic acid methyl ester
116-54-1

dichloroacetic acid methyl ester

(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol
76639-93-5, 105182-37-4, 118015-48-8

(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With triethylamine In methanol at 20℃;96%
With triethylamine In methanol for 18h; Ambient temperature;84%
With triethylamine for 3.5h; Heating; Yield given;
(1R,2S)-1-(4-methylsulfonylphenyl)-2-benzylamino-3-fluoro-1-propanol
895571-10-5

(1R,2S)-1-(4-methylsulfonylphenyl)-2-benzylamino-3-fluoro-1-propanol

ethyl 1,1-dichloroacetate
535-15-9

ethyl 1,1-dichloroacetate

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Stage #1: (1R,2S)-1-(4-methylsulfonylphenyl)-2-benzylamino-3-fluoro-1-propanol With sulfuric acid; hydrogen; palladium on activated charcoal In ethanol at 20℃; for 2h;
Stage #2: ethyl 1,1-dichloroacetate With triethylamine In methanol at 30℃; for 6h; Further stages.;
96%
(1R,2S)-2-amino-3-fluoro-1-(4-methylsulphonylphenyl)-1-propanol hydrochloride

(1R,2S)-2-amino-3-fluoro-1-(4-methylsulphonylphenyl)-1-propanol hydrochloride

dichloroacetic acid methyl ester
116-54-1

dichloroacetic acid methyl ester

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With triethylamine In methanol Heating;95%
With sodium hydrogencarbonate In methanol at 50℃; for 16h;5.6 g
With triethylamine In methanol at 50℃; for 10h;7.1 g
C12H12Cl2FNO3S

C12H12Cl2FNO3S

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With methanol; sodium acetate at 60℃; for 1h; Reagent/catalyst;95%
D-threo-2-(dichloromethyl)-5-(4-methanesulfonylphenyl)-4,5-dihydro-1,3-oxazol-4-yl methanol
126813-11-4

D-threo-2-(dichloromethyl)-5-(4-methanesulfonylphenyl)-4,5-dihydro-1,3-oxazol-4-yl methanol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; under 1520.1 - 2280.15 Torr; for 24h;93%
Multi-step reaction with 2 steps
1: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
2: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 25 °C
2: triethylamine tris(hydrogen fluoride) / acetonitrile / 10 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: phosgene / dichloromethane / 16 h / 20 - 25 °C / Cooling with ice
2: sodium fluoride / N,N-dimethyl-formamide / 7 h / 80 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol; water / 5 h / 70 °C / pH 6
View Scheme
dichloroacetic acid methyl ester
116-54-1

dichloroacetic acid methyl ester

(1R,2S)-3-fluoro-1-(4-(methylsulfonyl)phenyl)-2-nitropropan-1-ol

(1R,2S)-3-fluoro-1-(4-(methylsulfonyl)phenyl)-2-nitropropan-1-ol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Stage #1: (1R,2S)-3-fluoro-1-(4-(methylsulfonyl)phenyl)-2-nitropropan-1-ol With palladium 10% on activated carbon; hydrogen In methanol
Stage #2: dichloroacetic acid methyl ester With triethylamine In methanol at 20℃; for 18h;
70%
C13H15Cl2NO6S2
96795-01-6

C13H15Cl2NO6S2

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With triethylamine tris(hydrogen fluoride) In acetonitrile for 10h; Reflux;65%
dichloroacetic acid methyl ester
116-54-1

dichloroacetic acid methyl ester

(4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
108656-28-6

(4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Stage #1: (4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone With sodium hydroxide In ethanol at 80℃; for 3h;
Stage #2: With sodium acetate In tetrahydrofuran at 0℃; for 0.166667h;
Stage #3: dichloroacetic acid methyl ester In tetrahydrofuran at 25℃; for 5h;
56%
2,2-dichloro-N-{(4R,5R)-4-[4-(methylsulfonyl)phenyl]-2,2-dioxido-1,3,2-dioxathian-5-yl}acetamide

2,2-dichloro-N-{(4R,5R)-4-[4-(methylsulfonyl)phenyl]-2,2-dioxido-1,3,2-dioxathian-5-yl}acetamide

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Stage #1: 2,2-dichloro-N-{(4R,5R)-4-[4-(methylsulfonyl)phenyl]-2,2-dioxido-1,3,2-dioxathian-5-yl}acetamide With triethylamine tris(hydrogen fluoride) In 1,2-dichloro-ethane at 70℃; for 8h;
Stage #2: With hydrogenchloride In ethyl acetate at 0℃; for 2h;
35%
florfenicol phosphate
857859-74-6

florfenicol phosphate

A

C12H14Cl2NO7PS

C12H14Cl2NO7PS

B

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With sodium hydroxide In water pH=4.54 - 5.53; Conversion of starting material;A 0.17%
B 0.93%
With ethanolamine In water pH=4.48 - 5.51; Conversion of starting material;A 0.18%
B 0.7%
dichloroacetic acid methyl ester
116-54-1

dichloroacetic acid methyl ester

(1R,2S)-2-(2,3-dimethylbenzoyl)amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol
108656-27-5

(1R,2S)-2-(2,3-dimethylbenzoyl)amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol

A

thiamphenicol
15318-45-3

thiamphenicol

B

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
With hydrogenchloride; triethylamine 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
(1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol
4302-89-0

(1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multistep reaction;
dichloroacetic acid methyl ester
116-54-1

dichloroacetic acid methyl ester

(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol
76639-93-5, 105182-37-4, 118015-48-8

(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol

A

(1R,2S)-2-Dichloroacetamido-3-Fluoro-1-[4-(Methylsulfonyl)Phenyl]-1-Propanol(Florfenicol)

(1R,2S)-2-Dichloroacetamido-3-Fluoro-1-[4-(Methylsulfonyl)Phenyl]-1-Propanol(Florfenicol)

B

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
In methanol; water; toluene
para-methanesulfonylbenzaldehyde
5398-77-6

para-methanesulfonylbenzaldehyde

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 83 percent / piperidine / pyridine / 4 h / 95 - 100 °C
2: 1.) SOCl2, 2.) NaBH4 / 1) reflux, 1 h; 2) CH2Cl2, EtOH, 10 deg C, 1 h
3: 82 percent / 4 Anstroem molecular sieves, diisopropyl L-tartrate, Ti(OPr-i)4, t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / 4 h / -20 °C
4: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h
5: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5
6: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
7: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
Multi-step reaction with 7 steps
1.1: ethanol / 3 h / Inert atmosphere; Reflux
2.1: (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane / toluene / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere
2.2: 19 h / -10 - 20 °C / Molecular sieve; Inert atmosphere
3.1: lithium borohydride / tetrahydrofuran / 50 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: diethylamino-sulfur trifluoride; triethylamine / dichloromethane / 8 h / -40 - 20 °C / Inert atmosphere
5.1: water; toluene-4-sulfonic acid / acetonitrile / 24 h / 40 °C / Inert atmosphere
5.2: Inert atmosphere
6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 6 h / 20 °C / 760.05 Torr
7.1: triethylamine / methanol / 3 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide / dichloromethane; ethanol / 0 - 20 °C
1.2: 1 h / 20 °C / Cooling with ice
2.1: thionyl chloride / 8 h / 0 - 60 °C
2.2: 2 h / 20 - 60 °C
3.1: hydrogenchloride / water; methanol / 6 h / Reflux
3.2: 8 h / 0 - 60 °C
3.3: 6 h / 20 °C
4.1: sodium tetrahydroborate; methanol / 5 h / 0 - 20 °C
5.1: triethylamine; thionyl chloride / dichloromethane / 0 °C
5.2: 20 °C
6.1: triethylamine tris(hydrogen fluoride) / 1,2-dichloro-ethane / 8 h / 70 °C
6.2: 2 h / 0 - 20 °C
7.1: triethylamine / methanol / Heating
View Scheme
3-(4-methanesulfonyl-phenyl)-acrylic acid
5345-30-2, 88899-85-8

3-(4-methanesulfonyl-phenyl)-acrylic acid

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) SOCl2, 2.) NaBH4 / 1) reflux, 1 h; 2) CH2Cl2, EtOH, 10 deg C, 1 h
2: 82 percent / 4 Anstroem molecular sieves, diisopropyl L-tartrate, Ti(OPr-i)4, t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / 4 h / -20 °C
3: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h
4: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5
5: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
6: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
(1R,2R)-2-amino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol
51458-28-7

(1R,2R)-2-amino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / conc. H2SO4 / propan-2-ol / 1) 70 deg C, 1.5-2 h; 2) 50 deg C, 14 h
2: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
3: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
Multi-step reaction with 6 steps
1: K2CO3 / H2O / 1 h / Ambient temperature
2: EtONa / ethanol
3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
5: 70 percent / KOH / methanol / 7 h / -30 °C
6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
Multi-step reaction with 4 steps
1: 95 percent / K2CO3 / glycerol / 18 h / 115 °C
2: 95 percent Chromat. / (1,1,2,3,3,3-hexafluoropropyl)diethylamine (FPA) / CH2Cl2 / 2 h / 100 °C / 5171.5 Torr
3: 95 percent / 6 N HCl / 12 h / 100 - 105 °C
4: 84 percent / Et3N / methanol / 18 h / Ambient temperature
View Scheme
(E)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-ol
125872-64-2

(E)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-ol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 82 percent / 4 Anstroem molecular sieves, diisopropyl L-tartrate, Ti(OPr-i)4, t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / 4 h / -20 °C
2: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h
3: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5
4: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
5: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
Multi-step reaction with 10 steps
1: tert.-butylhydroperoxide; C3H7O(1-)*C34H32N2O4(2-)*V(3+) / dichloromethane; water / 72 h / 0 °C
2: N,N-dimethyl-formamide / 10 h / 20 °C
3: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C
4: triethylamine / dichloromethane / 2 h / 0 - 20 °C
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C
6: potassium hydroxide / methanol; water / 1 h / Reflux; Inert atmosphere
7: palladium 10% on activated carbon; formic acid / methanol / 10 h / 20 °C / Inert atmosphere
8: hydrogenchloride / water; isopropyl alcohol / 16 h / 50 - 70 °C
9: Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 12 h / 20 °C
10: sodium acetate / water; isopropyl alcohol / 3 h / pH 5 / Reflux
View Scheme
(S,S)-3-[4-(methylsulfonyl)phenyl]-2,3-epoxypropyl alcohol

(S,S)-3-[4-(methylsulfonyl)phenyl]-2,3-epoxypropyl alcohol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH, 2.) ZnCl2, 3.) 4 Angstroem molecular sieves / 1) THF, 5 deg C, 30 min; 2) THF, 5 deg C, 30 min; 3) THF, 55 deg C, 16 h
2: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5
3: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
4: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
Multi-step reaction with 9 steps
1: N,N-dimethyl-formamide / 10 h / 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C
3: triethylamine / dichloromethane / 2 h / 0 - 20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C
5: potassium hydroxide / methanol; water / 1 h / Reflux; Inert atmosphere
6: palladium 10% on activated carbon; formic acid / methanol / 10 h / 20 °C / Inert atmosphere
7: hydrogenchloride / water; isopropyl alcohol / 16 h / 50 - 70 °C
8: Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 12 h / 20 °C
9: sodium acetate / water; isopropyl alcohol / 3 h / pH 5 / Reflux
View Scheme
(3S,4R)-2-(dichloromethyl)-4,5-dihydro-α-[4-(methylsulfonyl)phenyl]oxazole-4-methanol
157142-64-8

(3S,4R)-2-(dichloromethyl)-4,5-dihydro-α-[4-(methylsulfonyl)phenyl]oxazole-4-methanol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Et3N, MeSO2Cl, 2.) aq. NaOH / 1) pyridine, 5 deg C, 2 h; 2) pyridine, pH 12.5
2: CF3CHCF2NEt2 / CH2Cl2 / 2 h / 100 °C
3: KOAc / methanol; propan-2-ol; H2O / 3 h / Heating; pH 5
View Scheme
(2R,3S,9bRS)-3-(mesyloxymethyl)-2-<4-(methylsulphonyl)phenyl>-2,3-dihydrooxazolo<2,3-a>isoindol-5(9bH)-one

(2R,3S,9bRS)-3-(mesyloxymethyl)-2-<4-(methylsulphonyl)phenyl>-2,3-dihydrooxazolo<2,3-a>isoindol-5(9bH)-one

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 27 percent Chromat. / hexadecyltributylphosphonium chloride, potassium fluoride hydrate / toluene; H2O / 7 h / Heating
2: 2N HCl / 6 h / Heating
3: Et3N / 3.5 h / Heating
View Scheme
(2R,3R,9bRS)-3-hydroxymethyl-2-<4-(methylsulphonyl)phenyl>-2,3-dihydrooxazolo<2,3-a>isoindol-5(9bH)-one

(2R,3R,9bRS)-3-hydroxymethyl-2-<4-(methylsulphonyl)phenyl>-2,3-dihydrooxazolo<2,3-a>isoindol-5(9bH)-one

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92.8 percent / pyridine / 0 °C
2: 27 percent Chromat. / hexadecyltributylphosphonium chloride, potassium fluoride hydrate / toluene; H2O / 7 h / Heating
3: 2N HCl / 6 h / Heating
4: Et3N / 3.5 h / Heating
View Scheme
(2R,3S,9bRS)-3-fluoromethyl-2-<4-(methylsulphonyl)phenyl>-2,3-dihydrooxazolo<2,3-a>isoindol-5(9bH)-one

(2R,3S,9bRS)-3-fluoromethyl-2-<4-(methylsulphonyl)phenyl>-2,3-dihydrooxazolo<2,3-a>isoindol-5(9bH)-one

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2N HCl / 6 h / Heating
2: Et3N / 3.5 h / Heating
View Scheme
(R*,R*)-(+)-thiomicamine
23150-35-8

(R*,R*)-(+)-thiomicamine

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: K2CO3 / H2O / 1 h / Ambient temperature
2: t-BuOK / ethanol / 3 h / Heating
3: 81 percent / H2O2 / H2O / 20 h / 45 °C
4: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
5: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
6: 70 percent / KOH / methanol / 7 h / -30 °C
7: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
Multi-step reaction with 7 steps
1: K2CO3 / H2O / 1 h / Ambient temperature
2: t-BuOK / toluene / 3 h / Heating
3: 81 percent / H2O2 / H2O / 20 h / 45 °C
4: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
5: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
6: 70 percent / KOH / methanol / 7 h / -30 °C
7: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
Multi-step reaction with 4 steps
1: 1.) K2CO3, 2.) CH3CO3H / 1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h
2: 95 percent Chromat. / (1,1,2,3,3,3-hexafluoropropyl)diethylamine (FPA) / CH2Cl2 / 2 h / 100 °C / 5171.5 Torr
3: 95 percent / 6 N HCl / 12 h / 100 - 105 °C
4: 84 percent / Et3N / methanol / 18 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 1.) K2CO3, 2.) CH3CO3H / 1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h
2: (2-chloro-1,1,2-trifluoroethyl)diethylamine (FAR) / CH2Cl2 / 5 h / 100 °C
3: 95 percent / 6 N HCl / 12 h / 100 - 105 °C
4: 84 percent / Et3N / methanol / 18 h / Ambient temperature
View Scheme
(4R,5R)-4-hydroxymethyl-5-<4-(methylthio)phenyl>-2-oxazolidinone
96795-21-0

(4R,5R)-4-hydroxymethyl-5-<4-(methylthio)phenyl>-2-oxazolidinone

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 81 percent / H2O2 / H2O / 20 h / 45 °C
2: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
3: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
4: 70 percent / KOH / methanol / 7 h / -30 °C
5: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
(1R,2R)-2-ethoxycarbonylamino-1-<4-(methylthio)phenyl>-1,3-propanediol
96795-20-9

(1R,2R)-2-ethoxycarbonylamino-1-<4-(methylthio)phenyl>-1,3-propanediol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: t-BuOK / ethanol / 3 h / Heating
2: 81 percent / H2O2 / H2O / 20 h / 45 °C
3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
5: 70 percent / KOH / methanol / 7 h / -30 °C
6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
Multi-step reaction with 6 steps
1: t-BuOK / toluene / 3 h / Heating
2: 81 percent / H2O2 / H2O / 20 h / 45 °C
3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
5: 70 percent / KOH / methanol / 7 h / -30 °C
6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
(4R,5R)-4-hydroxymethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
96795-22-1

(4R,5R)-4-hydroxymethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
2: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
3: 70 percent / KOH / methanol / 7 h / -30 °C
4: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
Multi-step reaction with 3 steps
1: hexafluoropropene-diethylamine adduct / dichloromethane / 1 h / 105 - 110 °C / Autoclave
2: hydrogenchloride / 1 h / Reflux
3: triethylamine / methanol / 20 °C
View Scheme
(4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
108656-28-6

(4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
2: 70 percent / KOH / methanol / 7 h / -30 °C
3: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / 1 h / Reflux
2: triethylamine / methanol / 20 °C
View Scheme
(1R,2R)-2-ethoxycarbonylamino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol
108656-26-4

(1R,2R)-2-ethoxycarbonylamino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: EtONa / ethanol
2: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
3: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
4: 70 percent / KOH / methanol / 7 h / -30 °C
5: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
(4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
108656-29-7

(4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone

Florfenicol
73231-34-2

Florfenicol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / KOH / methanol / 7 h / -30 °C
2: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h
View Scheme
succinic acid
110-15-6

succinic acid

Florfenicol
73231-34-2

Florfenicol

sodium 4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propoxy)-4-oxobutanoate
1073342-32-1

sodium 4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propoxy)-4-oxobutanoate

Conditions
ConditionsYield
Stage #1: succinic acid; Florfenicol With triethylamine In ethyl acetate at 20℃; for 1h;
Stage #2: With sodium hydrogencarbonate In ethyl acetate at 0 - 5℃; for 2h; Solvent;
97.8%
N-benzyloxycarbonyl-L-alanyl chloride
49760-60-3

N-benzyloxycarbonyl-L-alanyl chloride

Florfenicol
73231-34-2

Florfenicol

florfenicol-N-Cbz-L-alanine ester

florfenicol-N-Cbz-L-alanine ester

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at 20 - 90℃; for 10h; Reagent/catalyst; Solvent; Temperature;94.3%
Florfenicol
73231-34-2

Florfenicol

methyl chloroformate
79-22-1

methyl chloroformate

(1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl methyl carbonate

(1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl methyl carbonate

Conditions
ConditionsYield
With dmap; triethylamine In tetrahydrofuran at 0℃;93%
N-Z-Leucine chloride
87052-59-3

N-Z-Leucine chloride

Florfenicol
73231-34-2

Florfenicol

florfenicol-N-Cbz-L-leucine ester

florfenicol-N-Cbz-L-leucine ester

Conditions
ConditionsYield
With pyridine In chloroform at 20℃; for 8h; Reflux;89.64%
succinic acid anhydride
108-30-5

succinic acid anhydride

Florfenicol
73231-34-2

Florfenicol

4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propoxy)-4-oxobutanoic acid
1073342-33-2

4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propoxy)-4-oxobutanoic acid

Conditions
ConditionsYield
With dmap In acetone at 60℃; for 4h;88.1%
With dmap In acetone at 40 - 70℃;
Z-(L)-Val-Cl
87052-60-6

Z-(L)-Val-Cl

Florfenicol
73231-34-2

Florfenicol

florfenicol-N-Cbz-L-valine ester

florfenicol-N-Cbz-L-valine ester

Conditions
ConditionsYield
With pyridine; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 10h; Reflux;83.29%
Florfenicol
73231-34-2

Florfenicol

bis((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl) hydrogen phosphate
1450713-53-7

bis((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl) hydrogen phosphate

Conditions
ConditionsYield
Stage #1: Florfenicol With pyridine; trichlorophosphate In acetonitrile at 0 - 25℃; for 12.5h;
Stage #2: With water In acetonitrile at 0 - 25℃; for 8.16667h; Reagent/catalyst; Solvent;
80.72%
(S)-benzyloxycarbonyl-proline acid chloride
61350-60-5, 61350-62-7, 89705-40-8, 106709-50-6

(S)-benzyloxycarbonyl-proline acid chloride

Florfenicol
73231-34-2

Florfenicol

florfenicol-N-Cbz-L-proline ester

florfenicol-N-Cbz-L-proline ester

Conditions
ConditionsYield
With pyridine In chloroform at 20℃; for 10h; Reflux;70.39%
ethylenebis(chloroformate)
124-05-0

ethylenebis(chloroformate)

Florfenicol
73231-34-2

Florfenicol

bis((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl)ethane-1,2-diyl dicarbonate

bis((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propyl)ethane-1,2-diyl dicarbonate

Conditions
ConditionsYield
With dmap; triethylamine In tetrahydrofuran at 0 - 20℃;62%
Florfenicol
73231-34-2

Florfenicol

2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranoside
148926-02-7

2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranoside

2,2-dichloro-N-[(1R,2S)-3-fluoro-1-(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranosyloxy)-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide

2,2-dichloro-N-[(1R,2S)-3-fluoro-1-(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranosyloxy)-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide

Conditions
ConditionsYield
Stage #1: 2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranoside With trifluoromethylsulfonic anhydride; beta-pinene In dichloromethane at -50℃; for 0.75h;
Stage #2: Florfenicol In dichloromethane at -50 - 20℃; for 18h; stereoselective reaction;
55%
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

Florfenicol
73231-34-2

Florfenicol

2,2-Dichloro-N-[(1S,2R)-1-fluoromethyl-2-(4-methanesulfonyl-phenyl)-2-trimethylsilanyloxy-ethyl]-acetamide

2,2-Dichloro-N-[(1S,2R)-1-fluoromethyl-2-(4-methanesulfonyl-phenyl)-2-trimethylsilanyloxy-ethyl]-acetamide

Conditions
ConditionsYield
In acetonitrile at 50℃; for 0.166667h;
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View