Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryProduct Description Product Name 4-Chloropyrrolo[2,3-d]pyrimidine CAS No. 3680-69-1 Appearance White powder Assay ≥99% Capacity 50mt/year Min.packing 100gram
Cas:3680-69-1
Min.Order:1 Gram
FOB Price: $34.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:3680-69-1
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:3680-69-1
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryUnique advantages of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Cas 3680-69-1 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to almost white powder Storage:Cool dry place
Cas:3680-69-1
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiry4-Chloropyrrolo[2,3-d]pyrimidine CAS No.:3680-69-1 Name: 4-Chloropyrrolo[2,3-d]pyrimidine Synonyms: 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazapurine
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:3680-69-1
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:3680-69-1
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:3680-69-1
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:3680-69-1
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS NO:3680-69-1 Grade:Medical scientific research and export Molecular formula:C6H4ClN3 Molecular weight:153.57 Product Quality 12 years of chemical raw materials Mature operation of the industry
Cas:3680-69-1
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:3680-69-1
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry4-Chloropyrrolo[2,3-d]pyrimidine Basic information Product Name: 4-Chloropyrrolo[2,3-d]pyrimidine Synonyms: 4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO
Cas:3680-69-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:3680-69-1
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Cas:3680-69-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name 4-Chloropyrrolo[2,3-d]pyrimidine Synonyms 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazapurine CAS 3680-69-1 EINECS /
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla
Cas:3680-69-1
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:3680-69-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Synonyms: 4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRI
Cas:3680-69-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $130.0 / 154.0
Type:Trading Company
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:3680-69-1
Min.Order:100 Gram
FOB Price: $10.0
Type:Lab/Research institutions
inquiry4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali
Cas:3680-69-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:3680-69-1
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:3680-69-1
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Lab/Research institutions
inquiry6-Chloro-7-deazapurine CAS: 3680-69-1 Specification Items Specification Product name 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS 3680-69-1 Appearance
Cas:3680-69-1
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Conditions | Yield |
---|---|
With chlorine In 1-methyl-pyrrolidin-2-one; toluene at 160 - 180℃; Temperature; | 95% |
With 1,2,3-trichloropropane; chlorine In 1-methyl-pyrrolidin-2-one; toluene Reflux; | 95% |
With dmap; bis(trichloromethyl) carbonate In chlorobenzene at 50 - 60℃; for 6h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 94.2% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 7.5h; Reflux; | 94% |
Stage #1: 6-chloro-5-(2-methoxyvinyl)pyrimidin-4-ylamine With hydrogenchloride; water In tetrahydrofuran at 20℃; Reflux; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 1h; | |
With hydrogenchloride In tetrahydrofuran; water for 7.5h; Reflux; | 54.5 g |
Conditions | Yield |
---|---|
With trichlorophosphate for 2h; Reflux; | 93% |
With trichlorophosphate | 92% |
With trichlorophosphate for 4h; Reflux; | 91% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With trichlorophosphate for 3h; Reflux; | 93% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With hydrogenchloride In water at 50℃; for 4h; Reagent/catalyst; | 92% |
With hydrogenchloride; water In Petroleum ether at 50℃; for 4h; | 91% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 50℃; for 3h; Concentration; Temperature; Industrial scale; | 91.4% |
With hydrogenchloride In methanol; water at 50 - 60℃; for 3h; | 82% |
With acetic acid at 20℃; for 14h; | 26.1 g |
Conditions | Yield |
---|---|
With sodium methylate In methanol at 25 - 70℃; for 10h; | 91% |
Conditions | Yield |
---|---|
With sodium methylate In methanol at 30 - 70℃; for 10h; | 90.2% |
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium benzo[d][1,3]dioxol-5-yltrifluoroborate; PdCl2(1,1'-bis(diphenylphosphino)ferrocene); triethylamine In ethanol; dichloromethane for 19h; Reagent/catalyst; Reflux; | 90% |
Conditions | Yield |
---|---|
With trichlorophosphate at 100℃; for 5h; | 65.7% |
With trichlorophosphate for 5h; Reflux; | 54% |
With trichlorophosphate for 5h; Reflux; | 54% |
With trichlorophosphate for 5h; Reflux; | 54% |
2-(4,6-dichloropyrimidin-5-yl)acetaldehyde
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With ammonium hydroxide at 60 - 70℃; for 24h; | 34% |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / ethanol / 2 h / 40 °C 2: ammonium hydroxide / ethanol / 20 h / 70 °C 3: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / ethanol / 3 h / 40 °C 2: ammonium hydroxide / 3 h / 60 °C 3: hydrogenchloride / water / 4 h / 50 °C View Scheme |
ethyl 2-cyano-4,4-diethoxybutyrate
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 64 percent / NaOEt 2: 92 percent / aq. HCl 3: 81 percent / H2 / Raney Ni 4: 66 percent / POCl3 View Scheme | |
Multi-step reaction with 3 steps 1: NaOEt / ethanol 2: 1.) Raney-Nickel; 2.) HCl 3: POCl3 View Scheme | |
Multi-step reaction with 4 steps 1: 64 percent / EtONa / dimethylformamide; ethanol / 6 h / Heating 2: aq. NH3 / Raney nickel / 6 h / Heating 3: 86 percent / 1N aq. HCl / 1 h / 20 °C 4: 79 percent / POCl3 / 1.5 h / Heating View Scheme |
6-amino-5-(2,2-diethoxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / aq. HCl 2: 81 percent / H2 / Raney Ni 3: 66 percent / POCl3 View Scheme | |
Multi-step reaction with 3 steps 1: aq. NH3 / Raney nickel / 6 h / Heating 2: 86 percent / 1N aq. HCl / 1 h / 20 °C 3: 79 percent / POCl3 / 1.5 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 22 h 2: ammonium hydroxide / water / 72 h / Reflux 3: trichlorophosphate / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water 2.1: ammonium hydroxide / water 2.2: raney nickel / 5 h / 100 °C 3.1: trichlorophosphate / 5 h / 100 °C View Scheme |
2-thioxo-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81 percent / H2 / Raney Ni 2: 66 percent / POCl3 View Scheme | |
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 72 h / Reflux 2: trichlorophosphate / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / water 1.2: raney nickel / 5 h / 100 °C 2.1: trichlorophosphate / 5 h / 100 °C View Scheme |
6-amino-5-(2,2-diethoxy)-2-mercaptopyrimidine-4-ol
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) Raney-Nickel; 2.) HCl 2: POCl3 View Scheme | |
Multi-step reaction with 3 steps 1: ammonia / nickel / water / 90 °C 2: hydrogenchloride; water / 2.5 h / 20 °C 3: trichlorophosphate / 2.5 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: nickel / water / 1 h / Heating / reflux 3: trichlorophosphate / 1.5 h / Heating / reflux View Scheme |
4-amino-6-hydroxy-5-(2,2-diethoxyethyl)pyrimidine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / 1N aq. HCl / 1 h / 20 °C 2: 79 percent / POCl3 / 1.5 h / Heating View Scheme |
Conditions | Yield |
---|---|
With trichlorophosphate | A 49 mg (70%) B n/a |
6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 2.5 h / 20 °C 2: trichlorophosphate / 2.5 h / 100 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 4 h / 25 - 30 °C 2: trichlorophosphate / 1 h / 100 - 105 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride; water / 2.5 h / 20 °C 2: trichlorophosphate / 2.5 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 2: trichlorophosphate / 1.5 h / Heating / reflux View Scheme |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonia / water / 90 °C 2: hydrogenchloride / water / 2.5 h / 20 °C 3: trichlorophosphate / 2.5 h / 100 °C / Inert atmosphere View Scheme |
6-chloro-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; potassium tert-butylate at 90℃; for 0.833333h; | 505 mg |
5-allyl-4,6-dichloropyrimidine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium hydroxide / ethanol / 24 h / 60 °C / Industrial scale 2: ozone / methanol / -30 °C / Industrial scale 3: hydrogenchloride / methanol; water / 3 h / 50 °C / Industrial scale View Scheme | |
Multi-step reaction with 2 steps 1: ozone / methanol; dichloromethane / 2 h / -40 °C 2: ammonium hydroxide / 24 h / 60 - 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: ammonium hydroxide / ethanol / 24 h / 70 °C / Sealed tube 2: triethylamine; dimethyl sulfoxide; ozone / methanol / 2 h / -5 - 0 °C 3: acetic acid / 14 h / 20 °C View Scheme |
2-cyano-4,4-dimethoxybutyric acid ethyl ester
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium ethanolate / ethanol / Reflux 2: hydrogenchloride / water / 45 °C 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 50 °C View Scheme |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 45 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 50 °C View Scheme |
5-(prop-2-en-1-yl)pyrimidine-4,6-diol
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere 2: ozone / methanol; dichloromethane / 2 h / -40 °C 3: ammonium hydroxide / 24 h / 60 - 70 °C View Scheme | |
Multi-step reaction with 4 steps 1: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere 2: ammonium hydroxide / ethanol / 24 h / 70 °C / Sealed tube 3: triethylamine; dimethyl sulfoxide; ozone / methanol / 2 h / -5 - 0 °C 4: acetic acid / 14 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere 2: ozone / methanol; dichloromethane / 2 h / -40 °C 3: toluene-4-sulfonic acid / ethanol / 2 h / 40 °C 4: ammonium hydroxide / ethanol / 20 h / 70 °C 5: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C View Scheme |
4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / ethanol / 20 h / 70 °C 2: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C View Scheme |
dimethyl allylmalonate
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium methylate / methanol / 5 h / 0 - 60 °C 2: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere 3: ozone / methanol; dichloromethane / 2 h / -40 °C 4: ammonium hydroxide / 24 h / 60 - 70 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium methylate / methanol / 5 h / 0 - 60 °C 2: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere 3: ammonium hydroxide / ethanol / 24 h / 70 °C / Sealed tube 4: triethylamine; dimethyl sulfoxide; ozone / methanol / 2 h / -5 - 0 °C 5: acetic acid / 14 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: sodium methylate / methanol / 5 h / 0 - 60 °C 2: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere 3: ozone / methanol; dichloromethane / 2 h / -40 °C 4: toluene-4-sulfonic acid / ethanol / 2 h / 40 °C 5: ammonium hydroxide / ethanol / 20 h / 70 °C 6: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C View Scheme |
2-mercapto-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide; dihydrogen peroxide / water / 2 h / 15 - 20 °C 2: hydrogenchloride / water / 1 h 3: trichlorophosphate / 85 °C View Scheme |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 20 °C / pH 2 - 3 2: sodium hydroxide; dihydrogen peroxide / water / 2 h / 15 - 20 °C 3: hydrogenchloride / water / 1 h 4: trichlorophosphate / 85 °C View Scheme |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
methylamine
4-(methylamino)-7H-pyrrolo<2,3-d>pyrimidine
Conditions | Yield |
---|---|
In ethanol at 100℃; for 2h; Sealed tube; | 100% |
With hydrogenchloride In methanol for 6h; Heating; | 85% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With N-iodo-succinimide; sodium sulfate In ethanol; N,N-dimethyl-formamide | 100% |
With N-iodo-succinimide; sodium sulfate In ethanol; N,N-dimethyl-formamide | 100% |
With N-iodo-succinimide; sodium sulfate In ethanol; N,N-dimethyl-formamide | 100% |
(5-(methoxycarbonyl)-1-tosyl-1H-pyrrol-3-yl)boronic acid
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 170℃; for 0.166667h; Microwave irradiation; | 100% |
4-tert-butoxycarbonylamino-piperidine-4-carboxylic acid ethyl ester
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-tert-butoxycarbonylamino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 68h; | 100% |
With triethylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 68h; | 100% |
With triethylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 68h; | 100% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-chloro-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 5.5h; Stage #2: With water; ammonium chloride In tetrahydrofuran; hexane | 100% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-iodo-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With hydrogen iodide In water at 20℃; for 80h; Inert atmosphere; | 100% |
With hydrogen iodide at 20℃; for 80h; Inert atmosphere; | 98% |
With hydrogen iodide In water at 20℃; for 48h; | 91% |
(2-trimethylethylsilylethoxy)methyl chloride
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrole[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Cooling with ice; Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide Cooling with ice; | 100% |
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Cooling with ice; Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide for 1h; Cooling with ice; | 100% |
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 10℃; for 1h; Cooling with ice; Inert atmosphere; Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide; mineral oil at 10 - 20℃; | 97% |
triisopropylsilyl chloride
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-chloro-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: triisopropylsilyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 4.5h; Inert atmosphere; | 100% |
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In tetrahydrofuran; mineral oil at 0 - 6.8℃; for 0.916667h; Inert atmosphere; Stage #2: triisopropylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 4h; Inert atmosphere; Reflux; | 99% |
1H-pyrazolo[3,4-b]pyridin-5-amine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 6h; Reflux; | 100% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium carbonate In water at 100℃; for 48h; Sealed tube; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 80℃; for 52h; Inert atmosphere; Sealed tube; | 100% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane; water at 100℃; for 10h; | 100% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium carbonate In water for 18h; Reflux; | 100% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium phosphate In ethanol; water at 40 - 80℃; for 5h; Inert atmosphere; | 100% |
With potassium phosphate In ethanol; water at 80℃; for 5h; Inert atmosphere; | |
With potassium phosphate In ethanol; water at 80℃; for 5h; Temperature; Inert atmosphere; |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With N-Bromosuccinimide In acetonitrile at 100℃; for 0.166667h; microwave irradiation; | 99% |
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 12h; | 95% |
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 72h; | 95% |
N-methylcyclohexylamine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
N-cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
In 1,4-dioxane at 110℃; for 9h; Microwave irradiation; Sealed tube; | 99% |
Stage #1: N-methylcyclohexylamine; 4-chloro-1H-pyrrolo[2,3-d]pyrimidine In tert-butyl alcohol at 100℃; for 24h; Stage #2: With hydrogenchloride In water; tert-butyl alcohol pH=1; Stage #3: With sodium hydroxide In water; tert-butyl alcohol pH=14; | 88% |
In tert-butyl alcohol at 85℃; |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
1-t-Butoxycarbonylpiperazine
Conditions | Yield |
---|---|
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial; | 99% |
With triethylamine In butan-1-ol at 90℃; | 74% |
With triethylamine In N,N-dimethyl-formamide at 110℃; for 16h; | 59% |
tert-butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloro palladium(II); cesium fluoride In water; tert-butyl alcohol Suzuki Coupling; Inert atmosphere; Reflux; | 99% |
With [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II); cesium fluoride In water; tert-butyl alcohol Inert atmosphere; Reflux; | 99% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water for 1h; Reflux; |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80 - 85℃; for 5h; | 99% |
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In water; toluene; tert-butyl alcohol at 100℃; for 48h; Concentration; Temperature; Solvent; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; | 90% |
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran; water at 90℃; for 19h; Autoclave; Inert atmosphere; | 90% |
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In water; toluene; tert-butyl alcohol for 48h; Suzuki Coupling; Reflux; Inert atmosphere; | 84% |
tributylphenylstannane
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With 1,8-Cineole; bis-triphenylphosphine-palladium(II) chloride; triphenyl-arsane at 100℃; for 32h; Stille Cross-Coupling (Migita-Kosugi-Stille Coupling); | 99% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With potassium carbonate In water at 110℃; for 4h; | 99% |
Chloromethyl pivalate
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 14h; | 98.85% |
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: Chloromethyl pivalate In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 91% |
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere; Stage #2: Chloromethyl pivalate In tetrahydrofuran; mineral oil at 0 - 20℃; Product distribution / selectivity; Inert atmosphere; | 91% |
benzenesulfonyl chloride
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-chloro-7-(phenylsulfonyl)-7H-pyrrolo [2,3-d]pyrimidine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 0 - 20℃; | 98% |
With sodium hydride at 0 - 25℃; for 4h; | 98% |
With sodium t-butanolate In tetrahydrofuran at 10 - 22℃; for 2h; | 92% |
piperidine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃; | 98% |
With potassium hydroxide In water at 100℃; under 750.075 Torr; for 0.166667h; Microwave irradiation; | 84% |
In tert-butyl alcohol at 85℃; for 3h; | 60% |
In tert-butyl alcohol at 100℃; for 0.166667h; Microwave irradiation; |
3-chloro-4-fluorophenylamine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
(3-chloro-4-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Conditions | Yield |
---|---|
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃; | 98% |
2-fluoro-4-chloroaniline
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
(4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Conditions | Yield |
---|---|
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃; | 98% |
3-acetylenephenylamine
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
(3-ethynyl-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Conditions | Yield |
---|---|
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃; | 98% |
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In methanol under 760.051 Torr; for 16h; | 98% |
With ammonium formate; 20% Pd(OH)2 on carbon In methanol for 2h; Heating / reflux; | 97% |
With hydrogen; palladium on activated charcoal | 84% |
With ammonium hydroxide; hydrogen; palladium on activated charcoal In ethanol at 20℃; for 6h; | 83.7% |
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
p-toluenesulfonyl chloride
4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 0 - 20℃; for 6h; | 97% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 0.5h; Large scale; | 97.7% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; Industrial scale; | 97.7% |
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
methyl iodide
4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 4h; | 97% |
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 1h; | 94% |
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 6h; | 88% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View