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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Chloropyrrolo[2,3-d]pyrimidine Manufacturer/High quality/Best price/In stock

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product Name 4-Chloropyrrolo[2,3-d]pyrimidine CAS No. 3680-69-1 Appearance White powder Assay ≥99% Capacity 50mt/year Min.packing 100gram

4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Gram

FOB Price: $34.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

4-chloro-7H-pyrrolo[2,3-d]pyrimidine 99% 3680-69-1

Cas:3680-69-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

6-Chloro-7-deazapurine manufacturer/supplier

Cas:3680-69-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Cas 3680-69-1 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to almost white powder Storage:Cool dry place

High quality 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Cas 3680-69-1 with best price

Cas:3680-69-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

4-Chloropyrrolo[2,3-d]pyrimidine CAS No.:3680-69-1 Name: 4-Chloropyrrolo[2,3-d]pyrimidine Synonyms: 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazapurine

High purity 4-Chloropyrrolo[2,3-d]pyrimidine CAS No.:3680-69-1

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

4-Chloro-1H-pyrrolo(2,3-d)pyrimidine

Cas:3680-69-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 3680-69-1 GMP Manufacturer

Cas:3680-69-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS NO:3680-69-1 Grade:Medical scientific research and export Molecular formula:C6H4ClN3 Molecular weight:153.57 Product Quality 12 years of chemical raw materials Mature operation of the industry

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine/ CAS:3680-69-1/ raw material/ high-quality

Cas:3680-69-1

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

4-Chloropyrrolo[2,3-d]pyrimidine Basic information Product Name: 4-Chloropyrrolo[2,3-d]pyrimidine Synonyms: 4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO

best offer 4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 3680-69-1 with best quality

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

China Wholesale 4-Chloropyrrolo[2,3-d]pyrimidine CAS NO.3680-69-1

Cas:3680-69-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name 4-Chloropyrrolo[2,3-d]pyrimidine Synonyms 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazapurine CAS 3680-69-1 EINECS /

4-Chloropyrrolo[2,3-d]pyrimidine CAS: 3680-69-1

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS 3680-69-1

Cas:3680-69-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

7H-Pyrrolo[2,3-d]pyrimidine,4-chloro- 3680-69-1

Cas:3680-69-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Synonyms: 4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRI

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $130.0 / 154.0

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:100 Gram

FOB Price: $10.0

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1

Cas:3680-69-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

4-Chloropyrrolo[2,3-d]pyrimidine CAS NO.3680-69-1

Cas:3680-69-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3680-69-1

Cas:3680-69-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

4-Chloropyrrolo[2,3-d]pyrimidine CAS NO.3680-69-1

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

6-Chloro-7-deazapurine CAS: 3680-69-1 Specification Items Specification Product name 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS 3680-69-1 Appearance

Factory supply 6-Chloro-7-deazapurine

Cas:3680-69-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloropyrrolo[2,3-d]pyrimidine

Cas:3680-69-1

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

Allopurinol
3680-71-5

Allopurinol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With chlorine In 1-methyl-pyrrolidin-2-one; toluene at 160 - 180℃; Temperature;95%
With 1,2,3-trichloropropane; chlorine In 1-methyl-pyrrolidin-2-one; toluene Reflux;95%
With dmap; bis(trichloromethyl) carbonate In chlorobenzene at 50 - 60℃; for 6h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;94.2%
6-chloro-5-(2-methoxyvinyl)pyrimidin-4-ylamine

6-chloro-5-(2-methoxyvinyl)pyrimidin-4-ylamine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 7.5h; Reflux;94%
Stage #1: 6-chloro-5-(2-methoxyvinyl)pyrimidin-4-ylamine With hydrogenchloride; water In tetrahydrofuran at 20℃; Reflux;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 1h;
With hydrogenchloride In tetrahydrofuran; water for 7.5h; Reflux;54.5 g
7-deazahypoxanthine
3680-71-5

7-deazahypoxanthine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Reflux;93%
With trichlorophosphate92%
With trichlorophosphate for 4h; Reflux;91%
4-hydroxypyrrolo[2,3-D]pyrimidine

4-hydroxypyrrolo[2,3-D]pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With trichlorophosphate for 3h; Reflux;93%
4-amino-6-chloro-5-(2,2-diethoxyethyl)pyrimidine

4-amino-6-chloro-5-(2,2-diethoxyethyl)pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃; for 4h; Reagent/catalyst;92%
With hydrogenchloride; water In Petroleum ether at 50℃; for 4h;91%
4-amino-6-chloropyrimidine-5-acetaldehyde

4-amino-6-chloropyrimidine-5-acetaldehyde

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 50℃; for 3h; Concentration; Temperature; Industrial scale;91.4%
With hydrogenchloride In methanol; water at 50 - 60℃; for 3h;82%
With acetic acid at 20℃; for 14h;26.1 g
1,1-dichloro-2-cyano-4-methoxy-1,3-butadiene

1,1-dichloro-2-cyano-4-methoxy-1,3-butadiene

formamidine hydrochloride
6313-33-3

formamidine hydrochloride

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With sodium methylate In methanol at 25 - 70℃; for 10h;91%
1,1-dichloro-2-cyano-4-methoxy-1,3-butadiene

1,1-dichloro-2-cyano-4-methoxy-1,3-butadiene

formamidine acetic acid
3473-63-0

formamidine acetic acid

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With sodium methylate In methanol at 30 - 70℃; for 10h;90.2%
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
123148-78-7

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With potassium benzo[d][1,3]dioxol-5-yltrifluoroborate; PdCl2(1,1'-bis(diphenylphosphino)ferrocene); triethylamine In ethanol; dichloromethane for 19h; Reagent/catalyst; Reflux;90%
1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
3680-71-5

1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With trichlorophosphate at 100℃; for 5h;65.7%
With trichlorophosphate for 5h; Reflux;54%
With trichlorophosphate for 5h; Reflux;54%
With trichlorophosphate for 5h; Reflux;54%
2-(4,6-dichloropyrimidin-5-yl)acetaldehyde
16019-33-3

2-(4,6-dichloropyrimidin-5-yl)acetaldehyde

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With ammonium hydroxide at 60 - 70℃; for 24h;34%
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / ethanol / 2 h / 40 °C
2: ammonium hydroxide / ethanol / 20 h / 70 °C
3: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / ethanol / 3 h / 40 °C
2: ammonium hydroxide / 3 h / 60 °C
3: hydrogenchloride / water / 4 h / 50 °C
View Scheme
ethyl 2-cyano-4,4-diethoxybutyrate
52133-67-2

ethyl 2-cyano-4,4-diethoxybutyrate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 64 percent / NaOEt
2: 92 percent / aq. HCl
3: 81 percent / H2 / Raney Ni
4: 66 percent / POCl3
View Scheme
Multi-step reaction with 3 steps
1: NaOEt / ethanol
2: 1.) Raney-Nickel; 2.) HCl
3: POCl3
View Scheme
Multi-step reaction with 4 steps
1: 64 percent / EtONa / dimethylformamide; ethanol / 6 h / Heating
2: aq. NH3 / Raney nickel / 6 h / Heating
3: 86 percent / 1N aq. HCl / 1 h / 20 °C
4: 79 percent / POCl3 / 1.5 h / Heating
View Scheme
6-amino-5-(2,2-diethoxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
7400-05-7

6-amino-5-(2,2-diethoxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / aq. HCl
2: 81 percent / H2 / Raney Ni
3: 66 percent / POCl3
View Scheme
Multi-step reaction with 3 steps
1: aq. NH3 / Raney nickel / 6 h / Heating
2: 86 percent / 1N aq. HCl / 1 h / 20 °C
3: 79 percent / POCl3 / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 22 h
2: ammonium hydroxide / water / 72 h / Reflux
3: trichlorophosphate / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water
2.1: ammonium hydroxide / water
2.2: raney nickel / 5 h / 100 °C
3.1: trichlorophosphate / 5 h / 100 °C
View Scheme
2-thioxo-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
67831-84-9

2-thioxo-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81 percent / H2 / Raney Ni
2: 66 percent / POCl3
View Scheme
Multi-step reaction with 2 steps
1: ammonium hydroxide / water / 72 h / Reflux
2: trichlorophosphate / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: ammonium hydroxide / water
1.2: raney nickel / 5 h / 100 °C
2.1: trichlorophosphate / 5 h / 100 °C
View Scheme
6-amino-5-(2,2-diethoxy)-2-mercaptopyrimidine-4-ol
7400-05-7

6-amino-5-(2,2-diethoxy)-2-mercaptopyrimidine-4-ol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Raney-Nickel; 2.) HCl
2: POCl3
View Scheme
Multi-step reaction with 3 steps
1: ammonia / nickel / water / 90 °C
2: hydrogenchloride; water / 2.5 h / 20 °C
3: trichlorophosphate / 2.5 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: nickel / water / 1 h / Heating / reflux
3: trichlorophosphate / 1.5 h / Heating / reflux
View Scheme
4-amino-6-hydroxy-5-(2,2-diethoxyethyl)pyrimidine
7400-06-8

4-amino-6-hydroxy-5-(2,2-diethoxyethyl)pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 1N aq. HCl / 1 h / 20 °C
2: 79 percent / POCl3 / 1.5 h / Heating
View Scheme
7-deazahypoxanthine
3680-71-5

7-deazahypoxanthine

A

4-CHLORO-5,7-DIHYDRO-PYRROLO[2,3-D]PYRMIDIN-6-ONE

4-CHLORO-5,7-DIHYDRO-PYRROLO[2,3-D]PYRMIDIN-6-ONE

B

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With trichlorophosphateA 49 mg (70%)
B n/a
6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
7400-06-8

6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 2.5 h / 20 °C
2: trichlorophosphate / 2.5 h / 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 4 h / 25 - 30 °C
2: trichlorophosphate / 1 h / 100 - 105 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride; water / 2.5 h / 20 °C
2: trichlorophosphate / 2.5 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
2: trichlorophosphate / 1.5 h / Heating / reflux
View Scheme
6-amino-5-(2,2-diethoxyethyl)-2-mercaptopyrimidin-4-ol

6-amino-5-(2,2-diethoxyethyl)-2-mercaptopyrimidin-4-ol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonia / water / 90 °C
2: hydrogenchloride / water / 2.5 h / 20 °C
3: trichlorophosphate / 2.5 h / 100 °C / Inert atmosphere
View Scheme
6-chloro-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine
1615680-91-5

6-chloro-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; potassium tert-butylate at 90℃; for 0.833333h;505 mg
5-allyl-4,6-dichloropyrimidine
16019-31-1

5-allyl-4,6-dichloropyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonium hydroxide / ethanol / 24 h / 60 °C / Industrial scale
2: ozone / methanol / -30 °C / Industrial scale
3: hydrogenchloride / methanol; water / 3 h / 50 °C / Industrial scale
View Scheme
Multi-step reaction with 2 steps
1: ozone / methanol; dichloromethane / 2 h / -40 °C
2: ammonium hydroxide / 24 h / 60 - 70 °C
View Scheme
Multi-step reaction with 3 steps
1: ammonium hydroxide / ethanol / 24 h / 70 °C / Sealed tube
2: triethylamine; dimethyl sulfoxide; ozone / methanol / 2 h / -5 - 0 °C
3: acetic acid / 14 h / 20 °C
View Scheme
2-cyano-4,4-dimethoxybutyric acid ethyl ester
773076-83-8

2-cyano-4,4-dimethoxybutyric acid ethyl ester

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium ethanolate / ethanol / Reflux
2: hydrogenchloride / water / 45 °C
3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 50 °C
View Scheme
6-amino-5-(2,2-dimethoxyethyl)pyrimidin-4-ol

6-amino-5-(2,2-dimethoxyethyl)pyrimidin-4-ol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 45 °C
2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 50 °C
View Scheme
5-(prop-2-en-1-yl)pyrimidine-4,6-diol
16019-30-0

5-(prop-2-en-1-yl)pyrimidine-4,6-diol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere
2: ozone / methanol; dichloromethane / 2 h / -40 °C
3: ammonium hydroxide / 24 h / 60 - 70 °C
View Scheme
Multi-step reaction with 4 steps
1: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere
2: ammonium hydroxide / ethanol / 24 h / 70 °C / Sealed tube
3: triethylamine; dimethyl sulfoxide; ozone / methanol / 2 h / -5 - 0 °C
4: acetic acid / 14 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere
2: ozone / methanol; dichloromethane / 2 h / -40 °C
3: toluene-4-sulfonic acid / ethanol / 2 h / 40 °C
4: ammonium hydroxide / ethanol / 20 h / 70 °C
5: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C
View Scheme
4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine
14052-82-5

4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium hydroxide / ethanol / 20 h / 70 °C
2: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C
View Scheme
dimethyl allylmalonate
40637-56-7

dimethyl allylmalonate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium methylate / methanol / 5 h / 0 - 60 °C
2: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere
3: ozone / methanol; dichloromethane / 2 h / -40 °C
4: ammonium hydroxide / 24 h / 60 - 70 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium methylate / methanol / 5 h / 0 - 60 °C
2: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere
3: ammonium hydroxide / ethanol / 24 h / 70 °C / Sealed tube
4: triethylamine; dimethyl sulfoxide; ozone / methanol / 2 h / -5 - 0 °C
5: acetic acid / 14 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium methylate / methanol / 5 h / 0 - 60 °C
2: N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 3 h / 80 °C / Inert atmosphere
3: ozone / methanol; dichloromethane / 2 h / -40 °C
4: toluene-4-sulfonic acid / ethanol / 2 h / 40 °C
5: ammonium hydroxide / ethanol / 20 h / 70 °C
6: hydrogenchloride; water / Petroleum ether / 4 h / 50 °C
View Scheme
2-mercapto-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine
67831-84-9

2-mercapto-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; dihydrogen peroxide / water / 2 h / 15 - 20 °C
2: hydrogenchloride / water / 1 h
3: trichlorophosphate / 85 °C
View Scheme
C10H19N3O3S

C10H19N3O3S

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / water / 20 °C / pH 2 - 3
2: sodium hydroxide; dihydrogen peroxide / water / 2 h / 15 - 20 °C
3: hydrogenchloride / water / 1 h
4: trichlorophosphate / 85 °C
View Scheme
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

methylamine
74-89-5

methylamine

4-(methylamino)-7H-pyrrolo<2,3-d>pyrimidine
78727-16-9

4-(methylamino)-7H-pyrrolo<2,3-d>pyrimidine

Conditions
ConditionsYield
In ethanol at 100℃; for 2h; Sealed tube;100%
With hydrogenchloride In methanol for 6h; Heating;85%
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
123148-78-7

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With N-iodo-succinimide; sodium sulfate In ethanol; N,N-dimethyl-formamide100%
With N-iodo-succinimide; sodium sulfate In ethanol; N,N-dimethyl-formamide100%
With N-iodo-succinimide; sodium sulfate In ethanol; N,N-dimethyl-formamide100%
(5-(methoxycarbonyl)-1-tosyl-1H-pyrrol-3-yl)boronic acid
916177-00-9

(5-(methoxycarbonyl)-1-tosyl-1H-pyrrol-3-yl)boronic acid

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester

4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 170℃; for 0.166667h; Microwave irradiation;100%
4-tert-butoxycarbonylamino-piperidine-4-carboxylic acid ethyl ester
956460-98-3

4-tert-butoxycarbonylamino-piperidine-4-carboxylic acid ethyl ester

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-tert-butoxycarbonylamino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester
956460-97-2

4-tert-butoxycarbonylamino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 68h;100%
With triethylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 68h;100%
With triethylamine In 1-methyl-pyrrolidin-2-one at 110℃; for 68h;100%
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine
870706-50-6

4-chloro-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 5.5h;
Stage #2: With water; ammonium chloride In tetrahydrofuran; hexane
100%
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-iodo-7H-pyrrolo[2,3-d]pyrimidine
1100318-96-4

4-iodo-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With hydrogen iodide In water at 20℃; for 80h; Inert atmosphere;100%
With hydrogen iodide at 20℃; for 80h; Inert atmosphere;98%
With hydrogen iodide In water at 20℃; for 48h;91%
(2-trimethylethylsilylethoxy)methyl chloride
76513-69-4

(2-trimethylethylsilylethoxy)methyl chloride

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrole[2,3-d]pyrimidine
941685-26-3

4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrole[2,3-d]pyrimidine

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Cooling with ice;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide Cooling with ice;
100%
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Cooling with ice;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide for 1h; Cooling with ice;
100%
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 10℃; for 1h; Cooling with ice; Inert atmosphere;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide; mineral oil at 10 - 20℃;
97%
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine
870706-50-6

4-chloro-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: triisopropylsilyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 4.5h; Inert atmosphere;
100%
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In tetrahydrofuran; mineral oil at 0 - 6.8℃; for 0.916667h; Inert atmosphere;
Stage #2: triisopropylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 4h; Inert atmosphere; Reflux;
99%
1H-pyrazolo[3,4-b]pyridin-5-amine
942185-01-5

1H-pyrazolo[3,4-b]pyridin-5-amine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine

N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 6h; Reflux;100%
(+/-)-cis-4-methyl-1-(phenylmethyl)-piperidin-3-ylamine

(+/-)-cis-4-methyl-1-(phenylmethyl)-piperidin-3-ylamine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

cis-1-benzyl-4-methyl-N-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperidin-3-amine

cis-1-benzyl-4-methyl-N-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperidin-3-amine

Conditions
ConditionsYield
With potassium carbonate In water at 100℃; for 48h; Sealed tube;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(R)-tert-butyl (1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)carbamate

(R)-tert-butyl (1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 80℃; for 52h; Inert atmosphere; Sealed tube;100%
tert-butyl N-methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]carbamate

tert-butyl N-methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]carbamate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

C18H27N5O2

C18H27N5O2

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane; water at 100℃; for 10h;100%
(R)-N-methyl-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-amine

(R)-N-methyl-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-amine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

N-methyl-N-((R)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-methyl-N-((R)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions
ConditionsYield
With potassium carbonate In water for 18h; Reflux;100%
benzyl (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylate oxalate

benzyl (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylate oxalate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

benzyl (3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-carboxylate

benzyl (3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-carboxylate

Conditions
ConditionsYield
With potassium phosphate In ethanol; water at 40 - 80℃; for 5h; Inert atmosphere;100%
With potassium phosphate In ethanol; water at 80℃; for 5h; Inert atmosphere;
With potassium phosphate In ethanol; water at 80℃; for 5h; Temperature; Inert atmosphere;
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
22276-95-5

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With N-Bromosuccinimide In acetonitrile at 100℃; for 0.166667h; microwave irradiation;99%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 12h;95%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 72h;95%
N-methylcyclohexylamine
100-60-7

N-methylcyclohexylamine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

N-cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
252722-30-8

N-cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions
ConditionsYield
In 1,4-dioxane at 110℃; for 9h; Microwave irradiation; Sealed tube;99%
Stage #1: N-methylcyclohexylamine; 4-chloro-1H-pyrrolo[2,3-d]pyrimidine In tert-butyl alcohol at 100℃; for 24h;
Stage #2: With hydrogenchloride In water; tert-butyl alcohol pH=1;
Stage #3: With sodium hydroxide In water; tert-butyl alcohol pH=14;
88%
In tert-butyl alcohol at 85℃;
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial;99%
With triethylamine In butan-1-ol at 90℃;74%
With triethylamine In N,N-dimethyl-formamide at 110℃; for 16h;59%
tert-butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
1153949-15-5

tert-butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

1,1-dimethylethyl 3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-1-azetidinecarboxylate

1,1-dimethylethyl 3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-1-azetidinecarboxylate

Conditions
ConditionsYield
With [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloro palladium(II); cesium fluoride In water; tert-butyl alcohol Suzuki Coupling; Inert atmosphere; Reflux;99%
With [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II); cesium fluoride In water; tert-butyl alcohol Inert atmosphere; Reflux;99%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water for 1h; Reflux;
2-(1-(ethanesulfonyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-3-yl)acetonitrile

2-(1-(ethanesulfonyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-3-yl)acetonitrile

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Baricitinib
1187594-09-7

Baricitinib

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80 - 85℃; for 5h;99%
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In water; toluene; tert-butyl alcohol at 100℃; for 48h; Concentration; Temperature; Solvent; Reagent/catalyst; Suzuki Coupling; Inert atmosphere;90%
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran; water at 90℃; for 19h; Autoclave; Inert atmosphere;90%
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In water; toluene; tert-butyl alcohol for 48h; Suzuki Coupling; Reflux; Inert atmosphere;84%
tributylphenylstannane
960-16-7

tributylphenylstannane

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
1168106-39-5

4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With 1,8-Cineole; bis-triphenylphosphine-palladium(II) chloride; triphenyl-arsane at 100℃; for 32h; Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);99%
t-butyl (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylate

t-butyl (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

t-butyl (3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-carboxylate

t-butyl (3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In water at 110℃; for 4h;99%
Chloromethyl pivalate
18997-19-8

Chloromethyl pivalate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate
1146629-75-5

(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 14h;98.85%
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: Chloromethyl pivalate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
91%
Stage #1: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: Chloromethyl pivalate In tetrahydrofuran; mineral oil at 0 - 20℃; Product distribution / selectivity; Inert atmosphere;
91%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-(phenylsulfonyl)-7H-pyrrolo [2,3-d]pyrimidine
186519-89-1

4-chloro-7-(phenylsulfonyl)-7H-pyrrolo [2,3-d]pyrimidine

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃;98%
With sodium hydride at 0 - 25℃; for 4h;98%
With sodium t-butanolate In tetrahydrofuran at 10 - 22℃; for 2h;92%
piperidine
110-89-4

piperidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine
94581-94-9

4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃;98%
With potassium hydroxide In water at 100℃; under 750.075 Torr; for 0.166667h; Microwave irradiation;84%
In tert-butyl alcohol at 85℃; for 3h;60%
In tert-butyl alcohol at 100℃; for 0.166667h; Microwave irradiation;
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(3-chloro-4-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
346600-33-7

(3-chloro-4-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Conditions
ConditionsYield
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃;98%
2-fluoro-4-chloroaniline
57946-56-2

2-fluoro-4-chloroaniline

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
865364-20-1

(4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Conditions
ConditionsYield
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃;98%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(3-ethynyl-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
186519-85-7

(3-ethynyl-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Conditions
ConditionsYield
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃;98%
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

7H-pyrrolo[2,3-d]pyrimidine
271-70-5

7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol under 760.051 Torr; for 16h;98%
With ammonium formate; 20% Pd(OH)2 on carbon In methanol for 2h; Heating / reflux;97%
With hydrogen; palladium on activated charcoal84%
With ammonium hydroxide; hydrogen; palladium on activated charcoal In ethanol at 20℃; for 6h;83.7%
With hydrogen; palladium 10% on activated carbon In methanol at 20℃;
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1

4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 0 - 20℃; for 6h;97%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 0.5h; Large scale;97.7%
With dmap; triethylamine In dichloromethane at 0 - 20℃; Industrial scale;97.7%
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

methyl iodide
74-88-4

methyl iodide

4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin
7781-10-4

4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 4h;97%
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 1h;94%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;88%
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