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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Suzhou Lipin chemical Co., Ltd.

high quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:key intermediates Port:SHA

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO900

Intermediates 309956-78-3

Cas:309956-78-3

Min.Order:50 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (R)-3-(Boc-Amino)Piperidine

Cas:309956-78-3

Min.Order:1

Negotiable

Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Buy Reliable Quality High Purity (R)-3-(Boc-Amino)piperidine Low Price

Cas:309956-78-3

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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TAIZHOU DKD CHEMICAL CO, LTD.,

In stock Contract customization Low Temperature Reactions Fluorine Chemistry Hydrogenation Nitration Chlorination Appearance:white crystalline powder Storage:cool and dry warehouse Package:25KG/Bag Application: intermediate of Liragliptin Port:

Carbamicacid, N-(3R)-3-piperidinyl-, 1,1-dimethylethyl ester

Cas:309956-78-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to off white powder Complies Identification

High purity Various Specifications (R)-3-(Boc-Amino)piperidine CAS:309956-78-3

Cas:309956-78-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Hangzhou Think Chemical Co. Ltd

Linagliptin Intermediate 1-Bromo-2-Butyne[CAS:3355-28-0] (R)-3-(Boc-Amino)piperidine[CAS:309956-78-3] Name (R)-3-(Boc-Amino)piperidine Synonyms (R)-(+)-3-tert-Butoxycarbonyl

High purity (R)-3-(Boc-Amino)piperidine manufacture

Cas:309956-78-3

Min.Order:100 Gram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 309956-78-3 Carbamicacid, N-(3R)-3-piperidinyl-, 1,1-dimethylethyl ester

Cas:309956-78-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality (R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

CHemwill -- (R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

R-3-(Boc-Amino)piperidine/Linagliptin interMediate cas no: 309956-78-3

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1051.html Product Name (R)-3-(Boc-Amino)piperidine CAS No. 309956-

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM (R)-3-(Boc-Amino)piperidine -

Cas:309956-78-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

ProName:Best price (R)-3-(Boc-Amino)piperidine... CasNo:309956-78-3 Molecular Formula:C10H20N2O2 Appearance:white powder Application:medical intermediate DeliveryTime:3-15 working days PackAge:aluminium foil bag Port:any port in China Produ

(R)-3-(Boc-Amino)piperidine CAS309956-78-3

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 309956-78-3 with best quality

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Carbamicacid, N-(3R)-3-piperidinyl-, 1,1-dimethylethyl ester

Cas:309956-78-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diams

(R)-3-(Boc-Amino)PiperidineCAS:309956-78-3

Cas:309956-78-3

Min.Order:1 Metric Ton

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: (R)-3-(Boc-amino)piperidine Synonyms: (3R)-3-Piperidinyl-carbamic Acid 1,1-Dimethylethyl Ester; (3R)-3-[((tert-Butyloxycarbonyl)amino)]piperidine; (R)-3-(tert-Butoxycarbonylamino)pi

(R)-3-(Boc-amino)piperidine CAS: 309956-78-3

Cas:309956-78-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

(R)-3-(Boc-Amino)piperidine CAS NO.309956-78-3

Cas:309956-78-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage: Keep in a well

High purity (R)-3-Boc-Aminopiperidine 99%

Cas:309956-78-3

Min.Order:1 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(R)-3-(Boc-Amino)piperidine

Cas:309956-78-3

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Linagliptin Intermediate CAS 309956-78-3

Cas:309956-78-3

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical

(R)-3-(Boc-Amino)piperidine/309956-78-3/(R)-3-(Boc-Amino)piperidine Manufacturer in China

Cas:309956-78-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate
454713-13-4

tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol at 20 - 25℃; under 150015 Torr; for 20h;97%
With palladium 10% on activated carbon; hydrogen In methanol at 45℃; under 1140.08 Torr; for 2h;85%
With hydrogen; 10% palladium on activated carbon In metahnol at 20℃; for 24h;
(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester
485820-12-0

(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol; water at 35 - 40℃; under 2250.23 - 3000.3 Torr; for 2h; Time; Autoclave; Inert atmosphere;95.4%
With hydrogen; palladium 10% on activated carbon In ethanol at 20℃; under 760.051 Torr; for 168h;92%
In ethanol
t-butyl (R)-piperidin-3-ylcarbamate R-mandelate
1189160-63-1

t-butyl (R)-piperidin-3-ylcarbamate R-mandelate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
With sodium chloride; sodium hydroxide In water; butan-1-ol at 10 - 30℃;79.7%
(R)-2-tert-butyloxycarbonylamino-1,5-pentanedimethanesulfonate

(R)-2-tert-butyloxycarbonylamino-1,5-pentanedimethanesulfonate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
With ammonium hydroxide In acetonitrile at 30℃; for 48h;74%
Multi-step reaction with 2 steps
1: 2 h / 45 °C
2: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr
View Scheme
D-Glutamic acid
6893-26-1

D-Glutamic acid

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / 6 h / 30 °C
2.1: sodium tetrahydroborate; ethanol / 2 h / Cooling with ice; Reflux
3.1: triethylamine / dichloromethane / 0.5 h / 0 °C
3.2: 30 °C
4.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C
View Scheme
Multi-step reaction with 5 steps
1: water; N,N-dimethyl-formamide / 1 h / 20 - 30 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 10 h / -5 - 50 °C
3: triethylamine / dichloromethane / 1 h / 0 - 20 °C
4: 2 h / 45 °C
5: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr
View Scheme
1,5-dimethyl (2R)-2-[[(tert-butoxy)carbonyl]amino]pentanedioate

1,5-dimethyl (2R)-2-[[(tert-butoxy)carbonyl]amino]pentanedioate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate; ethanol / 2 h / Cooling with ice; Reflux
2.1: triethylamine / dichloromethane / 0.5 h / 0 °C
2.2: 30 °C
3.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / 6 h / 30 °C
2.1: sodium tetrahydroborate; ethanol / 2 h / Cooling with ice; Reflux
3.1: triethylamine / dichloromethane / 0.5 h / 0 °C
3.2: 30 °C
4.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C
View Scheme
Multi-step reaction with 5 steps
1: water; N,N-dimethyl-formamide / 1 h / 20 - 30 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 10 h / -5 - 50 °C
3: triethylamine / dichloromethane / 1 h / 0 - 20 °C
4: 2 h / 45 °C
5: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr
View Scheme
tert-butyl N-[(2R)-1,5-dihydroxypentan-2-yl]carbamate

tert-butyl N-[(2R)-1,5-dihydroxypentan-2-yl]carbamate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0.5 h / 0 °C
1.2: 30 °C
2.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
2: 2 h / 45 °C
3: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr
View Scheme
N-[(1,1-dimethylethoxy)carbonyl]-D-glutamic acid
34404-28-9

N-[(1,1-dimethylethoxy)carbonyl]-D-glutamic acid

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dimethylsulfide borane complex / tetrahydrofuran / 10 h / -5 - 50 °C
2: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3: 2 h / 45 °C
4: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr
View Scheme
1-benzyloxycarbonylpiperidine-3-carboxylic acid
78190-11-1

1-benzyloxycarbonylpiperidine-3-carboxylic acid

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: methanol / 40 - 50 °C
2: ethanol / 70 - 75 °C
3: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C
4: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C
5: sodium carbonate / methanol; water / 20 - 25 °C
6: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere
View Scheme
(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid
160706-62-7

(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C
2: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C
3: sodium carbonate / methanol; water / 20 - 25 °C
4: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere
View Scheme
C14H18N2O3

C14H18N2O3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C
2: sodium carbonate / methanol; water / 20 - 25 °C
3: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere
View Scheme
C8H11N*C14H17NO4

C8H11N*C14H17NO4

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ethanol / 70 - 75 °C
2: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C
3: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C
4: sodium carbonate / methanol; water / 20 - 25 °C
5: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere
View Scheme
(R)-1-benzylpiperidine-3-carboxylic azide

(R)-1-benzylpiperidine-3-carboxylic azide

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / water / 1 h / 100 °C
2: sodium hydroxide / water / 2 h / 20 °C
3: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr
View Scheme
Ethyl nipecotate
71962-74-8

Ethyl nipecotate

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: isopropyl alcohol; water / 0.5 h / Reflux
2: sodium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
3: hydrazine hydrate / butan-1-ol / 8 h / Reflux
4: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C
5: sulfuric acid / water / 1 h / 100 °C
6: sodium hydroxide / water / 2 h / 20 °C
7: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr
View Scheme
(R)-piperidine-3-carboxylic acid ethyl ester*l-tartaric acid

(R)-piperidine-3-carboxylic acid ethyl ester*l-tartaric acid

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
2: hydrazine hydrate / butan-1-ol / 8 h / Reflux
3: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C
4: sulfuric acid / water / 1 h / 100 °C
5: sodium hydroxide / water / 2 h / 20 °C
6: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr
View Scheme
(R)-1-benzylpiperidine-3-carboxylic acid ethyl ester
245529-50-4

(R)-1-benzylpiperidine-3-carboxylic acid ethyl ester

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrazine hydrate / butan-1-ol / 8 h / Reflux
2: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C
3: sulfuric acid / water / 1 h / 100 °C
4: sodium hydroxide / water / 2 h / 20 °C
5: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr
View Scheme
(R)-1- benzylpiperidine-3-carboxylic acid hydrazide

(R)-1- benzylpiperidine-3-carboxylic acid hydrazide

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C
2: sulfuric acid / water / 1 h / 100 °C
3: sodium hydroxide / water / 2 h / 20 °C
4: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr
View Scheme
(3R)-1-benzyl-3-aminopiperidine
168466-84-0

(3R)-1-benzyl-3-aminopiperidine

(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 2 h / 20 °C
2: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr
View Scheme
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

1,1-dimethylethyl ((3R)-1-{[4-(methylamino)-3-nitrophenyl]carbonyl}-3-piperidinyl)carbamate
1549812-10-3

1,1-dimethylethyl ((3R)-1-{[4-(methylamino)-3-nitrophenyl]carbonyl}-3-piperidinyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;100%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;100%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

3-methoxy-4-(methylamino)-5-nitrobenzoic acid
1549812-23-8

3-methoxy-4-(methylamino)-5-nitrobenzoic acid

(R)-(1-(3-methoxy-4-(methylamino)-5-nitrobenzoyl)piperidin-3-yl)carbamic acid tert-butyl ester
1549812-25-0

(R)-(1-(3-methoxy-4-(methylamino)-5-nitrobenzoyl)piperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran; N,N-dimethyl-formamide for 0.666667h; Cooling with ice;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; Solvent; Temperature;
100%
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In N,N-dimethyl-formamide for 1.5h;
19.4 g
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In N,N-dimethyl-formamide for 1.5h;
19.4 g
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In N,N-dimethyl-formamide for 1.5h;
19.4 g
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

3-bromo-5-fluoropyridine-2- carbonitrile
950670-18-5

3-bromo-5-fluoropyridine-2- carbonitrile

(R)-tert-butyl 1-(5-bromo-6-cyanopyridin-3-yl)piperidin-3-ylcarbamate

(R)-tert-butyl 1-(5-bromo-6-cyanopyridin-3-yl)piperidin-3-ylcarbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 1.5h;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

methyl 4-(6-carbamoyl-3-(methylthio)-1,2,4-triazin-5-ylamino)benzoate

methyl 4-(6-carbamoyl-3-(methylthio)-1,2,4-triazin-5-ylamino)benzoate

(R)-methyl 4-(3-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-6-carbamoyl-1,2,4-triazin-5-ylamino)benzoate

(R)-methyl 4-(3-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-6-carbamoyl-1,2,4-triazin-5-ylamino)benzoate

Conditions
ConditionsYield
Stage #1: methyl 4-(6-carbamoyl-3-(methylthio)-1,2,4-triazin-5-ylamino)benzoate With 3-chloro-benzenecarboperoxoic acid In 1-methyl-pyrrolidin-2-one at 20℃; for 1h;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 90℃; for 1.5h;
100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

5-chloro-2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)imidazole-4-carboxylic acid

5-chloro-2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)imidazole-4-carboxylic acid

tert-butyl N-[(3R)-1-[5-Chloro-2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)imidazole-4-carbonyl]piperidin-3-yl]carbamate

tert-butyl N-[(3R)-1-[5-Chloro-2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)imidazole-4-carbonyl]piperidin-3-yl]carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-(4-Cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)imidazole-4-carboxylic acid

2-(4-Cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)imidazole-4-carboxylic acid

tert-butyl N-[(3R)-1-[2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-1methoxyphenyl)imidazole-4-carbonyl]piperidin-3-yl]carbamate

tert-butyl N-[(3R)-1-[2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-1methoxyphenyl)imidazole-4-carbonyl]piperidin-3-yl]carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(R)-tert-butyl (1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)carbamate

(R)-tert-butyl (1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 80℃; for 52h; Inert atmosphere; Sealed tube;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-chloro-6,7-dimethoxyquinazolin-4-amine
23680-84-4

2-chloro-6,7-dimethoxyquinazolin-4-amine

tert-butyl (R)-(1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl)carbamate

tert-butyl (R)-(1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
In i-Amyl alcohol at 130℃; under 760.051 Torr; for 0.833333h; Microwave irradiation;100%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

1-(but-2-ynyl)-6-chloro-3-(prop-2-ynyl)pyrimidine-2,4(1H,3H)-dione

1-(but-2-ynyl)-6-chloro-3-(prop-2-ynyl)pyrimidine-2,4(1H,3H)-dione

tert-butyl (R)-(1-(3-(but-2-yn-1-yl)-2,6-dioxo-1-(prop-2-yn-1-yl)-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate

tert-butyl (R)-(1-(3-(but-2-yn-1-yl)-2,6-dioxo-1-(prop-2-yn-1-yl)-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 5h;99.8%
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 5h;99%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

3-(R)-aminopiperidine dihydrochloride

3-(R)-aminopiperidine dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether at 0 - 20℃; for 8h;99%
With thionyl chloride In methanol at 30℃; for 10h;
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

C13H12ClN3O2

C13H12ClN3O2

C23H31N5O4

C23H31N5O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 65℃; Temperature;98.2%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

(1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene
1215279-81-4

(1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene

tert-butyl (R)-1-((1R,2R)-4,6-dichloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl)piperidin-3-ylcarbamate
1571103-69-9

tert-butyl (R)-1-((1R,2R)-4,6-dichloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl)piperidin-3-ylcarbamate

Conditions
ConditionsYield
In acetonitrile at 80℃; regioselective reaction;98%
In acetonitrile at 70℃; for 15h;330 mg
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

7-but-2-ynyl-8-iodo-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

7-but-2-ynyl-8-iodo-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine

1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine

Conditions
ConditionsYield
With lithium hexamethyldisilazane In toluene at 60 - 65℃; Reagent/catalyst; Inert atmosphere;97.8%
With lithium hexamethyldisilazane In toluene at 60 - 65℃; Reagent/catalyst; Inert atmosphere;97.8%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

3,5-dichloro-pyrazine-2-carbonitrile
313339-92-3

3,5-dichloro-pyrazine-2-carbonitrile

tert-butyl N-[(3R)-1-(6-chloro-5-cyanopyrazin-2-yl)piperidin-3-yl]carbamate

tert-butyl N-[(3R)-1-(6-chloro-5-cyanopyrazin-2-yl)piperidin-3-yl]carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;97%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;93%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;2.5 g
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

(R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

(R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;97%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

C18H13BrFN5O3

C18H13BrFN5O3

C28H32FN7O5

C28H32FN7O5

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 2h;96.1%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

benzyl chloroformate
501-53-1

benzyl chloroformate

(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester
485820-12-0

(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 5℃; for 24h;96%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 4h; Saturated solution;
With triethylamine In tetrahydrofuran at 0 - 5℃; for 24h;
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
1246610-74-1

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 6h; Product distribution / selectivity;96%
With potassium carbonate at 80 - 90℃;90%
With tetrabutylammomium bromide; potassium carbonate; sodium iodide In acetonitrile for 25h; Reflux;89.3%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione
1246610-77-4

6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

(R)-piperidin-3-ylcarbamic acid tert-butyl ester hydrochloride
1217656-59-1

(R)-piperidin-3-ylcarbamic acid tert-butyl ester hydrochloride

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
1246610-74-1

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile

Conditions
ConditionsYield
at 100℃; for 3h;96%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Bromodiphenylmethane
776-74-9

Bromodiphenylmethane

(R)-tert-butyl (1-benzhydrylpiperidin-3-yl)carbamate

(R)-tert-butyl (1-benzhydrylpiperidin-3-yl)carbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 60℃; for 14h;96%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-bromo-1-(but-2-ynyl)-4-methyl-6-((4-methylquinazolin-2-yl)methyl)-1H-imidazo[4,5-b]pyridine-5,7-(4H,6H)-dione
853029-57-9

2-bromo-1-(but-2-ynyl)-4-methyl-6-((4-methylquinazolin-2-yl)methyl)-1H-imidazo[4,5-b]pyridine-5,7-(4H,6H)-dione

1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine

1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide; acetonitrile at 84 - 86℃; for 20h;95.3%
With potassium carbonate In dimethyl sulfoxide; acetonitrile at 20 - 86℃; for 20h; Temperature;95.3%
With potassium carbonate; potassium iodide In dimethyl sulfoxide at 80 - 85℃; Reagent/catalyst;91%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione
666816-98-4

8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione

2-chloromethyl-4-methylquinazoline
109113-72-6

2-chloromethyl-4-methylquinazoline

1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine

1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine

Conditions
ConditionsYield
Stage #1: 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione; 2-chloromethyl-4-methylquinazoline With potassium carbonate In 1-methyl-pyrrolidin-2-one; acetonitrile at 50℃; for 6h;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In 1-methyl-pyrrolidin-2-one; acetonitrile at 60℃; for 8h; Solvent; Temperature;
95.1%
With sodium carbonate at 55 - 60℃; for 6h; Concentration; Reagent/catalyst;91.8%
Stage #1: (R)-piperidin-3-ylcarbamic acid tert-butyl ester; 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione With 1-methyl-pyrrolidin-2-one; potassium carbonate; potassium iodide for 10h;
Stage #2: 2-chloromethyl-4-methylquinazoline for 12h; Time;
90%
Stage #1: 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione; 2-chloromethyl-4-methylquinazoline With potassium carbonate; potassium iodide In 1-methyl-pyrrolidin-2-one at 40 - 50℃;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester Reagent/catalyst; Solvent; Temperature;
86.7%
Stage #1: 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione; 2-chloromethyl-4-methylquinazoline With potassium carbonate; potassium iodide In 1-methyl-pyrrolidin-2-one at 40 - 50℃;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In 1-methyl-pyrrolidin-2-one Reagent/catalyst; Solvent; Temperature;
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

N-ethoxycarbonyl-4-piperidone
29976-53-2

N-ethoxycarbonyl-4-piperidone

C18H33N3O4
1346006-05-0

C18H33N3O4

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane95%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

7-but-2-ynyl-8-iodo-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

7-but-2-ynyl-8-iodo-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

Linagliptin

Linagliptin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 10h;94.1%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

1-fluoro-2-nitro-4-trifluoromethyl-benzene
367-86-2

1-fluoro-2-nitro-4-trifluoromethyl-benzene

(R)-tert-butyl 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-3-ylcarbamate

(R)-tert-butyl 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-3-ylcarbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at 70℃; for 14h;94%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione
666816-98-4

8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione

3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)piperidin-1-yl]xanthine
666816-91-7

3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)piperidin-1-yl]xanthine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 114℃; for 6h;94%
With potassium carbonate In dimethyl sulfoxide at 114℃; for 6h;94%
With potassium carbonate In dimethyl sulfoxide at 114℃; for 6h;94%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole
1188914-98-8

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole

tert-butyl (R)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate
1188915-59-4

tert-butyl (R)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate

Conditions
ConditionsYield
94%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;94%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole
1188914-98-8

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole

tert-butyl (S)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate
1188915-61-8

tert-butyl (S)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate

Conditions
ConditionsYield
at 20℃;94%

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