As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $5.0
Type:Lab/Research institutions
inquiryhigh quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:key intermediates Port:SHA
Cas:309956-78-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquirySichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO900
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:309956-78-3
Min.Order:1
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Type:Other
inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an
Cas:309956-78-3
Min.Order:1 Kilogram
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Type:Trading Company
inquiryThe company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:309956-78-3
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryIn stock Contract customization Low Temperature Reactions Fluorine Chemistry Hydrogenation Nitration Chlorination Appearance:white crystalline powder Storage:cool and dry warehouse Package:25KG/Bag Application: intermediate of Liragliptin Port:
Cas:309956-78-3
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryItems Standard Result Appearance White to off white powder Complies Identification
Cas:309956-78-3
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:309956-78-3
Min.Order:10 Gram
Negotiable
Type:Manufacturers
inquiryLinagliptin Intermediate 1-Bromo-2-Butyne[CAS:3355-28-0] (R)-3-(Boc-Amino)piperidine[CAS:309956-78-3] Name (R)-3-(Boc-Amino)piperidine Synonyms (R)-(+)-3-tert-Butoxycarbonyl
Cas:309956-78-3
Min.Order:100 Gram
Negotiable
Type:Other
inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
Cas:309956-78-3
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:309956-78-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99
Cas:309956-78-3
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiry
Cas:309956-78-3
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiryCHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $2.0 / 3.0
Type:Trading Company
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1051.html Product Name (R)-3-(Boc-Amino)piperidine CAS No. 309956-
Cas:309956-78-3
Min.Order:1 Gram
FOB Price: $45.0
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:309956-78-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:309956-78-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProName:Best price (R)-3-(Boc-Amino)piperidine... CasNo:309956-78-3 Molecular Formula:C10H20N2O2 Appearance:white powder Application:medical intermediate DeliveryTime:3-15 working days PackAge:aluminium foil bag Port:any port in China Produ
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Cas:309956-78-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diams
Cas:309956-78-3
Min.Order:1 Metric Ton
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryProduct Name: (R)-3-(Boc-amino)piperidine Synonyms: (3R)-3-Piperidinyl-carbamic Acid 1,1-Dimethylethyl Ester; (3R)-3-[((tert-Butyloxycarbonyl)amino)]piperidine; (R)-3-(tert-Butoxycarbonylamino)pi
Cas:309956-78-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:309956-78-3
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage: Keep in a well
Cas:309956-78-3
Min.Order:1 Gram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:309956-78-3
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:309956-78-3
Min.Order:100 Kilogram
FOB Price: $1.0 / 5.0
Type:Trading Company
inquiryQingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical
Cas:309956-78-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquirytert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethanol at 20 - 25℃; under 150015 Torr; for 20h; | 97% |
With palladium 10% on activated carbon; hydrogen In methanol at 45℃; under 1140.08 Torr; for 2h; | 85% |
With hydrogen; 10% palladium on activated carbon In metahnol at 20℃; for 24h; |
(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol; water at 35 - 40℃; under 2250.23 - 3000.3 Torr; for 2h; Time; Autoclave; Inert atmosphere; | 95.4% |
With hydrogen; palladium 10% on activated carbon In ethanol at 20℃; under 760.051 Torr; for 168h; | 92% |
In ethanol |
t-butyl (R)-piperidin-3-ylcarbamate R-mandelate
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium chloride; sodium hydroxide In water; butan-1-ol at 10 - 30℃; | 79.7% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With ammonium hydroxide In acetonitrile at 30℃; for 48h; | 74% |
Multi-step reaction with 2 steps 1: 2 h / 45 °C 2: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr View Scheme |
D-Glutamic acid
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / 6 h / 30 °C 2.1: sodium tetrahydroborate; ethanol / 2 h / Cooling with ice; Reflux 3.1: triethylamine / dichloromethane / 0.5 h / 0 °C 3.2: 30 °C 4.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C View Scheme | |
Multi-step reaction with 5 steps 1: water; N,N-dimethyl-formamide / 1 h / 20 - 30 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 10 h / -5 - 50 °C 3: triethylamine / dichloromethane / 1 h / 0 - 20 °C 4: 2 h / 45 °C 5: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate; ethanol / 2 h / Cooling with ice; Reflux 2.1: triethylamine / dichloromethane / 0.5 h / 0 °C 2.2: 30 °C 3.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C View Scheme |
di-tert-butyl dicarbonate
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / 6 h / 30 °C 2.1: sodium tetrahydroborate; ethanol / 2 h / Cooling with ice; Reflux 3.1: triethylamine / dichloromethane / 0.5 h / 0 °C 3.2: 30 °C 4.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C View Scheme | |
Multi-step reaction with 5 steps 1: water; N,N-dimethyl-formamide / 1 h / 20 - 30 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 10 h / -5 - 50 °C 3: triethylamine / dichloromethane / 1 h / 0 - 20 °C 4: 2 h / 45 °C 5: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0.5 h / 0 °C 1.2: 30 °C 2.1: ammonium hydroxide / acetonitrile / 48 h / 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: 2 h / 45 °C 3: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr View Scheme |
N-[(1,1-dimethylethoxy)carbonyl]-D-glutamic acid
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dimethylsulfide borane complex / tetrahydrofuran / 10 h / -5 - 50 °C 2: triethylamine / dichloromethane / 1 h / 0 - 20 °C 3: 2 h / 45 °C 4: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 45 °C / 1140.08 Torr View Scheme |
1-benzyloxycarbonylpiperidine-3-carboxylic acid
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: methanol / 40 - 50 °C 2: ethanol / 70 - 75 °C 3: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C 4: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C 5: sodium carbonate / methanol; water / 20 - 25 °C 6: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere View Scheme |
(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C 2: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C 3: sodium carbonate / methanol; water / 20 - 25 °C 4: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C 2: sodium carbonate / methanol; water / 20 - 25 °C 3: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: ethanol / 70 - 75 °C 2: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C 4: sodium carbonate / methanol; water / 20 - 25 °C 5: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 35 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / water / 1 h / 100 °C 2: sodium hydroxide / water / 2 h / 20 °C 3: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr View Scheme |
Ethyl nipecotate
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: isopropyl alcohol; water / 0.5 h / Reflux 2: sodium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 3: hydrazine hydrate / butan-1-ol / 8 h / Reflux 4: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C 5: sulfuric acid / water / 1 h / 100 °C 6: sodium hydroxide / water / 2 h / 20 °C 7: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 2: hydrazine hydrate / butan-1-ol / 8 h / Reflux 3: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C 4: sulfuric acid / water / 1 h / 100 °C 5: sodium hydroxide / water / 2 h / 20 °C 6: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr View Scheme |
(R)-1-benzylpiperidine-3-carboxylic acid ethyl ester
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrazine hydrate / butan-1-ol / 8 h / Reflux 2: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C 3: sulfuric acid / water / 1 h / 100 °C 4: sodium hydroxide / water / 2 h / 20 °C 5: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C 2: sulfuric acid / water / 1 h / 100 °C 3: sodium hydroxide / water / 2 h / 20 °C 4: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr View Scheme |
(3R)-1-benzyl-3-aminopiperidine
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 2 h / 20 °C 2: 5%-palladium/activated carbon; hydrogen / ethanol / 20 h / 20 - 25 °C / 150015 Torr View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
4-(methylamino)-3-nitrobenzoic acid
1,1-dimethylethyl ((3R)-1-{[4-(methylamino)-3-nitrophenyl]carbonyl}-3-piperidinyl)carbamate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h; | 100% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h; | 100% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
3-methoxy-4-(methylamino)-5-nitrobenzoic acid
(R)-(1-(3-methoxy-4-(methylamino)-5-nitrobenzoyl)piperidin-3-yl)carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran; N,N-dimethyl-formamide for 0.666667h; Cooling with ice; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; Solvent; Temperature; | 100% |
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In N,N-dimethyl-formamide for 1.5h; | 19.4 g |
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In N,N-dimethyl-formamide for 1.5h; | 19.4 g |
Stage #1: 3-methoxy-4-(methylamino)-5-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In N,N-dimethyl-formamide for 1.5h; | 19.4 g |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
3-bromo-5-fluoropyridine-2- carbonitrile
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 1.5h; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: methyl 4-(6-carbamoyl-3-(methylthio)-1,2,4-triazin-5-ylamino)benzoate With 3-chloro-benzenecarboperoxoic acid In 1-methyl-pyrrolidin-2-one at 20℃; for 1h; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 90℃; for 1.5h; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 80℃; for 52h; Inert atmosphere; Sealed tube; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
2-chloro-6,7-dimethoxyquinazolin-4-amine
Conditions | Yield |
---|---|
In i-Amyl alcohol at 130℃; under 760.051 Torr; for 0.833333h; Microwave irradiation; | 100% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 5h; | 99.8% |
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 5h; | 99% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In tert-butyl methyl ether at 0 - 20℃; for 8h; | 99% |
With thionyl chloride In methanol at 30℃; for 10h; |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 65℃; Temperature; | 98.2% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
(1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene
tert-butyl (R)-1-((1R,2R)-4,6-dichloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl)piperidin-3-ylcarbamate
Conditions | Yield |
---|---|
In acetonitrile at 80℃; regioselective reaction; | 98% |
In acetonitrile at 70℃; for 15h; | 330 mg |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In toluene at 60 - 65℃; Reagent/catalyst; Inert atmosphere; | 97.8% |
With lithium hexamethyldisilazane In toluene at 60 - 65℃; Reagent/catalyst; Inert atmosphere; | 97.8% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
3,5-dichloro-pyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; | 97% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; | 93% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; | 2.5 g |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
2,3-dichloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h; | 97% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 2h; | 96.1% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
benzyl chloroformate
(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 5℃; for 24h; | 96% |
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 4h; Saturated solution; | |
With triethylamine In tetrahydrofuran at 0 - 5℃; for 24h; |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 6h; Product distribution / selectivity; | 96% |
With potassium carbonate at 80 - 90℃; | 90% |
With tetrabutylammomium bromide; potassium carbonate; sodium iodide In acetonitrile for 25h; Reflux; | 89.3% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione
(R)-piperidin-3-ylcarbamic acid tert-butyl ester hydrochloride
2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
Conditions | Yield |
---|---|
at 100℃; for 3h; | 96% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Bromodiphenylmethane
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 60℃; for 14h; | 96% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
2-bromo-1-(but-2-ynyl)-4-methyl-6-((4-methylquinazolin-2-yl)methyl)-1H-imidazo[4,5-b]pyridine-5,7-(4H,6H)-dione
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide; acetonitrile at 84 - 86℃; for 20h; | 95.3% |
With potassium carbonate In dimethyl sulfoxide; acetonitrile at 20 - 86℃; for 20h; Temperature; | 95.3% |
With potassium carbonate; potassium iodide In dimethyl sulfoxide at 80 - 85℃; Reagent/catalyst; | 91% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione
2-chloromethyl-4-methylquinazoline
Conditions | Yield |
---|---|
Stage #1: 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione; 2-chloromethyl-4-methylquinazoline With potassium carbonate In 1-methyl-pyrrolidin-2-one; acetonitrile at 50℃; for 6h; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In 1-methyl-pyrrolidin-2-one; acetonitrile at 60℃; for 8h; Solvent; Temperature; | 95.1% |
With sodium carbonate at 55 - 60℃; for 6h; Concentration; Reagent/catalyst; | 91.8% |
Stage #1: (R)-piperidin-3-ylcarbamic acid tert-butyl ester; 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione With 1-methyl-pyrrolidin-2-one; potassium carbonate; potassium iodide for 10h; Stage #2: 2-chloromethyl-4-methylquinazoline for 12h; Time; | 90% |
Stage #1: 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione; 2-chloromethyl-4-methylquinazoline With potassium carbonate; potassium iodide In 1-methyl-pyrrolidin-2-one at 40 - 50℃; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester Reagent/catalyst; Solvent; Temperature; | 86.7% |
Stage #1: 8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione; 2-chloromethyl-4-methylquinazoline With potassium carbonate; potassium iodide In 1-methyl-pyrrolidin-2-one at 40 - 50℃; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester In 1-methyl-pyrrolidin-2-one Reagent/catalyst; Solvent; Temperature; |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
N-ethoxycarbonyl-4-piperidone
C18H33N3O4
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane | 95% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 10h; | 94.1% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
1-fluoro-2-nitro-4-trifluoromethyl-benzene
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran at 70℃; for 14h; | 94% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione
3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)piperidin-1-yl]xanthine
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 114℃; for 6h; | 94% |
With potassium carbonate In dimethyl sulfoxide at 114℃; for 6h; | 94% |
With potassium carbonate In dimethyl sulfoxide at 114℃; for 6h; | 94% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole
tert-butyl (R)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate
Conditions | Yield |
---|---|
94% | |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 94% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole
tert-butyl (S)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate
Conditions | Yield |
---|---|
at 20℃; | 94% |
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