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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile

Cas:865758-96-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Wuhan Fortuna Chemical Co.,Ltd

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile CAS 865758-96-9 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical &

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile CAS 865758-96-9

Cas:865758-96-9

Min.Order:10 Gram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile

Cas:865758-96-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile

Cas:865758-96-9

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-benzonitrile

Cas:865758-96-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1050.html Product Name 2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile

2-Cyanobenzyl bromide2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile

Cas:865758-96-9

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--865758-96-9--2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals

TIANFUCHEM--865758-96-9--2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile factory price

Cas:865758-96-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Pharma Intermediate CAS No: 865758-96-9

Cas:865758-96-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 865758-96-9 with competitive price

Cas:865758-96-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile Synonyms: Benzonitrile, 2-[(6-chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]- CAS: 865758-96-9 MF: C13H10ClN3O2 Appearance:White powder Storag

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile

Cas:865758-96-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal powder Storage:Store in sealed container

CAS NO. 865758-96-9 Alogliptin Related Compound 28 for industrial use

Cas:865758-96-9

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzonitrile,2-[(6-chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]- 865758-96-9

Cas:865758-96-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Alogliptin Intermediate CAS 865758-96-9

Cas:865758-96-9

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile CAS:865758-96-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of che

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile CAS:865758-96-9

Cas:865758-96-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Alogliptin Related Compound 28

Cas:865758-96-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 865758-96-92-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile

Cas:865758-96-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:865758-96-9

Cas:865758-96-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

2-((6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile CAS:865758-96-9 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile

Cas:865758-96-9

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile 865758-96-9

Cas:865758-96-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

2-((6-Chloro-3,4-dihydro-3-methyl-2,4-dioxopyrimidin-1(2H)-yl)methyl)benzonitrile 865758-96-9

Cas:865758-96-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name 2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile Molecular Structure Molecular Formula

2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile

Cas:865758-96-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-[(6-CHLORO-3,4-DIHYDRO-3-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)METHYL]BENZONITRILE CAS: 865758-96-9

Cas:865758-96-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-((6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

Cas:865758-96-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitri

Cas:865758-96-9

Min.Order:100 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile

Cas:865758-96-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzonitrile,2-[(6-chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-

Cas:865758-96-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

3-methyl-6-chlorouracil
4318-56-3

3-methyl-6-chlorouracil

2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 3-methyl-6-chlorouracil With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 23℃; for 0.25h; Schlenk technique; Inert atmosphere;
Stage #2: 2-(bromomethyl)benzonitrile In tetrahydrofuran at 65℃; for 2h; Schlenk technique; Inert atmosphere;
96%
With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine at 60 - 65℃; for 3h; Large scale;96.42%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40 - 45℃; Solvent; Temperature;95.8%
3-methyl-6-chlorouracil
4318-56-3

3-methyl-6-chlorouracil

2-cyanobenzyl chloride
612-13-5

2-cyanobenzyl chloride

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 60℃; for 1h;85.62%
With potassium carbonate; potassium iodide In N,N-dimethyl acetamide at 50 - 100℃;
2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile
865758-95-8

2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile

dimethyl sulfate
77-78-1

dimethyl sulfate

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.25h;
Stage #2: dimethyl sulfate In N,N-dimethyl-formamide for 12h; Solvent; Reagent/catalyst;
84.78%
2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile
865758-95-8

2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile

methyl iodide
74-88-4

methyl iodide

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile With sodium hydride; lithium bromide In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 35℃; Further stages.;
72%
Stage #1: 2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile With sodium hydride; lithium bromide In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 35℃; Inert atmosphere;
72%
Stage #1: 2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile With sodium hydride; lithium bromide In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 80℃; Inert atmosphere;
70%
methyl iodide
74-88-4

methyl iodide

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile With sodium hydride; lithium bromide In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20 - 35℃;
72%
Stage #1: 2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile With sodium hydride; lithium bromide In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 35℃;
72%
1-(2-cyanobenzyl)-3-methylpyrimidine-2,4,6(1H,3H,5H)-trione
1246610-72-9

1-(2-cyanobenzyl)-3-methylpyrimidine-2,4,6(1H,3H,5H)-trione

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
With phosphorus pentachloride; N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate In acetonitrile for 4 - 5h; Product distribution / selectivity; Reflux;70.5%
1-(2-cyanobenzyl)-3-methylpyrimidine-2,4,6(1H,3H,5H)-trione
1246610-72-9

1-(2-cyanobenzyl)-3-methylpyrimidine-2,4,6(1H,3H,5H)-trione

A

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

B

C13H10ClN3O2

C13H10ClN3O2

Conditions
ConditionsYield
Stage #1: 1-(2-cyanobenzyl)-3-methylpyrimidine-2,4,6(1H,3H,5H)-trione With trichlorophosphate at 0℃;
Stage #2: With water at 0 - 110℃;
A 37%
B n/a
2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide; dimethylsulfoxide / 0.5 h / 0 °C
1.2: LiBr / dimethylformamide; 1,2-dimethoxy-ethane / 0.25 h / 0 - 20 °C
1.3: 54 percent / dimethylformamide; dimethylsulfoxide / 0 - 20 °C
2.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C
2.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.25 h / 0 °C / Inert atmosphere
1.3: 0 - 20 °C / Inert atmosphere
2.1: sodium hydride; lithium bromide / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere
2.2: 20 - 35 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one; toluene / 70 - 80 °C
2: potassium carbonate / acetone / 50 - 60 °C
View Scheme
1-methyl-2,4,6-pyrimidinetrione
2565-47-1

1-methyl-2,4,6-pyrimidinetrione

2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-methyl-2,4,6-pyrimidinetrione With N,N-dimethyl-aniline; trichlorophosphate In toluene at 90 - 95℃; for 2h;
Stage #2: 2-(bromomethyl)benzonitrile With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 60 - 65℃; Temperature; Concentration;
40 g
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
1246610-74-1

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 6h; Product distribution / selectivity;96%
With potassium carbonate at 80 - 90℃;90%
With tetrabutylammomium bromide; potassium carbonate; sodium iodide In acetonitrile for 25h; Reflux;89.3%
3-(R)-aminopiperidine dihydrochloride

3-(R)-aminopiperidine dihydrochloride

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

Alogliptin hydrochloride
1246610-75-2

Alogliptin hydrochloride

Conditions
ConditionsYield
Stage #1: 3-(R)-aminopiperidine dihydrochloride; 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With potassium carbonate In water; isopropyl alcohol at 75 - 80℃; Large scale;
Stage #2: With hydrogenchloride In chloroform; water at -5 - 0℃; for 2h; Reagent/catalyst; Large scale;
95.1%
Stage #1: 3-(R)-aminopiperidine dihydrochloride; 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile In water; isopropyl alcohol at 60 - 65℃; Inert atmosphere;
Stage #2: With potassium carbonate In water; isopropyl alcohol at 60 - 65℃; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; isopropyl alcohol at 0 - 15℃; Inert atmosphere;
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(R)-piperidine-3-carboxamide p-toluenesulfonate

(R)-piperidine-3-carboxamide p-toluenesulfonate

(R)-1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide

(R)-1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide

Conditions
ConditionsYield
With potassium carbonate In water; isopropyl alcohol at 65℃; for 23h;95%
With potassium carbonate In water; isopropyl alcohol at 70℃; for 18h; Temperature;93%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

C18H21N5O2

C18H21N5O2

C31H30N8O4

C31H30N8O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 5h; Temperature;93%
3-(R)-aminopiperidine dihydrochloride

3-(R)-aminopiperidine dihydrochloride

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With potassium hydrogencarbonate In isopropyl alcohol; acetonitrile at 60℃; for 6h;92.7%
With triethylamine In isopropyl alcohol at 65℃; for 17h;85%
With tetra-n-butylphosphonium chloride; sodium hydrogencarbonate In water; toluene at 60 - 70℃; Solvent; Temperature;85.7%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

benzyl N-[(3R)-3-piperidyl]carbamate
478646-32-1

benzyl N-[(3R)-3-piperidyl]carbamate

benzyl N-[(3R)-1-{3-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl}piperidin-3-yl]carbamate

benzyl N-[(3R)-1-{3-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl}piperidin-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 8h; Solvent;92.7%
With cetyltrimethylammonim bromide; potassium carbonate In acetone for 24h; Solvent; Reagent/catalyst; Reflux;87.7%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester With triethylamine In N,N-dimethyl-formamide at 23℃; for 2h; Schlenk technique; Inert atmosphere;
Stage #3: With trifluoroacetic acid In dichloromethane; N,N-dimethyl-formamide at 23℃; for 1h; Schlenk technique; Inert atmosphere;
92%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(3R)-3-aminopyrrolidine dihydrochloride
103831-11-4, 116183-81-4, 116183-83-6, 122458-34-8

(3R)-3-aminopyrrolidine dihydrochloride

(R)-6-(3-aminopyrrolidin-1-yl)-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

(R)-6-(3-aminopyrrolidin-1-yl)-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With sodium hydrogencarbonate In isopropyl alcohol at 100℃; for 2h; Molecular sieve;84%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(S)-3-aminopyrrolidine dihydrochloride
103831-11-4, 116183-81-4, 116183-83-6, 122458-34-8

(S)-3-aminopyrrolidine dihydrochloride

(S)-6-(3-aminopyrrolidin-1-yl)-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

(S)-6-(3-aminopyrrolidin-1-yl)-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With sodium hydrogencarbonate In isopropyl alcohol at 100℃; for 2h; Molecular sieve;82%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(R)-5-azaspiro[2.4]heptan-7-amine dihydrochloride

(R)-5-azaspiro[2.4]heptan-7-amine dihydrochloride

(R)-6-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

(R)-6-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With sodium hydrogencarbonate In isopropyl alcohol at 100℃; for 2h; Molecular sieve;81%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

ethylenediamine
107-15-3

ethylenediamine

C15H17N5O2

C15H17N5O2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 4h; Reflux;80%
tert-butyl (3R)3-aminopiperidine-1-carboxylate
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

C23H29N5O4

C23H29N5O4

Conditions
ConditionsYield
With sodium carbonate In isopropyl alcohol for 13h; Time; Reflux;78%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

1-methyl-1-propanethiol
513-53-1

1-methyl-1-propanethiol

2-((6-(sec-butylthio)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

2-((6-(sec-butylthio)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: 1-methyl-1-propanethiol With potassium phosphate In N,N-dimethyl-formamide at 50℃; for 2h; Schlenk technique; Inert atmosphere;
76%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

thiophenol
108-98-5

thiophenol

2-((3-methyl-2,4-dioxo-6-(phenylthio)-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

2-((3-methyl-2,4-dioxo-6-(phenylthio)-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: thiophenol With potassium phosphate In N,N-dimethyl-formamide at 50℃; for 2h; Schlenk technique; Inert atmosphere;
72%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(R)-3-piperidinyl phthalimide hydrochloride

(R)-3-piperidinyl phthalimide hydrochloride

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; 3-(R)-piperidinyl phthalimide hydrochloride With sodium hydrogencarbonate In methanol at 100℃; for 0.75h;
Stage #2: With methanol; hydrazine hydrate for 4h; Reagent/catalyst; Temperature; Reflux; Further stages;
70%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

C13H9Cl2N3O2

C13H9Cl2N3O2

Conditions
ConditionsYield
With N-chloro-succinimide In 1,2-dichloro-ethane at 80℃; for 8h; Solvent; Temperature;65.8%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

3-(R)-aminopiperidine dihydrochloride
943528-10-7

3-(R)-aminopiperidine dihydrochloride

trifluoroacetic acid
76-05-1

trifluoroacetic acid

2-{6-[3(R)-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}benzonitrile trifluoroacetate

2-{6-[3(R)-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}benzonitrile trifluoroacetate

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; 3-(R)-aminopiperidine dihydrochloride With sodium hydrogencarbonate In methanol at 100℃; for 2h; Molecular sieve;
Stage #2: trifluoroacetic acid
56%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

DL-3-aminohexahydro-1H-azepin
69154-03-6

DL-3-aminohexahydro-1H-azepin

trifluoroacetic acid
76-05-1

trifluoroacetic acid

A

2-{6-[(+/-)-3-aminoazepan-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}benzonitrile trifluoroacetate

2-{6-[(+/-)-3-aminoazepan-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}benzonitrile trifluoroacetate

B

2-{6-[(+/-)-azepan-3-ylamino]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}benzonitrile trifluoroacetate

2-{6-[(+/-)-azepan-3-ylamino]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}benzonitrile trifluoroacetate

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; DL-3-aminohexahydro-1H-azepin With sodium hydrogencarbonate In methanol at 100℃; Molecular sieve;
Stage #2: trifluoroacetic acid
A 50%
B 11%
3-(R)-aminopiperidine dihydrochloride

3-(R)-aminopiperidine dihydrochloride

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile hydrochloride

2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile hydrochloride

Conditions
ConditionsYield
Stage #1: 3-(R)-aminopiperidine dihydrochloride; 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With triethylamine In water; isopropyl alcohol at 65℃; for 48h;
Stage #2: With hydrogenchloride In ethanol
47.53%
In water; isopropyl alcohol at 58 - 68℃;
With sodium carbonate; potassium iodide In isopropyl alcohol at 65 - 70℃;40 g
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

tert-butyl alcohol
75-65-0

tert-butyl alcohol

C17H19N3O3

C17H19N3O3

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 70℃; for 12h;44%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(5-azaspiro[2.5]oct-8-yl)carbamic acid tert-butyl ester
1232542-24-3

(5-azaspiro[2.5]oct-8-yl)carbamic acid tert-butyl ester

tert-butyl 5-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)5-azaspiro[2.5]octan-8-ylcarbamate
1232542-25-4

tert-butyl 5-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)5-azaspiro[2.5]octan-8-ylcarbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dimethyl sulfoxide at 100℃; for 2h; Inert atmosphere;40%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

ethanol
64-17-5

ethanol

C15H15N3O3

C15H15N3O3

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 73℃; for 8h;34.5%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

isopropyl alcohol
67-63-0

isopropyl alcohol

C16H17N3O3

C16H17N3O3

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 68℃; for 16h;23%

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