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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Alogliptin Manufacturer/High quality/Best price/In stock

Cas:850649-61-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

Alogliptin

Cas:850649-61-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5 GMP Manufacturer

Cas:850649-61-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Alogliptin

Cas:850649-61-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Cas:850649-61-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Alogliptin

Cas:850649-61-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

1 Factory price 2 High quality 3 Good servicechengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw mater

Pharmaceutical intermediates

Cas:850649-61-5

Min.Order:1 Gram

FOB Price: $1000.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Cas:850649-61-5

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Basic information Product Name: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Synonyms: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA);Alogliptin;Unii-jhc049lo86;2-[[6-

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Cas:850649-61-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Cas:850649-61-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 850649-61-5 with best quality

Cas:850649-61-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Off-White crystalline powder Storage:Store in sealed contain

Alogliptin An Orally Administered Antidiabetic Drugs 850649-61-5

Cas:850649-61-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Alogliptin 850649-61-5

Cas:850649-61-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Alogliptin CAS 850649-61-5

Cas:850649-61-5

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Basic information Product Name: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) CAS: 850649-61-5 MF: C18H21N5O2 MW: 339.39 EINECS: 821-899-3 ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Structure ALOGLIPTIN(ALOGLIPT

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Cas:850649-61-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) CAS: 850649-61-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) CAS: 850649-61-5

Cas:850649-61-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Alogliptin

Cas:850649-61-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

Factory Supply Alogliptin Benzoate

Cas:850649-61-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:850649-61-5 Transp

Alogliptin

Cas:850649-61-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

CAS 850649-61-5 Alogliptin Pharmaceutical Chemicals

Cas:850649-61-5

Min.Order:1 Gram

FOB Price: $280.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Alogliptin

Cas:850649-61-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white crystal powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Sha

Sell/Synthesis 850649-61-5 Alogliptin 99.9% white crystal powder

Cas:850649-61-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

Chinese supplier of Alogliptin 850649-61-5 in stock from China supplier factory manufacturer

Cas:850649-61-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

SYR-322 Alogliptin 850649-61-5

Cas:850649-61-5

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ALOGLIPTIN

Cas:850649-61-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Alogliptin

Cas:850649-61-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Alogliptin

Cas:850649-61-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Alogliptin/High quality/Best price

Cas:850649-61-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Pharmaceutical intermediates

Cas:850649-61-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

3-(R)-aminopiperidine dihydrochloride

3-(R)-aminopiperidine dihydrochloride

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With potassium hydrogencarbonate In isopropyl alcohol; acetonitrile at 60℃; for 6h;92.7%
With triethylamine In isopropyl alcohol at 65℃; for 17h;85%
With tetra-n-butylphosphonium chloride; sodium hydrogencarbonate In water; toluene at 60 - 70℃; Solvent; Temperature;85.7%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester With triethylamine In N,N-dimethyl-formamide at 23℃; for 2h; Schlenk technique; Inert atmosphere;
Stage #3: With trifluoroacetic acid In dichloromethane; N,N-dimethyl-formamide at 23℃; for 1h; Schlenk technique; Inert atmosphere;
92%
2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
1246610-74-1

2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With hydrogenchloride In methanol; dichloromethane; water at 0 - 5℃; for 4h;91%
With trifluoroacetic acid In methanol at 65℃; for 7h; Reagent/catalyst; Solvent;83%
With citric acid for 2h; Reagent/catalyst; Reflux;77.82%
(R)-1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide

(R)-1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With pyridine; [bis(acetoxy)iodo]benzene In water; isopropyl alcohol at 20℃; for 3h;87%
With pyridine; bis-[(trifluoroacetoxy)iodo]benzene In water; isopropyl alcohol at 20℃; for 3h; Solvent; Hofmann Rearrangement;87.2%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

C22H31N5O3

C22H31N5O3

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
In tetrahydrofuran at 45℃; for 5.5h;86.5%
2-{6-[3(R)-Amino-piperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

2-{6-[3(R)-Amino-piperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With benzaldehyde In isopropyl alcohol at 60℃; under 675.068 Torr; for 24h;82%
3-(R)-aminopiperidine dihydrochloride

3-(R)-aminopiperidine dihydrochloride

3-methyl-6-chlorouracil
4318-56-3

3-methyl-6-chlorouracil

2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Stage #1: 3-methyl-6-chlorouracil; 2-(bromomethyl)benzonitrile With dmap In acetonitrile at 80℃; for 6h; Green chemistry;
Stage #2: 3-(R)-aminopiperidine dihydrochloride In acetonitrile for 8h; Reflux; Green chemistry;
73%
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

(R)-3-piperidinyl phthalimide hydrochloride

(R)-3-piperidinyl phthalimide hydrochloride

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; 3-(R)-piperidinyl phthalimide hydrochloride With sodium hydrogencarbonate In methanol at 100℃; for 0.75h;
Stage #2: With methanol; hydrazine hydrate for 4h; Reagent/catalyst; Temperature; Reflux; Further stages;
70%
2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile
865758-95-8

2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C
1.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C
2.1: 2.7 g / NaHCO3; molecular sieves 4 Angstroem / ethanol / 4 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 50 - 60 °C
2: sodium hydrogencarbonate / methanol / 6 h / 65 - 70 °C / Molecular sieve
View Scheme
Multi-step reaction with 2 steps
1.1: lithium bromide; sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 80 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / isopropyl alcohol / 2 h / 100 °C / Molecular sieve
View Scheme
2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaH / dimethylformamide; dimethylsulfoxide / 0.5 h / 0 °C
1.2: LiBr / dimethylformamide; 1,2-dimethoxy-ethane / 0.25 h / 0 - 20 °C
1.3: 54 percent / dimethylformamide; dimethylsulfoxide / 0 - 20 °C
2.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C
2.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C
3.1: 2.7 g / NaHCO3; molecular sieves 4 Angstroem / ethanol / 4 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one; toluene / 70 - 80 °C
2: potassium carbonate / acetone / 50 - 60 °C
3: sodium hydrogencarbonate / methanol / 6 h / 65 - 70 °C / Molecular sieve
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2.1: lithium bromide; sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 80 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / isopropyl alcohol / 2 h / 100 °C / Molecular sieve
View Scheme
3-methyl-6-chlorouracil
4318-56-3

3-methyl-6-chlorouracil

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl acetamide / 50 - 100 °C
2: potassium carbonate / N,N-dimethyl acetamide / Heating
3: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 50 - 100 °C
2: potassium carbonate / N,N-dimethyl acetamide / Heating
3: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: tributyl-amine / toluene / 5 h / 80 °C
2: triethylamine / isopropyl alcohol / 17 h / 65 °C
View Scheme
2-cyanobenzyl chloride
612-13-5

2-cyanobenzyl chloride

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 50 - 100 °C
2: potassium carbonate / N,N-dimethyl acetamide / Heating
3: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 60 °C
2: triethylamine / isopropyl alcohol; water / 13 h / 60 °C
View Scheme
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
865758-96-9

2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl acetamide / Heating
2: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / methanol / 3 h / 100 °C / Molecular sieve
2: hydrazine hydrate / methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / 6 h / 70 - 80 °C
2: hydrogenchloride / dichloromethane; ethanol / -5 - 20 °C
View Scheme
2-({6-[(3R)-3-(5-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)piperidin-1-yl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

2-({6-[(3R)-3-(5-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)piperidin-1-yl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 0.58 h / 25 - 30 °C
1.2: 25 - 55 °C
2.1: ethanolamine / 60 - 65 °C
View Scheme
2-({3-methyl-6-[(3R)-3-(5-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)piperidin-1-yl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

2-({3-methyl-6-[(3R)-3-(5-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)piperidin-1-yl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With ethanolamine at 60 - 65℃;
(R)-piperidin-3-ylamine
127294-73-9

(R)-piperidin-3-ylamine

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid / toluene / 3 h / Reflux
2: sodium hydrogencarbonate / methanol / 3 h / 100 °C / Molecular sieve
3: hydrazine hydrate / methanol / 2 h / Reflux
View Scheme
((R)-3-piperidinyl)-2,5-pyrrolidinedione

((R)-3-piperidinyl)-2,5-pyrrolidinedione

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / methanol / 3 h / 100 °C / Molecular sieve
2: hydrazine hydrate / methanol / 2 h / Reflux
View Scheme
C22H23N5O4

C22H23N5O4

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 2h; Reflux;197.7 g
1,4,5,6-tetrahydropyridine-3-carboxamide
7032-11-3

1,4,5,6-tetrahydropyridine-3-carboxamide

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen / methanol / 18 h / 65 °C / 8625.86 Torr / Autoclave
2: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C
3: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: ditrifluoroacetato[(S)-(+)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane]ruthenium(II) complex; hydrogen; lithium bromide monohydrate / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave
2: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C
3: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: ethanol / 20 °C
2: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave
3: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C
4: bis-[(trifluoroacetoxy)iodo]benzene; pyridine / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
nicotinamide
98-92-0

nicotinamide

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol / 20 h / 40 °C / 750.08 Torr / Autoclave
1.2: 3.5 h / 10 - 35 °C
2.1: ditrifluoroacetato[(RP,R′P)-1,1′-bis[(S)-α-(dimethylamino)benzyl]-2,2′-bis(diphenylphosphino)ferrocene]ruthenium(II); toluene-4-sulfonic acid; hydrogen; potassium bromide / isopropyl alcohol / 25 h / 5 - 50 °C / 6750.68 Torr / Autoclave
3.1: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C
4.1: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 5%-palladium/activated carbon; hydrogen / methanol / 14 h / 45 °C / 750.08 Torr / Autoclave
2: dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen / methanol / 18 h / 65 °C / 8625.86 Torr / Autoclave
3: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C
4: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 5%-palladium/activated carbon; hydrogen / methanol / 14 h / 45 °C / 750.08 Torr / Autoclave
2: ditrifluoroacetato[(S)-(+)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane]ruthenium(II) complex; hydrogen; lithium bromide monohydrate / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave
3: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C
4: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogen; palladium on carbon type-K / methanol / 21 h / 40 °C / 750.08 Torr / Autoclave
2: ethanol / 20 °C
3: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave
4: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C
5: bis-[(trifluoroacetoxy)iodo]benzene; pyridine / isopropyl alcohol; water / 3 h / 20 °C
View Scheme
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 75 °C
1.2: 75 °C
2.1: trifluoroacetic acid / dichloromethane / 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: diethyl ether / 10 h / -15 - -10 °C
1.2: 8 h / 35 °C
2.1: tetrahydrofuran / 5.5 h / 45 °C
View Scheme
Multi-step reaction with 3 steps
1.1: diethyl ether / 10 h / -15 - -10 °C
1.2: 8 h / 35 °C
2.1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C
2.2: 2 h / 50 °C
3.1: hydrogenchloride / dichloromethane; methanol; water / 4 h / 0 - 5 °C
View Scheme
3-methyl-6-chlorouracil
4318-56-3

3-methyl-6-chlorouracil

2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 23 °C / Schlenk technique; Inert atmosphere
1.2: 2 h / 65 °C / Schlenk technique; Inert atmosphere
2.1: palladium diacetate; (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate / N,N-dimethyl-formamide / 0.08 h / Schlenk technique; Inert atmosphere
2.2: 2 h / 23 °C / Schlenk technique; Inert atmosphere
2.3: 1 h / 23 °C / Schlenk technique; Inert atmosphere
View Scheme
ethyl (R)-3-(3-Boc-aminopiperidin-1-yl)-3-oxopropanoate

ethyl (R)-3-(3-Boc-aminopiperidin-1-yl)-3-oxopropanoate

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium ethanolate / ethanol / 6 h / Inert atmosphere; Reflux
2: trifluoroacetic acid / methanol / 7 h / 65 °C
View Scheme
C22H31N5O3

C22H31N5O3

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C
1.2: 2 h / 50 °C
2.1: hydrogenchloride / dichloromethane; methanol; water / 4 h / 0 - 5 °C
View Scheme
2-(aminomethyl)benzonitrile
344957-25-1

2-(aminomethyl)benzonitrile

alogliptin
850649-61-5

alogliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diethyl ether / 10 h / -15 - -10 °C
1.2: 8 h / 35 °C
2.1: tetrahydrofuran / 5.5 h / 45 °C
View Scheme
Multi-step reaction with 3 steps
1.1: diethyl ether / 10 h / -15 - -10 °C
1.2: 8 h / 35 °C
2.1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C
2.2: 2 h / 50 °C
3.1: hydrogenchloride / dichloromethane; methanol; water / 4 h / 0 - 5 °C
View Scheme
nicotinamide
98-92-0

nicotinamide

A

alogliptin
850649-61-5

alogliptin

B

C37H40N10O5

C37H40N10O5

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; palladium on carbon type-K / methanol / 21 h / 40 °C / 750.08 Torr / Autoclave
2: ethanol / 20 °C
3: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave
4: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C
5: bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide / water; acetonitrile / 4 h / 0 - 20 °C
View Scheme
(R)-1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide

(R)-1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide

A

alogliptin
850649-61-5

alogliptin

B

C37H40N10O5

C37H40N10O5

Conditions
ConditionsYield
With potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile at 20℃; for 1h; Reagent/catalyst;
With bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide In water; acetonitrile at 0 - 20℃; for 4h;
1,4,5,6-tetrahydropyridine-3-carboxamide
7032-11-3

1,4,5,6-tetrahydropyridine-3-carboxamide

A

alogliptin
850649-61-5

alogliptin

B

C37H40N10O5

C37H40N10O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethanol / 20 °C
2: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave
3: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C
4: bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide / water; acetonitrile / 4 h / 0 - 20 °C
View Scheme
alogliptin
850649-61-5

alogliptin

benzoic acid
65-85-0

benzoic acid

Alogliptin benzoate

Alogliptin benzoate

Conditions
ConditionsYield
In ethanol at 50 - 80℃;95.7%
In tetrahydrofuran for 1.5h; Reflux; Large scale;94.68%
In ethanol at 60 - 70℃; for 0.166667h;94.3%
alogliptin
850649-61-5

alogliptin

C18H19N7O2

C18H19N7O2

Conditions
ConditionsYield
With fluorosulfonyl azide; potassium hydrogencarbonate In tert-butyl methyl ether; water; N,N-dimethyl-formamide at 20℃; for 0.0833333h;90%
alogliptin
850649-61-5

alogliptin

2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]Methyl]-N-hydroxyamidinobenzene

2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]Methyl]-N-hydroxyamidinobenzene

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water at 85 - 90℃; for 20h;80.9%
alogliptin
850649-61-5

alogliptin

2(13)CN(1-)*Zn(2+)

2(13)CN(1-)*Zn(2+)

C17(13)CH21N5O2

C17(13)CH21N5O2

Conditions
ConditionsYield
With C10H12O2NiC8H12-1,5-cyclo; triphenylborane; diphenyl(methyl)phosphine In 1-methyl-pyrrolidin-2-one at 100℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;58%
alogliptin
850649-61-5

alogliptin

C18H23N5O3

C18H23N5O3

Conditions
ConditionsYield
With sodium hydroxide In water; isopropyl alcohol for 9h; Reagent/catalyst; Solvent; Reflux;45.7%
alogliptin
850649-61-5

alogliptin

C23H28N2O4

C23H28N2O4

C41H47N7O5

C41H47N7O5

Conditions
ConditionsYield
Stage #1: C23H28N2O4 With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0℃; for 0.666667h;
Stage #2: alogliptin In dichloromethane at 20℃; for 6h;
30%
alogliptin
850649-61-5

alogliptin

2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

Conditions
ConditionsYield
With thionyl chloride In chloroform at 100℃; for 0.5h;
With thionyl chloride In chloroform at 100℃; for 0.5h; Inert atmosphere;
alogliptin
850649-61-5

alogliptin

2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane at 20℃; for 1h;
alogliptin
850649-61-5

alogliptin

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

2-{6-[3(R)-amino-piperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile p-toluenesulfonate
1428858-00-7

2-{6-[3(R)-amino-piperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile p-toluenesulfonate

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; for 3h; Product distribution / selectivity; Inert atmosphere;
alogliptin
850649-61-5

alogliptin

Alogliptin hydrochloride
1246610-75-2

Alogliptin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane at 20℃; for 1.16667h; Inert atmosphere;
alogliptin
850649-61-5

alogliptin

alogliptin sulfate

alogliptin sulfate

Conditions
ConditionsYield
With sulfuric acid In ethanol for 3h; Solvent; Reflux;1.3 g
alogliptin
850649-61-5

alogliptin

alogliptin nitrate

alogliptin nitrate

Conditions
ConditionsYield
With nitric acid In ethanol for 3h; Solvent; Reflux;1.4 g
alogliptin
850649-61-5

alogliptin

benzoic acid
65-85-0

benzoic acid

alogliptin benzoate

alogliptin benzoate

Conditions
ConditionsYield
In ethanol at 75 - 80℃; for 2h;12 g
alogliptin
850649-61-5

alogliptin

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

alogliptin fumarate

alogliptin fumarate

Conditions
ConditionsYield
In ethanol for 3h; Solvent; Reflux;1.7 g
alogliptin
850649-61-5

alogliptin

malic acid
617-48-1

malic acid

alogliptin malate

alogliptin malate

Conditions
ConditionsYield
In ethanol for 3h; Solvent; Reflux;1.8 g
alogliptin
850649-61-5

alogliptin

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

alogliptin tosylate

alogliptin tosylate

Conditions
ConditionsYield
In ethanol for 3h; Solvent; Reflux;1.6 g
alogliptin
850649-61-5

alogliptin

oxalic acid
144-62-7

oxalic acid

alogliptin oxalate

alogliptin oxalate

Conditions
ConditionsYield
In ethanol for 3h; Solvent; Reflux;1.8 g
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