DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:850649-61-5
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:850649-61-5
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:850649-61-5
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
1 Factory price 2 High quality 3 Good servicechengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw mater
Cas:850649-61-5
Min.Order:1 Gram
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Type:Trading Company
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:850649-61-5
Min.Order:1 Kilogram
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inquiryALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Basic information Product Name: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Synonyms: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA);Alogliptin;Unii-jhc049lo86;2-[[6-
Cas:850649-61-5
Min.Order:1 Kilogram
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:850649-61-5
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:850649-61-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Off-White crystalline powder Storage:Store in sealed contain
Cas:850649-61-5
Min.Order:100 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Min.Order:1 Kilogram
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:850649-61-5
Min.Order:10 Gram
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Type:Trading Company
inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:850649-61-5
Min.Order:100 Kilogram
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Type:Trading Company
inquiryALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Basic information Product Name: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) CAS: 850649-61-5 MF: C18H21N5O2 MW: 339.39 EINECS: 821-899-3 ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Structure ALOGLIPTIN(ALOGLIPT
Cas:850649-61-5
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) CAS: 850649-61-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu
Cas:850649-61-5
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers
Cas:850649-61-5
Min.Order:10 Gram
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Type:Lab/Research institutions
inquirySpecification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:850649-61-5 Transp
Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em
Cas:850649-61-5
Min.Order:1 Gram
FOB Price: $280.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white crystal powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Sha
Cas:850649-61-5
Min.Order:0 Metric Ton
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inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:850649-61-5
Min.Order:10 Kilogram
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Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:850649-61-5
Min.Order:100 Milligram
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Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:850649-61-5
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:850649-61-5
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiry2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
alogliptin
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In isopropyl alcohol; acetonitrile at 60℃; for 6h; | 92.7% |
With triethylamine In isopropyl alcohol at 65℃; for 17h; | 85% |
With tetra-n-butylphosphonium chloride; sodium hydrogencarbonate In water; toluene at 60 - 70℃; Solvent; Temperature; | 85.7% |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
alogliptin
Conditions | Yield |
---|---|
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere; Stage #2: (R)-piperidin-3-ylcarbamic acid tert-butyl ester With triethylamine In N,N-dimethyl-formamide at 23℃; for 2h; Schlenk technique; Inert atmosphere; Stage #3: With trifluoroacetic acid In dichloromethane; N,N-dimethyl-formamide at 23℃; for 1h; Schlenk technique; Inert atmosphere; | 92% |
2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
alogliptin
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; dichloromethane; water at 0 - 5℃; for 4h; | 91% |
With trifluoroacetic acid In methanol at 65℃; for 7h; Reagent/catalyst; Solvent; | 83% |
With citric acid for 2h; Reagent/catalyst; Reflux; | 77.82% |
alogliptin
Conditions | Yield |
---|---|
With pyridine; [bis(acetoxy)iodo]benzene In water; isopropyl alcohol at 20℃; for 3h; | 87% |
With pyridine; bis-[(trifluoroacetoxy)iodo]benzene In water; isopropyl alcohol at 20℃; for 3h; Solvent; Hofmann Rearrangement; | 87.2% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 45℃; for 5.5h; | 86.5% |
alogliptin
Conditions | Yield |
---|---|
With benzaldehyde In isopropyl alcohol at 60℃; under 675.068 Torr; for 24h; | 82% |
Conditions | Yield |
---|---|
Stage #1: 3-methyl-6-chlorouracil; 2-(bromomethyl)benzonitrile With dmap In acetonitrile at 80℃; for 6h; Green chemistry; Stage #2: 3-(R)-aminopiperidine dihydrochloride In acetonitrile for 8h; Reflux; Green chemistry; | 73% |
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
alogliptin
Conditions | Yield |
---|---|
Stage #1: 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; 3-(R)-piperidinyl phthalimide hydrochloride With sodium hydrogencarbonate In methanol at 100℃; for 0.75h; Stage #2: With methanol; hydrazine hydrate for 4h; Reagent/catalyst; Temperature; Reflux; Further stages; | 70% |
2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C 1.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C 2.1: 2.7 g / NaHCO3; molecular sieves 4 Angstroem / ethanol / 4 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 50 - 60 °C 2: sodium hydrogencarbonate / methanol / 6 h / 65 - 70 °C / Molecular sieve View Scheme | |
Multi-step reaction with 2 steps 1.1: lithium bromide; sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere 1.2: 80 °C / Inert atmosphere 2.1: sodium hydrogencarbonate / isopropyl alcohol / 2 h / 100 °C / Molecular sieve View Scheme |
2-(bromomethyl)benzonitrile
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide; dimethylsulfoxide / 0.5 h / 0 °C 1.2: LiBr / dimethylformamide; 1,2-dimethoxy-ethane / 0.25 h / 0 - 20 °C 1.3: 54 percent / dimethylformamide; dimethylsulfoxide / 0 - 20 °C 2.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C 2.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C 3.1: 2.7 g / NaHCO3; molecular sieves 4 Angstroem / ethanol / 4 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one; toluene / 70 - 80 °C 2: potassium carbonate / acetone / 50 - 60 °C 3: sodium hydrogencarbonate / methanol / 6 h / 65 - 70 °C / Molecular sieve View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C 2.1: lithium bromide; sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere 2.2: 80 °C / Inert atmosphere 3.1: sodium hydrogencarbonate / isopropyl alcohol / 2 h / 100 °C / Molecular sieve View Scheme |
3-methyl-6-chlorouracil
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl acetamide / 50 - 100 °C 2: potassium carbonate / N,N-dimethyl acetamide / Heating 3: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 50 - 100 °C 2: potassium carbonate / N,N-dimethyl acetamide / Heating 3: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: tributyl-amine / toluene / 5 h / 80 °C 2: triethylamine / isopropyl alcohol / 17 h / 65 °C View Scheme |
2-cyanobenzyl chloride
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 50 - 100 °C 2: potassium carbonate / N,N-dimethyl acetamide / Heating 3: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 60 °C 2: triethylamine / isopropyl alcohol; water / 13 h / 60 °C View Scheme |
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl acetamide / Heating 2: hydrogenchloride; ethanol / dichloromethane / -5 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / methanol / 3 h / 100 °C / Molecular sieve 2: hydrazine hydrate / methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / 6 h / 70 - 80 °C 2: hydrogenchloride / dichloromethane; ethanol / -5 - 20 °C View Scheme |
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 0.58 h / 25 - 30 °C 1.2: 25 - 55 °C 2.1: ethanolamine / 60 - 65 °C View Scheme |
alogliptin
Conditions | Yield |
---|---|
With ethanolamine at 60 - 65℃; |
(R)-piperidin-3-ylamine
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid / toluene / 3 h / Reflux 2: sodium hydrogencarbonate / methanol / 3 h / 100 °C / Molecular sieve 3: hydrazine hydrate / methanol / 2 h / Reflux View Scheme |
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / methanol / 3 h / 100 °C / Molecular sieve 2: hydrazine hydrate / methanol / 2 h / Reflux View Scheme |
alogliptin
Conditions | Yield |
---|---|
With hydrazine hydrate In methanol for 2h; Reflux; | 197.7 g |
1,4,5,6-tetrahydropyridine-3-carboxamide
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen / methanol / 18 h / 65 °C / 8625.86 Torr / Autoclave 2: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C 3: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: ditrifluoroacetato[(S)-(+)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane]ruthenium(II) complex; hydrogen; lithium bromide monohydrate / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave 2: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C 3: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: ethanol / 20 °C 2: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave 3: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C 4: bis-[(trifluoroacetoxy)iodo]benzene; pyridine / isopropyl alcohol; water / 3 h / 20 °C View Scheme |
nicotinamide
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 5%-palladium/activated carbon; hydrogen / methanol / 20 h / 40 °C / 750.08 Torr / Autoclave 1.2: 3.5 h / 10 - 35 °C 2.1: ditrifluoroacetato[(RP,R′P)-1,1′-bis[(S)-α-(dimethylamino)benzyl]-2,2′-bis(diphenylphosphino)ferrocene]ruthenium(II); toluene-4-sulfonic acid; hydrogen; potassium bromide / isopropyl alcohol / 25 h / 5 - 50 °C / 6750.68 Torr / Autoclave 3.1: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C 4.1: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 14 h / 45 °C / 750.08 Torr / Autoclave 2: dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen / methanol / 18 h / 65 °C / 8625.86 Torr / Autoclave 3: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C 4: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 14 h / 45 °C / 750.08 Torr / Autoclave 2: ditrifluoroacetato[(S)-(+)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane]ruthenium(II) complex; hydrogen; lithium bromide monohydrate / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave 3: potassium carbonate / isopropyl alcohol; water / 23 h / 65 °C 4: pyridine; [bis(acetoxy)iodo]benzene / isopropyl alcohol; water / 3 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: hydrogen; palladium on carbon type-K / methanol / 21 h / 40 °C / 750.08 Torr / Autoclave 2: ethanol / 20 °C 3: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave 4: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C 5: bis-[(trifluoroacetoxy)iodo]benzene; pyridine / isopropyl alcohol; water / 3 h / 20 °C View Scheme |
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 75 °C 1.2: 75 °C 2.1: trifluoroacetic acid / dichloromethane / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: diethyl ether / 10 h / -15 - -10 °C 1.2: 8 h / 35 °C 2.1: tetrahydrofuran / 5.5 h / 45 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: diethyl ether / 10 h / -15 - -10 °C 1.2: 8 h / 35 °C 2.1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C 2.2: 2 h / 50 °C 3.1: hydrogenchloride / dichloromethane; methanol; water / 4 h / 0 - 5 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 23 °C / Schlenk technique; Inert atmosphere 1.2: 2 h / 65 °C / Schlenk technique; Inert atmosphere 2.1: palladium diacetate; (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate / N,N-dimethyl-formamide / 0.08 h / Schlenk technique; Inert atmosphere 2.2: 2 h / 23 °C / Schlenk technique; Inert atmosphere 2.3: 1 h / 23 °C / Schlenk technique; Inert atmosphere View Scheme |
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium ethanolate / ethanol / 6 h / Inert atmosphere; Reflux 2: trifluoroacetic acid / methanol / 7 h / 65 °C View Scheme |
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C 1.2: 2 h / 50 °C 2.1: hydrogenchloride / dichloromethane; methanol; water / 4 h / 0 - 5 °C View Scheme |
2-(aminomethyl)benzonitrile
alogliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: diethyl ether / 10 h / -15 - -10 °C 1.2: 8 h / 35 °C 2.1: tetrahydrofuran / 5.5 h / 45 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: diethyl ether / 10 h / -15 - -10 °C 1.2: 8 h / 35 °C 2.1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C 2.2: 2 h / 50 °C 3.1: hydrogenchloride / dichloromethane; methanol; water / 4 h / 0 - 5 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen; palladium on carbon type-K / methanol / 21 h / 40 °C / 750.08 Torr / Autoclave 2: ethanol / 20 °C 3: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave 4: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C 5: bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide / water; acetonitrile / 4 h / 0 - 20 °C View Scheme |
A
alogliptin
Conditions | Yield |
---|---|
With potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile at 20℃; for 1h; Reagent/catalyst; | |
With bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide In water; acetonitrile at 0 - 20℃; for 4h; |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ethanol / 20 °C 2: Ru-(CF3CO2)2{(S)-phanephos}; potassium bromide; hydrogen / methanol / 15 h / 50 °C / 7500.75 Torr / Autoclave 3: potassium carbonate / isopropyl alcohol; water / 18 h / 70 °C 4: bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide / water; acetonitrile / 4 h / 0 - 20 °C View Scheme |
Conditions | Yield |
---|---|
In ethanol at 50 - 80℃; | 95.7% |
In tetrahydrofuran for 1.5h; Reflux; Large scale; | 94.68% |
In ethanol at 60 - 70℃; for 0.166667h; | 94.3% |
alogliptin
Conditions | Yield |
---|---|
With fluorosulfonyl azide; potassium hydrogencarbonate In tert-butyl methyl ether; water; N,N-dimethyl-formamide at 20℃; for 0.0833333h; | 90% |
alogliptin
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water at 85 - 90℃; for 20h; | 80.9% |
Conditions | Yield |
---|---|
With C10H12O2NiC8H12-1,5-cyclo; triphenylborane; diphenyl(methyl)phosphine In 1-methyl-pyrrolidin-2-one at 100℃; for 18h; Inert atmosphere; Glovebox; Sealed tube; | 58% |
alogliptin
Conditions | Yield |
---|---|
With sodium hydroxide In water; isopropyl alcohol for 9h; Reagent/catalyst; Solvent; Reflux; | 45.7% |
Conditions | Yield |
---|---|
Stage #1: C23H28N2O4 With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0℃; for 0.666667h; Stage #2: alogliptin In dichloromethane at 20℃; for 6h; | 30% |
alogliptin
Conditions | Yield |
---|---|
With thionyl chloride In chloroform at 100℃; for 0.5h; | |
With thionyl chloride In chloroform at 100℃; for 0.5h; Inert atmosphere; |
alogliptin
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane at 20℃; for 1h; |
alogliptin
toluene-4-sulfonic acid
2-{6-[3(R)-amino-piperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile p-toluenesulfonate
Conditions | Yield |
---|---|
In 1,4-dioxane at 20℃; for 3h; Product distribution / selectivity; Inert atmosphere; |
alogliptin
Alogliptin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane at 20℃; for 1.16667h; Inert atmosphere; |
alogliptin
Conditions | Yield |
---|---|
With sulfuric acid In ethanol for 3h; Solvent; Reflux; | 1.3 g |
alogliptin
Conditions | Yield |
---|---|
With nitric acid In ethanol for 3h; Solvent; Reflux; | 1.4 g |
Conditions | Yield |
---|---|
In ethanol at 75 - 80℃; for 2h; | 12 g |
Conditions | Yield |
---|---|
In ethanol for 3h; Solvent; Reflux; | 1.7 g |
Conditions | Yield |
---|---|
In ethanol for 3h; Solvent; Reflux; | 1.8 g |
Conditions | Yield |
---|---|
In ethanol for 3h; Solvent; Reflux; | 1.6 g |
Conditions | Yield |
---|---|
In ethanol for 3h; Solvent; Reflux; | 1.8 g |
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