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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,3-Dichloro-5-(trifluoromethyl)pyridine Manufacturer/High quality/Best price/In stock

Cas:69045-84-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,3-Dichloro-5-Trifluoromethylpyridine supplier in China

Cas:69045-84-7

Min.Order:1 Metric Ton

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Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,3-dichloro-5-trifluoromethylpyridine

Cas:69045-84-7

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,3-Dichloro-5-Trifluoromethylpyridine

Cas:69045-84-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,3-Dichloro-5-(trifluoromethyl)-pyridine

Cas:69045-84-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 69045-84-7 with fast shipping

Cas:69045-84-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High quality 99% 2,3-Dichloro-5-(trifluoromethyl)pyridine CAS NO 69045-84-7

Cas:69045-84-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product name 2,3-Dichloro-5-(trifluoromethyl)pyridine CAS NO. 69045-84-7 Other names 2,3-Dichloro-5-(trifluoromethyl)pyridine

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environmental protection safety smooth&

2,3-dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,3-Dichloro-5-trifluoromethyl pyridine 69045-84-7

Cas:69045-84-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

2,3-Dichloro-5-trifluoromethyl pyridine/ LIDE PHARMA- Factory supply / Best price

Cas:69045-84-7

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2,3-Dichloro-5-(trifluoromethyl)pyridine CAS:69045-84-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

2,3-Dichloro-5-(trifluoromethyl)pyridine CAS:69045-84-7

Cas:69045-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:69045-84-7

Cas:69045-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe,

2,3-Dichloro-5-(trifluoromethyl)pyridine Cas 69045-84-7 2,3-dichloro-5-trifluoropyridine

Cas:69045-84-7

Min.Order:1 Kilogram

FOB Price: $70.0 / 100.0

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,3-Dichloro-5-(Trifluoromethyl)Pyridine

Cas:69045-84-7

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:0 Metric Ton

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Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:0

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Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

2,3-dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Gram

Negotiable

Type:Other

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Gram

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Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:100 Gram

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Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,3-Dichloro-5-(trifluoromethyl)pyridine Manufacturer/High quality/Best price/In stock CAS NO.69045-84-7

Cas:69045-84-7

Min.Order:10 Gram

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Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

High quality 99% 2,3-Dichloro-5-(trifluoromethyl)pyridine CAS NO 69045-84-7

Cas:69045-84-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pesticides Intermediate 2,3-Dichloro-5-Trifluoromethylpyridine CAS 52334-81-3

Cas:69045-84-7

Min.Order:1 Liter

FOB Price: $4.5 / 5.0

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 2,3-Dichloro-5-Trifluoromethyl Pyridine CAS No.:69045-84-7 Molecule Formula:C12H10ClF3N2O Molecule Weight:290.67 Purity: 99.0% Package: 25kg/drum Description:Light yellow liquid Manufacture Standards:Enterprise Standard

Best Quality 2,3-Dichloro-5-Trifluoromethyl Pyridine

Cas:69045-84-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,3-Dichloro-5-(trifluoromethyl)pyridine

Cas:69045-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With hydrogen fluoride; tungsten(VI) chloride at 170 - 180℃; under 1500.15 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave;92%
With antimony(III) fluoride for 0.166667h; Heating; Irradiation;80.4%
With pyridine; iron(III) chloride; hydrogen fluoride at 130 - 175℃; Autoclave;73%
2,2-dichloro-3,3,3-trifluoro-propionaldehyde
82107-24-2

2,2-dichloro-3,3,3-trifluoro-propionaldehyde

acrylonitrile
107-13-1

acrylonitrile

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
copper(l) chloride In acetonitrile at 190℃; for 0.5h;60%
antimony(III) fluoride
7783-56-4

antimony(III) fluoride

2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With antimonypentachloride
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With iron(III) chloride In water
With antimonypentachloride; iron(III) chloride In water
With chlorine; iron(III) chloride
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere;
Stage #2: With chlorine at 0 - 150℃; under 15001.5 Torr; for 20h; Temperature; Reagent/catalyst; Inert atmosphere;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

tungsten(VI) chloride
13283-01-7

tungsten(VI) chloride

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With FeCl3
nickel
7440-02-0

nickel

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With FeCl3 In (2S)-N-methyl-1-phenylpropan-2-amine hydrate
4-formyl-2,4-dichloro-5,5,5-trifluorovaleronitrile

4-formyl-2,4-dichloro-5,5,5-trifluorovaleronitrile

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-trichloromethyl-pyridine
3099-50-1

3-trichloromethyl-pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: phosphorus pentachloride / 16 h / 210 °C / Autoclave
3: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
5-chloro-3-trichloromethyl pyridine

5-chloro-3-trichloromethyl pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
nicotinic acid
59-67-6

nicotinic acid

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 14 h / 210 °C / 1500.15 - 27752.8 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 64 h / 185 °C / 18751.9 - 30003 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 72 h / 185 °C / 18751.9 - 30003 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
3-Methylpyridine
108-99-6

3-Methylpyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrachloromethane; chlorine / 0 h / 350 - 400 °C
2: chlorine / 6 h / 150 - 160 °C
3: hydrogen fluoride / 11 h / 170 °C
View Scheme
2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorine / 6 h / 150 - 160 °C
2: hydrogen fluoride / 11 h / 170 °C
View Scheme
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

A

2,6-dichloro-3-(trifluoromethyl)pyridine
55304-75-1

2,6-dichloro-3-(trifluoromethyl)pyridine

B

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere;
Stage #2: With chlorine at 0 - 150℃; under 15001.5 Torr; for 20h; Reagent/catalyst; Inert atmosphere;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

A

2,3,6-trichloro-5-trifluoromethylpyridine
80289-91-4

2,3,6-trichloro-5-trifluoromethylpyridine

B

2,6-dichloro-3-(trifluoromethyl)pyridine
55304-75-1

2,6-dichloro-3-(trifluoromethyl)pyridine

C

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere;
Stage #2: With chlorine at 0 - 200℃; under 15001.5 Torr; for 20h; Inert atmosphere;
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate; cesium fluoride In dimethyl sulfoxide at 120℃; under 18.7519 - 22.5023 Torr; for 4h; Product distribution / selectivity;100%
With potassium carbonate; cesium fluoride In 1-methyl-pyrrolidin-2-one at 70℃; for 1 - 3h; Product distribution / selectivity;98%
With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride In N,N-dimethyl acetamide at 170℃; for 5h; Temperature;97%
2,6-dimethyl-4-nitro phenol
2423-71-4

2,6-dimethyl-4-nitro phenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-(2,6-dimethyl-4-nitrophenoxy)-5-trifluoromethylpyridine
875774-91-7

3-chloro-2-(2,6-dimethyl-4-nitrophenoxy)-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium carbonate In ISOPROPYLAMIDE; water; ethyl acetate100%
With potassium carbonate In ISOPROPYLAMIDE at 155 - 165℃; for 1h;100%
salicylaldehyde
90-02-8

salicylaldehyde

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)benzaldehyde
1379461-07-0

2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)benzaldehyde

Conditions
ConditionsYield
Stage #1: salicylaldehyde With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide; mineral oil at 0 - 50℃; for 2h;
100%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl methyl(piperidin-4-yl)carbamate
108612-54-0

tert-butyl methyl(piperidin-4-yl)carbamate

N-methyl tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}piperidin-4-yl]carbamate

N-methyl tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}piperidin-4-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
With potassium tert-butylate; palladium diacetate; DavePhos In toluene at 120℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere;63%
3-(tert-butoxycarbonylamino)pyrrolidine
99724-19-3

3-(tert-butoxycarbonylamino)pyrrolidine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}pyrrolidin-3-yl]carbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}pyrrolidin-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
5-tert-butoxycarbonylamino-1-aminopentane
51644-96-3

5-tert-butoxycarbonylamino-1-aminopentane

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [5-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminopentan-1-yl]carbamate

tert-butyl [5-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminopentan-1-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
(endo)-(8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester
287114-25-4

(endo)-(8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [8-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azabicyclo[3.2.1]octan-3-yl]carbamate

tert-butyl [8-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azabicyclo[3.2.1]octan-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

acetonitrile
75-05-8

acetonitrile

2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile
157764-10-8

2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions
ConditionsYield
With sodium methylate at 130℃; under 21002.1 Torr; for 16h; Pressure; Temperature; Reagent/catalyst; Inert atmosphere;99.2%
tert-butyl N-(azepane-4-yl)carbamate

tert-butyl N-(azepane-4-yl)carbamate

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azepan-4-yl]carbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azepan-4-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;99%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

t-butyl piperidin-3-ylcarbamate
184637-48-7

t-butyl piperidin-3-ylcarbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}-piperidin-3-yl]carbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}-piperidin-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃;99%
nitromethane
75-52-5

nitromethane

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-nitromethyl-5-(trifluoromethyl)pyridine

3-chloro-2-nitromethyl-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; potassium hydroxide at 15℃; Concentration; Temperature; Reagent/catalyst;98.7%
With potassium tert-butylate In dimethyl sulfoxide at 0 - 27℃; for 14.25h;95.7%
With potassium hydroxide In dimethyl sulfoxide at 20 - 50℃; for 3.25h;73.9%
With potassium hydroxide In dimethyl sulfoxide at 20℃;
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine
89570-82-1

3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 50℃; for 2h;98.3%
With hydrazine hydrate In ethanol Reflux;86%
With hydrazine hydrate In ethanol at 40℃; for 24h;85.8%
5-amino-2-chlorophenol
6358-06-1

5-amino-2-chlorophenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

4-chloro 3-(3chloro-5-trifluoromethylpyridin-2-yloxy)aniline

4-chloro 3-(3chloro-5-trifluoromethylpyridin-2-yloxy)aniline

Conditions
ConditionsYield
With potassium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In toluene at 60℃; for 1h; Reagent/catalyst; Temperature;98.2%
2,6-dichloro-4-benzyloxyphenol
155916-12-4

2,6-dichloro-4-benzyloxyphenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3,5-dichloro-4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-1-benzyloxybenzene

3,5-dichloro-4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-1-benzyloxybenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide98%
tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate
1448447-86-6

tert-butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;98%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

acrylonitrile
107-13-1

acrylonitrile

3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile
1053658-44-8

3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;98%
1-amino-4-[(tert-butyloxycarbonyl)amino]butane
68076-36-8

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [4-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminobutan-1-yl]carbamate

tert-butyl [4-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminobutan-1-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;98%
N-(p-tolyl)-1H-pyrrole-2-carboxamide
1208109-63-0

N-(p-tolyl)-1H-pyrrole-2-carboxamide

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

5-(p-tolyl)-3-(trifluoromethyl)pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one
1344146-20-8

5-(p-tolyl)-3-(trifluoromethyl)pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 7h; Reflux;97%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 50℃; for 1h;97%
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine With potassium carbonate In dimethyl sulfoxide at 20℃; for 0.25h;
Stage #2: ethyl 2-cyanoacetate In dimethyl sulfoxide at 80℃; for 2.5h;
90.6%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 70 - 80℃; for 2.5h;
Stage #1: ethyl 2-cyanoacetate With tetrabutyl-ammonium chloride; sodium methylate In methanol at 25℃; for 0.5h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In methanol at 70℃; for 1h; Reagent/catalyst; Solvent;
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine; ethyl 2-cyanoacetate With potassium carbonate In dimethyl sulfoxide at 70℃; for 12h;
Stage #2: With hydrogenchloride In water
2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenol

2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenoxy]-5-trifluoromethylpyridine

3-chloro-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenoxy]-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;97%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

(R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

(R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;97%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine
69045-89-2

2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
96.9%
96.9%
93.5%
3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole
628331-02-2

3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole
628331-03-3

1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole

Conditions
ConditionsYield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 50℃;96%
acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate
1448447-79-7

butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h; Catalytic behavior; Reagent/catalyst;96%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

methyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate
1448447-84-4

methyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;96%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

phenylboronic acid
98-80-6

phenylboronic acid

3-chloro-2-phenyl-5-(trifluoromethyl)pyridine
370878-67-4

3-chloro-2-phenyl-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In methanol; acetonitrile at 50℃; for 24h; Suzuki Coupling; Inert atmosphere; regioselective reaction;96%
ethanol
64-17-5

ethanol

carbon monoxide
201230-82-2

carbon monoxide

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate
120083-60-5

diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate

Conditions
ConditionsYield
With sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride at 120℃; under 11251.1 Torr; for 18h;95%
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate at 150℃; under 11400.8 Torr; for 2h; Autoclave;92%
With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

(R)-2-(4-hydroxyphenoxy)propionic acid
94050-90-5

(R)-2-(4-hydroxyphenoxy)propionic acid

(R)-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)phenoxy]propanoic acid
95977-29-0

(R)-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)phenoxy]propanoic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide95%
Stage #1: (R)-2-(4-hydroxyphenoxy)propionic acid With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 1h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine at 70 - 80℃; for 8h;
84.4%
Stage #1: (R)-2-(4-hydroxyphenoxy)propionic acid With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 1h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 70 - 80℃; for 8h;
84.4%

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