Product Name

  • Name

    2,3-Dichloro-5-(trifluoromethyl)pyridine

  • EINECS 410-340-5
  • CAS No. 69045-84-7
  • Article Data22
  • CAS DataBase
  • Density 1.542 g/cm3
  • Solubility
  • Melting Point 8-9 °C
  • Formula C6H2Cl2F3N
  • Boiling Point 188.5 °C at 760 mmHg
  • Molecular Weight 215.99
  • Flash Point 79.4 °C
  • Transport Information UN 3082 9/PG 3
  • Appearance Light yellow liquid
  • Safety 24-26-37/39-61
  • Risk Codes 20/22-41-43-51/53-36/37/38
  • Molecular Structure Molecular Structure of 69045-84-7 (2,3-Dichloro-5-(trifluoromethyl)pyridine)
  • Hazard Symbols HarmfulXn, DangerousN, IrritantXi
  • Synonyms 2,3-Dichloro-5-(trifluoromethyl)pyridine;5,6-Dichloro-3-(trifluoromethyl)pyridine;2,3-Dichloro-5-trifluoromethylpyridine;Pyridine,2,3-dichloro-5-(trifluoromethyl)-;
  • PSA 12.89000
  • LogP 3.40720

Synthetic route

2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With hydrogen fluoride; tungsten(VI) chloride at 170 - 180℃; under 1500.15 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave;92%
With antimony(III) fluoride for 0.166667h; Heating; Irradiation;80.4%
With pyridine; iron(III) chloride; hydrogen fluoride at 130 - 175℃; Autoclave;73%
2,2-dichloro-3,3,3-trifluoro-propionaldehyde
82107-24-2

2,2-dichloro-3,3,3-trifluoro-propionaldehyde

acrylonitrile
107-13-1

acrylonitrile

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
copper(l) chloride In acetonitrile at 190℃; for 0.5h;60%
antimony(III) fluoride
7783-56-4

antimony(III) fluoride

2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With antimonypentachloride
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With iron(III) chloride In water
With antimonypentachloride; iron(III) chloride In water
With chlorine; iron(III) chloride
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere;
Stage #2: With chlorine at 0 - 150℃; under 15001.5 Torr; for 20h; Temperature; Reagent/catalyst; Inert atmosphere;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

tungsten(VI) chloride
13283-01-7

tungsten(VI) chloride

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With FeCl3
nickel
7440-02-0

nickel

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With FeCl3 In (2S)-N-methyl-1-phenylpropan-2-amine hydrate
4-formyl-2,4-dichloro-5,5,5-trifluorovaleronitrile

4-formyl-2,4-dichloro-5,5,5-trifluorovaleronitrile

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-trichloromethyl-pyridine
3099-50-1

3-trichloromethyl-pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: phosphorus pentachloride / 16 h / 210 °C / Autoclave
3: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
5-chloro-3-trichloromethyl pyridine

5-chloro-3-trichloromethyl pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
nicotinic acid
59-67-6

nicotinic acid

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 14 h / 210 °C / 1500.15 - 27752.8 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 64 h / 185 °C / 18751.9 - 30003 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 72 h / 185 °C / 18751.9 - 30003 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
View Scheme
3-Methylpyridine
108-99-6

3-Methylpyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrachloromethane; chlorine / 0 h / 350 - 400 °C
2: chlorine / 6 h / 150 - 160 °C
3: hydrogen fluoride / 11 h / 170 °C
View Scheme
2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorine / 6 h / 150 - 160 °C
2: hydrogen fluoride / 11 h / 170 °C
View Scheme
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

A

2,6-dichloro-3-(trifluoromethyl)pyridine
55304-75-1

2,6-dichloro-3-(trifluoromethyl)pyridine

B

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere;
Stage #2: With chlorine at 0 - 150℃; under 15001.5 Torr; for 20h; Reagent/catalyst; Inert atmosphere;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

A

2,3,6-trichloro-5-trifluoromethylpyridine
80289-91-4

2,3,6-trichloro-5-trifluoromethylpyridine

B

2,6-dichloro-3-(trifluoromethyl)pyridine
55304-75-1

2,6-dichloro-3-(trifluoromethyl)pyridine

C

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere;
Stage #2: With chlorine at 0 - 200℃; under 15001.5 Torr; for 20h; Inert atmosphere;
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate; cesium fluoride In dimethyl sulfoxide at 120℃; under 18.7519 - 22.5023 Torr; for 4h; Product distribution / selectivity;100%
With potassium carbonate; cesium fluoride In 1-methyl-pyrrolidin-2-one at 70℃; for 1 - 3h; Product distribution / selectivity;98%
With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride In N,N-dimethyl acetamide at 170℃; for 5h; Temperature;97%
2,6-dimethyl-4-nitro phenol
2423-71-4

2,6-dimethyl-4-nitro phenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-(2,6-dimethyl-4-nitrophenoxy)-5-trifluoromethylpyridine
875774-91-7

3-chloro-2-(2,6-dimethyl-4-nitrophenoxy)-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium carbonate In ISOPROPYLAMIDE; water; ethyl acetate100%
With potassium carbonate In ISOPROPYLAMIDE at 155 - 165℃; for 1h;100%
salicylaldehyde
90-02-8

salicylaldehyde

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)benzaldehyde
1379461-07-0

2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)benzaldehyde

Conditions
ConditionsYield
Stage #1: salicylaldehyde With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide; mineral oil at 0 - 50℃; for 2h;
100%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl methyl(piperidin-4-yl)carbamate
108612-54-0

tert-butyl methyl(piperidin-4-yl)carbamate

N-methyl tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}piperidin-4-yl]carbamate

N-methyl tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}piperidin-4-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
With potassium tert-butylate; palladium diacetate; DavePhos In toluene at 120℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere;63%
3-(tert-butoxycarbonylamino)pyrrolidine
99724-19-3

3-(tert-butoxycarbonylamino)pyrrolidine

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}pyrrolidin-3-yl]carbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}pyrrolidin-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
5-tert-butoxycarbonylamino-1-aminopentane
51644-96-3

5-tert-butoxycarbonylamino-1-aminopentane

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [5-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminopentan-1-yl]carbamate

tert-butyl [5-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminopentan-1-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
(endo)-(8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester
287114-25-4

(endo)-(8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [8-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azabicyclo[3.2.1]octan-3-yl]carbamate

tert-butyl [8-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azabicyclo[3.2.1]octan-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;100%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

acetonitrile
75-05-8

acetonitrile

2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile
157764-10-8

2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions
ConditionsYield
With sodium methylate at 130℃; under 21002.1 Torr; for 16h; Pressure; Temperature; Reagent/catalyst; Inert atmosphere;99.2%
tert-butyl N-(azepane-4-yl)carbamate

tert-butyl N-(azepane-4-yl)carbamate

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azepan-4-yl]carbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azepan-4-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;99%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

t-butyl piperidin-3-ylcarbamate
184637-48-7

t-butyl piperidin-3-ylcarbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}-piperidin-3-yl]carbamate

tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}-piperidin-3-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃;99%
nitromethane
75-52-5

nitromethane

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-nitromethyl-5-(trifluoromethyl)pyridine

3-chloro-2-nitromethyl-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; potassium hydroxide at 15℃; Concentration; Temperature; Reagent/catalyst;98.7%
With potassium tert-butylate In dimethyl sulfoxide at 0 - 27℃; for 14.25h;95.7%
With potassium hydroxide In dimethyl sulfoxide at 20 - 50℃; for 3.25h;73.9%
With potassium hydroxide In dimethyl sulfoxide at 20℃;
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine
89570-82-1

3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 50℃; for 2h;98.3%
With hydrazine hydrate In ethanol Reflux;86%
With hydrazine hydrate In ethanol at 40℃; for 24h;85.8%
5-amino-2-chlorophenol
6358-06-1

5-amino-2-chlorophenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

4-chloro 3-(3chloro-5-trifluoromethylpyridin-2-yloxy)aniline

4-chloro 3-(3chloro-5-trifluoromethylpyridin-2-yloxy)aniline

Conditions
ConditionsYield
With potassium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In toluene at 60℃; for 1h; Reagent/catalyst; Temperature;98.2%
2,6-dichloro-4-benzyloxyphenol
155916-12-4

2,6-dichloro-4-benzyloxyphenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3,5-dichloro-4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-1-benzyloxybenzene

3,5-dichloro-4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-1-benzyloxybenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide98%
tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate
1448447-86-6

tert-butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;98%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

acrylonitrile
107-13-1

acrylonitrile

3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile
1053658-44-8

3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;98%
1-amino-4-[(tert-butyloxycarbonyl)amino]butane
68076-36-8

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

tert-butyl [4-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminobutan-1-yl]carbamate

tert-butyl [4-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminobutan-1-yl]carbamate

Conditions
ConditionsYield
With potassium carbonate at 100 - 120℃;98%
N-(p-tolyl)-1H-pyrrole-2-carboxamide
1208109-63-0

N-(p-tolyl)-1H-pyrrole-2-carboxamide

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

5-(p-tolyl)-3-(trifluoromethyl)pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one
1344146-20-8

5-(p-tolyl)-3-(trifluoromethyl)pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 7h; Reflux;97%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 50℃; for 1h;97%
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine With potassium carbonate In dimethyl sulfoxide at 20℃; for 0.25h;
Stage #2: ethyl 2-cyanoacetate In dimethyl sulfoxide at 80℃; for 2.5h;
90.6%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 70 - 80℃; for 2.5h;
Stage #1: ethyl 2-cyanoacetate With tetrabutyl-ammonium chloride; sodium methylate In methanol at 25℃; for 0.5h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In methanol at 70℃; for 1h; Reagent/catalyst; Solvent;
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine; ethyl 2-cyanoacetate With potassium carbonate In dimethyl sulfoxide at 70℃; for 12h;
Stage #2: With hydrogenchloride In water
2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenol

2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenol

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenoxy]-5-trifluoromethylpyridine

3-chloro-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenoxy]-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;97%
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
309956-78-3

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

(R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

(R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;97%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine
69045-89-2

2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
96.9%
96.9%
93.5%
3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole
628331-02-2

3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole
628331-03-3

1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole

Conditions
ConditionsYield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 50℃;96%
acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate
1448447-79-7

butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h; Catalytic behavior; Reagent/catalyst;96%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

methyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate
1448447-84-4

methyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;96%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

phenylboronic acid
98-80-6

phenylboronic acid

3-chloro-2-phenyl-5-(trifluoromethyl)pyridine
370878-67-4

3-chloro-2-phenyl-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In methanol; acetonitrile at 50℃; for 24h; Suzuki Coupling; Inert atmosphere; regioselective reaction;96%
ethanol
64-17-5

ethanol

carbon monoxide
201230-82-2

carbon monoxide

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate
120083-60-5

diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate

Conditions
ConditionsYield
With sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride at 120℃; under 11251.1 Torr; for 18h;95%
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate at 150℃; under 11400.8 Torr; for 2h; Autoclave;92%
With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

(R)-2-(4-hydroxyphenoxy)propionic acid
94050-90-5

(R)-2-(4-hydroxyphenoxy)propionic acid

(R)-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)phenoxy]propanoic acid
95977-29-0

(R)-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)phenoxy]propanoic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide95%
Stage #1: (R)-2-(4-hydroxyphenoxy)propionic acid With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 1h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine at 70 - 80℃; for 8h;
84.4%
Stage #1: (R)-2-(4-hydroxyphenoxy)propionic acid With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 1h;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 70 - 80℃; for 8h;
84.4%

2,3-Dichloro-5-(trifluoromethyl)pyridine Chemical Properties


IUPAC Name: 2,3-Dichloro-5-(trifluoromethyl)pyridine
Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)C(F)(F)F
InChI: InChI=1S/C6H2Cl2F3N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
InChIKey: ABNQGNFVSFKJGI-UHFFFAOYSA-N
Empirical Formula: C6H2Cl2F3N
Molecular Weight: 215.988 
EINECS: 410-340-5
Product Categories: Halides; Pyridines; Pyridine; Pyridine series; Chloropyridines; Halopyridines; C6Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks 
Appearance: Light yellow liquid
Index of Refraction: 1.47
Molar Refractivity: 39.11 cm3
Molar Volume: 140 cm3
Surface Tension: 30.9 dyne/cm
Density: 1.542 g/cm3
Flash Point: 79.4 °C
Enthalpy of Vaporization: 40.73 kJ/mol
Boiling Point: 188.5 °C at 760 mmHg
Vapour Pressure: 0.825 mmHg at 25°C
Melting Point of 2,3-Dichloro-5-trifluoromethyl pyridine (CAS NO.69045-84-7): 8-9 °C

2,3-Dichloro-5-(trifluoromethyl)pyridine Safety Profile

Hazard Codes: Xn,IrritantXi,  N
Risk Statements:
41:  Risk of serious damage to eyes 
43:  May cause sensitization by skin contact 
20/22:  Harmful by inhalation and if swallowed 
36/37/38:  Irritating to eyes, respiratory system and skin 
51/53:  Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
Safety Statements:
24:  Avoid contact with skin 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 
61:  Avoid release to the environment. Refer to special instructions safety data sheet
37/39:  Wear suitable gloves and eye/face protection 
RIDADR:UN 3082 9/PG 3
WGK Germany:2
Hazard Note:Irritant

2,3-Dichloro-5-(trifluoromethyl)pyridine Specification

 2,3-Dichloro-5-trifluoromethyl pyridine (CAS NO.69045-84-7), its Synonyms are Pyridine, 2,3-dichloro-5-(trifluoromethyl)- ; 2,3-Dichloro-5-(trifluoromethyl)pyridine .

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