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inquiryProduct name 2-Chloro-5-trifluoromethylpyridine Synonyms 2-chloride-5-(trifluoromethoxy)pyridine;2-Cchloro-5-(Trifluoromethyl)pyridine;2-Chloro-5-(trifluoromethyl)pyridine, 98+%;2-Chloro-5-(Trifluoro
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryProduct name: 2-Chloro-5-Trifluoromethyl Pyridine CAS No.: 52334-81-3 Molecule Formula:C6H3ClF3N Molecule Weight:181.54 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
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inquiry3-(trifluoromethyl)pyridine
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With 1% Pd on activated carbon; chlorine at 235℃; for 24h; Temperature; Reagent/catalyst; Inert atmosphere; | 94.9% |
2-chloro-5-(Trichloromethyl)-pyridine
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With hydrogen fluoride; mercury(II) oxide | 87% |
With antimony(III) fluoride for 0.166667h; Heating; | 54.5% |
With hydrogen fluoride | |
With hydrogen fluoride at 130℃; Temperature; |
3-Methylpyridine
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With magnesium fluoride; hydrogen fluoride; chlorine at 220 - 280℃; for 8h; Temperature; Reagent/catalyst; Inert atmosphere; | 76.7% |
2-chloro-5-trifluoromethylpyridine 1-oxide
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 31℃; for 16h; Sealed tube; Irradiation; | 59% |
3-(trifluoromethyl)pyridine-N-oxide
A
2-chloro-5-trifluoromethylpyridine
B
2-chloro-3-trifluoromethyl-pyridine
Conditions | Yield |
---|---|
Stage #1: 3-(trifluoromethyl)pyridine-N-oxide With trichlorophosphate In 1,2-dichloro-ethane at 105 - 125℃; for 7h; Stage #2: With triethylamine In 1,2-dichloro-ethane at -30 - -20℃; for 3h; | A 25.34% B 50.34% |
2-choro-5-iodopyridine
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 90℃; for 4h; Sealed tube; Inert atmosphere; | 38% |
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; silver fluoride In N,N-dimethyl-formamide at 100℃; for 1h; Inert atmosphere; Sealed tube; chemoselective reaction; | 98 %Spectr. |
2-choro-5-iodopyridine
sodium 2,2,2-trifluoroacetate
A
2,5-bis(trifluoromethyl)pyridine
B
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; copper(l) iodide at 160℃; for 4h; | A 7 % Chromat. B 85 % Chromat. |
2-chloro-5-(Trichloromethyl)-pyridine
A
2-chloro-5-trifluoromethylpyridine
B
2-fluoro-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With antimony(III) fluoride |
6-Chloro-3-pyridinecarboxylic acid
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With hydrogen fluoride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate | |
With hydrogen fluoride | |
With sodium hydroxide; hydrogen fluoride |
6-hydroxy-3-pyridinecarboxylic acid
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With phosphorus pentachloride In water |
2-hydroxy-5-(trifluoromethyl)pyridine
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With phosphorus pentachloride In water | |
With trichlorophosphate In N-methyl-acetamide; water |
antimony(III) fluoride
2-chloro-5-(Trichloromethyl)-pyridine
2-chloro-5-trifluoromethylpyridine
6-hydroxy-3-pyridinecarboxylic acid
5-(trifluoromethyl)-2(1H)-pyridone
phosphorus pentachloride
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With trichlorophosphate In water |
2-choro-5-iodopyridine
(trifluoromethyl)triethylsilane
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20 - 60℃; Inert atmosphere; | 69 %Spectr. |
Langlois reagent
6-chloropyridin-3-ylboronic acid
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium hydrogencarbonate In methanol; water at 0 - 20℃; for 12h; | 85 %Spectr. |
2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate
6-chloropyridin-3-ylboronic acid
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; fluorobenzene; copper diacetate In ethyl acetate at 20℃; for 20h; Inert atmosphere; | 16 %Spectr. |
(trifluoromethyl)trimethylsilane
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide; triphenylphosphine In N,N-dimethyl-formamide at 65℃; for 12h; regioselective reaction; | 72 %Spectr. |
3-Methylpyridine
A
2,6-dichloro-3-(trifluoromethyl)pyridine
B
2-chloro-5-trifluoromethylpyridine
C
2-chloro-3-trifluoromethyl-pyridine
Conditions | Yield |
---|---|
With hydrogen fluoride; chlorine at 200 - 400℃; for 30h; Large scale; | A 47.7 %Chromat. B 3.7 %Chromat. C 14.5 %Chromat. |
3-Hydroxybenzyl alcohol
2-chloro-5-trifluoromethylpyridine
[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 95 - 105℃; for 5h; Product distribution / selectivity; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 90 - 95℃; for 16h; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h; Product distribution / selectivity; | 53% |
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h; | 53% |
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h; | 53% |
5-bromo-2-chlorophenol
2-chloro-5-trifluoromethylpyridine
2-(5-bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; for 12h; | 100% |
8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine
2-chloro-5-trifluoromethylpyridine
8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-(1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water at 130℃; for 1.5h; Microwave irradiation; | 100% |
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Sealed tube; Inert atmosphere; | 100% |
3-Bromophenol
2-chloro-5-trifluoromethylpyridine
2-(3-bromophenoxy)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 16h; Inert atmosphere; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 110℃; |
Thien-3-ylboronic acid
2-chloro-5-trifluoromethylpyridine
2-(thiophen-3-yl)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 19h; Suzuki-Miyaura coupling; Inert atmosphere; | 99% |
trimethoxonium tetrafluoroborate
2-chloro-5-trifluoromethylpyridine
C7H6ClF3N(1+)*BF4(1-)
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 99% |
triethyloxonium fluoroborate
2-chloro-5-trifluoromethylpyridine
1-ethyl-5-trifluoromethyl-2-chloropyridinium tetrafluoroborate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 99% |
2-chloro-5-trifluoromethylpyridine
4-tert-butylphenylboronic acid
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling; | 99% |
2-chloro-5-trifluoromethylpyridine
tributyl(thien-2-yl)stannane
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In toluene for 16h; Inert atmosphere; Reflux; | 99% |
2,4-di-tert-Butylphenol
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium tert-butylate In ammonia at -78℃; for 1h; Irradiation; add of 1,3-dinitrobenzene or galvinoxyl; | 98% |
2-chloro-5-trifluoromethylpyridine
Benzimidazol-2-thiol
Conditions | Yield |
---|---|
With potassium tert-butylate for 0.5h; Irradiation; | 98% |
With sodium hydroxide 2.) DMF, reflux, 3 h; Yield given. Multistep reaction; |
2-chloro-5-trifluoromethylpyridine
2-hydroxyethanethiol
Conditions | Yield |
---|---|
With potassium tert-butylate for 0.166667h; Irradiation; | 98% |
2-chloro-5-trifluoromethylpyridine
di-4-methoxyphenylzinc
2-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With tripiperidino-phosphine; nickel dichloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 60℃; for 1h; Negishi cross-coupling reaction; | 98% |
2-chloro-5-trifluoromethylpyridine
1H-Pyrazolo[3,4-b]pyridine
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; zinc diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere; | 98% |
2-chloro-5-trifluoromethylpyridine
hydroquinone
2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With sodium hydrogensulfite; potassium hydroxide In N,N-dimethyl-formamide at 50 - 90℃; for 6h; Temperature; Reagent/catalyst; | 97.8% |
With potassium carbonate In N,N-dimethyl-formamide at 60 - 90℃; for 4h; | 75% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; |
N,N-dimethyl-cyclohexanamine
2-chloro-5-trifluoromethylpyridine
A
N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine
B
Cyclohexyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h; | A 2% B 97% |
2-chloro-5-trifluoromethylpyridine
5,5’-bis(trifluoromethyl)-2,2’-bipyridine
Conditions | Yield |
---|---|
With potassium hydroxide In water; N,N-dimethyl-formamide at 35℃; for 12h; Ullmann Condensation; Inert atmosphere; | 97% |
With manganese; nickel(II) bromide trihydrate In N,N-dimethyl-formamide at 20 - 60℃; for 20h; Inert atmosphere; | 70% |
With [2,2]bipyridinyl; nickel diacetate; sodium tert-pentoxide In tetrahydrofuran at 25℃; for 0.0377778h; | 57% |
2-chloro-5-trifluoromethylpyridine
2-mercapto-3H-quinazolin-4-one
Conditions | Yield |
---|---|
With potassium tert-butylate for 0.416667h; Irradiation; | 97% |
2-chloro-5-trifluoromethylpyridine
ethyl 3-methylpyrazole-4-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃; | 97% |
2-chloro-5-trifluoromethylpyridine
2,4-dimethoxypyrimidin-5-ylboronic acid
2,4-dimethoxy-5-(5-(trifluoromethyl)pyridin-2-yl)pyrimidine
Conditions | Yield |
---|---|
With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); tetrabutylammomium bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90℃; for 5h; Suzuki-Miyaura cross-coupling; Continuous flow reactor; Inert atmosphere; | 97% |
2-chloro-5-trifluoromethylpyridine
4-hydroxy-benzaldehyde
4-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 140℃; for 10h; | 97% |
Stage #1: 4-hydroxy-benzaldehyde With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 2-chloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 20 - 105℃; for 10h; |
dmap
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 120℃; for 3h; Temperature; | 97% |
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In n-heptane; water | 96.3% |
In ice-water; N,N-dimethyl-formamide | 67% |
N,N'-dimethylbenzylamine
2-chloro-5-trifluoromethylpyridine
A
N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h; | A 96% B 2% |
2-chloro-5-trifluoromethylpyridine
4-methoxy-phenol
5-(trifluoromethyl)-2-(4-methoxyphenoxy)pyridine
Conditions | Yield |
---|---|
With aluminum oxide; potassium fluoride In N,N-dimethyl-formamide at 120℃; for 5h; | 96% |
In water; dimethyl sulfoxide |
2-chloro-5-trifluoromethylpyridine
phenylboronic acid
2-phenyl-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling; | 96% |
Stage #1: 2-chloro-5-trifluoromethylpyridine; phenylboronic acid With palladium diacetate; (R)-6-dicyclohexylphoshino-6'-diphenylphosphino-3,3'-dimethoxy-2,2',4,4'-tetramethyl-1,1'-biphenyl In dodecane; butan-1-ol at 25℃; for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; Stage #2: With cesiumhydroxide monohydrate In dodecane; water; butan-1-ol at 25℃; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; | 95% |
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 24h; Suzuki-Miyaura coupling; Inert atmosphere; | 94% |
p-hydroxymethylphenylboronic acid
2-chloro-5-trifluoromethylpyridine
[4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol
Conditions | Yield |
---|---|
With C37H44ClN2O3PPd; caesium carbonate In water at 100℃; for 12h; Suzuki Coupling; Schlenk technique; Inert atmosphere; | 96% |
palladium dichloride |
ethyl 3-isopropyl-1H-pyrazole-4-carboxylate
2-chloro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃; | 96% |
2-chloro-5-trifluoromethylpyridine
(RS)-2-methylpiperazine
3-methyl-1-(5-trifluoromethyl-pyridin-2-yl)-piperazine
Conditions | Yield |
---|---|
With triethylamine In toluene at 150℃; for 20h; | 96% |
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