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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Chloro-5-trifluoromethylpyridine Manufacturer/High quality/Best price/In stock

Cas:52334-81-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloro-5-Trifluoromethylpyridine supplier in China

Cas:52334-81-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-chloro-5-(trifluoromethyl)pyridine

Cas:52334-81-3

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Chloro-5-Trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-5-(trifluoromethyl)-pyridine

Cas:52334-81-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

2-Chloro-5-(trifluoromethyl)pyridine CAS: 52334-81-3

Cas:52334-81-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM--2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 52334-81-3 with fast shipping

Cas:52334-81-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name 2-Chloro-5-trifluoromethylpyridine Synonyms 2-chloride-5-(trifluoromethoxy)pyridine;2-Cchloro-5-(Trifluoromethyl)pyridine;2-Chloro-5-(trifluoromethyl)pyridine, 98+%;2-Chloro-5-(Trifluoro

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pyridine,2-chloro-5-(trifluoromethyl)- 52334-81-3

Cas:52334-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2-Chloro-5-trifluoromethylpyridine CAS:52334-81-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

2-Chloro-5-trifluoromethylpyridine CAS:52334-81-3

Cas:52334-81-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pyridine,2-chloro-5-(trifluoromethyl)-

Cas:52334-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High purity 2-Chloro-5-trifluoromethylpyridine CAS NO.52334-81-3

Cas:52334-81-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbo

2-chloro-5-(trifluoromethyl)pyridine

Cas:52334-81-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

2-Chloro-5-(trifluoromethyl)pyridine cas:52334-81-3

Cas:52334-81-3

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-5-Trifluoromethylpyridine (2,5-Ctf)

Cas:52334-81-3

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-5-(trifluoromethyl)pyridine

Cas:52334-81-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-Chloro-5-trifluoromethylpyridine /High quality/Best price

Cas:52334-81-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Chloro-5-trifluoromethylpyridine Manufacturer/High quality/Best price/In stock CAS NO.52334-81-3

Cas:52334-81-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

High quality 2-Chloro-5-Trifluoromethylpyridine CAS 52334-81-3

Cas:52334-81-3

Min.Order:1 Liter

FOB Price: $4.5 / 5.0

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 2-Chloro-5-Trifluoromethyl Pyridine CAS No.: 52334-81-3 Molecule Formula:C6H3ClF3N Molecule Weight:181.54 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price 2-Chloro-5-Trifluoromethyl Pyridine

Cas:52334-81-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

6-Chloro-alpha,alpha,alpha-trifluoro-3-picolineCAS NO.:52334-81-3

Cas:52334-81-3

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-Chloro-5-trifluoromethylpyridine

Cas:52334-81-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

3-(trifluoromethyl)pyridine
3796-23-4

3-(trifluoromethyl)pyridine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With 1% Pd on activated carbon; chlorine at 235℃; for 24h; Temperature; Reagent/catalyst; Inert atmosphere;94.9%
2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With hydrogen fluoride; mercury(II) oxide87%
With antimony(III) fluoride for 0.166667h; Heating;54.5%
With hydrogen fluoride
With hydrogen fluoride at 130℃; Temperature;
3-Methylpyridine
108-99-6

3-Methylpyridine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With magnesium fluoride; hydrogen fluoride; chlorine at 220 - 280℃; for 8h; Temperature; Reagent/catalyst; Inert atmosphere;76.7%
2-chloro-5-trifluoromethylpyridine 1-oxide
261956-65-4

2-chloro-5-trifluoromethylpyridine 1-oxide

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 31℃; for 16h; Sealed tube; Irradiation;59%
3-(trifluoromethyl)pyridine-N-oxide
22253-72-1

3-(trifluoromethyl)pyridine-N-oxide

A

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

B

2-chloro-3-trifluoromethyl-pyridine
65753-47-1

2-chloro-3-trifluoromethyl-pyridine

Conditions
ConditionsYield
Stage #1: 3-(trifluoromethyl)pyridine-N-oxide With trichlorophosphate In 1,2-dichloro-ethane at 105 - 125℃; for 7h;
Stage #2: With triethylamine In 1,2-dichloro-ethane at -30 - -20℃; for 3h;
A 25.34%
B 50.34%
2-choro-5-iodopyridine
69045-79-0

2-choro-5-iodopyridine

trimethylsilyl 2-chloro-2,2-difluoroacetate

trimethylsilyl 2-chloro-2,2-difluoroacetate

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 90℃; for 4h; Sealed tube; Inert atmosphere;38%
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; silver fluoride In N,N-dimethyl-formamide at 100℃; for 1h; Inert atmosphere; Sealed tube; chemoselective reaction;98 %Spectr.
2-choro-5-iodopyridine
69045-79-0

2-choro-5-iodopyridine

sodium 2,2,2-trifluoroacetate
2923-18-4

sodium 2,2,2-trifluoroacetate

A

2,5-bis(trifluoromethyl)pyridine
20857-44-7

2,5-bis(trifluoromethyl)pyridine

B

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; copper(l) iodide at 160℃; for 4h;A 7 % Chromat.
B 85 % Chromat.
2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

A

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

B

2-fluoro-5-(trifluoromethyl)pyridine
69045-82-5

2-fluoro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With antimony(III) fluoride
6-Chloro-3-pyridinecarboxylic acid
5326-23-8

6-Chloro-3-pyridinecarboxylic acid

sulfur tetrafluoride

sulfur tetrafluoride

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With hydrogen fluoride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate
With hydrogen fluoride
With sodium hydroxide; hydrogen fluoride
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

sulfur tetrafluoride

sulfur tetrafluoride

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With phosphorus pentachloride In water
2-hydroxy-5-(trifluoromethyl)pyridine
33252-63-0

2-hydroxy-5-(trifluoromethyl)pyridine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With phosphorus pentachloride In water
With trichlorophosphate In N-methyl-acetamide; water
antimony(III) fluoride
7783-56-4

antimony(III) fluoride

2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

sulfur tetrafluorde

sulfur tetrafluorde

5-(trifluoromethyl)-2(1H)-pyridone
33252-63-0

5-(trifluoromethyl)-2(1H)-pyridone

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With trichlorophosphate In water
2-choro-5-iodopyridine
69045-79-0

2-choro-5-iodopyridine

(trifluoromethyl)triethylsilane
120120-26-5

(trifluoromethyl)triethylsilane

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20 - 60℃; Inert atmosphere;69 %Spectr.
Langlois reagent
2926-29-6

Langlois reagent

6-chloropyridin-3-ylboronic acid
444120-91-6

6-chloropyridin-3-ylboronic acid

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With tert.-butylhydroperoxide; tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium hydrogencarbonate In methanol; water at 0 - 20℃; for 12h;85 %Spectr.
2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate
1214756-50-9

2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate

6-chloropyridin-3-ylboronic acid
444120-91-6

6-chloropyridin-3-ylboronic acid

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; fluorobenzene; copper diacetate In ethyl acetate at 20℃; for 20h; Inert atmosphere;16 %Spectr.
(6-chloropyridin-3-yl)(mesityl)iodonium triflate

(6-chloropyridin-3-yl)(mesityl)iodonium triflate

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide; triphenylphosphine In N,N-dimethyl-formamide at 65℃; for 12h; regioselective reaction;72 %Spectr.
3-Methylpyridine
108-99-6

3-Methylpyridine

A

2,6-dichloro-3-(trifluoromethyl)pyridine
55304-75-1

2,6-dichloro-3-(trifluoromethyl)pyridine

B

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

C

2-chloro-3-trifluoromethyl-pyridine
65753-47-1

2-chloro-3-trifluoromethyl-pyridine

Conditions
ConditionsYield
With hydrogen fluoride; chlorine at 200 - 400℃; for 30h; Large scale;A 47.7 %Chromat.
B 3.7 %Chromat.
C 14.5 %Chromat.
3-Hydroxybenzyl alcohol
620-24-6

3-Hydroxybenzyl alcohol

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol
1020325-22-7

[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 105℃; for 5h; Product distribution / selectivity;100%
With potassium carbonate In N,N-dimethyl-formamide at 90 - 95℃; for 16h;100%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h; Product distribution / selectivity;53%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h;53%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h;53%
5-bromo-2-chlorophenol
183802-98-4

5-bromo-2-chlorophenol

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-(5-bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine
1020330-54-4

2-(5-bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; for 12h;100%
8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine
1403396-21-3

8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-(1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine
1403396-51-9

8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-(1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water at 130℃; for 1.5h; Microwave irradiation;100%
(7S)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine-4 (5H)-one

(7S)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine-4 (5H)-one

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

C13H11F3N4O

C13H11F3N4O

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Sealed tube; Inert atmosphere;100%
3-Bromophenol
591-20-8

3-Bromophenol

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-(3-bromophenoxy)-5-(trifluoromethyl)pyridine
693828-63-6

2-(3-bromophenoxy)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 16h; Inert atmosphere;99%
With potassium carbonate In N,N-dimethyl-formamide at 110℃;
Thien-3-ylboronic acid
6165-69-1

Thien-3-ylboronic acid

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-(thiophen-3-yl)-5-(trifluoromethyl)pyridine
1092384-65-0

2-(thiophen-3-yl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 19h; Suzuki-Miyaura coupling; Inert atmosphere;99%
trimethoxonium tetrafluoroborate
420-37-1

trimethoxonium tetrafluoroborate

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

C7H6ClF3N(1+)*BF4(1-)
1622456-59-0

C7H6ClF3N(1+)*BF4(1-)

Conditions
ConditionsYield
In dichloromethane at 20℃;99%
triethyloxonium fluoroborate
368-39-8

triethyloxonium fluoroborate

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

1-ethyl-5-trifluoromethyl-2-chloropyridinium tetrafluoroborate
1622456-61-4

1-ethyl-5-trifluoromethyl-2-chloropyridinium tetrafluoroborate

Conditions
ConditionsYield
In dichloromethane at 20℃;99%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

4-tert-butylphenylboronic acid
123324-71-0

4-tert-butylphenylboronic acid

2-(4-(tert-butyl)phenyl)-5-(trifluoromethyl)pyridine

2-(4-(tert-butyl)phenyl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;99%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

tributyl(thien-2-yl)stannane
54663-78-4

tributyl(thien-2-yl)stannane

2-(thiophen-2-yl)-5-(trifluoromethyl)pyridine

2-(thiophen-2-yl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In toluene for 16h; Inert atmosphere; Reflux;99%
2,4-di-tert-Butylphenol
96-76-4

2,4-di-tert-Butylphenol

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

1-<2-(5-trifluoromethylpyridyl)>-2-hydroxy-3,5-di-tert-butylbenzene

1-<2-(5-trifluoromethylpyridyl)>-2-hydroxy-3,5-di-tert-butylbenzene

Conditions
ConditionsYield
With potassium tert-butylate In ammonia at -78℃; for 1h; Irradiation; add of 1,3-dinitrobenzene or galvinoxyl;98%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

Benzimidazol-2-thiol
134469-07-1

Benzimidazol-2-thiol

2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>-1H-benzimidazole

2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>-1H-benzimidazole

Conditions
ConditionsYield
With potassium tert-butylate for 0.5h; Irradiation;98%
With sodium hydroxide 2.) DMF, reflux, 3 h; Yield given. Multistep reaction;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-hydroxyethanethiol
60-24-2

2-hydroxyethanethiol

2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>ethanol

2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>ethanol

Conditions
ConditionsYield
With potassium tert-butylate for 0.166667h; Irradiation;98%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

di-4-methoxyphenylzinc
97302-05-1

di-4-methoxyphenylzinc

2-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine
296776-84-6

2-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tripiperidino-phosphine; nickel dichloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 60℃; for 1h; Negishi cross-coupling reaction;98%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

1H-Pyrazolo[3,4-b]pyridine
271-73-8

1H-Pyrazolo[3,4-b]pyridine

1-(4-(trifluoromethyl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine

1-(4-(trifluoromethyl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; zinc diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;98%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

hydroquinone
123-31-9

hydroquinone

2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine
69045-85-8

2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine

Conditions
ConditionsYield
With sodium hydrogensulfite; potassium hydroxide In N,N-dimethyl-formamide at 50 - 90℃; for 6h; Temperature; Reagent/catalyst;97.8%
With potassium carbonate In N,N-dimethyl-formamide at 60 - 90℃; for 4h;75%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
N,N-dimethyl-cyclohexanamine
98-94-2

N,N-dimethyl-cyclohexanamine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

A

N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine
136539-99-6

N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine

B

Cyclohexyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine
136539-98-5

Cyclohexyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine

Conditions
ConditionsYield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;A 2%
B 97%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

5,5’-bis(trifluoromethyl)-2,2’-bipyridine
142946-80-3

5,5’-bis(trifluoromethyl)-2,2’-bipyridine

Conditions
ConditionsYield
With potassium hydroxide In water; N,N-dimethyl-formamide at 35℃; for 12h; Ullmann Condensation; Inert atmosphere;97%
With manganese; nickel(II) bromide trihydrate In N,N-dimethyl-formamide at 20 - 60℃; for 20h; Inert atmosphere;70%
With [2,2]bipyridinyl; nickel diacetate; sodium tert-pentoxide In tetrahydrofuran at 25℃; for 0.0377778h;57%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-mercapto-3H-quinazolin-4-one
13906-09-7

2-mercapto-3H-quinazolin-4-one

2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>quinazolin-4(3H)-one

2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>quinazolin-4(3H)-one

Conditions
ConditionsYield
With potassium tert-butylate for 0.416667h; Irradiation;97%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

ethyl 3-methylpyrazole-4-carboxylate
85290-78-4

ethyl 3-methylpyrazole-4-carboxylate

ethyl 3-methyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

ethyl 3-methyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃;97%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2,4-dimethoxypyrimidin-5-ylboronic acid
89641-18-9

2,4-dimethoxypyrimidin-5-ylboronic acid

2,4-dimethoxy-5-(5-(trifluoromethyl)pyridin-2-yl)pyrimidine
1334531-16-6

2,4-dimethoxy-5-(5-(trifluoromethyl)pyridin-2-yl)pyrimidine

Conditions
ConditionsYield
With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); tetrabutylammomium bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90℃; for 5h; Suzuki-Miyaura cross-coupling; Continuous flow reactor; Inert atmosphere;97%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde
103962-21-6

4-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 140℃; for 10h;97%
Stage #1: 4-hydroxy-benzaldehyde With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: 2-chloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 20 - 105℃; for 10h;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

1-(5-trifluoromethyl-2-pyridyl)-4-(dimethylamino)pyridinium chloride

1-(5-trifluoromethyl-2-pyridyl)-4-(dimethylamino)pyridinium chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 3h; Temperature;97%
3-(2,6-dichloro-4-(benzyloxy)phenoxy)-1-propyl alcohol

3-(2,6-dichloro-4-(benzyloxy)phenoxy)-1-propyl alcohol

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

1-benzyloxy-3,5-dichloro-4-[3-(5-trifluoromethylpyridin-2-yloxy)propyloxy]benzene

1-benzyloxy-3,5-dichloro-4-[3-(5-trifluoromethylpyridin-2-yloxy)propyloxy]benzene

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In n-heptane; water96.3%
In ice-water; N,N-dimethyl-formamide67%
N,N'-dimethylbenzylamine
103-83-3

N,N'-dimethylbenzylamine

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

A

N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine
136539-99-6

N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine

B

Benzyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine

Benzyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine

Conditions
ConditionsYield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;A 96%
B 2%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

4-methoxy-phenol
150-76-5

4-methoxy-phenol

5-(trifluoromethyl)-2-(4-methoxyphenoxy)pyridine
69045-86-9

5-(trifluoromethyl)-2-(4-methoxyphenoxy)pyridine

Conditions
ConditionsYield
With aluminum oxide; potassium fluoride In N,N-dimethyl-formamide at 120℃; for 5h;96%
In water; dimethyl sulfoxide
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

phenylboronic acid
98-80-6

phenylboronic acid

2-phenyl-5-(trifluoromethyl)pyridine
188527-56-2

2-phenyl-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;96%
Stage #1: 2-chloro-5-trifluoromethylpyridine; phenylboronic acid With palladium diacetate; (R)-6-dicyclohexylphoshino-6'-diphenylphosphino-3,3'-dimethoxy-2,2',4,4'-tetramethyl-1,1'-biphenyl In dodecane; butan-1-ol at 25℃; for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox;
Stage #2: With cesiumhydroxide monohydrate In dodecane; water; butan-1-ol at 25℃; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox;
95%
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 24h; Suzuki-Miyaura coupling; Inert atmosphere;94%
p-hydroxymethylphenylboronic acid
59016-93-2

p-hydroxymethylphenylboronic acid

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

[4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol
613239-75-1

[4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol

Conditions
ConditionsYield
With C37H44ClN2O3PPd; caesium carbonate In water at 100℃; for 12h; Suzuki Coupling; Schlenk technique; Inert atmosphere;96%
palladium dichloride
ethyl 3-isopropyl-1H-pyrazole-4-carboxylate
342026-17-9

ethyl 3-isopropyl-1H-pyrazole-4-carboxylate

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

ethyl 3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

ethyl 3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃;96%
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

(RS)-2-methylpiperazine
109-07-9

(RS)-2-methylpiperazine

3-methyl-1-(5-trifluoromethyl-pyridin-2-yl)-piperazine
866785-24-2

3-methyl-1-(5-trifluoromethyl-pyridin-2-yl)-piperazine

Conditions
ConditionsYield
With triethylamine In toluene at 150℃; for 20h;96%

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