2-Chloro-5-trifluoromethylpyridine supplier

Name
2-Chloro-5-trifluoromethylpyridine
EINECS 257-856-5
CAS No. 52334-81-3
Article Data24
CAS DataBase
Density 1.417 g/cm³
Solubility
Melting Point 29-33 °C
Formula C₆H₃ClF₃N
Boiling Point 171.636 °C at 760 mmHg
Molecular Weight 181.545
Flash Point 57.604 °C
Transport Information UN 2811
Appearance white to yellowish crystalline low melting solid
Safety 26-37/39-36/37/39-45-22-16
Risk Codes 36/37/38-20/21/22-25-11
Molecular Structure
Hazard Symbols Xn, Xi, T, F
Synonyms 2-Chloro-5-(trifluoromethyl)pyridine;5-Trifluoromethyl-2-chloropyridine;2,5-CTF;
PSA 12.89000
LogP 2.75380

Synthetic route

: 3796-23-4
3-(trifluoromethyl)pyridine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With 1% Pd on activated carbon; chlorine at 235℃; for 24h; Temperature; Reagent/catalyst; Inert atmosphere;	94.9%

: 69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With hydrogen fluoride; mercury(II) oxide	87%
With antimony(III) fluoride for 0.166667h; Heating;	54.5%
With hydrogen fluoride
With hydrogen fluoride at 130℃; Temperature;

: 108-99-6
3-Methylpyridine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With magnesium fluoride; hydrogen fluoride; chlorine at 220 - 280℃; for 8h; Temperature; Reagent/catalyst; Inert atmosphere;	76.7%

: 261956-65-4
2-chloro-5-trifluoromethylpyridine 1-oxide

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 31℃; for 16h; Sealed tube; Irradiation;	59%

: 22253-72-1
3-(trifluoromethyl)pyridine-N-oxide

A: 52334-81-3
2-chloro-5-trifluoromethylpyridine

B: 65753-47-1
2-chloro-3-trifluoromethyl-pyridine

Conditions

Conditions	Yield
Stage #1: 3-(trifluoromethyl)pyridine-N-oxide With trichlorophosphate In 1,2-dichloro-ethane at 105 - 125℃; for 7h; Stage #2: With triethylamine In 1,2-dichloro-ethane at -30 - -20℃; for 3h;	A 25.34% B 50.34%

: 69045-79-0
2-choro-5-iodopyridine

: trimethylsilyl 2-chloro-2,2-difluoroacetate

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With potassium fluoride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 90℃; for 4h; Sealed tube; Inert atmosphere;	38%
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; silver fluoride In N,N-dimethyl-formamide at 100℃; for 1h; Inert atmosphere; Sealed tube; chemoselective reaction;	98 %Spectr.

: 69045-79-0
2-choro-5-iodopyridine

: 2923-18-4
sodium 2,2,2-trifluoroacetate

A: 20857-44-7
2,5-bis(trifluoromethyl)pyridine

B: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; copper(l) iodide at 160℃; for 4h;	A 7 % Chromat. B 85 % Chromat.

...Expand

: 69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine

A: 52334-81-3
2-chloro-5-trifluoromethylpyridine

B: 69045-82-5
2-fluoro-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With antimony(III) fluoride

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: sulfur tetrafluoride

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With hydrogen fluoride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate
With hydrogen fluoride
With sodium hydroxide; hydrogen fluoride

: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

: sulfur tetrafluoride

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With phosphorus pentachloride In water

: 33252-63-0
2-hydroxy-5-(trifluoromethyl)pyridine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With phosphorus pentachloride In water
With trichlorophosphate In N-methyl-acetamide; water

: 7783-56-4
antimony(III) fluoride

: 69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

sulfur tetrafluorde: sulfur tetrafluorde

: 33252-63-0
5-(trifluoromethyl)-2(1H)-pyridone

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With trichlorophosphate In water

...Expand

: 69045-79-0
2-choro-5-iodopyridine

: 120120-26-5
(trifluoromethyl)triethylsilane

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20 - 60℃; Inert atmosphere;	69 %Spectr.

: 2926-29-6
Langlois reagent

: 444120-91-6
6-chloropyridin-3-ylboronic acid

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium hydrogencarbonate In methanol; water at 0 - 20℃; for 12h;	85 %Spectr.

: 1214756-50-9
2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate

: 444120-91-6
6-chloropyridin-3-ylboronic acid

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With 2,4,6-trimethyl-pyridine; fluorobenzene; copper diacetate In ethyl acetate at 20℃; for 20h; Inert atmosphere;	16 %Spectr.

: (6-chloropyridin-3-yl)(mesityl)iodonium triflate

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With potassium fluoride; copper(l) iodide; triphenylphosphine In N,N-dimethyl-formamide at 65℃; for 12h; regioselective reaction;	72 %Spectr.

: 108-99-6
3-Methylpyridine

A: 55304-75-1
2,6-dichloro-3-(trifluoromethyl)pyridine

B: 52334-81-3
2-chloro-5-trifluoromethylpyridine

C: 65753-47-1
2-chloro-3-trifluoromethyl-pyridine

Conditions

Conditions	Yield
With hydrogen fluoride; chlorine at 200 - 400℃; for 30h; Large scale;	A 47.7 %Chromat. B 3.7 %Chromat. C 14.5 %Chromat.

...Expand

: 620-24-6
3-Hydroxybenzyl alcohol

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1020325-22-7
[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 105℃; for 5h; Product distribution / selectivity;	100%
With potassium carbonate In N,N-dimethyl-formamide at 90 - 95℃; for 16h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h; Product distribution / selectivity;	53%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h;	53%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h;	53%

: 183802-98-4
5-bromo-2-chlorophenol

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1020330-54-4
2-(5-bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; for 12h;	100%

: 1403396-21-3
8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1403396-51-9
8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-(1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water at 130℃; for 1.5h; Microwave irradiation;	100%

: (7S)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine-4 (5H)-one

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: C13H11F3N4O

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Sealed tube; Inert atmosphere;	100%

: 591-20-8
3-Bromophenol

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 693828-63-6
2-(3-bromophenoxy)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 16h; Inert atmosphere;	99%
With potassium carbonate In N,N-dimethyl-formamide at 110℃;

: 6165-69-1
Thien-3-ylboronic acid

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1092384-65-0
2-(thiophen-3-yl)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 19h; Suzuki-Miyaura coupling; Inert atmosphere;	99%

: 420-37-1
trimethoxonium tetrafluoroborate

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1622456-59-0
C7H6ClF3N(1+)*BF4(1-)

Conditions

Conditions	Yield
In dichloromethane at 20℃;	99%

: 368-39-8
triethyloxonium fluoroborate

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1622456-61-4
1-ethyl-5-trifluoromethyl-2-chloropyridinium tetrafluoroborate

Conditions

Conditions	Yield
In dichloromethane at 20℃;	99%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 123324-71-0
4-tert-butylphenylboronic acid

: 2-(4-(tert-butyl)phenyl)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;	99%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 54663-78-4
tributyl(thien-2-yl)stannane

: 2-(thiophen-2-yl)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In toluene for 16h; Inert atmosphere; Reflux;	99%

: 96-76-4
2,4-di-tert-Butylphenol

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1-<2-(5-trifluoromethylpyridyl)>-2-hydroxy-3,5-di-tert-butylbenzene

Conditions

Conditions	Yield
With potassium tert-butylate In ammonia at -78℃; for 1h; Irradiation; add of 1,3-dinitrobenzene or galvinoxyl;	98%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 134469-07-1
Benzimidazol-2-thiol

: 2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>-1H-benzimidazole

Conditions

Conditions	Yield
With potassium tert-butylate for 0.5h; Irradiation;	98%
With sodium hydroxide 2.) DMF, reflux, 3 h; Yield given. Multistep reaction;

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 60-24-2
2-hydroxyethanethiol

: 2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>ethanol

Conditions

Conditions	Yield
With potassium tert-butylate for 0.166667h; Irradiation;	98%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 97302-05-1
di-4-methoxyphenylzinc

: 296776-84-6
2-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With tripiperidino-phosphine; nickel dichloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 60℃; for 1h; Negishi cross-coupling reaction;	98%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 271-73-8
1H-Pyrazolo[3,4-b]pyridine

: 1-(4-(trifluoromethyl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; zinc diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	98%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 123-31-9
hydroquinone

: 69045-85-8
2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine

Conditions

Conditions	Yield
With sodium hydrogensulfite; potassium hydroxide In N,N-dimethyl-formamide at 50 - 90℃; for 6h; Temperature; Reagent/catalyst;	97.8%
With potassium carbonate In N,N-dimethyl-formamide at 60 - 90℃; for 4h;	75%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;

: 98-94-2
N,N-dimethyl-cyclohexanamine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

A: 136539-99-6
N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine

B: 136539-98-5
Cyclohexyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 2% B 97%

...Expand

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 142946-80-3
5,5’-bis(trifluoromethyl)-2,2’-bipyridine

Conditions

Conditions	Yield
With potassium hydroxide In water; N,N-dimethyl-formamide at 35℃; for 12h; Ullmann Condensation; Inert atmosphere;	97%
With manganese; nickel(II) bromide trihydrate In N,N-dimethyl-formamide at 20 - 60℃; for 20h; Inert atmosphere;	70%
With [2,2]bipyridinyl; nickel diacetate; sodium tert-pentoxide In tetrahydrofuran at 25℃; for 0.0377778h;	57%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 13906-09-7
2-mercapto-3H-quinazolin-4-one

: 2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>quinazolin-4(3H)-one

Conditions

Conditions	Yield
With potassium tert-butylate for 0.416667h; Irradiation;	97%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 85290-78-4
ethyl 3-methylpyrazole-4-carboxylate

: ethyl 3-methyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃;	97%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1334531-16-6
2,4-dimethoxy-5-(5-(trifluoromethyl)pyridin-2-yl)pyrimidine

Conditions

Conditions	Yield
With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); tetrabutylammomium bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90℃; for 5h; Suzuki-Miyaura cross-coupling; Continuous flow reactor; Inert atmosphere;	97%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 123-08-0
4-hydroxy-benzaldehyde

: 103962-21-6
4-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 140℃; for 10h;	97%
Stage #1: 4-hydroxy-benzaldehyde With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 2-chloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 20 - 105℃; for 10h;

: 1122-58-3
dmap

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1-(5-trifluoromethyl-2-pyridyl)-4-(dimethylamino)pyridinium chloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 3h; Temperature;	97%

: 3-(2,6-dichloro-4-(benzyloxy)phenoxy)-1-propyl alcohol

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1-benzyloxy-3,5-dichloro-4-[3-(5-trifluoromethylpyridin-2-yloxy)propyloxy]benzene

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In n-heptane; water	96.3%
In ice-water; N,N-dimethyl-formamide	67%

: 103-83-3
N,N'-dimethylbenzylamine

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

A: 136539-99-6
N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine

B: Benzyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 96% B 2%

...Expand

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 150-76-5
4-methoxy-phenol

: 69045-86-9
5-(trifluoromethyl)-2-(4-methoxyphenoxy)pyridine

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl-formamide at 120℃; for 5h;	96%
In water; dimethyl sulfoxide

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 98-80-6
phenylboronic acid

: 188527-56-2
2-phenyl-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;	96%
Stage #1: 2-chloro-5-trifluoromethylpyridine; phenylboronic acid With palladium diacetate; (R)-6-dicyclohexylphoshino-6'-diphenylphosphino-3,3'-dimethoxy-2,2',4,4'-tetramethyl-1,1'-biphenyl In dodecane; butan-1-ol at 25℃; for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; Stage #2: With cesiumhydroxide monohydrate In dodecane; water; butan-1-ol at 25℃; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox;	95%
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 24h; Suzuki-Miyaura coupling; Inert atmosphere;	94%

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 613239-75-1
[4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol

Conditions

Conditions	Yield
With C37H44ClN2O3PPd; caesium carbonate In water at 100℃; for 12h; Suzuki Coupling; Schlenk technique; Inert atmosphere;	96%
palladium dichloride

: 342026-17-9
ethyl 3-isopropyl-1H-pyrazole-4-carboxylate

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: ethyl 3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃;	96%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 109-07-9
(RS)-2-methylpiperazine

: 866785-24-2
3-methyl-1-(5-trifluoromethyl-pyridin-2-yl)-piperazine

Conditions

Conditions	Yield
With triethylamine In toluene at 150℃; for 20h;	96%

2-Chloro-5-trifluoromethylpyridine Specification

The IUPAC name of 2-Chloro-5-(trifluoromethyl)pyridine is 2-chloro-5-(trifluoromethyl)pyridine. With the CAS registry number 52334-81-3, it is also named as Pyridine, 2-chloro-5-(trifluoromethyl)-. The product's categories are Blocks; Fluoro Compounds; Pyridines; Pyridine; Pyridines, Pyrimidines, Purines and Pteredines; Pyridine Series; Halides; Pyridines Derivates; Chloropyridines; Halopyridines; C6 Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks. Besides, it is white to yellowish crystalline low melting solid, which should be stored in tightly sealed containers in a cool, dry place at 0-6 °C. And you should ensure that the workplaces have good ventilated or exhaust devices. In addition, its molecular formula is C₆H₃ClF₃N and molecular weight is 181.54.

The other characteristics of this product can be summarized as: (1)EINECS: 257-856-5; (2)ACD/LogP: 2.32; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 2.315; (5)ACD/LogD (pH 7.4): 2.315; (6)ACD/BCF (pH 5.5): 33.837; (7)ACD/BCF (pH 7.4): 33.837; (8)ACD/KOC (pH 5.5): 432.864; (9)ACD/KOC (pH 7.4): 432.864; (10)#H bond acceptors: 1; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 0; (13)Polar Surface Area: 12.89 Å²; (14)Index of Refraction: 1.447; (15)Molar Refractivity: 34.219 cm³; (16)Molar Volume: 128.118 cm³; (17)Polarizability: 13.565×10^-24cm³; (18)Surface Tension: 27.918 dyne/cm; (19)Density: 1.417 g/cm³; (20)Flash Point: 57.604 °C; (21)Melting Point: 29-33 °C; (22)Enthalpy of Vaporization: 39.126 kJ/mol; (23)Boiling Point: 171.636 °C at 760 mmHg; (24)Vapour Pressure: 1.844 mmHg at 25 °C.

Preparation of 2-Chloro-5-(trifluoromethyl)pyridine: frist of all, you can use Cl₂ to react with 2-Chloro-5-methylpyridine. And you would obtain 2-Chloro-5-trichloromethylpyridine. Then you will get this chemical by fluorination.

Uses of 2-Chloro-5-(trifluoromethyl)pyridine: this chemical can be used as an intermediate of Fluazifop. What's more, it can react with [1,4]diazepane to get 1,4-bis-(5-trifluoromethyl-pyridin-2-yl)-[1,4]diazepane.

This reaction needs triethylamine, polytetrafluoroethylene (PTFE) and tetrahydrofuran at temperature of 100 °C for 4 days. The yield is 89 %.

When you are using this chemical, please be cautious about it as the following: it is highly flammable, so please keep away from sources of ignition. It is also harmful by inhalation, in contact with skin and if swallowed. And it is toxic if swallowed. Please do not breathe dust. Moreover, it irritates to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection. Additionally, in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C1=CC(=NC=C1C(F)(F)F)Cl
(2)InChI: InChI=1S/C6H3ClF3N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H
(3)InChIKey: JFZJMSDDOOAOIV-UHFFFAOYSA-N

Product Name

2-Chloro-5-trifluoromethylpyridine

Synthetic route

2-Chloro-5-trifluoromethylpyridine Specification

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