CAS No.157764-10-8,2-[3-Chloro-5-(trifluoroMethyl)-2-pyridinyl]-acetonitrile Suppliers

ZiBO KuoDing Trade company Ltd

3-Chlor-5-(trifluormethyl)-2-pyridinyl]acetonitril intermediate for pesticide. Appearance:brown and yelllow liquid Storage:room temperature Package:180kg/drum Application:intermediate for synthesis. Transportation:by air or by sea Port:shanghai p

3-Chloro-5-(trifluoromethyl)pyridine-2-acetonitrile

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Qingdao Beluga Import and Export Co., LTD

2-[3-Chloro-5-(trifluoroMethyl)-2-pyridinyl]-acetonitrile CAS:157764-10-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spe

2-[3-Chloro-5-(trifluoroMethyl)-2-pyridinyl]-acetonitrile CAS:157764-10-8

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]ACETONITRILE

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

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Zibo Hangyu Biotechnology Development Co., Ltd

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Henan Tianfu Chemical Co., Ltd.

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Antimex Chemical Limied

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ZHEJIANG JIUZHOU CHEM CO.,LTD

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Amadis Chemical Co., Ltd.

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ENAO Chemical Co, Limited

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Nanjing Norris Pharm Technology Co., Ltd.

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We keep a long-term friendly cooperation with many famous universities and research institutions in China, which provide us strong support on the research and development for new products. Application:We keep a long-term friendly cooperation with man

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Xi'an Zhenghao Biotechnology Co., Ltd

Advantageous manufacturers Storage:low temperature storage Application:Research and development of pharmaceutical intermediates

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Synthetic route

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 75-05-8
acetonitrile

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
With sodium methylate at 130℃; under 21002.1 Torr; for 16h; Pressure; Temperature; Reagent/catalyst; Inert atmosphere;	99.2%

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 105-56-6
ethyl 2-cyanoacetate

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine; ethyl 2-cyanoacetate With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 70℃; for 3h; Stage #2: With hydrogenchloride In 1-methyl-pyrrolidin-2-one; water at 130℃; for 2h; pH=2;	94%
Stage #1: ethyl 2-cyanoacetate With 18-crown-6 ether; potassium carbonate In ethyl acetate at 25℃; for 0.5h; Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In ethyl acetate at 70℃; for 1h; Stage #3: With hydrogenchloride In N,N-dimethyl-formamide for 3h; pH=2; Reagent/catalyst; Solvent; Reflux;

: 658066-43-4
methyl [3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)acetate

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
With water; sodium chloride In dimethyl sulfoxide at 160℃;	91%
With water; sodium chloride In dimethyl sulfoxide at 160℃;	91%
With sodium chloride In water; dimethyl sulfoxide at 160℃;

: ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide at 130℃; for 4h; pH=2;	86.2%
Stage #1: ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate With hydrogenchloride In water; N,N-dimethyl-formamide for 6h; pH=3; Heating; Stage #2: With potassium hydroxide In water at 20℃;	85%
With hydrogenchloride In water for 5h; Reflux;	54 g

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 105-34-0
methyl 2-cyanoacetate

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 2h; Solvent; Temperature; Reagent/catalyst;	83%

: (3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyano-acetic acid tert-butyl ester

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
With trifluoroacetic acid

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: t-BuOK / tetrahydrofuran 2: TFA View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 20 °C 1.2: 2.5 h / 80 °C 2.1: hydrogenchloride / N,N-dimethyl-formamide / 4 h / 130 °C / pH 2 View Scheme
Multi-step reaction with 2 steps 1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 2.5 h / 70 - 80 °C 2: hydrogenchloride / water / 5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 70 °C 2.1: hydrogenchloride / water; N,N-dimethyl-formamide / 6 h / pH 3 / Heating 2.2: 20 °C View Scheme

: 141-78-6
ethyl acetate

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 744209-92-5
2-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-3-oxo-butyronitrile

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran	100%

: 75-03-6
ethyl iodide

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 856245-46-0
2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butanenitrile

Conditions

Conditions	Yield
Stage #1: 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile With potassium tert-butylate In tetrahydrofuran at -5℃; for 2h; Stage #2: ethyl iodide In tetrahydrofuran at 20℃;	100%
Stage #1: 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile In tetrahydrofuran at -5℃; for 2h; Stage #2: ethyl iodide at 20℃;	100%

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 658066-35-4
fluopyram

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen; sodium carbonate In ethyl acetate at 60℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Pressure; Solvent; Temperature;	82%

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 658066-44-5
2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1-ethanamine

Conditions

Conditions	Yield
With hydrogen In tert-butyl methyl ether at 25℃; under 15001.5 Torr; for 4h; Autoclave;	76.59%
With sulfuric acid; palladium on activated charcoal; tetrabutylammomium bromide; hydrogen In methanol at 20℃; under 3750.38 Torr; for 4h; Autoclave;	70%
With hydrogen; 5%-palladium/activated carbon In acetic acid at 20℃; under 4500.45 Torr; for 15h; Product distribution / selectivity;	19%
With sulfuric acid; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium bromide In methanol at 20℃; under 3750.38 Torr; Reagent/catalyst;	91.34 %Chromat.
With hydrogen; acetic anhydride at 80℃; for 4h; Reagent/catalyst; Temperature;

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-3-hydroxy-3-(2-(trifluoromethyl)phenyl)acrylonitrile

Conditions

Conditions	Yield
Stage #1: 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Stage #2: 2-trifluoromethylbenzoyl chloride In tetrahydrofuran; mineral oil for 1h;	75%

: 108-24-7
acetic anhydride

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 3-chloro-5-(trifluoromethyl)-2-ethylacetamide-pyridinyl

Conditions

Conditions	Yield
With hydrogen; 5%-palladium/activated carbon In acetic acid at 20℃; under 22502.3 Torr; for 5h;	71%

: 743456-60-2
1-methyl-3-trifluoromethyl-1H pyrazole-4-carboxylic acid-anhydride

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 743456-54-4
1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid [2-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-ethyl]-amide

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel dichloride In acetonitrile at 0 - 20℃; for 4h;	40%

: 74-88-4
methyl iodide

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

A: 1431842-75-9
2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propanenitrile

B: 157763-90-1
2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylpropanenitrile

Conditions

Conditions	Yield
Stage #1: 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile With potassium tert-butylate In tetrahydrofuran at 5℃; for 2h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 5 - 20℃; for 72h; Inert atmosphere;	A 32% B 22%
Stage #1: 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile With potassium tert-butylate In tetrahydrofuran at 5℃; for 2h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 5 - 20℃; for 72h; Inert atmosphere;	A 32% B 22%
Stage #1: 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile With potassium tert-butylate In tetrahydrofuran at 5℃; for 2h; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 72h; Inert atmosphere;	A 32% B 22%

...Expand

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 744209-98-1
4-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-5-methyl-2H-pyrazol-3-ylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 744210-18-2
7-chloro-3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 744210-07-9
3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: [3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating 5: acetonitrile / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: [3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-bis-(2-methoxy-ethyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating 5: acetonitrile / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: butyl-[3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating 5: acetonitrile / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: [3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-cyclopropylmethyl-propyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating 5: acetonitrile / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: benzyl-[3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating 5: acetonitrile / Heating View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: dibutyl-[3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / sodium hydride / tetrahydrofuran 2: hydrazine hydrobromide / ethanol; H2O / Heating 3: dioxane / Heating 4: POCl3 / acetonitrile / Heating 5: acetonitrile / Heating View Scheme

: 64-19-7
acetic acid

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 658066-45-6
[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethanamine acetate

Conditions

Conditions	Yield
With hydrogen; 5%-palladium/activated carbon at 20℃; under 3750.38 Torr;

: 107-04-0
1-Bromo-2-chloroethane

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 1433906-75-2
1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropanecarbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 60℃; for 3h;

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 1433906-77-4
2-methyl-propane-2-sulfinic acid 1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-methylidene amide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 3 h / 60 °C 2: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 144 h / -78 - 20 °C 3: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 20 °C View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 1433906-72-9
1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 3 h / 60 °C 2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 144 h / -78 - 20 °C 3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 20 °C 4.1: dichloromethane; diethyl ether / 18 h / -48 - 20 °C 4.2: 2 h / 20 °C View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 1433905-35-1
N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 3 h / 60 °C 2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 144 h / -78 - 20 °C 3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 20 °C 4.1: dichloromethane; diethyl ether / 18 h / -48 - 20 °C 4.2: 2 h / 20 °C 5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 3 h / 60 °C
2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 144 h / -78 - 20 °C
3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 20 °C
4.1: dichloromethane; diethyl ether / 18 h / -48 - 20 °C
4.2: 2 h / 20 °C
5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
View Scheme

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

: 1433906-73-0
C-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-methylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 3 h / 60 °C 2: ammonia; hydrogen / methanol / 17 h / 20 °C / 2250.23 Torr / Sealed tube View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / acetonitrile / 20 °C / Inert atmosphere 2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme

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Xi'an Zhenghao Biotechnology Co., Ltd

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