6427-66-3Relevant articles and documents
Design, synthesis and biological evaluation of novel 4-substituted coumarin derivatives as antitumor agents
An, Ran,Hou, Zhuang,Li, Jian-Teng,Yu, Hao-Nan,Mou, Yan-Hua,Guo, Chun
, (2018)
Herein, fifteen new compounds containing coumarin, 1,2,3-triazole and benzoyl-substituted arylamine moieties were designed, synthesized and tested in vitro for their anticancer activity. The results showed that all tested compounds had moderate antiproliferative activity against MDA-MB-231, a human breast cancer cell line, under both normoxic and hypoxic conditions. Furthermore, the 4-substituted coumarin linked with benzoyl 3,4-dimethoxyaniline through 1,2,3-triazole (compound 5e) displayed the most prominent antiproliferative activities with an IC50 value of 0.03 μM, about 5000 times stronger than 4-hydroxycoumarin (IC50 > 100 μM) and 20 times stronger than doxorubicin (IC50 = 0.60 μM). Meanwhile, almost all compounds revealed general enhancement of proliferation-inhibiting activity under hypoxia, contrasted with normoxia. A docking analysis showed that compound 5e had potential to inhibit carbonic anhydrase IX (CA IX).
Isolation of molybdenum(vi) from simulated leachates of irradiated uranium-aluminum targets using diluted and undiluted sulfate ionic liquids
Raiguel, Stijn,Dehaen, Wim,Binnemans, Koen
, p. 3948 - 3960 (2019)
A method is presented to separate molybdenum from other elements commonly present in oxidative alkaline leachates of irradiated uranium-aluminum targets for the production of molybdenum-99. The separation was accomplished by selective extraction of molybdate anions using triazolium and phosphonium sulfate ionic liquid extractants, either diluted in 1-octanol or undiluted. Molybdenum was then stripped from the organic phase using a sodium hydrogen carbonate solution. The extractant was regenerated by contacting the organic phase with an alkaline sulfate solution. The extraction mechanism and the influence of the diluent on the extractant performance were investigated. The reported method provides a promising alternative to state-of-the-art chromatographic processes, showing potential for limiting the production of radioactive waste.
Combinatorial synthesis of new fluorescent scaffolds using click chemistry
Cleemann, Felix,Karuso, Peter,Kum-Cheung, Wendy Loa
supporting information, (2021/12/08)
Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled using copper(I)- or ruthenium(II)- catalyzed 1,3-dipolar cycloaddition reactions. Using non-fluorescent aromatic azides and aromatic acetylenes, covering a range of electron rich and poor building blocks, the Huisgen cycloaddition afford 1,4-disubstituted or 1,5-disubstituted 1,2,3-triazoles. Using a combinatorial approach by running reaction in parallel in polypropylene 96-well plates we discovered several new fluorescent 1,2,3-triazoles scaffolds. These compounds show diverse interactions with biomolecules that could find applications in biology in, for example, fluorescence microscopy or biomolecule quantification.
Synthesis of Azaylide-Based Amphiphiles by the Staudinger Reaction
Kishida, Natsuki,Suzuki, Hayate,Toyota, Shinji,Yamashina, Masahiro,Yoshizawa, Michito
supporting information, p. 17915 - 17919 (2021/07/09)
Catalyst- and reagent-free reactions are powerful tools creating various functional molecules and materials. However, such chemical bonds are usually hydrolysable or require specific functional groups, which limits their use in aqueous media. Herein, we report the development of new amphiphiles through the Staudinger reaction. Simple mixing of chlorinated aryl azide with a hydrophilic moiety and various triarylphosphines (PAr3) gave rise to azaylide-based amphiphiles NPAr3, rapidly and quantitatively. The obtained NPAr3 formed ca. 2 nm-sized spherical aggregates (NPAr3)n in water. The hydrolysis of NPAr3 was significantly suppressed as compared with those of non-chlorinated amphiphiles nNPAr3. Computational studies revealed that the stability is mainly governed by the decrease in LUMO around the phosphorus atom owing to the o-substituted halogen groups. Furthermore, hydrophobic dyes such as Nile red and BODIPY were encapsulated by the spherical aggregates (NPAr3)n in water.
