643013-14-3

Basic information

• Product Name: 4-(4-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)thiazol-2-amine
• Synonyms: 4-(4-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)thiazol-2-amine
• CAS NO: 643013-14-3
• Molecular Weight: 354.783
• Mol File: 643013-14-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)thiazol-2-amine(643013-14-3)
• EPA Substance Registry System: 4-(4-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)thiazol-2-amine(643013-14-3)

Safety Data

• Hazardous Substances Data: 643013-14-3(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 117174-71-7 N-((4-trifluoromethylphenyl)thiocarbamoyl)benzamide 
• 1736-72-7 1-(4-(trifluoromethyl)phenyl)thiourea 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 643013-15-4 4-{[[4-(4-chlorophenyl)thiazol-2-yl]-(4-trifluoromethylphenyl)amino]methyl}benzoic acid methyl ester 

Relevant articles and documents

Antibacterial synergist, preparation method and uses thereof

The present invention relates to an antibacterial synergist, a preparation method and uses thereof, and specifically discloses a compound represented by a formula (I) and having antibacterial synergyactivity, or an optical isomer, a cis-trans isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. The present invention further discloses a medical composition containing the compound, and uses thereof. According to the present invention, the compound can effectively enhance the antibacterial activity of polymyxin B against Acinetobacter baumannii and Klebsiella pneumoniae, and can be used for the antibacterial treatment of pathogenic bacteria insensitive to polymyxin or having low bacterial inhibition activity. The formula (I) is defined in the specification.

Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors

Sphingosine kinases (SphK1, SphK2) are main regulators of sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in numerous physiological and pathophysiological functions. SphKs are targets for novel anti-cancer and anti-inflammatory agents that can promote cell apoptosis and modulate autoimmune diseases. Herein, we describe the design, synthesis and evaluation of an aminothiazole class of SphK inhibitors. Potent inhibitors have been discovered through a series of modifications using the known SKI-II scaffold to define structure-activity relationships. We identified N-(4-methylthiazol-2-yl)-(2,4′-bithiazol)-2′-amine (24, ST-1803; IC50values: 7.3 μM (SphK1), 6.5 μM (SphK2)) as a promising candidate for further in vivo investigations and structural development.