64321-95-5

Basic information

• Product Name: METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE
• Synonyms: METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE;Benzoic acid, 2-aMino-3-(trifluoroMethyl)-, Methyl ester;3-(Trifluoromethyl)anthranilic acid methyl ester;Methyl 2-amino-3-(trifluoromethyl)
• CAS NO: 64321-95-5
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.16
• Mol File: 64321-95-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 262.1 °C at 760 mmHg
• Flash Point: 112.3 °C
• Appearance: /
• Density: 1.343 g/cm³
• Vapor Pressure: 0.0111mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE(64321-95-5)
• EPA Substance Registry System: METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE(64321-95-5)

Safety Data

• Hazardous Substances Data: 64321-95-5(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-3-trifluoromethylbenzoate is a chemical compound with the molecular formula C9H8F3NO2. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a white to off-white crystalline powder with a melting point of 89-93 °C. METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE is a derivative of benzoic acid and contains an amino group and a trifluoromethyl group, making it useful in various organic synthesis reactions. It has a wide range of potential applications in the pharmaceutical and agricultural industries, making it a valuable chemical compound in the field of organic chemistry.

InChI:InChI=1/C9H8F3NO2/c1-15-8(14)5-3-2-4-6(7(5)13)9(10,11)12/h2-4H,13H2,1H3

Upstream product

• 67-56-1 methanol 
• 391-12-8 7-trifluoromethylisatin 
• 313-12-2 2-amino-3-(trifluoromethyl)benzoic acid 
• 887144-94-7 Togni's reagent II 
• 134-20-3 2-carbomethoxyaniline 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 177420-63-2 2-bromo-3-(trifluoromethyl)benzoic acid 
• 1214362-28-3 methyl 2-bromo-3-(trifluoromethyl)benzoate 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. Compounds of the disclosure have activity as dual modulators of Janus kinase (JAK), alone, or in combination with one or more of an additional mechanism, including a tyrosine kinase, such as TrkA or Syk, and PDE4, and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK and PDE4 by administering a compound herein described.

Visible-light-promoted radical C-H trifluoromethylation of free anilines

The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free anilines with the commercially available and easily handled Togni reagent at room temperature. The resulting products were successfully transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds. This protocol provides an economical and powerful route to trifluoromethylated free anilines.

Oxidation von Isatinen zu Anthranilsaeureestern

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