64340-42-7

Basic information

• Product Name: Naphtho[2,3-b]furan-2(3H)-one,3a,4,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aS,8aS,9aS)-
• Synonyms: Naphtho[2,3-b]furan-2(3H)-one,3a,4,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, [3aS-(3aa,8ab,9aa)]-; (-)-Diplophyllin; Diplophyllin
• CAS NO: 64340-42-7
• Molecular Formula: C15H20 O2
• Molecular Weight: 232.323
• Mol File: 64340-42-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Naphtho[2,3-b]furan-2(3H)-one,3a,4,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aS,8aS,9aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphtho[2,3-b]furan-2(3H)-one,3a,4,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aS,8aS,9aS)-(64340-42-7)
• EPA Substance Registry System: Naphtho[2,3-b]furan-2(3H)-one,3a,4,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aS,8aS,9aS)-(64340-42-7)

Safety Data

• Hazardous Substances Data: 64340-42-7(Hazardous Substances Data)

Upstream product

• 91914-36-2 11α-phenylseleno-7,8αH-eudesm-4-en-12,8-olide 
• 481-05-0 artemisin 
• 1750-99-8 6-epiartemisin 
• 171861-47-5 (S)-2-((2R,3S,4aS)-3-Hydroxy-4a,8-dimethyl-7-oxo-1,2,3,4,4a,7-hexahydro-naphthalen-2-yl)-propionic acid 
• 89362-29-8 3,3-ethanedithio-11α(H)-eudesm-4,5-dien-8,13-olide 
• 91914-35-1 methyl 8α-hydroxy-3-oxo-7αH,11βH-eudesma-1,4-dien-12-oate 
• 58964-73-1 methyl (11S)-3-oxo-8β-hydroxy-7αH-eudesma-1,4-dien-12-oate 
• 58964-75-3 methyl (11S)-3,8-dioxo-7αH-eudesma-1,4-dien-12-oate 
• 58976-58-2 3-oxo-11α(H)-eudesm-1,4-dien-8β,13-olide 
• 58976-59-3 3-oxo-7α,11α(H)-eudesm-4-en-8β,12-olide 
• 58511-25-4 7,8,11α,8βH-eudesm-4-en-12,8-olide 
• 470-17-7 isoalantolactone 
• 113306-91-5 11α-bromo-7,8αH-eudesm-4-en-12,8-olide 

Downstream Products

• 6752-90-5 telekin 

Relevant articles and documents

Acidic isomerization of alantolactone derivatives

A series of derivatives of the natural sesquiterpene lactones alantolactone (1) and isoalantolactone (2) was prepared. The α-methylene-γ- lactone moiety was retained in the structures of these for further modifications using reactions that affected exclusively the nonconjugated double bonds of the decalin ring.

Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane

The daunorubicin and doxorubicin anthracycline antibiotics were modified with the Inula helenium L. sesquiterpene lactones (alantolactone, isoalantolactone, and alloalantolactone) and with their epoxy derivatives. Antiproliferative properties of these conjugates were studied on tumor and normal cell lines. The daunorubicin conjugates with the sesquiterpene lactones (isoalantolactone, allantolactone, and alloalantolactone) and with their epoxy derivatives were found to exhibit the higher activity against human tumor cell lines than the corresponding doxorubicin conjugates. The daunorubicin conjugate with epoxyisoalantolactone proved to be the most effective compound, because it was more cytotoxic than daunorubicin towards a number of cell lines, including those daunorubicin-resistant, and did not affect normal human cells.

Synthesis of yomogin, 1-deoxyivangustin, and 1-deoxy-8-epiivangustin

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