644989-79-7Relevant articles and documents
Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization
Vidya, Ramdas,Eggen, MariJean,Nair, Sajiv K.,Georg, Gunda I.,Himes, Richard H.
, p. 9687 - 9693 (2007/10/03)
An efficient and concise approach to the synthesis of the macrolide core of the cryptophycins has been developed. A novel macrolactonization utilizing a reactive acyl-β-lactam intermediate incorporates the β-amino acid moiety within the 16-membered macrol