647840-35-5Relevant articles and documents
New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 4
Takeda, Yasuyuki,Uoto, Kouichi,Chiba, Jun,Horiuchi, Takao,Iwahana, Michio,Atsumi, Ryo,Ono, Chiho,Terasawa, Hirofumi,Soga, Tsunehiko
, p. 4431 - 4447 (2007/10/03)
It was shown that a new taxane analogue 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, was prone to be metabolized by human liver microsomes. We identified a major metabolite, M-1, generated by h