6480-66-6 Usage
Description
2,6-Dichloro-4-methoxyaniline (CAS# 6480-66-6) is an organic compound characterized by its pale yellow solid appearance. It is primarily utilized in the field of organic synthesis, where it serves as a valuable intermediate for the creation of various chemical products.
Uses
Used in Organic Synthesis:
2,6-Dichloro-4-methoxyaniline is used as a synthetic intermediate for the production of a wide range of chemical compounds. Its unique molecular structure, featuring two chlorine atoms at the 2nd and 6th positions and a methoxy group at the 4th position of the aniline backbone, allows it to participate in various chemical reactions, making it a versatile building block in the synthesis of pharmaceuticals, dyes, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,6-Dichloro-4-methoxyaniline is used as a key component in the development of new drugs. Its chemical properties enable it to be modified and functionalized to create molecules with specific biological activities, targeting various therapeutic areas such as cardiovascular, neurological, and oncological diseases.
Used in Dye Manufacturing:
2,6-Dichloro-4-methoxyaniline is also employed in the dye manufacturing industry as a starting material for the synthesis of various types of dyes. These dyes find applications in different sectors, including textiles, plastics, and printing inks, where they impart color and enhance the visual appeal of the final products.
Used in Chemical Research:
Due to its unique chemical structure, 2,6-Dichloro-4-methoxyaniline is a valuable compound for research purposes. It is used in academic and industrial laboratories to study various aspects of organic chemistry, such as reaction mechanisms, stereochemistry, and the development of new synthetic methods. This research contributes to the advancement of chemical science and the discovery of novel applications for this versatile compound.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 47, p. 2816, 2004 DOI: 10.1021/jm030891w
Check Digit Verification of cas no
The CAS Registry Mumber 6480-66-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,8 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6480-66:
(6*6)+(5*4)+(4*8)+(3*0)+(2*6)+(1*6)=106
106 % 10 = 6
So 6480-66-6 is a valid CAS Registry Number.
InChI:InChI=1S/C7H7Cl2NO/c1-11-4-2-5(8)7(10)6(9)3-4/h2-3H,10H2,1H3
6480-66-6Relevant articles and documents
Synthesis of sterically hindered polychlorinated biphenyl derivatives
Joshi,Vyas,Duffel,Parkin,Lehmler
scheme or table, p. 1045 - 1054 (2011/06/20)
A series of sterically hindered (methoxylated) polychlorinated biphenyl derivatives were synthesized using the Suzuki and the Ullmann coupling reactions. The Suzuki coupling with Pd(dba)2-dicyclohexylphosphino-2,6- dimethoxybiphenyl (DPDB) gave better yields (65-98%) compared to the classic Ullmann coupling reaction (20-38%). Despite the reactive catalyst system, no significant coupling with aromatic chlorine substituents was observed. Crystal structure analysis of four PCB derivatives revealed solid state dihedral angles ranging from 69.7 to 81.0, which indicates that these highly ortho-substituted PCB derivatives have some conformational flexibility. Georg Thieme Verlag Stuttgart.
Synthesis of deuterium labelled 4'-hydroxydiclofenac
Waterhouse, Ian
, p. 1075 - 1083 (2007/10/03)
Diclofenac is a potentially useful substrate for the study of drug-drug interactions caused by modulation of the activity of specific isoforms of cytochrome P450. The synthesis of a deuterium labelled version of its principal human metabolite, 4'-hydroxydiclofenac, for use as an internal standard in LC-MS-MS studies, is described.
Hydrohalogenation of 1,4-Benzoquinone Mono- and Bis(O-acyloximes)
Avdeenko,Glinyanaya
, p. 1154 - 1159 (2007/10/03)
Hydrohalogenation of 1,4-benzoquinone O-acyloximes involves intermediate formation of corresponding 1,4-benzoquinone monooximes and hydroxyamino derivatives. The final hydrochlorination products are 2,6-dichloro-4-alkoxyanilines, hydrobromination yields 3,5-dibromo-4-aminophenol as the final product. O-Acyl- and O,O′-diacyl-1,4-benzoquinone dioximes do not undergo hydrohalogenation.
