74672-01-8

Basic information

• Product Name: 1,5-Dichloro-3-Methoxy-2-nitrobenzene
• Synonyms: 1,5-Dichloro-3-Methoxy-2-nitrobenzene
• CAS NO: 74672-01-8
• Molecular Formula: C₇H₅Cl₂NO₃
• Molecular Weight: 222.0255
• Mol File: 74672-01-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 72.5 °C
• Boiling Point: 322.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.488±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,5-Dichloro-3-Methoxy-2-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Dichloro-3-Methoxy-2-nitrobenzene(74672-01-8)
• EPA Substance Registry System: 1,5-Dichloro-3-Methoxy-2-nitrobenzene(74672-01-8)

Safety Data

• Hazardous Substances Data: 74672-01-8(Hazardous Substances Data)

Usage

General Description

1,5-Dichloro-3-methoxy-2-nitrobenzene is a chemical compound generally characterized by the presence of nitro, methyl ether, and chloro functional groups. This means it can participate in various types of organic reactions. Exact properties such as boiling point, melting point, or density may vary based on the specific conditions such as pressure and temperature, however, it is known to be composed of carbon (C), hydrogen (H), nitrogen (N), oxygen (O), and chlorine (Cl) atoms. Its potential uses or applications depend heavily on its reactivity and are largely determined by the specific industry's needs. Like many similar compounds, it should be handled with care due to potential safety risks associated with its properties.

Upstream product

• 18708-70-8 2,4,6-trichloronitrobenzene 
• 124-41-4 sodium methylate 
• 74672-02-9 3,5-dichloro-2-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 50590-08-4 3,5-dichloro-4-nitrophenol 
• 33719-74-3 3,5-dichloroanisole 
• 591-35-5 3,5-dichlorophenol 

Downstream Products

• 83-21-6 5-chloro-1,3-dimethoxy-2-nitro-benzene 
• 16766-31-7 4,6-Dichloroguaiacol 
• 93839-14-6 2,4-dichloro-6-methoxyaniline 
• 74672-00-7 5-Chlor-3-hydroxy-2-nitrodiphenylamin 
• 6480-66-6 2,6-dichloro-4-methoxyaniline 
• 158966-63-3 1-(2,4-Dichloro-6-methoxy-phenyl)-1H-pyrrole 
• 158966-66-6 2-Chloro-1-(2,4-dichloro-6-methoxy-phenyl)-1H-pyrrole 
• 171058-86-9 2,3-Dichloro-1-(2,4-dichloro-6-methoxy-phenyl)-1H-pyrrole 
• 158966-74-6 1-(2,4-Dichloro-6-methoxy-phenyl)-1H-pyrrole-2-carboxylic acid 
• 158966-76-8 4,5-Dichloro-1-(2,4-dichloro-6-methoxy-phenyl)-1H-pyrrole-2-carboxylic acid 
• 70643-29-7 8-Chlor-1,5-dihydro-6-hydroxy-1-phenyl-2H-1,5-benzodiazepin-2,4(3H)-dion 
• 74672-04-1 6-Chlor-4-hydroxy-1-phenyl-2-benzimidazolessigsaeure-ethylester 
• 74672-03-0 N-(5-Chlor-3-hydroxy-2-nitrophenyl)-N-phenyl-malonsaeure-ethylester-amid 

Relevant articles and documents

Synthesis of sterically hindered polychlorinated biphenyl derivatives

A series of sterically hindered (methoxylated) polychlorinated biphenyl derivatives were synthesized using the Suzuki and the Ullmann coupling reactions. The Suzuki coupling with Pd(dba)2-dicyclohexylphosphino-2,6- dimethoxybiphenyl (DPDB) gave better yields (65-98%) compared to the classic Ullmann coupling reaction (20-38%). Despite the reactive catalyst system, no significant coupling with aromatic chlorine substituents was observed. Crystal structure analysis of four PCB derivatives revealed solid state dihedral angles ranging from 69.7 to 81.0, which indicates that these highly ortho-substituted PCB derivatives have some conformational flexibility. Georg Thieme Verlag Stuttgart.

2,2',3,3',6,6'-Hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11

The structural basis of species differences in cytochrome P450 2B- mediated hydroxylation of 2,2',3,3',6,6'-hexachlorobiphenyl (236HCB) was evaluated by using 14 site-directed mutants of cytochrome P450 2B1 and three point mutants of 2B11 expressed in Escherichia coli. To facilitate metabolite identification, seven possible products, including three hydroxylated and four dihydroxylated hexachlorobiphenyls, were synthesized by direct functionalization of precursors and Ullmann and crossed Ullmann reactions. HPLC and GCfMS analysis and comparison with authentic standards revealed that 2B1, 2B11, and all their mutants produced 4,5-dihydroxy-236HCB and 5-hydroxy- 236HCB, while 2B11 L363V and 2B1 I114V mutants also catalyzed hydroxylation at the 4-position. The amount of products formed by 2B1 mutants I114V, F206L, L209A, T302S, V363A, V363L, V367A, I477A, I477L, G478S, I480A, and I480L was smaller than that of the wild type. I477V exhibited unaltered 236HCB metabolism, and I480V produced twice as much dihydroxy product as the wild type. For 2B11, substitution of Val-114 or Asp-290 with Ile decreased the product yields. Replacement of Leu-363 with Val dramatically altered the profile of 236HCB metabolites. In addition to an increase in the overall level of hydroxylation, the mutant mainly catalyzed hydroxylation at the 4- position. Incubation of P450 2B1 with 5-hydroxy-236HCB produced 4,5- dihydroxy-236HCB, which indicates that 4,5-dihydroxy-236HCB may be formed by a direct hydroxylation of 5-hydroxy-236HCB. The findings from this study demonstrate the importance of residues 114, 206, 209, 302, 363, 367, 477, 478, and 480 in 2B1 and 114, 290, and 363 in 2B11 for 236HCB metabolism.