648908-76-3Relevant articles and documents
10-(2-Benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: A potential inhibitor of GAR transformylase and AICAR transformylase
Marsilje, Thomas H.,Hedrick, Michael P.,Desharnais, Joel,Capps, Kevin,Tavassoli, Ali,Zhang, Yan,Wilson, Ian A.,Benkovic, Stephen J.,Boger, Dale L.
, p. 4503 - 4509 (2007/10/03)
The design and synthesis of 10-(2-benzoxazolcarbonyl)-DDACTHF (1) as an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. Ketone 1 and the corresponding alcohol 13 were evaluated for inhibition of GAR Tfase and AICAR Tfase and the former was found to be a potent inhibitor of recombinant human (rh) GAR Tfase (Ki=600 nM).