648908-77-4

Basic information

• Product Name: Benzoic acid, 4-[2-(2-benzoxazolyl)-2-oxoethyl]-, methyl ester
• CAS NO: 648908-77-4
• Molecular Formula: C17H13NO4
• Molecular Weight: 295.295
• Mol File: 648908-77-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[2-(2-benzoxazolyl)-2-oxoethyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[2-(2-benzoxazolyl)-2-oxoethyl]-, methyl ester(648908-77-4)
• EPA Substance Registry System: Benzoic acid, 4-[2-(2-benzoxazolyl)-2-oxoethyl]-, methyl ester(648908-77-4)

Safety Data

• Hazardous Substances Data: 648908-77-4(Hazardous Substances Data)

Upstream product

• 106918-32-5 4-carbomethoxyphenylacetaldehyde 
• 648908-76-3 methyl 4-[2-(1,3-benzoxazol-2-yl)-2-hydroxyethyl]benzoate 

Downstream Products

• 648908-84-3 di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate 

Relevant articles and documents

10-(2-Benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: A potential inhibitor of GAR transformylase and AICAR transformylase

The design and synthesis of 10-(2-benzoxazolcarbonyl)-DDACTHF (1) as an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. Ketone 1 and the corresponding alcohol 13 were evaluated for inhibition of GAR Tfase and AICAR Tfase and the former was found to be a potent inhibitor of recombinant human (rh) GAR Tfase (Ki=600 nM).