6493-83-0

Basic information

• Product Name: 1-Propanone, 2-methoxy-1-phenyl-
• CAS NO: 6493-83-0
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Mol File: 6493-83-0.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-methoxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-methoxy-1-phenyl-(6493-83-0)
• EPA Substance Registry System: 1-Propanone, 2-methoxy-1-phenyl-(6493-83-0)

Safety Data

• Hazardous Substances Data: 6493-83-0(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Sweet, floral

Common uses

Production of fragrances and flavors, solvent, intermediate in the synthesis of pharmaceuticals and other organic compounds

Safety precautions

Flammable, may cause irritation to skin, eyes, and respiratory system if not used properly

Upstream product

• 67-56-1 methanol 
• 14088-57-4 2-diazo-1-phenyl-1-propanone 
• 5650-40-8 2-hydroxypropiophenone 
• 74-88-4 methyl iodide 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 
• 64-17-5 ethanol 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 98990-64-8 4-Nitro-benzenesulfonic acid 1-methyl-2-oxo-2-phenyl-ethyl ester 
• 4304-93-2 2-methyl-1-methoxy-1-phenyl-oxirane 
• 117984-78-8 triethyl((1-phenylprop-1-en-1-yl)oxy)silane 
• 4079-52-1 methoxymethyl phenyl ketone 
• 6084-15-7 2-iodo-1-phenylpropan-1-one 
• 93-55-0 1-phenyl-propan-1-one 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 

Downstream Products

• 61840-86-6 3-Methoxy-2-phenyl-butan-2-ol 
• 38868-78-9 2,2-dimethoxy-1-phenylpropan-1-one 
• 33524-68-4 5-methyl-3,4,6-triphenyl-pyran-2-one 
• 769-59-5 3-phenyl-butan-2-one 
• 61840-86-6 (±)-erythro-3-methoxy-2-phenylbutan-2-ol 
• 225111-84-2 (1R,2S)-2-methoxy-1-phenyl-1-propanol 
• 623575-45-1 (1S,2S)-2-methoxy-1-phenyl-1-propanol 
• 128571-73-3 (1R,2R)-2-methoxy-1-phenyl-1-propanol 
• 877869-49-3 (Z)-methyl 4-methoxy-2-methyl-3-phenyl-2-pentenoate 
• 36391-93-2 1,2-dimethoxy-1-phenylpropane 
• 91111-01-2 (R)-1-oxo-1-phenylpropan-2-yl acetate 
• 5650-40-8 (R)-2-hydroxy-1-phenylpropan-1-one 
• 5650-40-8 (S)-2-hydroxypropiophenone 
• 19347-08-1 acetic acid 1-methyl-2-oxo-2-phenyl-ethyl ester 

Relevant articles and documents

Rapid, One-Step Synthesis of α-Ketoacetals via Electrophilic Etherification

Herein, we report a rapid, one-step synthesis of α-ketoacetals via electrophilic etherification of α-alkoxy enolates and monoperoxyacetals. Methyl, primary, and secondary α-ketoacetals were obtained in 44-63% yields from tetrahydropyranyl substrates; usin

Mechanistic Insight into Additions of Allylic Grignard Reagents to Carbonyl Compounds

Allylic Grignard reagents exhibit high reactivity and low selectivity in additions to carbonyl compounds. Additions of allylic Grignard reagents to carbonyl compounds were investigated using prenylmagnesium chloride as a mechanistic probe. When the carbonyl group is relatively unhindered, the addition proceeds through a six-membered transition state with allylic transposition. This process generally occurs with no diastereoselectivity because the reaction rates approach the diffusion limit. With hindered ketones, however, this pathway is disfavored, and the addition proceeds through a transition state resembling that of other Grignard reagents.

Additions of Organomagnesium Halides to α-Alkoxy Ketones: Revision of the Chelation-Control Model

The chelation-control model explains the high diastereoselectivity obtained in additions of organometallic nucleophiles to α-alkoxy ketones but fails for reactions of allylmagnesium halides. Low diastereoselectivity in ethereal solvents results from no chelation-induced rate acceleration. Additions of allylmagnesium bromide to carbonyl compounds are diastereoselective using CH2Cl2 as the solvent even though rate acceleration is still absent. Stereoselectivity likely arises from the predominance of the chelated form in solution. Therefore, a revised chelation-control model is proposed.