64991-61-3

Basic information

• Product Name: diphenyl(4-pyridyl)methyl chloride hydrochloride
• Synonyms: diphenyl(4-pyridyl)methyl chloride hydrochloride
• CAS NO: 64991-61-3
• Molecular Weight: 316.23
• Mol File: 64991-61-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diphenyl(4-pyridyl)methyl chloride hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl(4-pyridyl)methyl chloride hydrochloride(64991-61-3)
• EPA Substance Registry System: diphenyl(4-pyridyl)methyl chloride hydrochloride(64991-61-3)

Safety Data

• Hazardous Substances Data: 64991-61-3(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 14548-46-0 4-Benzoylpyridine 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 

Downstream Products

• 921588-02-5 6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexanol 
• 921588-06-9 (Z)-4-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]2-buten-1-ol 
• 859206-63-6 5'-[diphenyl(4-pyridyl)methyl]amino-2',5'-dideoxyuridine 
• 108229-08-9 N-Cyclododecylidene-N'-(diphenyl-pyridin-4-yl-methyl)-hydrazine 
• 90334-45-5 N-(Diphenyl-pyridin-4-yl-methyl)-N'-[1-methyl-hept-(Z)-ylidene]-hydrazine 
• 90334-44-4 N-Cyclohexylidene-N'-(diphenyl-pyridin-4-yl-methyl)-hydrazine 
• 108229-07-8 acetone diphenyl-4-pyridylmethylhydrazone 
• 77422-49-2 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-3-phenyl-propionic acid 
• 77431-74-4 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-3-phenyl-propionic acid methyl ester 
• 77422-47-0 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 77422-41-4 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 
• 62982-22-3 (S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionic acid 
• 77422-44-7 (S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionic acid methyl ester 
• 77422-48-1 {(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-acetic acid methyl ester 

Relevant articles and documents

Modified 5'-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase

2'-Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this Plasmodium falciparum enzyme. Herein we report further structure-activity studies; in particular, variations of the 5'-trityl group, the introduction of various substituents at the 3'-position of deoxyuridine, and modifications of the base. Compounds were tested against both the enzyme and the parasite. Variations of the 5'-trityl group and of the 3'-substituent were well tolerated and yielded active compounds. However, there is a clear requirement for the uracil base for activity, because modifications of the uracil ring result in loss of enzyme inhibition and significant decreases in antiplasmodial action. Fewer trips to the dUMP: dUTPase is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this P.falciparum enzyme. Herein we report further structure-activity studies of the 5'-trityl group, the introduction of various substituents at the 3'-position of deoxyuridine, and modifications of the base.

AZO ANIONS IN SYNTHESIS. USE OF TRITYL- AND DIPHENYL-4-PYRIDYLMETHYLHYDRAZONES FOR REDUCTIVE C-C BOND FORMATION.

The lithium salts of trityl- and diphenyl-4-pyridylmethyl-hydrazones of both aldehydes and ketones react with electrophiles (alkyl halides, aldehydes, ketones, crotonates) at low temperature to form C-trapped azo compounds; these intermediates decompose homolytically with loss of nitrogen below room temperature and can be diverted in a synthetically useful way to alkanes, alkenes, alcohols or saturated esters.