1620-30-0

Basic information

• Product Name: Diphenyl(4-pyridyl)methanol
• Synonyms: ALPHA,ALPHA-DIPHENYL-4-PYRIDINEMETHANOL;ALPHA,ALPHA-DIPHENYL-4-PYRIDYLMETHANOL;ALPHA-(4-PYRIDYL)BENZHYDROL;A,A-DIPHENYL-4-PYRIDINEMETHANOL;A-4-PYRIDYLBENZHYDROL;DIPHENYL(4-PYRIDYL)METHANOL;(4-Pyridyl)benzhydrol;α-(4-Pyridyl)benzhydrol
• CAS NO: 1620-30-0
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.32
• EINECS: 216-584-7
• Product Categories: Pharmaceutical Intermediates;Heterocyclic Compounds
• Mol File: 1620-30-0.mol
• Article Data: 19

Chemical Properties

• Melting Point: 240 °C
• Boiling Point: 445.268 °C at 760 mmHg
• Flash Point: 223.09 °C
• Appearance: /
• Density: 1.169 g/cm³
• Vapor Pressure: 1.04E-08mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: Diphenyl(4-pyridyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: Diphenyl(4-pyridyl)methanol(1620-30-0)
• EPA Substance Registry System: Diphenyl(4-pyridyl)methanol(1620-30-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39-36/37/39-22
• WGK Germany: 3
• Hazardous Substances Data: 1620-30-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 1903, 1990 DOI: 10.1002/jhet.5570270711

InChI:InChI=1/C18H15NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-14,20H

Upstream product

• 54750-97-9 4-lithiopyridine 
• 119-61-9 benzophenone 
• 55-22-1 pyridine-4-carboxylic acid 
• 1570-45-2 isonicotinic acid ethylester 
• 14548-46-0 4-Benzoylpyridine 
• 591-51-5 phenyllithium 
• 110-91-8 morpholine 
• 100-48-1 pyridine-4-carbonitrile 
• 626-61-9 4-Chloropyridine 
• 100-70-9 2-Cyanopyridine 
• 464-72-2 tetraphenylethane-1,2-diol 
• 109-89-7 diethylamine 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 108770-97-4 4-pyridyl phenyl sulfoxide 

Downstream Products

• 109810-27-7 4-(methoxydiphenylmethyl)pyridine 
• 113012-26-3 4-(hydroxy-diphenyl-methyl)-1-methyl-pyridinium iodide 
• 3678-72-6 diphenyl-4-pyridylmethane 
• 5704-22-3 4-(diphenylmethyl)-1-methylpiperidine 
• 115-46-8 C₁₈H₂₁NO 
• 62982-12-1 S-(diphenyl-4-pyridylmethyl)-L-cysteine 
• 64991-61-3 diphenyl(4-pyridyl)methyl chloride hydrochloride 
• 164725-87-5 2-Ethoxycarbonylmethyl-4-(hydroxy-diphenyl-methyl)-2H-pyridine-1-carboxylic acid methyl ester 

Relevant articles and documents

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Preparation method of alpha, alpha-diphenyl-4-piperidine methanol

The invention discloses a preparation method of alpha, alpha-diphenyl-4-piperidine methanol, which comprises the following steps of by using benzophenone and 4-cyanopyridine as raw materials, carrying out free radical coupling reaction under the action of alkali metal to obtain alpha, alpha-diphenyl-4-piperidine methanol, reacting the obtained alpha, alpha-diphenyl-4-pyridine methanol with a benzylation reagent to generate N-benzyl-alpha, alpha-diphenyl-4-pyridine methanol, carrying out hydroboration reduction on the N-benzyl-alpha, alpha-diphenyl-4-pyridine methanol to obtain (1-benzyl-1, 2, 3, 6-tetrahydropyridine-4-yl)benzhydrol, ane enabling (1-benzyl-1, 2, 3, 6-tetrahydropyridine-4-yl)benzhydrol to be subjected to catalytic hydrogenation and debenzylation protection to obtain alpha, alpha-diphenyl-4-piperidine methanol. The method has the advantages of cheap and accessible raw materials, high reaction yield and high controllability, and is suitable for industrial production requirements.

Preparation method of diphenyl(4-pyridyl)methanol

The invention relates to a preparation method of diphenyl(4-pyridyl)methanol. According to the method, benzophenone and 4-cyanopyridine are taken as raw materials to carrying out a one-step reaction to prepare the diphenyl(4-pyridyl)methanol. The preparation method is simple in process, low in cost, high in yield and high in controllability, and is suitable for industrial production.