65490-17-7

Basic information

• Product Name: Phenol, 4-methoxy-2-(1-methylethenyl)-
• CAS NO: 65490-17-7
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Mol File: 65490-17-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 4-methoxy-2-(1-methylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-methoxy-2-(1-methylethenyl)-(65490-17-7)
• EPA Substance Registry System: Phenol, 4-methoxy-2-(1-methylethenyl)-(65490-17-7)

Safety Data

• Hazardous Substances Data: 65490-17-7(Hazardous Substances Data)

Upstream product

• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 6295-35-8 6-methoxy-4-methyl-chromen-2-one 

Downstream Products

• 1610359-53-9 9-methoxy-4-methyl-1,2-diphenylspiro[4,5]deca-1,3,7,9-tetraen-6-one 
• 1416217-41-8 1-benzyl-6-chloro-4'-(2-hydroxy-5-methoxyphenyl)-6'-methoxy-4'-methyl-3',4'-dihydro-1'H-spiro[indoline-3,2'-quinolin]-2-one 
• 1392836-30-4 2-((2S,4S)-2-(3,4-dichlorophenyl)-6-methoxy-4-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-4-methoxyphenol 
• 1392836-27-9 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)-4-methoxyphenol 

Relevant articles and documents

OH-directed alkynylation of 2-vinylphenols with ethynyl benziodoxolones: A fast access to terminal 1,3-enynes

The first direct alkynylation of 2-vinylphenols was developed. The rationally optimized hypervalent iodine reagent TIPS-EBX in combination with [(CpRhCl2)2] as a C-H-activating transition metal catalyst enables the construction of a variety of highly substituted 1,3-enynes in high yields of up to 98 %. This novel C-H activation method shows excellent chemoselectivity and exclusive (Z)-stereoselectivity, and it is also remarkably mild and tolerates a variety of functional groups. Furthermore, synthetic modifications of the resulting 1,3-enynes were demonstrated. To our knowledge, this is the first example for an OH-directed C-H alkynylation with hypervalent iodine reagents.

Ethylene glycol as hydrogen donor for the syntheses of thymol analogues via hydrolysis of 4-methylcoumarins

Treatment of 4-methylcoumarins with potassium hydroxide in ethylene glycol resulted in the formation of the 'normal' 2-isopropenylphenols and/or the 'abnormal' 2-isopropylphenols depending on the nature of the substrates. The solvent ethylene glycol was b