6576-06-3

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
• Synonyms: 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE;Ethanone, 1-(4-methoxyphenyl)-2-(4-pyridinyl)-
• CAS NO: 6576-06-3
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Mol File: 6576-06-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(6576-06-3)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(6576-06-3)

Safety Data

• Hazardous Substances Data: 6576-06-3(Hazardous Substances Data)

Usage

Description

1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE, also known as 4-Methoxy-1-acetyl-2-pyridyl benzene, is a yellowish crystalline solid with the molecular formula C14H13NO2 and a molecular weight of 227.26 g/mol. It is a chemical compound commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds, including antipsychotic and antihistamine drugs. It may also have potential applications in agricultural and veterinary medicine.
Used in Pharmaceutical Industry:
1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE is used as a building block for the synthesis of various pharmaceutical compounds, such as antipsychotic and antihistamine drugs, due to its unique chemical structure and properties.
Used in Agricultural and Veterinary Medicine:
1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE may have potential applications in agricultural and veterinary medicine, although the specific uses have not been detailed in the provided materials.

Upstream product

• 108-89-4 picoline 
• 94-30-4 ethyl 4-methoxybenzoate 
• 874-90-8 4-methoxybenzonitrile 
• 6580-93-4 4-<2-Hydroxy-2-(p-methoxyphenyl)ethyl>pyridine 
• 303162-29-0 (4-methoxyphenyl)(2-methylaziridin-1-yl)methanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 94-00-8 4-pyridinecarboxylic acid phenyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 171001-11-9 (R*,S*)-1-(4-methoxyphenyl)-1-phenyl-2-(4-pyridinyl)ethanol 
• 97422-32-7 [4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine 
• 171000-98-9 (E)-1-(4-hydroxyphenyl)-1-phenyl-2-(4-pyridinyl)ethene 

Relevant articles and documents

THERAPEUTIC METHODS AND COMPOUNDS

The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R1-R5 Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful to treat malaria.

Continuous-Flow Synthesis of 2 H -Azirines and Their Diastereoselective Transformation to Aziridines

Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-subst

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors

A novel series of 4-phenyl-5-pyridyl-1,3-thiazole analogues possessing potent in vitro inhibitory activity against p38 mitogen-activated protein kinase and the release of tumor necrosis factor-α (TNF-α) from human monocytic THP-1 cells stimulated by lipopolysaccharide has been identified. Subsequent structure-activity relationship (SAR) studies and optimization for absorption, distribution, metabolism, and elimination (ADME) profiles led to the identification of compounds 7g and 10b as orally active lead candidates that block the in vivo production of proinflammatory cytokine (TNF-α). In pharmacokinetic studies, compound 10b showed good oral administration in mice and demonstrated significant in vivo anti-inflammatory activity in an anti-collagen monoclonal antibody-induced arthritis mouse model (minimum effective dose (MED)=30 mg/kg). Further elucidation of this class of compounds may provide novel anti-inflammatory agents, such as anti-rheumatoid arthritis drugs.