65836-73-9Relevant articles and documents
Aggregation-induced emission behavior of a pH-controlled molecular shuttle based on a tetraphenylethene moiety
Han, Xie,Cao, Meijiao,Xu, Zhiqiang,Wu, Di,Chen, Zhao,Wu, Anxin,Liu, Sheng Hua,Yin, Jun
, p. 9767 - 9774 (2015/10/05)
Tetraphenylethene (TPE) with aggregation-induced emission (AIE) behavior as a popular backbone is applied widely in the construction of functional supramolecular systems. In this work, a TPE-based linear molecule having amide and amine units is synthesize
Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor
Huynh, Tracey,Valant, Celine,Crosby, Ian T.,Sexton, Patrick M.,Christopoulos, Arthur,Capuano, Ben
, p. 8196 - 8200 (2013/11/06)
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library of putative M4 PAMs derived from VU0152100 and VU10005. These compounds investigate the pharmacological effects of previously identified methoxy and fluoro substituents, providing useful estimates of affinity (KB), cooperativity (αβ), and direct agonist properties (τB).