660837-08-1

Basic information

• Product Name: 4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine
• Synonyms: 4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine;2-(2-Methyl-5-aminophenylamino)-4-(3-pyridyl)thiazole;4-Methyl-N3-[4-(3-pyridinyl)-2-thiazolyl]-1,3-benzenediamine;6-methyl-N1-(5-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine
• CAS NO: 660837-08-1
• Molecular Formula: C₁₅H₁₄N₄S
• Molecular Weight: 282.36346
• Mol File: 660837-08-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 509.391 °C at 760 mmHg
• Flash Point: 261.87 °C
• Appearance: /
• Density: 1.312 g/cm³
• PKA: 4.69±0.10(Predicted)
• CAS DataBase Reference: 4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine(660837-08-1)
• EPA Substance Registry System: 4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine(660837-08-1)

Safety Data

• Hazardous Substances Data: 660837-08-1(Hazardous Substances Data)

Usage

General Description

4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diamine is a synthetic compound bearing the characteristics of a chemically organic structure. It contains atoms of carbon, nitrogen, oxygen and sulfur orbiting around the central benzene ring. The specificity of its structure indicates its potential role in scientific research, most likely in biochemical research and pharmacology where it may be studied for its chemical reactivity, binding affinity or potential biological activity. Currently, there is limited information available about this compound; thus, further studies are essential for understanding its properties and potential applications. It's important to handle such compounds with care due to potential risks and unknown health hazards that might exist.

Upstream product

• 1048007-94-8 N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)thiazol-2-amine 
• 17694-68-7 3-(2-bromoacetyl)pyridine hydrobromide 
• 99-55-8 2-methyl-5-nitroaniline 
• 350-03-8 methyl-3-pyridylketone 
• 660838-06-2 N-(2-methyl-5-tert-butoxycarbonylamino)phenyl-thiourea 
• 790299-78-4 2-methyl-5-tert-butoxycarbonylaminoaniline hydrobromide salt 

Downstream Products

• 790299-79-5 masitinib 

Relevant articles and documents

2,3-dimethyl-6-urea -2H-indazoles and its preparation method and application

The invention discloses a 2, 3-dimethyl-6-urea-2H-indazole compound shown by the following general formula (I), medicinal salt or a solvent compound thereof, wherein Ar is substituted or unsubstituted phenyl or aromatic matrix. The invention also discloses a preparation method and application of the compound. The compound can regulate signal transduction of tyrosine kinase, inhibit bad cellular proliferation, and particularly has obvious curative effect for tumors.

PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS

The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (I) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.

2-(3-AMINOARYL) AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS

The present invention relates to the use of masitinib or a pharmaceutically acceptable salt thereof, and in particular of masitinib mesylate, for the preparation of a medicament for the treatment of GIST, to the use of this therapy for the treatment of GIST, and a method of treating mammals, including humans, suffering from GIST by administering to said mammal in need of such treatment an effective dose of masitinib, and in particular masitinib mesylate