660852-86-8 Usage
Description
(R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER is a chiral compound derived from oxazolidine-3,4-dicarboxylic acid, featuring a (R)-2,2-dimethyl oxazolidine group and a tert-butyl ester group. Its (R)designation highlights its specific stereochemistry, which is crucial for its potential applications in various fields.
Uses
Used in Pharmaceutical and Medicinal Chemistry:
(R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER is used as a chiral building block for the synthesis of other compounds, particularly in the development of pharmaceuticals and medicines. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is essential for ensuring the desired biological activity and reducing potential side effects.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER serves as a valuable intermediate, facilitating the construction of complex molecular structures. Its presence can enhance the efficiency and selectivity of various chemical reactions, contributing to the advancement of synthetic methodologies.
Used in Drug Discovery:
(R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER is utilized in drug discovery processes, where its potential biological activity and pharmacological effects are explored. Researchers investigate its interactions with biological targets to identify new therapeutic agents or optimize existing ones.
Used as a Chiral Resolving Agent:
In the context of chiral chemistry, (R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER can be employed as a chiral resolving agent. This application is vital for the separation and purification of enantiomers, ensuring that only the desired stereoisomer is obtained for use in pharmaceuticals or other applications where stereochemistry plays a critical role.
Check Digit Verification of cas no
The CAS Registry Mumber 660852-86-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,0,8,5 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 660852-86:
(8*6)+(7*6)+(6*0)+(5*8)+(4*5)+(3*2)+(2*8)+(1*6)=178
178 % 10 = 8
So 660852-86-8 is a valid CAS Registry Number.
660852-86-8Relevant articles and documents
ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
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Paragraph 0481; 0484, (2015/09/23)
Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta- associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
NMR characterization and conformational analysis of a potent papain-family cathepsin L-like cysteine protease inhibitor with different behaviour in polar and apolar media
Rotondo, Archimede,Ettari, Roberta,Zappalà, Maria,De Micheli, Carlo,Rotondo, Enrico
, p. 337 - 343 (2015/01/16)
We recently reported the synthesis, of a potent papain-family cathepsin L-like cysteine protease inhibitor, as new lead compound for the development of new drugs that can be used as antiprotozoal agents. The investigation of its conformational profile is
Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position
Qian, Wenjian,Park, Jung-Eun,Liu, Fa,Lee, Kyung S.,Burke Jr., Terrence R.
, p. 3996 - 4003 (2013/07/27)
Protein-protein interactions (PPIs) mediated by the polo-box domain (PBD) of polo-like kinase 1 (Plk1) serve important roles in cell proliferation. Critical elements in the high affinity recognition of peptides and proteins by PBD are derived from pThr/pS
