663179-23-5

Basic information

• Product Name: 3-(tert-butyl-dimethyl-silanyloxy)-3-(4-dimethylcarbamoyloxy-phenyl)-propionic acid ethyl ester
• Synonyms: 3-(tert-butyl-dimethyl-silanyloxy)-3-(4-dimethylcarbamoyloxy-phenyl)-propionic acid ethyl ester
• CAS NO: 663179-23-5
• Molecular Weight: 395.571
• Mol File: 663179-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(tert-butyl-dimethyl-silanyloxy)-3-(4-dimethylcarbamoyloxy-phenyl)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-butyl-dimethyl-silanyloxy)-3-(4-dimethylcarbamoyloxy-phenyl)-propionic acid ethyl ester(663179-23-5)
• EPA Substance Registry System: 3-(tert-butyl-dimethyl-silanyloxy)-3-(4-dimethylcarbamoyloxy-phenyl)-propionic acid ethyl ester(663179-23-5)

Safety Data

• Hazardous Substances Data: 663179-23-5(Hazardous Substances Data)

Upstream product

• 92310-70-8 4-formylphenyl N,N-dimethylcarbamate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 578730-04-8 3-(4-dimethylcarbamoyloxyphenyl)-3-hydroxypropionic acid ethyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 663180-14-1 dimethyl-carbamic acid 4-[1-(tert-butyl-dimethyl-silanyloxy)-3-(4-nitro-phenoxy)-propyl]-phenyl ester 
• 663180-16-3 dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester 
• 578730-06-0 dimethylcarbamic acid 4-[1-bromo-3-(4-nitrophenoxy)propyl]phenyl ester 
• 578730-05-9 dimethylcarbamic acid 4-[1-(tert-butyldimethylsilanyloxy)-3-hydroxypropyl]phenyl ester 

Relevant articles and documents

Design, Synthesis and Structure-Activity Relationships of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter as Potential Agents for Alzheimer's Disease

We have designed and synthesized a dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT) as a novel class of treatment drugs for Alzheimer's disease on the basis of a hypothetical model of the AChE active site. Dual inhibitions of AChE and SERT would bring about greater therapeutic effects than AChE inhibition alone and avoid adverse peripheral effects caused by excessive AChE inhibition. Compound (S)-6j exhibited potent inhibitory activities against AChE (IC50 = 101 nM) and SERT (IC50 = 42 nM). Furthermore, (S)-6j showed inhibitory activities of both AChE and SERT in mice brain following oral administration.