66464-86-6

Basic information

• Product Name: 3-CHLOROPHENYLACETYLHYDRAZIDE
• Synonyms: 3-CHLOROPHENYLACETYLHYDRAZIDE;(3-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE;3-Chloro-benzeneacetic acid hydrazide;2-(3-CHLOROPHENYL)ACETOHYDRAZINE
• CAS NO: 66464-86-6
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Mol File: 66464-86-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 394.9 °C at 760 mmHg
• Flash Point: 192.6 °C
• Appearance: /
• Density: 1.283 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CHLOROPHENYLACETYLHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROPHENYLACETYLHYDRAZIDE(66464-86-6)
• EPA Substance Registry System: 3-CHLOROPHENYLACETYLHYDRAZIDE(66464-86-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 66464-86-6(Hazardous Substances Data)

Usage

General Description

3-CHLOROPHENYLACETYLHYDRAZIDE, also known as 3-chlorophenylacetylhydrazine, is a chemical compound with the molecular formula C8H9ClN2O. It is a white to off-white crystalline powder that is used as a reagent and intermediate in the synthesis of other organic compounds. 3-CHLOROPHENYLACETYLHYDRAZIDE has applications in the pharmaceutical industry, where it is used in the production of hydrazide derivatives of drugs, as well as in the manufacture of agricultural chemicals. It is also utilized in research and development laboratories for its potential medicinal and biocidal properties. However, it is important to handle this chemical with caution, as it may be harmful if ingested, inhaled, or absorbed through the skin, and proper safety measures should be followed when working with it.

Upstream product

• 14062-29-4 ethyl 2-(3-chlorophenyl)acetate 
• 1878-65-5 3-chlorophenylacetic acid 
• 53088-68-9 methyl 3-chlorophenylacetate 

Downstream Products

• 34547-05-2 5-(3-chloro-benzyl)-3H-[1,3,4]oxadiazol-2-one 
• 858954-57-1 2-(3-chlorophenyl)-N'-[(1E)-(2-hydroxyphenyl)methylidene]acetohydrazide 
• 871708-14-4 (3-chloro-phenyl)-acetic acid-[1-(3-amino-1H-indazol-5-yl)-meth-(E)-yliden]-hydrazide 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF

The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.

Thiadiazole-based Thioglycosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors

A series of thiadiazole-based thioglycosides were synthesized as SGLT2 inhibitors from D-glucose, D-galactose and a variety of phenylacetic acids via a convenient protocol in 8 steps and evaluated in vivo with an oral glucose tolerance test (OGTT), and 5-benzyl-1,3,4-thiadiazol-2-yl 1-thio-β-D-glucopyranoside (1a) was the most efficacious to suppress the blood glucose excursion during OGTT.