14062-29-4

Basic information

• Product Name: ETHYL 3-CHLOROPHENYLACETATE
• Synonyms: ETHYL 3-CHLOROPHENYLACETATE;Ethyl 3-chlorophenylacetate, 98+%;(3-CHLOROPHENYL)ACETIC ACID ETHYL ESTER;Ethyl 3-chlorophenylacetate, 98+% 25GR;Ethyl 3-chlorophenylacetate, 98+% 5GR;Ethyl 2-(3-chlorophenyl)acetate
• CAS NO: 14062-29-4
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.65
• EINECS: 1533716-785-6
• Mol File: 14062-29-4.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 258.431°C at 760 mmHg
• Flash Point: 118.312°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.512-1.514
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL 3-CHLOROPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-CHLOROPHENYLACETATE(14062-29-4)
• EPA Substance Registry System: ETHYL 3-CHLOROPHENYLACETATE(14062-29-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/22
• Safety Statements: 37/39-26
• Hazardous Substances Data: 14062-29-4(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C10H11ClO2/c1-2-13-10(12)7-8-4-3-5-9(11)6-8/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 1529-41-5 3-chloro-benzeneacetonitrile 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 58357-84-9 2-(3-chlorophenyl)acetamide 
• 7023-78-1 2-diazo-1-(3-chlorophenyl)ethanone 
• 6048-06-2 ethyl-p-chlorocinnamate 
• 20511-20-0 ethyl p-methylcinnamate 
• 1878-65-5 3-chlorophenylacetic acid 
• 63503-60-6 3-chlorophenylboronic acid 
• 105-36-2 ethyl bromoacetate 
• 618-46-2 m-Chlorobenzoyl chloride 
• 201230-82-2 carbon monoxide 
• 108-41-8 1-chloro-3-methylbenzene 
• 585524-80-7 2-(3-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 

Downstream Products

• 41024-33-3 (+/-)-α-bromo-(3-chlorophenyl)acetic acid ethyl ester 
• 82129-59-7 1-(3-chlorophenyl)-2,4-pentanedione 
• 200215-46-9 3-oxo-2-(3-chlorophenyl)propionic acid ethyl ester 
• 93307-66-5 2-(3-chlorophenyl)malonic acid diethyl ester 
• 946005-77-2 C₁₃H₁₃N₂O₂Cl 
• 946005-78-3 C₁₁H₉N₂O₂Cl 
• 926008-51-7 5-(3-chlorophenyl)pyrimidine-4,6-diol 

Relevant articles and documents

Divergent Synthesis of α-Fluorinated Carbonyl and Carboxyl Derivatives by Double Electrophilic Activation of Amides

A straightforward and divergent entry to α-fluorinated carbonyl and carboxyl derivatives is reported. Upon activation of amides with triflic anhydride and a 2-halo-pyridine and subsequent trapping of the resulting keteniminium ions with nucleophiles followed by a second electrophilic activation with NFSI and final hydrolysis, a range of amides can be transformed to α-fluorinated ketones, esters, and amides under mild conditions. Moreover, this reaction can be performed to yield enantioenriched products with a traceless chiral auxiliary.

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Selective aryne formation via Grob fragmentation from the [2+2] cycloadducts of 3-triflyloxyarynes

A chemoselective ring-opening protocol of the formal [2+2] cycloadducts of 3-triflyloxyarynes was developed to generate 2,3-aryne intermediate via Grob fragmentation. A variety of 1,3-di- and 1, 2, 3-trisubstituted arenes could be readily accessed through this [2+2] cycloaddition-2,3-aryne formation sequence. The regioselectivity in these transformations originates from the steric repulsion of the aliphatic chain.