946005-78-3Relevant articles and documents
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling
Gemma, Sandra,Kukreja, Gagan,Campiani, Giuseppe,Butini, Stefania,Bernetti, Matteo,Joshi, Bhupendra P.,Savini, Luisa,Basilico, Nicoletta,Taramelli, Donatella,Yardley, Vanessa,Bertamino, Alessia,Novellino, Ettore,Persico, Marco,Catalanotti, Bruno,Fattorusso, Caterina
, p. 3535 - 3539 (2008/02/07)
The design, synthesis, and antiplasmodial activity of antimalarial heterodimers based on the 1,4-bis(3-aminopropyl)piperazine linker is reported. In this series key structural elements derived from quinoline antimalarials were coupled to fragments capable