66490-33-3 Usage
Description
4-Chloro-benzo[b]thiophene is an organic chemical compound belonging to the class of benzothiophenes. It features a benzene ring fused with a thiophene ring, with a chlorine atom attached at the 4th position. 4-chloroBenzo[b]thiophene is characterized by its unique chemical structure and properties, making it a versatile intermediate in the synthesis of various pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Industry:
4-Chloro-benzo[b]thiophene is used as a key intermediate in the synthesis of 1-aryloxy-3-piperidinylpropan-2-ols, which are compounds with dual 5-HT1A receptor antagonism. These compounds have potential applications in the treatment of various central nervous system disorders, such as anxiety, depression, and schizophrenia, due to their ability to modulate serotonin receptor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 66490-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,4,9 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66490-33:
(7*6)+(6*6)+(5*4)+(4*9)+(3*0)+(2*3)+(1*3)=143
143 % 10 = 3
So 66490-33-3 is a valid CAS Registry Number.
66490-33-3Relevant articles and documents
Unexpected formation of 4,7-dihalobenzo[b]thiophenes using Ohira-Bestmann reagent and reactivity of the halogen-substituted benzo[b]thiophenes in Suzuki-Miyaura coupling with phenylboronic acid
Toyota, Kozo,Mutoh, Hirotaka,Kishi, Hiroki,Mikami, Shinichi,Tanaka, Hiroki,Yoshida, Shuhei,Naganuma, Daisuke
, p. 1355 - 1374 (2019/12/23)
Reaction of 2-(1-adamantylsulfanyl)-3,6-dihalobenzaldehydes with Ohira-Bestmann reagent gave 4,7-dihalobenzo[b]thiophenes along with normal alkyne products. Nine types of 4,7-dihalobenzo[b]thiophenes bearing chlorine, bromine, or iodine atoms, were prepared by this method. Regioselectivity in Suzuki-Miyaura cross coupling reactions of the 4,7-dihalobenzo[b]thiophenes with PhB(OH)2 was also studied.
Substituted oxoazaheterocyclyl compounds
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Page/Page column 68, (2008/06/13)
This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..