66504-71-0

Basic information

• Product Name: 2-bromo-2-chlorophenyl acetic acid methyl ester
• Synonyms: 2-bromo-2-chlorophenyl acetic acid methyl ester;methyl 2-bromo-2-(2-chlorophenyl)acetate
• CAS NO: 66504-71-0
• Molecular Formula: C9H9BrClO2
• Molecular Weight: 264.52356
• Mol File: 66504-71-0.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-2-chlorophenyl acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2-chlorophenyl acetic acid methyl ester(66504-71-0)
• EPA Substance Registry System: 2-bromo-2-chlorophenyl acetic acid methyl ester(66504-71-0)

Safety Data

• Hazardous Substances Data: 66504-71-0(Hazardous Substances Data)

Usage

General Description

2-bromo-2-chlorophenyl acetic acid methyl ester is a chemical compound with the molecular formula C9H8BrClO2. It is also known as fenac or diclofenac and is used as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. It works by inhibiting the production of prostaglandins, which are responsible for pain and inflammation in the body. However, it can also cause side effects such as stomach ulcers and kidney problems, and should be used with caution. 2-bromo-2-chlorophenyl acetic acid methyl ester is often found in pharmaceutical products and is considered an important medication in the treatment of various conditions such as arthritis, migraines, and menstrual cramps.

Upstream product

• 67-56-1 methanol 
• 138647-05-9 2-bromo-2-(2-chlorophenyl)acetyl chloride 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 10421-85-9 2-chloromandelic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 101-41-7 benzeneacetic acid methyl ester 
• 85259-19-4 methyl 2-bromo-2-(2-chlorophenyl)acetate 
• 141109-25-3 (S)-(+)-2-bromo-2-(2-chlorophenyl)acetic acid 

Relevant articles and documents

Method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling aqueous solution method

The invention provides a method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling an aqueous solution method. According to the method, o-chlorophenylacetic acid is adopted as a main raw material, an organic solvent and water in an appropriate proportion are optimized to serve as a bromination mixed solvent, a two-phase reaction mode is adopted in the reaction process, a bromine-containing wastewater solution can be reused without complex treatment, a target product is prepared through bromination and esterification reactions, and the yield reaches78% or above; the method provided by the invention is based on a technical scheme of recycling an aqueous solution containing a bromination reagent. In the process production process, the input amountof a new bromination reagent is reduced to a great extent, the bromine atom utilization rate of the bromination reagent is increased, the problems of wastewater treatment and discharge are reduced, the pressure of environmental pollution is reduced, meanwhile, the reaction conditions are relatively mild, treatment is simple, and industrial production is facilitated.

HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

Synthesis and Antibacterial Screening of 1,3,4-Thiadiazoles, 1,2,4-Triazoles, and 1,3,4-Oxadiazoles Containing Piperazine Nucleus

A series of novel 1,3,4-thiadiazoles, 1,2,4-triazoles, and 1,3,4-oxadiazoles were synthesized by cyclization of substituted 1-(2-(2-chlorophenyl)-2-(4-(2,3-dichlorophenyl)piperazin-1-yl)acetyl)thiosemicarbazide. The structures of all newly synthesized compounds were elucidated on the basis of spectral studies. Some of them were screened for their antibacterial activity. The compounds 6b, 6c, 8e, 9a, and 9b have shown moderate activity towards Bacillus Subtilis and Escherichia Coli.