67022-39-3 Usage
Description
Methotrexate γ-Methyl Ester is a derivative of Methotrexate, which is a folic acid antagonist. It is characterized by the presence of a γ-methyl ester group, which differentiates it from the parent compound. Methotrexate γ-Methyl Ester is an impurity found in Methotrexate, a medication with established antineoplastic and antirheumatic properties.
Uses
1. Used in Anticancer Applications:
Methotrexate γ-Methyl Ester is used as an antineoplastic agent for the treatment of various types of cancer. It functions by inhibiting the activity of dihydrofolate reductase, a key enzyme involved in the synthesis of DNA and RNA, thereby disrupting the rapid cell division associated with cancerous growth.
2. Used in Antirheumatic Applications:
Methotrexate γ-Methyl Ester is also utilized as an antirheumatic agent, particularly in the management of autoimmune diseases such as rheumatoid arthritis. It exhibits anti-inflammatory and immunosuppressive effects, which help alleviate symptoms and slow the progression of the disease.
3. Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methotrexate γ-Methyl Ester is used as an impurity in the production of Methotrexate (M260675). The presence of this impurity is essential for the development and formulation of the final drug product, as it contributes to the overall efficacy and therapeutic potential of Methotrexate.
4. Used in Research and Development:
Methotrexate γ-Methyl Ester serves as a valuable compound in the field of research and development, particularly in the study of folic acid antagonists and their potential applications in cancer treatment and autoimmune disease management. It provides researchers with insights into the structure-activity relationships and mechanisms of action of related compounds, paving the way for the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 67022-39-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,0,2 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 67022-39:
(7*6)+(6*7)+(5*0)+(4*2)+(3*2)+(2*3)+(1*9)=113
113 % 10 = 3
So 67022-39-3 is a valid CAS Registry Number.
67022-39-3Relevant articles and documents
The use of Tris-lipidation to modify drug cytotoxicity in multidrug resistant cells expressing P-glycoprotein or MRP1
Davey, Ross A.,Davey, Mary W.,Cullen, Karen V.,Wells, Xanthe E.,Francis, Craig L.,Williams, Hua-Ming,Yang, Qi,Moghaddam, Minoo J.,Widmer, Fred,Whittaker, Robert G.
, p. 1280 - 1286 (2007/10/03)
1. Increasing the lipophilicity is a strategy often used to improve a compound's cellular uptake and retention but this may also convert it into a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associated pro
Syntheses of α- and γ-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism
Piper,Montgomery,Sirotnak,Chello
, p. 182 - 187 (2007/10/02)
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