67438-50-0

Basic information

• Product Name: Hydrazinecarbothioamide, 2-[[2-(4-chlorophenyl)-1H-indol-3-yl]methylene]-N-phenyl-
• CAS NO: 67438-50-0
• Molecular Formula: C22H17ClN4S
• Molecular Weight: 404.923
• Mol File: 67438-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Hydrazinecarbothioamide, 2-[[2-(4-chlorophenyl)-1H-indol-3-yl]methylene]-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbothioamide, 2-[[2-(4-chlorophenyl)-1H-indol-3-yl]methylene]-N-phenyl-(67438-50-0)
• EPA Substance Registry System: Hydrazinecarbothioamide, 2-[[2-(4-chlorophenyl)-1H-indol-3-yl]methylene]-N-phenyl-(67438-50-0)

Safety Data

• Hazardous Substances Data: 67438-50-0(Hazardous Substances Data)

Upstream product

• 1217-83-0 2-(4-chlorophenyl)-1H-indole-3-carbaldehyde 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 103-72-0 phenyl isothiocyanate 
• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 100-63-0 phenylhydrazine 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 67438-67-9 3-phenyl-4-oxothiazolin-2-yl<2-(p-chlorophenyl)-indol-3-yl> hydrazone 

Relevant articles and documents

Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study

In this work, two novel series of indole-thiosemicarbazone derivatives were designed, synthesized, and evaluated for their cytotoxic activity against MCF-7, A-549, and Hep-G2 cell lines in comparison to etoposide and colchicine as the reference drugs. Generally, the synthesized compounds showed better cytotoxicity towards A-549 and Hep-G2 than MCF-7. Among them, (2E)-2-{[2-(4-chlorophenyl)-1H-indol-3-yl]methylidene}-N-(4-methoxyphenyl)hydrazinecarbothioamide (8l) was found to be the most potent compound against A-549 and Hep-G2, at least three times more potent than etoposide. The morphological analysis by the acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that compound 8l induced apoptosis in A-549 cells. Moreover, molecular docking methodology was exploited to elucidate the details of molecular interactions of the studied compounds with putative targets.