67528-24-9 Usage
Description
(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol, also known as (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol, is an organic compound with the molecular formula C9H9BrO. It is a chiral compound, meaning it has a non-superimposable mirror image, and exists as a pair of enantiomers. This chemical is known for its use in asymmetric synthesis and as a building block in the production of pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Industry:
(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol is used as a building block for the production of pharmaceuticals and other organic compounds. Its chiral nature makes it a valuable component in the synthesis of various drugs and medicinal compounds.
Used in Asymmetric Synthesis:
(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol is used as a key intermediate in asymmetric synthesis, a technique that allows for the selective formation of one enantiomer over another. This is crucial in the production of enantiomerically pure compounds, which are often necessary for biological activity and pharmaceutical applications.
Used in Synthesis of Natural Products:
(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol is used in the synthesis of natural products, which are complex organic compounds found in nature. Its unique structure and reactivity make it a useful component in the creation of these natural products.
Used in Chiral Ligand Synthesis:
(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol is used as a chiral ligand in catalytic reactions. Chiral ligands are essential for enantioselective catalysis, a process that allows for the selective formation of one enantiomer over another in a chemical reaction.
Used in Medicinal Chemistry Research:
(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol has applications in the field of medicinal chemistry and is being explored for its potential biological activity. Its unique properties and reactivity make it a promising candidate for the development of new drugs and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 67528-24-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,5,2 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 67528-24:
(7*6)+(6*7)+(5*5)+(4*2)+(3*8)+(2*2)+(1*4)=149
149 % 10 = 9
So 67528-24-9 is a valid CAS Registry Number.
67528-24-9Relevant articles and documents
A convenient synthesis of (1S,2R)-1,2-indene oxide and trans-(1S,2S)-2-bromo-1-indanol via oxazaborolidine-catalyzed borane reduction
Choi, Ok Kyoung,Cho, Byung Tae
, p. 903 - 907 (2001)
A facile synthesis of (1S,2R)-indene oxide with >99% e.e. and (1S,2S)-trans-2-bromo-1-indanol with 87% e.e. has been established by employing CBS-oxazaborolidine-catalyzed asymmetric borane reduction of 2-p-toluenesulfonyloxy-1-indanone using N-ethyl-N-isopropylaniline-borane complex as the borane carrier.
Synthesis of enantiomerically pure (1S, 2R)-epoxy indane and cis-(1R, 2S)-2-amino-1-indanol
Mitrochkine,Eydoux,Martres,Gil,Heumann,Reglier
, p. 59 - 62 (1995)
Enantiomerically pure (1S, 2R)-epoxy indane and cis-(1R, 2S)-2-amino-1-indanol were synthesized via highly enantioselective lipase catalyzed transesterification of racemic trans-2-bromo-1-indanol.
Halohydrin and its derivatives low priced high-efficient synthetic method (by machine translation)
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Paragraph 0108; 0109; 0110; 0111, (2017/08/25)
The invention discloses a halohydrin low priced high-efficient synthetic method, the organic solvent of formula I shown in the olefin compound with a halide, sulfoxide and additive mixing, by the olefin of hydroxy halogenate reaction, can be a high selectivity of the halohydrin the system results in the type II shown, wherein R1 , R2 , R3 , R4 , R5 And R6 Are selected from hydrogen, halogen, alkyl, hydroxyalkyl, alkoxy, ester, acyl, amido, dialkyl amino, aryl, substituted aromatic, heterocyclic aromatic group or substituted heterocyclic aromatic, R1 , R2 , R3 , R4 , R5 And R6 The presence of the respective independent may be identical or different; or R1 And R2 , R1 And R3 , R2 And R4 , R3 And R4 , R5 And R6 Combining to form a cycloalkyl or substituted cycloalkyl, benzo ring alkyl or substituted cycloalkyl, heterocycle or substituted heterocycle; M selected from hydrogen, lithium, sodium, potassium, cesium, beryllium, magnesium, calcium, strontium, barium, zinc, copper, iron, ammonium or tetraalkyl ammonium; X chlorine, bromine or iodine. (by machine translation)