676596-81-9

Basic information

• Product Name: Benzene, 1-(bromomethyl)-2-iodo-3,5-dimethoxy-
• CAS NO: 676596-81-9
• Molecular Formula: C9H10BrIO2
• Molecular Weight: 356.986
• Mol File: 676596-81-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(bromomethyl)-2-iodo-3,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(bromomethyl)-2-iodo-3,5-dimethoxy-(676596-81-9)
• EPA Substance Registry System: Benzene, 1-(bromomethyl)-2-iodo-3,5-dimethoxy-(676596-81-9)

Safety Data

• Hazardous Substances Data: 676596-81-9(Hazardous Substances Data)

Upstream product

• 877-88-3 3,5-dimethoxybenzyl bromide 
• 74726-77-5 2-iodo-3,5-bis(methoxy)benzenemethanol 
• 705-76-0 3,5-dimethoxybenzyl alcohol 

Relevant articles and documents

Three-component coupling approach toward the synthesis of a resorcylic acid lactone framework

A resorcylic acid lactone (RAL) framework was constructed based on a three-component coupling approach. The key step was the intermolecular alkylation of a protected cyanohydrin with an aromatic scaffold, and the subsequent carbonylative esterification of the aryl iodide with an alcohol. This sequence allowed the rapid assembly of three components without extra protection/deprotection steps. This synthetic strategy enables the ketone at the 2′ position to be masked as a protected cyanohydrin during the ester formation, thus avoiding an undesired isocoumarin formation. This method should be widely applicable to the synthesis of various types of RAL frameworks.

Syntheses and radical scavenging activities of resveratrol derivatives

Nine new resveratrol derivatives, having bromo, iodo, and fluoroethyl groups, were designed and synthesized. All compounds having free phenol groups showed good free radical scavenging activity. Among them, 2-bromoresveratrol 19 has a similar free radical scavenging activity to (+)-catechin.