74726-77-5

Basic information

• Product Name: 2-iodo-3,5-bis(methoxy)benzenemethanol
• Synonyms: 2-iodo-3,5-bis(methoxy)benzenemethanol
• CAS NO: 74726-77-5
• Molecular Weight: 294.089
• Mol File: 74726-77-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-iodo-3,5-bis(methoxy)benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-3,5-bis(methoxy)benzenemethanol(74726-77-5)
• EPA Substance Registry System: 2-iodo-3,5-bis(methoxy)benzenemethanol(74726-77-5)

Safety Data

• Hazardous Substances Data: 74726-77-5(Hazardous Substances Data)

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 74726-76-4 2-bromo-3,5-dimethoxybenzyl alcohol 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 19491-18-0 methyl 2-bromo-3,5-dimethoxybenzoate 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 

Downstream Products

• 250160-58-8 1-azidomethyl-2-iodo-3,5-dimethoxy-benzene 
• 153786-93-7 2-iodo-3,5-dimethoxybenzyl acetate 
• 1256350-54-5 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid 
• 676596-81-9 1-(bromomethyl)-2-iodo-3,5-dimethoxybenzene 

Relevant articles and documents

Symmetry-based approach to oligostilbenoids: Rapid entry to viniferifuran, shoreaphenol, malibatol A, and diptoindonesin G

The recognition of the local symmetric image within benzofuran-based natural oligostilbenoids guided us to design a modular synthetic approach to these molecules by utilizing a three-step sequence consisting of Sonogashira coupling, iodocyclization, and S

Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by Dictyostelium discoideum

4-Methyl-5-pentylbenzene-1,3-diol (MPBD) is a secondary metabolite of SteelyA polyketide synthase, which controls cell aggregation and spore maturation of Dictyostelium discoideum. In this study, chemical synthesis of MPBD and its derivatives was achieved. Structure-activity relationship (SAR) studies for antimicrobial activities against Escherichia coli and Bacillus subtilis were also conducted.

Total synthesis of (+)-papulacandin D

A total synthesis of (+)-papulacandin D has been achieved in 31 steps, in a 9.2% overall yield from commercially available materials. The synthetic strategy divided the molecule into two nearly equal sized subunits, the spirocyclic C-arylglycopyranoside and the polyunsaturated fatty acid side-chain. The C-arylglycopyranoside was prepared in 11 steps in a 30% overall yield from triacetoxyglucal. The fatty acid side-chain was also prepared in 11 steps in a 30% overall yield from geraniol. The key strategic transformations in the synthesis are: (1) a palladium-catalyzed, organosilanolate-based cross-coupling reaction of a dimethylglucal-silanol with an electron-rich and sterically hindered aromatic iodide and (2) a Lewis-base catalyzed, enantioselective allylation reaction of a dienal and allyltrichlorosilane. A critical element in the successful execution of the synthesis was the development of a suitable protecting group strategy that satisfied a number of stringent criteria.