67733-54-4

Basic information

• Product Name: (5β,6α)-6-Hydroxy-3-oxo-cholan-24-oic Acid
• Synonyms: (5β,6α)-6-Hydroxy-3-oxo-cholan-24-oic Acid
• CAS NO: 67733-54-4
• Molecular Formula: C24H38O4
• Molecular Weight: 390.55612
• Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 67733-54-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• CAS DataBase Reference: (5β,6α)-6-Hydroxy-3-oxo-cholan-24-oic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (5β,6α)-6-Hydroxy-3-oxo-cholan-24-oic Acid(67733-54-4)
• EPA Substance Registry System: (5β,6α)-6-Hydroxy-3-oxo-cholan-24-oic Acid(67733-54-4)

Safety Data

• Hazardous Substances Data: 67733-54-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

6α-Hydroxy bile acid analog. A receptor-specific activator of nuclear liver X receptor alpha.

Upstream product

• 186581-53-3 diazomethane 
• 1181-65-3 3α,6α-dihydroxy-5β-cholanic acid 3,6-diacetate, methyl ester 
• 83-49-8 Hyodeoxycholic Acid 
• 2868-48-6 methyl hyodeoxycholate 

Downstream Products

• 3022-90-0 6α-(toluene-sulfonyl-(4)-oxy)-3-oxo-5β-cholanoic acid-(24)-methyl ester 
• 3360-89-2 3α-oxo-6α-hydroxy-5β-cholan-24-oic acid methyl ester 
• 108630-52-0 3,3-ethanediyldioxy-24,24-diphenyl-5β-chol-23-en-6α-ol 
• 108516-80-9 3,3-ethanediyldioxy-24,24-diphenyl-5β-chola-20(22)ξ,23-dien-6α-ol 
• 108628-51-9 6α-acetoxy-3,3-ethanediyldioxy-24,24-diphenyl-5β-chol-23-ene 
• 108955-68-6 3,3-ethanediyldioxy-24,24-diphenyl-6α-(toluene-4-sulfonyloxy)-5β-chola-20(22)ξ,23-diene 

Relevant articles and documents

3-carbonyl-6alpha-hydroxyl-5beta-cholanic acid synthesis method

The invention discloses a 3-carbonyl-6alpha-hydroxyl-5beta-cholanic acid synthesis method. The hyodeoxycholic acid (HDCA) is used to have an oxidizing reaction with an oxidizing agent, a 3-hydroxyl ishighly selectively oxidized to synthesize a target product, the synthesis process is simple in flow and is easy to control, the source of the raw material is wide, the raw material is easy to get, and the 3-carbonyl-6alpha-hydroxyl-5beta-cholanic acid can be produced on a large scale.

Regiospecific oxidoreductions catalyzed by a new Pseudomonas paucimobilis hydroxysteroid dehydrogenase

The preparative-scale regio- and stereo-specific oxidation of hydroxy groups and reduction of keto functions at C(3) of several C21 bile acids, catalyzed by a new 3α-hydroxysteroid dehydrogenase (3α-HSDH) is reported. The crude enzyme, isolated from the cells of Pseudomonas paucimobilis, revealed the presence of a further enzymatic fraction containing a secondary alcohol dehydrogenase (SADH), that has been used to recycle the cofactor.