677708-75-7

Basic information

• Product Name: 1,2-Benzisothiazole, 3-[4-[2-(2-nitrophenyl)ethyl]-1-piperazinyl]-
• CAS NO: 677708-75-7
• Molecular Formula: C19H20N4O2S
• Molecular Weight: 368.459
• Mol File: 677708-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisothiazole, 3-[4-[2-(2-nitrophenyl)ethyl]-1-piperazinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisothiazole, 3-[4-[2-(2-nitrophenyl)ethyl]-1-piperazinyl]-(677708-75-7)
• EPA Substance Registry System: 1,2-Benzisothiazole, 3-[4-[2-(2-nitrophenyl)ethyl]-1-piperazinyl]-(677708-75-7)

Safety Data

• Hazardous Substances Data: 677708-75-7(Hazardous Substances Data)

Upstream product

• 69628-96-2 p-toluenesulfonic acid o-nitrophenethyl ester 
• 87691-88-1 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 103-82-2 phenylacetic acid 
• 865786-99-8 1-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-2-(2-nitro-phenyl)-ethanone 

Downstream Products

• 677708-39-3 8-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-phenyl-3,4-dihydro-1H-quinolin-2-one 
• 677708-84-8 8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-Phenyl-1,2,3,4-tetrahydro-quinoline 
• 677708-74-6 N-{2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-3-phenyl-acrylamide 
• 677708-73-5 {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-3-chloro-2,2-dimethyl-propionamide 
• 677708-72-4 {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-3-chloro-propionamide 
• 690972-26-0 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-amide 
• 884324-89-4 N-{2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-acrylamide 
• 677708-76-8 2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenylamine 

Relevant articles and documents

8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity

Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia.

PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES

This invention relates to compounds of the formula (1) wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.