679407-02-4

Basic information

• Product Name: 2'-cyano-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide
• CAS NO: 679407-02-4
• Molecular Weight: 487.345
• Mol File: 679407-02-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-cyano-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-cyano-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide(679407-02-4)
• EPA Substance Registry System: 2'-cyano-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide(679407-02-4)

Safety Data

• Hazardous Substances Data: 679407-02-4(Hazardous Substances Data)

Upstream product

• 229343-30-0 2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide 
• 5728-44-9 2'-cyano[1,1'-biphenyl]-4-carboxylic acid 
• 2042-37-7 o-cyanobromobenzene 
• 14047-29-1 4-carboxyphenylboronic acid 

Relevant articles and documents

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

Anthranilamides 4 and 5 were designed and synthesized as selective and orally bioavailable factor Xa inhibitors. Structural modifications aimed at lowering their lipophilicity were performed at the central phenyl ring and at the S4 binding biphenyl region by incorporating water solublizing substituents. The resulting compounds (e.g., 7, 8, 14, 30a, and 32b) are highly potent in vitro, and show improved activity in human plasma-based thrombin generation assay.